Brain tumors is one of the leading cause of cancer which is common among children and teenagers. Glioblastoma (GBM) is most common grade four tumor, is malignant and contains dead tumor cells. It is also called as Glioblastoma multiforme, it has variants of giant cell Glioblastoma and gliosarcoma found in cerebral hemisphere of brain. The exact cause of this tumor is not known but is also found in spinal cord and represents about 15.4% of all primary brain tumors. Glioblastoma is also difficult to treat because of number of different types of cells and thus combines various treatment plans combined. The drugs involved in treating glioblastoma are antineoplastic orcytotoxic drugs. There is significant development in chemotherapy drugs to treat the malignant tumors and each year there are new drugs in the market to overcome the blood-brain barrier.
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