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Chapter 2




The Chemistry of Life
Section 1: The Nature of
         Matter
Objectives
• What three subatomic particles make up
  atoms?
• How are all the isotopes of an element
  similar?
• What are the two types of chemical
  bonds?
The Big Idea
• Life Depends on chemistry
• Chemical reactions keep you
  alive
Atom
• Basic unit of matter
Democrites
Subatomic particles
• Protons - Positively charged (+)        Bind together
                                          to form the
• Neutrons - Not charged (neutral)        nucleus
• Electrons - Negatively charged (-)

                                Protons
 Electrons                                     Nucleus

                                   Neutrons
Element
• A pure substance that consists
  of just one type of atom
An elements atomic number = number of
protons
                            Atomic number
                  6

                C
               Carbon
               12.011
Isotope
• Atoms of the same element
  that differ in the number of
  neutrons they contain
Nonradioactive carbon-12   Nonradioactive carbon-13   Radioactive carbon-14




        6 electrons               6 electrons                 6 electrons
        6 protons                 6 protons                   6 protons
        6 neutrons                7 neutrons                  8 neutrons
The Sum of protons and neutrons in the nucleus of an
atom is its mass number


                         6

                       C
                     Carbon
                                        Mass number
                     12.011
• The weighted average of the
  masses of an elements isotope is
  called its atomic mass
Radioactive isotopes
• Can be dangerous
• Can be used
  practically
 – Radioactive dating
 – Treat cancer
 – Kill bacteria
Compounds
• A substance formed by the
  chemical combination of two or
  more elements in definite
  proportions
• Ex) H2O, NaCl
Table Salt
Ionic Bonds
• Formed when one or more
  electrons are transferred from
  one atom to another
Sodium atom (Na)          Chlorine atom (Cl)   Sodium ion (Na+)   Chloride ion (Cl-)




                  Transfer
                 of electron

 Protons +11                   Protons +17       Protons +11        Protons +17
 Electrons -11                 Electrons -17     Electrons -10      Electrons -18
 Charge      0                 Charge      0     Charge     +1      Charge     -1
• If an atom loses an electron it
  becomes positive

• If an atom gains an electron it
  becomes negative
Ions
• Positively and negatively
  charged atoms
Covalent Bonds
• Forms when electrons are
  shared between atoms
Molecule
• The structure that results when
  atoms are joined together by a
  covalent bond
• Smallest unit of most compounds
Van der Waals Forces
• A slight attraction that
  develops between the
  oppositely charged regions of
  nearby molecules due to
  unequal sharing of electrons
Homework
1. Describe the structure of an atom.
   Atoms are made up of protons and
   neutrons in a nucleus. Electrons are
   in constant motion in the space
   around the nucleus.
2. Why do all isotopes of an element
   have the same chemical properties
   They have the same number of
   electrons
3. What is a covalent bond?
   A bond formed when electrons are
  shared between atoms
4. What is a compound? How are they
  related to molecules
  A compound is a substance formed
  by the chemical combination of two or
  more elements in definite proportions.
  A molecule is the smallest unit of
  most compounds
5. How do Van der Waals forces
 hold molecules together?
 When the sharing of electrons
 are unequal, a molecule has
 regions that are charged. An
 attraction can occur between
 oppositely charged regions of
 nearby molecules
6. How are ionic bonds and Van
 der Waals forces similar? How
 are they different?
 In both cases, particles are
 held together by attractions
 between opposite charges.
 The difference is that ionic
 charges are stronger
Section 2: Properties of
        Water
Objectives
• Why are water molecules polar?
• What are acidic solutions? What
  are basic solutions?
The Big Idea
• Much of our planet is covered in
  water
• Water is necessary for life to exist
• If life exists on other planets,
  there most likely is water present
• Water has many properties that
  make life possible
Polarity
   (-)     The oxygen atom has
           a stronger attraction for
           electrons




   (+)
Hydrogen Bonds
• Because of waters partial
  charges, they can attract each
  other and create hydrogen bonds
• Not as strong as covalent or ionic
  bonds
• Waters ability to create multiple
  hydrogen bonds gives it many
  special properties
Cohesion
• Attraction between molecules of
  the same substance
Adhesion
• Attraction molecules of different
  substances
Mixture
• Material composed of two or more
  elements or compounds that are
  physically mixed but not
  chemically combined
• Ex.) salt & pepper, earths
  atmosphere
Solutions
• Mixture of two or more
  substances in which the
  molecules are evenly distributed
• Ex.) salt water
• Settles out over time
Solutions
             Cl-
  Cl-      Na+

                    Na+


           Water
Water
Solute
• Substance that is dissolved
• Ex.) salt
Solvent
• The substance that does the
  dissolving
• Ex.) Water
Suspensions
• Mixture of water and non-
  dissolved materials
• Ex.) sugar solution, blood
• Separate into pieces so small,
  they never settle out
The pH scale
• Indicated the concentration of
  hydrogen ions in a solution
Acid




Neutral




  Base
Acids
• Any compound that forms H+
  (hydrogen) ions in solution
Base
• A compound that produces OH-
  (hydroxide) ions in solution
Buffers
• Weak acids or bases that can
  react with strong acids or bases
  to prevent sharp, sudden pH
  changes
Homework
1. Use the structure of a water
   molecule to explain why its polar
   Oxygen atom has greater
   attraction for electrons, therefore
   the oxygen atom is negative and
   the hydrogen end is positive
2. Compare acidic and basic
 solutions in terms of their H+ ion
 and OH- ion concentrations
 Acid have more H+ ions than OH-
 ions, and bases have more OH-
 ions than H+ ions
3. What is the difference between a
 solution and a suspension?
 In a solution, all components are
 evenly distributed. In a
 suspension, un-dissolved
 particles are suspended
4. What does pH measure?
 The concentration of H+ ions in a
 solution

5. The strong acid hydrogen floride
 (HF) can be dissolved in pure
 water. Will the pH of the solution
 be greater or less than 7?
 less than 7
Section 3: Carbon Compounds
Objective
• What are the functions of each
  group of organic compounds?
Interest Grabber
 Section 2-3   Life’s backbone
• Most of the compounds that make up living
  things contain carbon. In fact, carbon makes
  up the basic structure, or “backbone,” of these
  compounds. Each atom of carbon has four
  electrons in its outer energy level, which
  makes it possible for each carbon atom to
  form four bonds with other atoms.

• As a result, carbon atoms can form long
  chains. A huge number of different carbon
  compounds exist. Each compound has a
  different structure. For example, carbon chains
  can be straight or branching. Also, other kinds
  of atoms can be attached to the carbon chain.
Methane   Acetylene   Butadiene   Benzene   Isooctane
Macromolecules “giant molecules”
• Formed by a process called
  polymerization
Monomers
• Smaller units
Polymers
• Linked up monomers
Carbohydrates
• Compounds made up of carbon,
  hydrogen, and oxygen atoms
  usually in a ratio of 1:2:1
• Main source of energy
• The monomers of starch are
  sugars
• Single sugar molecules are called
  monosaccharides
• The large macromolecules formed
  from monosaccharides are known
  as polysaccharides
Starch




         Glucose
Lipids
• Made mostly from carbon and
  hydrogen atoms
• Used to store energy
Lipid   Glycerol




Fatty Acids
Proteins
• Macromolecules that contain
  nitrogen as well as carbon,
  hydrogen, and oxygen
• Proteins are polymers of
  molecules called amino acids
Amino Acids


          Carboxyl group



General structure          Alanine   Serine
• More than 20 different amino
  acids, can join to any other amino
  acid
• The instructions for arranging
  amino acids into many different
  proteins are stored in DNA
• Each protein has a specific role
• The shape of proteins can be very
  important
Proteins



Amino
Acids
Nucleic Acids
• Macromolecules containing hydrogen,
  oxygen, nitrogen, carbon, and
  phosphorus
 Double
 Helix
Nucleotides
 • Consists of 3 parts: 5-carbon sugar,
   phosphate group and nitrogen base
                                   Nitrogen Base




Phosphate
group


                            5-Carbon Sugar
2 kinds of nucleic acids
• RNA (ribonucleic acids) –
  contains sugar ribose

• DNA (deoxyribonucleic acid) –
  contains sugar deoxyribose
Homework
1. Name four groups of organic compounds
   found in living things
   carbohydrate, lipid, protein, nucleic acids

2. Describe at least one function of each
    group of organic compounds
    carbohydrates – energy
    lipids – store energy
    proteins – form tissue
    nucleic acids – transmit hereditary
    information
3. Compare the structures and
 functions of lipids and starches
 Lipids are made from carbon and
 hydrogen. Starches are made of
 carbon, hydrogen and oxygen.
 They both can be used to store
 energy
Section 4: Chemical
Reactions and Enzymes
Objectives
• What happens to chemical bonds
  during chemical reactions?
• How do energy changes affect
  whether a chemical reaction will
  occur?
• Why are enzymes important to
  living things?
The Big Idea
• Living things are made up of
  chemical compounds
• Everything that happens to an
  organism is based on chemical
  reactions
Chemical Reactions
• A process that changes or
  transforms one set of chemicals
  into another
Reactants
• Elements or compounds that
  enter into a reaction
Products
• Elements or compounds
  produced by a chemical reaction
Example Reaction: Getting
      rid of carbon dioxide
 • In the blood

CO2 + H20  H2CO3 (carbonic acid)

 • In the lungs
H2CO3  CO2 + H2O
              Released as you
              breathe
Energy in reactions
      Energy-Absorbing Reaction         Energy-Releasing Reaction




                       Products                          Activation
                                                         energy

               Activation energy
                                   Reactants

Reactants
                                                        Products
Activation Energy
• The energy that is needed to get
  a reaction started
Enzymes
• Some chemical reactions are too
  slow or have activation energies
  that are too high to make them
  practical for living tissue
• These chemical reactions are
  made possible by catalysts
Catalyst
• Substance that speeds up the
  rate of chemical reactions
• Work by lowering a reactions
  activation energy
Enzyme
•   Biological catalysts
•   Speed up reactions in cells
•   Very specific
•   Named for the reaction is catylzes
•   Enzyme names always end in
    -ase
Reaction pathway
without enzyme             Activation energy
                           without enzyme




Reactants                                Activation
                                         energy
            Reaction pathway
                                         with enzyme
            with enzyme


                                               Products
Substrates
• The reactants of enzyme
  catalyzed reactions
• The active site of the enzyme and
  the substrate have
  complementary shapes
• Fit like a lock and key
Enzyme Action



  Enzyme – substrate complex
Enzyme
      ADP      (hexokinase)                      Glucose


                                                            Substrates

Products

                                                      ATP
 Glucose-6-
 phosphate



    Products                  Active site
    are released
                                                               Substrates
                              Enzyme-substrate                 bind to
                              complex
                                                               enzyme


                              Substrates
                              are converted
                              into products
Regulation of Enzyme Activity
• Enzymes are affected by any
  variable that affects chemical
  reactions
1. pH
2. Temperature
3. Concentration
   of enzyme
Homework
1. What happens to chemical bonds
   during chemical reactions
   Bonds are broken in reactants and
   new bonds are formed in products

2. Describe the role of energy in
   chemical reactions
   some chemical reactions release
   energy, and other chemical
   reactions absorb energy. Energy
   changes determine how easily a
   chemical reaction will occur
3. What are enzymes, and how are
 they important to living things?
 Enzymes are biological catylasts.
 Cells use enzymes to speed up
 virtually every important chemical
 reaction that takes place in cells
4. Describe how enzymes work,
 including the role of the enzyme
 substrate complex
 Substrates, the reactants of an
 enzyme-catylzed reaction, attach
 to the enzyme at an active site
 and form an enzyme – substrate
 complex. Once the complex is
 formed, the enzyme helps convert
 substrate into product
5. A change in pH can change the
  protein. How might a change in pH
  affect the function of an enzyme such
  as hexokinase (hint: think about the
  analogy of the lock and key)
  A change in pH could change the
  shape of hexokinase. This change
  would diminish the ability of glucose
  and ATP to bind to the active site of
  the enzyme.

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The Chemistry of Life

  • 2. Section 1: The Nature of Matter
  • 3. Objectives • What three subatomic particles make up atoms? • How are all the isotopes of an element similar? • What are the two types of chemical bonds?
  • 4. The Big Idea • Life Depends on chemistry • Chemical reactions keep you alive
  • 7. Subatomic particles • Protons - Positively charged (+) Bind together to form the • Neutrons - Not charged (neutral) nucleus • Electrons - Negatively charged (-) Protons Electrons Nucleus Neutrons
  • 8.
  • 9. Element • A pure substance that consists of just one type of atom
  • 10.
  • 11. An elements atomic number = number of protons Atomic number 6 C Carbon 12.011
  • 12. Isotope • Atoms of the same element that differ in the number of neutrons they contain
  • 13. Nonradioactive carbon-12 Nonradioactive carbon-13 Radioactive carbon-14 6 electrons 6 electrons 6 electrons 6 protons 6 protons 6 protons 6 neutrons 7 neutrons 8 neutrons
  • 14. The Sum of protons and neutrons in the nucleus of an atom is its mass number 6 C Carbon Mass number 12.011
  • 15. • The weighted average of the masses of an elements isotope is called its atomic mass
  • 16. Radioactive isotopes • Can be dangerous • Can be used practically – Radioactive dating – Treat cancer – Kill bacteria
  • 17. Compounds • A substance formed by the chemical combination of two or more elements in definite proportions • Ex) H2O, NaCl
  • 18.
  • 19.
  • 20.
  • 21.
  • 23. Ionic Bonds • Formed when one or more electrons are transferred from one atom to another
  • 24. Sodium atom (Na) Chlorine atom (Cl) Sodium ion (Na+) Chloride ion (Cl-) Transfer of electron Protons +11 Protons +17 Protons +11 Protons +17 Electrons -11 Electrons -17 Electrons -10 Electrons -18 Charge 0 Charge 0 Charge +1 Charge -1
  • 25. • If an atom loses an electron it becomes positive • If an atom gains an electron it becomes negative
  • 26. Ions • Positively and negatively charged atoms
  • 27.
  • 28. Covalent Bonds • Forms when electrons are shared between atoms
  • 29.
  • 30. Molecule • The structure that results when atoms are joined together by a covalent bond • Smallest unit of most compounds
  • 31. Van der Waals Forces • A slight attraction that develops between the oppositely charged regions of nearby molecules due to unequal sharing of electrons
  • 32.
  • 33.
  • 35. 1. Describe the structure of an atom. Atoms are made up of protons and neutrons in a nucleus. Electrons are in constant motion in the space around the nucleus. 2. Why do all isotopes of an element have the same chemical properties They have the same number of electrons
  • 36. 3. What is a covalent bond? A bond formed when electrons are shared between atoms 4. What is a compound? How are they related to molecules A compound is a substance formed by the chemical combination of two or more elements in definite proportions. A molecule is the smallest unit of most compounds
  • 37. 5. How do Van der Waals forces hold molecules together? When the sharing of electrons are unequal, a molecule has regions that are charged. An attraction can occur between oppositely charged regions of nearby molecules
  • 38. 6. How are ionic bonds and Van der Waals forces similar? How are they different? In both cases, particles are held together by attractions between opposite charges. The difference is that ionic charges are stronger
  • 40. Objectives • Why are water molecules polar? • What are acidic solutions? What are basic solutions?
  • 41. The Big Idea • Much of our planet is covered in water • Water is necessary for life to exist • If life exists on other planets, there most likely is water present • Water has many properties that make life possible
  • 42. Polarity (-) The oxygen atom has a stronger attraction for electrons (+)
  • 43. Hydrogen Bonds • Because of waters partial charges, they can attract each other and create hydrogen bonds • Not as strong as covalent or ionic bonds • Waters ability to create multiple hydrogen bonds gives it many special properties
  • 44. Cohesion • Attraction between molecules of the same substance
  • 45.
  • 46.
  • 47. Adhesion • Attraction molecules of different substances
  • 48.
  • 49. Mixture • Material composed of two or more elements or compounds that are physically mixed but not chemically combined • Ex.) salt & pepper, earths atmosphere
  • 50. Solutions • Mixture of two or more substances in which the molecules are evenly distributed • Ex.) salt water • Settles out over time
  • 51. Solutions Cl- Cl- Na+ Na+ Water Water
  • 52. Solute • Substance that is dissolved • Ex.) salt
  • 53. Solvent • The substance that does the dissolving • Ex.) Water
  • 54. Suspensions • Mixture of water and non- dissolved materials • Ex.) sugar solution, blood • Separate into pieces so small, they never settle out
  • 55. The pH scale • Indicated the concentration of hydrogen ions in a solution
  • 57. Acids • Any compound that forms H+ (hydrogen) ions in solution
  • 58. Base • A compound that produces OH- (hydroxide) ions in solution
  • 59. Buffers • Weak acids or bases that can react with strong acids or bases to prevent sharp, sudden pH changes
  • 61. 1. Use the structure of a water molecule to explain why its polar Oxygen atom has greater attraction for electrons, therefore the oxygen atom is negative and the hydrogen end is positive
  • 62. 2. Compare acidic and basic solutions in terms of their H+ ion and OH- ion concentrations Acid have more H+ ions than OH- ions, and bases have more OH- ions than H+ ions
  • 63. 3. What is the difference between a solution and a suspension? In a solution, all components are evenly distributed. In a suspension, un-dissolved particles are suspended
  • 64. 4. What does pH measure? The concentration of H+ ions in a solution 5. The strong acid hydrogen floride (HF) can be dissolved in pure water. Will the pH of the solution be greater or less than 7? less than 7
  • 65. Section 3: Carbon Compounds
  • 66. Objective • What are the functions of each group of organic compounds?
  • 67. Interest Grabber Section 2-3 Life’s backbone • Most of the compounds that make up living things contain carbon. In fact, carbon makes up the basic structure, or “backbone,” of these compounds. Each atom of carbon has four electrons in its outer energy level, which makes it possible for each carbon atom to form four bonds with other atoms. • As a result, carbon atoms can form long chains. A huge number of different carbon compounds exist. Each compound has a different structure. For example, carbon chains can be straight or branching. Also, other kinds of atoms can be attached to the carbon chain.
  • 68. Methane Acetylene Butadiene Benzene Isooctane
  • 69. Macromolecules “giant molecules” • Formed by a process called polymerization
  • 72. Carbohydrates • Compounds made up of carbon, hydrogen, and oxygen atoms usually in a ratio of 1:2:1 • Main source of energy • The monomers of starch are sugars
  • 73. • Single sugar molecules are called monosaccharides • The large macromolecules formed from monosaccharides are known as polysaccharides
  • 74. Starch Glucose
  • 75. Lipids • Made mostly from carbon and hydrogen atoms • Used to store energy
  • 76. Lipid Glycerol Fatty Acids
  • 77. Proteins • Macromolecules that contain nitrogen as well as carbon, hydrogen, and oxygen • Proteins are polymers of molecules called amino acids
  • 78. Amino Acids Carboxyl group General structure Alanine Serine
  • 79. • More than 20 different amino acids, can join to any other amino acid • The instructions for arranging amino acids into many different proteins are stored in DNA • Each protein has a specific role • The shape of proteins can be very important
  • 81. Nucleic Acids • Macromolecules containing hydrogen, oxygen, nitrogen, carbon, and phosphorus Double Helix
  • 82. Nucleotides • Consists of 3 parts: 5-carbon sugar, phosphate group and nitrogen base Nitrogen Base Phosphate group 5-Carbon Sugar
  • 83. 2 kinds of nucleic acids • RNA (ribonucleic acids) – contains sugar ribose • DNA (deoxyribonucleic acid) – contains sugar deoxyribose
  • 85. 1. Name four groups of organic compounds found in living things carbohydrate, lipid, protein, nucleic acids 2. Describe at least one function of each group of organic compounds carbohydrates – energy lipids – store energy proteins – form tissue nucleic acids – transmit hereditary information
  • 86. 3. Compare the structures and functions of lipids and starches Lipids are made from carbon and hydrogen. Starches are made of carbon, hydrogen and oxygen. They both can be used to store energy
  • 88. Objectives • What happens to chemical bonds during chemical reactions? • How do energy changes affect whether a chemical reaction will occur? • Why are enzymes important to living things?
  • 89. The Big Idea • Living things are made up of chemical compounds • Everything that happens to an organism is based on chemical reactions
  • 90. Chemical Reactions • A process that changes or transforms one set of chemicals into another
  • 91. Reactants • Elements or compounds that enter into a reaction
  • 92. Products • Elements or compounds produced by a chemical reaction
  • 93. Example Reaction: Getting rid of carbon dioxide • In the blood CO2 + H20  H2CO3 (carbonic acid) • In the lungs H2CO3  CO2 + H2O Released as you breathe
  • 94. Energy in reactions Energy-Absorbing Reaction Energy-Releasing Reaction Products Activation energy Activation energy Reactants Reactants Products
  • 95. Activation Energy • The energy that is needed to get a reaction started
  • 96.
  • 97. Enzymes • Some chemical reactions are too slow or have activation energies that are too high to make them practical for living tissue • These chemical reactions are made possible by catalysts
  • 98. Catalyst • Substance that speeds up the rate of chemical reactions • Work by lowering a reactions activation energy
  • 99. Enzyme • Biological catalysts • Speed up reactions in cells • Very specific • Named for the reaction is catylzes • Enzyme names always end in -ase
  • 100. Reaction pathway without enzyme Activation energy without enzyme Reactants Activation energy Reaction pathway with enzyme with enzyme Products
  • 101. Substrates • The reactants of enzyme catalyzed reactions • The active site of the enzyme and the substrate have complementary shapes • Fit like a lock and key
  • 102. Enzyme Action Enzyme – substrate complex
  • 103. Enzyme ADP (hexokinase) Glucose Substrates Products ATP Glucose-6- phosphate Products Active site are released Substrates Enzyme-substrate bind to complex enzyme Substrates are converted into products
  • 104. Regulation of Enzyme Activity • Enzymes are affected by any variable that affects chemical reactions 1. pH 2. Temperature 3. Concentration of enzyme
  • 105.
  • 107. 1. What happens to chemical bonds during chemical reactions Bonds are broken in reactants and new bonds are formed in products 2. Describe the role of energy in chemical reactions some chemical reactions release energy, and other chemical reactions absorb energy. Energy changes determine how easily a chemical reaction will occur
  • 108. 3. What are enzymes, and how are they important to living things? Enzymes are biological catylasts. Cells use enzymes to speed up virtually every important chemical reaction that takes place in cells
  • 109. 4. Describe how enzymes work, including the role of the enzyme substrate complex Substrates, the reactants of an enzyme-catylzed reaction, attach to the enzyme at an active site and form an enzyme – substrate complex. Once the complex is formed, the enzyme helps convert substrate into product
  • 110. 5. A change in pH can change the protein. How might a change in pH affect the function of an enzyme such as hexokinase (hint: think about the analogy of the lock and key) A change in pH could change the shape of hexokinase. This change would diminish the ability of glucose and ATP to bind to the active site of the enzyme.

Notas do Editor

  1. Sodium – silver colored metal, soft enough to cut with a knife
  2. Sodium reacting explosively in water
  3. Chlorine – poisonous green gas used to kill many people in WWII
  4. Combination of sodium and chlorine