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MIREOT Minimal information to reference external ontology terms Mélanie Courtot, Frank Gibson, Allyson L. Lister, James Malone, Daniel Schober, Ryan R. Brinkman and Alan Ruttenberg ICBO: International Conference on Biomedical Ontology University at Buffalo, NY ▪ July 24-26, 2009 Session 4: Creating ontologies that work together
Background –  the OBI project ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Modeling experimental processes See the OBI poster for more information
Some material entities in OBI anatomical entity (FMA, CARO) protein complex (Gene Ontology) molecular entity (ChEBI) organism  (NCBI taxonomy) processed material material entity chemical entities in solution device cell culture organization cell (Cell Ontology) PCR product
Ontologies that OBI uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Challenges of imports
Possible Solutions ,[object Object],[object Object],[object Object]
1. Create our own terms ,[object Object],[object Object],[object Object],OBI: cell OBI: cancer CL: cell NCI: cancer
2. Import modules ,[object Object],[object Object],OBI Cell  Ontology
3. Full import ,[object Object],[object Object],[object Object],! OBI FMA
Observation ,[object Object],[object Object],[object Object],[object Object]
Our Proposal: Import only classes that are needed  ,[object Object],[object Object],[object Object]
Implementation ,[object Object],[object Object]
Define the minimal information we need ,[object Object],[object Object],[object Object],[object Object]
Additional information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Step 1: “import” the term external.owl ,[object Object],[object Object],[object Object],[object Object],Perl script
Step 2: add information ,[object Object],[object Object],[object Object],Use external.owl to generate SPARQL queries external.owl externalDerived.owl
Step 3: Plug it in external.owl externalDerived.owl Pre-release update obi.owl IMPORTS
Summary ,[object Object],[object Object],[object Object]
OntoFox: a Web Server for MIREOTing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://ontofox.hegroup.org
Some links ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thank you ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NIH (R01EB005034), the EC EMERALD project (LSHG-CT-2006-037686), the BBSRC (BB/C008200/1, BB/D524283/1, BB/E025080/1),  the EU FP7 DebugIT project (ICT-2007.5.2-217139),  and the Michael Smith Foundation for Health Research.   PHAC/CIHR Influenza Research Network The OBI Consortium

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MIREOT

  • 1. MIREOT Minimal information to reference external ontology terms Mélanie Courtot, Frank Gibson, Allyson L. Lister, James Malone, Daniel Schober, Ryan R. Brinkman and Alan Ruttenberg ICBO: International Conference on Biomedical Ontology University at Buffalo, NY ▪ July 24-26, 2009 Session 4: Creating ontologies that work together
  • 2.
  • 3. Modeling experimental processes See the OBI poster for more information
  • 4. Some material entities in OBI anatomical entity (FMA, CARO) protein complex (Gene Ontology) molecular entity (ChEBI) organism (NCBI taxonomy) processed material material entity chemical entities in solution device cell culture organization cell (Cell Ontology) PCR product
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18. Step 3: Plug it in external.owl externalDerived.owl Pre-release update obi.owl IMPORTS
  • 19.
  • 20.
  • 21.
  • 22.

Notas do Editor

  1. Terms necessary for describing biomedical investigations as well as defining necessary cross-product terms are already available in a number of OBO ontologies.
  2. For example, OBI's scope include materials made and produced for investigations, many of which are derived from natural entities described in the GO cellular component Ontology, Cell Ontology, and ChEBI, qualities of which can be described by terms in PATO OBI is committed to using existing terms from other ontologies - OBI follows OBO Foundry principles
  3. ChEBI encompasses molecular entities, with focus on 'small" chemical coumpounds, PATO is an ontology of phenotypic qualities, intended for use in a number of applications, primarily defining composite phenotypes and phenotype annotation. the FMA is a domain ontology that represents a coherent body of explicit declarative knowledge about human anatomy. The Cell Ontology is designed as a structured controlled vocabulary for cell types. The NCBI Taxonomy database is a curated set of names and classifications for all of the organisms that are represented in GenBank
  4. First, some OWL tools ( e.g., Protégé, SWOOP) can neither load or reason over very large ontologies, such as the NCBI Taxonomy 2 or the Foundational Model of Anatomy 3 , making direct OWL imports of such ontologies impractical. Second, different resources may have been constructed using different design principles, which may not align. Importing such ontologies as a whole could lead to inconsistencies or unintended inferences.
  5. Script uses external.owl to create sparql queries based on templates for each resource.
  6. Keeping files separated from the “main” ontology allows us to destroy externalDerived.owl, containing the additional information more prone to change, before each release, and we can easily regenerate it in order to distribute up to date information. Also we hope that in the future we would be able to import whole ontologies, and the replacement would then be easy.