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Syntactic Mediation in Grid and Web Service Architectures Martin Szomszor Terry R. Payne Luc Moreau University of Southampton myGrid [ http://www.mygrid.org.uk]
Syntactic Mediation… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
…  in Grid and Web Services ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Grid and Web Services ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
myGrid  -  Bioinformatics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Taverna Workbench
A Bioinformatics Use Case ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bio Example - Workflow ,[object Object],[object Object],Get  Sequence Data Sequence Data Alignment Result Sequence Alignment XEMBL Service DDBJ-XML Service NCBI Blast Accession Number
Bio Example - Workflow ,[object Object],[object Object],[object Object],Accession Number XEMBL Service Sequence Data Alignment Result NCBI Blast Service Accession Number DDBJ-XML Service Sequence Data Alignment Result NCBI Blast Service
Syntactic Compatibility ,[object Object],Conceptually the same type But different syntactic types XEMBL Service Sequence Data NCBI Blast Service XEMBL Service BSML  Sequence  Record NCBI Blast Service FASTA  Formatted Sequence
Syntactic Mediation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Assisted Mediation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Syntactic Mediation XEMBL Service NCBI Blast Service FASTA  Formatted  Sequence   Alignment Results   Conceptual representation of sequence data Transform XML output from XEMBL service to OWL concept instance Serialise OWL concept instance to XML for input to NCBI Blast Service BSML Sequence Record   Accession Number
Bioinformatics Use Case: Sequence Data Ontology authors journal title Key: Object property Subconcept Sequence_Data description accession_id sequence has_feature has_reference Reference Sequence_Feature location Feature_Source lab_host isolate mol_type organsim Feature_CDS translation product protien_id Sequence_Location start end BSML_Sequence_Data date_created date_last_updated DDBJ_Sequence_Data version division
Transformation of XML to OWL <Sequence ic-acckey=&quot;AB000059&quot;> <Feature-table> <Feature class=&quot;SOURCE&quot;> <Qualifier value-type=&quot;isolate” value=&quot;Som1&quot;/> <Qualifier value-type=&quot;organism” value=&quot;Feline …”/> <Interval-loc startpos=&quot;1&quot; endpos=&quot;1755&quot;/> </Feature> </Feature-table> </Sequence> Sequence Data Accession_ID Feature Source Location has-Feature isolate organism has-location start end AB000059 Som1 Feline … 1 1755
Transformation of OWL to XML Sequence Data Accession_ID Feature Source Location has-Feature isolate organism has-location start end <DDBJXML> <ACCESSION>AB000059</ACCESSION> <FEATURES> <source> <location>1..1755</location> <qualifiers name=&quot;isolate&quot;>Som1</qualifiers> <qualifiers name=&quot;organsim&quot;>Felis ...</qualifiers> </source> </FEATURES> </DDBJXML> AB000059 Som1 Feline … 1 1755
Mapping Language ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Example Mapping 1 ,[object Object],<Sequence ic-acckey=&quot;AB000059&quot;> Sequence Data Accession_ID {xml} Sequence[ic-acckey = $accession] <-> {owl} Sequence_Data( Accession_id($accession)) $accession AB000059
Example Mapping 2 ,[object Object],Sequence Data sequence {xml} Sequence( seq-data($sequence)) <-> {owl} Sequence_Data( sequence($sequence)) $sequence <Sequence> <seq-data>aatagagtg…</seq-data> </Sequence> aatagagtg…
Example Mapping 3 ,[object Object],<Reference> <RefAuthors>Horiuchi M.</RefAuthors> <RefTitle>evolutionary…</RefTitle> <RefJournal>Unpublished</RefJournal> </Reference> Reference author {xml} Reference( RefAuthors($author), RefTitle($title), RefJournal($journal)) <-> {owl} Reference( author($author), title($title), journal($journal)) title journal Horiuchi, M. Evolutionary… Unpublished
Example Mapping 4 ,[object Object],<location>1:1755</location> Sequence_Location start {xml} location( split($start, “:”, $end) ) <-> {owl} Sequence_Location( start($start), end($end) ) end 1 1755
Example Mapping 5 ,[object Object],[object Object],<feature-table> <Reference> <RefAuthors>Horiuchi M.</RefAuthors> <RefTitle>evolutionary…</RefTitle> <RefJournal>Unpublished</RefJournal> </Reference> <Reference> <RefAuthors>Horiuchi M.</RefAuthors> <RefJournal>EMBL/GenBank/DDBJ…</RefJournal> </Reference> </feature-table>
Example Mapping 5 ,[object Object],Reference author title journal Reference author journal Sequence_Data has-reference has-reference Horiuchi, M. Evolutionary… Unpublished Horiuchi, M. EMBL/GenBank/DDBJ…
Example Mapping 5 ,[object Object],{xml} feature-table( Reference( RefAuthors($author), RefTitle($title), RefJournal($journal) )… ) <-> {owl} Sequence_Data( Reference( author($authors), title($title), journal($journal) )… ) sequence
Mapping Language (BNF)
Mapping Language Engine ,[object Object],[object Object],[object Object]
Transformation Process ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Assisted data mediation for WS XEMBL Service NCBI Blast Service BSML Sequence Record   Accession Number   FASTA  Formatted  Sequence   Alignment Results   Conceptual representation of sequence data Transform XML output from XEMBL service to OWL concept instance Serialise OWL concept instance to XML for input to NCBI Blast Service
Assisted data mediation for WS XEMBL Service NCBI Blast Service FASTA  Formatted  Sequence   Alignment Results   Mapping Language Engine Mapping   Mapping Language Engine Mapping   BSML Sequence Record   Accession Number   OWL instance
Comparison  of Approaches Create one mapping to conceptual model Must create mappings to all other compatible formats Addition of Data 1 mapping from each data format to its conceptual model. For  n  compatible data formats,  n  mappings required 1 mapping for each pair of compatible data formats. For  n  compatible formats,  n 2  mappings required Number of Mappings Mappings from data format to common conceptual model Direct mappings between compatible data formats
Why OWL? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusions ,[object Object],[object Object]
Further Work ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Questions and comments?

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Syntactic Mediation in Grid and Web Service Architectures

  • 1. Syntactic Mediation in Grid and Web Service Architectures Martin Szomszor Terry R. Payne Luc Moreau University of Southampton myGrid [ http://www.mygrid.org.uk]
  • 2.
  • 3.
  • 4.
  • 5.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. Syntactic Mediation XEMBL Service NCBI Blast Service FASTA Formatted Sequence Alignment Results Conceptual representation of sequence data Transform XML output from XEMBL service to OWL concept instance Serialise OWL concept instance to XML for input to NCBI Blast Service BSML Sequence Record Accession Number
  • 14. Bioinformatics Use Case: Sequence Data Ontology authors journal title Key: Object property Subconcept Sequence_Data description accession_id sequence has_feature has_reference Reference Sequence_Feature location Feature_Source lab_host isolate mol_type organsim Feature_CDS translation product protien_id Sequence_Location start end BSML_Sequence_Data date_created date_last_updated DDBJ_Sequence_Data version division
  • 15. Transformation of XML to OWL <Sequence ic-acckey=&quot;AB000059&quot;> <Feature-table> <Feature class=&quot;SOURCE&quot;> <Qualifier value-type=&quot;isolate” value=&quot;Som1&quot;/> <Qualifier value-type=&quot;organism” value=&quot;Feline …”/> <Interval-loc startpos=&quot;1&quot; endpos=&quot;1755&quot;/> </Feature> </Feature-table> </Sequence> Sequence Data Accession_ID Feature Source Location has-Feature isolate organism has-location start end AB000059 Som1 Feline … 1 1755
  • 16. Transformation of OWL to XML Sequence Data Accession_ID Feature Source Location has-Feature isolate organism has-location start end <DDBJXML> <ACCESSION>AB000059</ACCESSION> <FEATURES> <source> <location>1..1755</location> <qualifiers name=&quot;isolate&quot;>Som1</qualifiers> <qualifiers name=&quot;organsim&quot;>Felis ...</qualifiers> </source> </FEATURES> </DDBJXML> AB000059 Som1 Feline … 1 1755
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  • 28. Assisted data mediation for WS XEMBL Service NCBI Blast Service BSML Sequence Record Accession Number FASTA Formatted Sequence Alignment Results Conceptual representation of sequence data Transform XML output from XEMBL service to OWL concept instance Serialise OWL concept instance to XML for input to NCBI Blast Service
  • 29. Assisted data mediation for WS XEMBL Service NCBI Blast Service FASTA Formatted Sequence Alignment Results Mapping Language Engine Mapping Mapping Language Engine Mapping BSML Sequence Record Accession Number OWL instance
  • 30. Comparison of Approaches Create one mapping to conceptual model Must create mappings to all other compatible formats Addition of Data 1 mapping from each data format to its conceptual model. For n compatible data formats, n mappings required 1 mapping for each pair of compatible data formats. For n compatible formats, n 2 mappings required Number of Mappings Mappings from data format to common conceptual model Direct mappings between compatible data formats
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Notas do Editor

  1. Welcome The term mediation is often overloaded…