6. CLINICAL DIFFERENCES B/W HD & NHL HD NHL 1.Cellular derivation unresolved 90% B – cell, 10% T- cell, rarely monocytic 2.Localised to a single group of LN Involvement of multiple peripheral LN 3.Spreads by contiguity Non contiguous spread 4.Mesnteric LN & Waldeyer's ring rarely involved Commonly involved 5.Exta nodal involvement uncommon Common 6.BM involvement uncommon Common 7.Chromosomal translocation yet to be described Common 8. Curability >75% <30-40%