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                                                                                                                                                                                                                         Hyperphosphatemia
HYPERPHOSPHATEMIA                                                              	                                                                                    ICD-9CM # ​
                                                                                                                                                                              995.5 ​
                                                                                                                                                                                    Child Maltreatment Syndrome
                                                                                                                                             Rhabdomyolysis
                                                                                             Cell destruction
                                                                                                                                             Hyperpyrexia
                                                                                                                                             Hemolysis
                                                                                                                                                                      Leukemia
                                                                                                                                             Neoplastic
                                                                                   CPK Ͼ110 mg/dl                                                                     Lymphoma
                                                                                                                                             Tumor lysis syndrome
                                                                                   LDH Ͼ220 mg/dl
                                                                                   UA Ͼ7.5 mg/dl


                                                       Increased               Check
                                                       phosphorus load         LDH,          Cutaneous          White phosphorus burns
                                                                               UA,
                                                                               CPK                                   Transfusion of stored blood
                                                                                             Parenteral
                                                                                                                     Intravenous PO4             Replacement therapy
                                                                                                                                                 PO4-containing laxatives or enemas
                                                                                             Enteral            PO4 intake
                                                                                                                                                 Etidronate disodium
                                                                                                                Vit D intoxication
                                                                                                                                                           Respiratory acidosis

                                                                                                                                             Anion gap 8-13


                                                                                                                                       Check
                                                                                                                      Acidosis         anion
                                                                                                                                       gap
                                                                                            HCOϪ Ͻ22 mEq/L
                                                                                               3


                      UPO4 Ͼ1500 mg/day                                                                                                      Anion gap Ͼ13
                                                                                           Check                                                                    Lactic acidosis
                                                       Redistribution of phosphorus                                                                                 Diabetic ketoacidosis
                                                                                           HCOϪ3
                                                                                                                                                                    Tissue ischemia

                                                                                            HCOϪ Ͼ22 mEq/L
                                                                                               3
 Hyperphosphatemia            Check
 (SPO4 Ͼ5.2 mg/dl)            UPO4                                                                                                                   Cortical hyperostosis
                                                                                                                      Miscellaneous causes
                                                                                                                                                     Familial hyperphosphatemia

                                                                                                                             Acute renal failure
                      UPO4 Ͻ1500 mg/day                                                        Decreased filtration                                                                  Hypoparathyroidism
                                                                                                                             Chronic renal failure
                                                                         CrCI Ͻ25 ml/min                                                                              PTH Ͻ29 pmol/L


                                       Decreased             Measure                                                                                       Check
                                       PO4 excretion         CrCI                                                                                          Ca
                                                                                                                                    Ca Ͻ8.5 mg/dl
                                                                         CrCI Ͼ25 ml/min                                                                            PTH 29-81 pmol/L
                                                                                                                                                                                              Pseudohypoparathyroidism
                                                                                               Decreased tubular            Check                                                             Abnormal PTH
                                                                                               clearance                    Ca                                                                Multiple myeloma

                                                                                                                                                                                  Hyperthyroidism
                                                                                                                                 Ca 8.5-10.4 mg/dl           Hormonal             Acromegaly
                                                                                                                                                                                  Postmenopausal
                                                                                                                                                                                  Volume contraction
FIGURE 3-166  ​ pproach to hyperphosphatemia. CT, Computed tomography; MRI, magnetic resonance imaging; T,
                  A                                                                                                                                                               Mg deficiency
                                                                                                                                                             Nonhormonal
thyroxine; TSH, thyroid-stimulating hormone. (From Healey PM: Common medical diagnosis: an algorithmic approach, ed                                                              Hyperthermia
3, Philadelphia, 2000, WB Saunders.)                                                                                                                                              Tumor calcinosis

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Hyperphosphatemia

  • 1. 1278 Hyperphosphatemia HYPERPHOSPHATEMIA ICD-9CM # ​ 995.5 ​ Child Maltreatment Syndrome Rhabdomyolysis Cell destruction Hyperpyrexia Hemolysis Leukemia Neoplastic CPK Ͼ110 mg/dl Lymphoma Tumor lysis syndrome LDH Ͼ220 mg/dl UA Ͼ7.5 mg/dl Increased Check phosphorus load LDH, Cutaneous White phosphorus burns UA, CPK Transfusion of stored blood Parenteral Intravenous PO4 Replacement therapy PO4-containing laxatives or enemas Enteral PO4 intake Etidronate disodium Vit D intoxication Respiratory acidosis Anion gap 8-13 Check Acidosis anion gap HCOϪ Ͻ22 mEq/L 3 UPO4 Ͼ1500 mg/day Anion gap Ͼ13 Check Lactic acidosis Redistribution of phosphorus Diabetic ketoacidosis HCOϪ3 Tissue ischemia HCOϪ Ͼ22 mEq/L 3 Hyperphosphatemia Check (SPO4 Ͼ5.2 mg/dl) UPO4 Cortical hyperostosis Miscellaneous causes Familial hyperphosphatemia Acute renal failure UPO4 Ͻ1500 mg/day Decreased filtration Hypoparathyroidism Chronic renal failure CrCI Ͻ25 ml/min PTH Ͻ29 pmol/L Decreased Measure Check PO4 excretion CrCI Ca Ca Ͻ8.5 mg/dl CrCI Ͼ25 ml/min PTH 29-81 pmol/L Pseudohypoparathyroidism Decreased tubular Check Abnormal PTH clearance Ca Multiple myeloma Hyperthyroidism Ca 8.5-10.4 mg/dl Hormonal Acromegaly Postmenopausal Volume contraction FIGURE 3-166  ​ pproach to hyperphosphatemia. CT, Computed tomography; MRI, magnetic resonance imaging; T, A Mg deficiency Nonhormonal thyroxine; TSH, thyroid-stimulating hormone. (From Healey PM: Common medical diagnosis: an algorithmic approach, ed Hyperthermia 3, Philadelphia, 2000, WB Saunders.) Tumor calcinosis