This document discusses ocular drug delivery systems. It begins by outlining the anatomy of the human eye and general pathways for ocular absorption. Several factors that affect intraocular bioavailability are then described, including inflow/outflow of lacrimal fluids and drug interaction with lacrimal proteins. The role of polymers in ocular drug delivery systems is discussed in terms of solution viscosity and mucoadhesive properties. Various classifications of ophthalmic dosage forms are presented, including ocular controlled release systems such as ophthalmic inserts. Desirable properties of controlled release ocular inserts and different types including non-erodible and erodible inserts are defined. Recent advances in ocular drug delivery technologies such as g

1. Ocular Drug Delivery System Presented by : Mahesh W. Thube, M.Pharm II, Dept. Of P’ceu, GCP, Aurangabad.

2. Human eye consist of :-

3. Mechanism Of Ocular Absorption

4. General Pathway For Ocular Absorption

6. 2. Efficient naso-lacrimal drainage.

7. 3. Interaction of drug with proteins of Lacrimal fluid.

9. Polymer Mucoadhesive Vehicle: Retained in the eye due to non-covalent bonding between with conjuctival mucine.

11. Ocular indication of controlled-release systems

12. Ocular Control Release System: Ophthalmic Inserts Definition:- Solid or Semisolid in nature, - Placed in lower Fornix - Composed of Polymeric vehicle containing drug. Desired Criteria For Control Release Ocular Inserts.

14. Types Of Ocular Control Release System

16. Oval flexible ocular insert,

20. Composition: HPC without preservative.

21. Weight:5mg,

22. Dimension:Diameter:12.5mm, Length:3.5mm

24. Composition : Acryl amide, Vinyl Pyrolidone, Ethylacrylate.

25. Weight 15-16 mg.In 10-15 sec Softens; In 10-15 min. turns in Viscous Liquids; After 30-60min. Becomes Polymeric Solution.

26. Advantages of SODI : Single SODI application :replaces 4-12 eye drops Instillation, or 3-6 application of Ointments. Once a day treatment of Glaucoma & Trachoma. 3)Minidisc: It is made up of counter disc with Convex front & Concave back surface in contact with eye ball. 4-5mm in diameter. Composition : Silicon based pre polymer. Hydrophilic or Hydrophobic. Drug release from 170 hr.

27. C) Nanoparticle:

28. D) Liposome

29. Advances in ocular drug delivery 1. Ophthalmic gel for pilocarpine Poloxamer 407 (low viscosity, optical clarity, mucomimetic property) 2. Ophthalmic prodrug Dipivalyl epinephrine (Dipivefrin) Lipophilic  increase in corneal absorption Esterase within cornea and aqueous humor 3. Continuous delivery system based upon the osmotic property Thin flat layer, contoured three-dimensional unit Conform to the space of the upper cul-de-sac Delivery of diethyl carbamazine in ocular onchocerciasis

30. 4.Gel delivery system Biodegradable polyisobutyl-cyanoacrylate (PIBCA) colloidal particulate system of pilocarpine to incorporate it into a Pluronic F127 (PF 127)-based gel delivery system. 5)Mucoadhesive Polymer. mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics.

31. Reference: N.K.Jain, Advances in Controlled & Novel Drug Delivery, CBS Publication, & distributor, New Delhi, pg No.219-223. Remington & Gennaro ; The Science & Practice Of Pharmacy. Mack Publication Company. Easton, Pennsylvania. Pg. No. 1563-1567. Web Sites: www.vision-care-guide.com www.google/images/eye/anatomy& physiology

32. Thank You....! Creativity is allowing oneself to make mistakes. Art is knowing which one to keep.