What is Spondyloarthritis? What is Psoriatic Arthritis?

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2011 Juvenile Arthritis Conference

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How are JSpA and JPsA diagnosed ? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

JIA Subtypes Few Joints (less than 5) = Oligoarticular Many Joints (5 or more) = Polyarticular Fever/rash = Systemic SpA (spine) = ERA With Psoriasis = PsA ?

Juvenile Spondyloarthritis (Enthesitis-Related Arthritis) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Juvenile Psoriatic Arthritis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Two Subgroups of JPsA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

How common is juvenile arthritis ? ,[object Object],[object Object],[object Object],Lawrence RA, et al. , Arth Rheum 1998; 41:778-799 Sacks J et al ., Arth Rheum 2007; 57:1439-1455

Management of JIA ,[object Object],[object Object],[object Object],[object Object]

Treatment Pyramid NSAIDS, PT/OT GLUCOCORTICOIDS Methotrexate, Corticosteroid injections Biologics (anti-TNF, anti-IL-1, anti-IL-6) EXP

Management of JIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Biologics Frequently Used in Juvenile Arthritis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Why is it important to do research in children ? To practice evidence-based medicine If we don’t do research, every treatment becomes a poorly controlled experiment

Observational Studies ,[object Object],[object Object],[object Object],[object Object],[object Object]

Translational Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Thank you for your attention! National Institute of Arthritis and Musculoskeletal and Skin Diseases

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What is Spondyloarthritis? What is Psoriatic Arthritis?

1. 2011 Juvenile Arthritis Conference Bob Colbert MD, PhD Senior Investigator Chief, Pediatric Translational Research Branch NIAMS/NIH Juvenile Spondyloarthritis and Psoriatic Arthritis

5. What is Spondyloarthritis?

6. Sacroiliac Joints

7. Dactylitis

8. Psoriatic Skin Rash

9. Psoriatic Nail Changes

10.

11.

12. JIA Subtypes Few Joints (less than 5) = Oligoarticular Many Joints (5 or more) = Polyarticular Fever/rash = Systemic SpA (spine) = ERA With Psoriasis = PsA ?

13.

14.

15.

16.

17. How do we treat JIA ?

18.

19. Treatment Pyramid NSAIDS, PT/OT GLUCOCORTICOIDS Methotrexate, Corticosteroid injections Biologics (anti-TNF, anti-IL-1, anti-IL-6) EXP

20.

21.

22.

23. Why is it important to do research in children ? To practice evidence-based medicine If we don’t do research, every treatment becomes a poorly controlled experiment

24.

25.

26. Spondyloarthritis

27. Thank you for your attention! National Institute of Arthritis and Musculoskeletal and Skin Diseases

28.

What is Spondyloarthritis? What is Psoriatic Arthritis?

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What is Spondyloarthritis? What is Psoriatic Arthritis?