16 rencontres biomédicale LIR Michel Haissaguerre

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Association LIR

2ND INTERNATIONAL RESEARCH MEETING 4 JUNE 2010- HÔTEL DE MARIGNY PARIS

Saúde e medicina

Targeting the Electrical Heart From identified cells to novel approaches against: Cardiac Arrhythmias Sudden Death Heart Failure Major Impact of Cardiac Electrical disorders on human Health

Human Cardiac Arrhythmias ,[object Object],[object Object],Fibrillations = multiple foci/circuits Chaos

The most common : Atrial Fibrillation ,[object Object],[object Object],[object Object],[object Object],[object Object],In 2050 ( Olmsted County Study) 16 M in USA 25 M in Europe Atria Ventricles

[object Object],Mapping the genesis of chaos NEJM 1998 Results - Episodes of AF originate from Sources outside the heart - in vascular wall (pulmonary veins) Proof of Concept: local energy delivery eliminate recurrences

Curative therapy of Paroxysmal Atrial Fibrillation 10 000 pts treated in 2000 - 200 000 patients in 2010 ,[object Object],[object Object],Birth of a specific biotechnological industry ( X 5 next 10 years) (Sources: Philips-GE-Siemens) Thermo-exclusion of venous foci

Research Perspectives ,[object Object],[object Object],[object Object],[object Object]

INTERNATIONAL AWARDS ,[object Object],[object Object],[object Object],[object Object],INNOVATIONS Platelet GPIIbIIIa and P2Y12 receptors (Antiaggregants) Coinvention of Resynchronisation Propranolol in hemangioma Catheters, devices, softwares

Sudden death is not a ‘cardiac arrest’ but Ventricular Fibrillation in 80% ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],300 000 adults/yr Survival rate 2% Fatal Electrical Tornado during night- M 57

First maps in Humans with multiple VFs: initiation by Purkinje cells (<2 % of cardiac mass) Arborized Network of Purkinje cells Lancet 2003 - Circulation 2004 et 2006 Proof of Responsibility : Focal energy eliminates recurrences F 37 yr- Arrhythmic storm

Research Perspectives ,[object Object],[object Object],[object Object],Unique tools for mapping

Heart Failure ,[object Object],[object Object],Unknown Role of Abnormal activation via Purkinje disease ? >50% of HF patients have electrical dysfunction Its role is largely unexplored

Original Research Projects ,[object Object],[object Object],[object Object],[object Object]

Unique Translational Research Center on Cardiac Electrical Disorders- BORDEAUX Top level international expertise : Whole heart ElectroPhysiology Computer Sciences ( Signal-Modelisation ) Cardiac Imaging Public & Private institutions Industrial Partnership *

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16 rencontres biomédicale LIR Michel Haissaguerre

2. Targeting the Electrical Heart From identified cells to novel approaches against: Cardiac Arrhythmias Sudden Death Heart Failure Major Impact of Cardiac Electrical disorders on human Health

10. First maps in Humans with multiple VFs: initiation by Purkinje cells (<2 % of cardiac mass) Arborized Network of Purkinje cells Lancet 2003 - Circulation 2004 et 2006 Proof of Responsibility : Focal energy eliminates recurrences F 37 yr- Arrhythmic storm

11.

12.

13.

14. Unique Translational Research Center on Cardiac Electrical Disorders- BORDEAUX Top level international expertise : Whole heart ElectroPhysiology Computer Sciences ( Signal-Modelisation ) Cardiac Imaging Public & Private institutions Industrial Partnership *

16 rencontres biomédicale LIR Michel Haissaguerre

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16 rencontres biomédicale LIR Michel Haissaguerre