The document discusses the new Artistry Pure White skincare line. It provides an overview of the brand's research and development process, key ingredients and technologies used, clinical study results, and product benefits. The line aims to prevent, treat, and protect the skin through a holistic approach to balancing melanin production and maintaining natural white beauty. Common questions about the products are also addressed.
4. AGENDA
• All about ARTISTRY
• Internal & External Experts
• Process of development
• Skin factors – causes of unbalanced
melanin production
• Pure White System – A Perfect
Balance to Natural White Beauty
• Selling tips
5. Artistry is currently sold inArtistry is currently sold in
over 50 countriesover 50 countries
worldwide!worldwide!
Asia is the region with greatest sales, with
almost 80% of the total Artistry sales!
6. The ARTISTRY brand is the only direct-sell
brand classified in the prestige category.
7. • Over 35 years experience
• Over $1 Billion in annual sales globally
• 114 Worldwide Patents
• 78 Patents Pending
• 88 Publications
9. Artistry is about truth.
Truth in science – by focusing on your skin’s health
and its appearance. Cultivating emerging
technologies and the collective knowledge of leading
practitioners in the field of dermatology gives.
Artistry, the cutting edge in modern skin care.
10. Artistry is about truth.
Truth in beauty – by celebrating the individual beauty
with every woman. Experience the endless, exception
benefits Artistry skin care and cosmetics provide
15. Internal and External Experts
New Artistry Pure White has
been developed by foremost
leaders in the field of skin care
research and science.
16. Dr. Di Qu
Senior Research Scientist
INTERNAL EXPERTS
Genius – The Mind Behind Pure White
17. In collaboration with:
• Dr. Amit Chandra,
Analytical Chemist
• Debbie Deppa,
Senior Research Scientist
• Dr. David Fast,
Molecular Biologist
• Jesse Leverett,
Senior Research Scientist
INTERNAL EXPERTS:
Center for Skin Health Research
• Chris Masotti, Group Leader
Skin Care Product Development
• Dr. Steve Missler, Biochemist
• Dr. Esther Patrick, Toxicologist
• Dr. Haeri Roh-Schmidt,
Molecular Biologist
• Louise Schneider, Senior
Scientist
• Dr. Paul Seehra, Biomedical
Engineer
18. EXTERNAL EXPERT
Dr. John Pawelek
• Yale University
• Recognized authority
on pigmentation research
development
• Artistry Scientific Advisory
Board member
Credibility – Validating the Technology
19. Olivier van Doorne
World Wide Creative Director,
SelectNY
EXTERNAL EXPERT
Design – The inspiration behind the look
20. Process of Developing New IngredientsProcess of Developing New Ingredients
Literature Search Obtain Botanicals Polar N-Polar
Further Isolate fractions
Bio Assay Activity Screens Activity???
21. In House Efficacy Testing – In Vitro Studies
• Relationship of product
pH and whitening efficacy
• Tyrosinase inhibition test
• Pigment inhibition test on
Melanoderm (a skin model
of reconstructed human
epidermis with melanocytes)
22. In House Efficacy Testing – In Vitro Studies
Control Pure White Essence Treated
23. Process of Testing New Ingredients
Searching for synergistic effects
Bearberry Acerola
cherry Lemon
Cucumber
24. Formulation – The Science of the Art
• Investigate chemical
compatibility of 20 – 30
ingredients in a formula
• Test for desired texture
• Test for skin feel
• Develop desired fragrance
• Conduct stability test at various
conditions (room temperature,
4’C, 40’C, 50’C, and freeze and
thaw)
Chemical
Physical
microbiological
25. Clinical Study – Safety and Efficacy
• Independent testing labs
• On the Asian skin
• All skin types
• Self-perceived sensitive
skin
• Clinically graded by
dermatologists
• Irritation study
• Acnegenecity study
26. Process Scale Up in the Pilot Plant
Pilot Plant for Process Development
32. Main causes of unbalanced melanin production
• UV Rays
• Stress
• Hormones
• Immediate Skin
Darkening
33. Causes of Melanin Formation
U.V. Light Genes Hormones Inflammation
Melanocyte
Produce
Tyrosinase (enzyme)
Produce Melanin
(eumelanin and
phaeomelanin)Transfer to
epidermal cells
Epidermal
Cells
Cytokine or other signals
α-MSH
(melanocyte stimulating hormone)
34. Formation of Melanin in Skin
• Melanin is produced by pigment cells called melanocytes
• Melanocytes live at the Dermal-Epidermal Junction and
produce melanin containing vesicles called melanosomes
• Melanosomes transfer to keratinocytes (epidermal cells) to
protect the skin from harmful UV rays
Melanocyte
Epidermis
DEJ
Dermis
46. The technologies of multiple pigmentation inhibition
mechanisms and cell protection are the key components of
the ARTISTRY patent pending holistic approach to skin
whitening. It is important to achieve high efficacy in skin
whitening, but it is equally important to provide adequate
cell protection after whitening, because skin with reduced
levels of melanin is more vulnerable to environmental
insults.
ARTISTRY Pure White is the only brand that balances
these two effects.
Pure White Advantage
- Dr. Di QU
50. Prevent, Protect, Treat the Holistic Approach
Reduces melanin
production by 86%
(based on in-vitro test)
Pure White Balancing Complex
Featuring White Tea
52. I (Normal to Dry) II (Normal to Oily)
Ingredient Name Function Toner Moisturiser Toner Moisturiser
Pure White
Balancing
Complex
Prevent, Treat
Protect x x x x
HLM+ and NMFs Moisturising xx xx x x
Inhibits Oil
Production NA NA x x
Oil Control
Technologies
Microsponge
to absorb
surface oil NA NA NA x
Pure White Special Ingredients
53. Sebum
Treating Oily Skin - Sebum Control
Over Production of Skin Oil
Sebaceous gland
Prevent Irritation and Inflammation
54. Oil Control: By Absorptoin & Inhibition
Sebaceous gland
Microsponge particles
Zn PCA
Cu PCA
Avocado oil
Treating Oily Skin - Sebum Control
Prevent Irritation and Inflammation
55. Rose Absolute
& Rose Oil
Tuberose
Absolute
Jasmine
Absolute
Pure White FLORAL FRAGRANCE
56. 1. Restores your skin to its “Natural White Beauty”
Pure White System Claims
70
4 wks 8 wks 12 wks
60
50
40
30
20
10
0
Skin Tone
Clinically tested,
improvement in skin
tone (dark to light) by
19.2% in 4 wks
37.8% in 8 wks
65.9% in 12 wks
57. 2. Clinically tested, Pure White visibly whitens skin
just 12 days. 45% improvement in skin
transparency*
* When used with Pure White Essence
Pure White System Claims
4 times more whitening actives than
previous products when cleanser, toner,
moisturiser and crème are used together
58. Pure White System Claims
3. Clinically tested:
• Normal to Dry I System increases
moisture content
• Normal to Oily II System controls oil production
and diminishes appearance of pores
• 93.5% of panelists indicate that Pure White
was suitable for their skin type
• 94% of panelists gave Pure White a high approval
rating (product, package, fragrance)
59. 4. Products work synergistically to prevent, treat and
protect the skin from discolouration as they
effectively yet gently whiten
Pure White System Claims
5. Tested on Asian Skin, including Sensitive Skin
Dermatologist tested, allergy tested, non-
comedogenic/non-acnegenic tested
6. All products feature HLM+ to optimize skins
moisturisation
62. • Gentle to your skin with strong
cleansing power
• Silky foam refreshes skin
• First step of holistic whitening
CLEANSER
All Skin Types
63. • A milky formula with a
dew–like texture provides
optimal moisturization
• Treats dry skin, reducing the chance
of irritation
• Second step of holistic whitening,
prepares skin for Essence
TONER I
Normal to Dry
64. • A clear, liquid leaves your skin
feeling refreshed and shine-free
• Controls surface oil
and refines pores
• Second step of holistic
whitening, prepares skin
for Essence
TONER II
Normal to Oily
65. ESSENCE
All Skin Types
• Synergistically enhances the whitening
performance of the other new
Pure White products
• Gently yet effectively lightens your skin
• Third step of holistic whitening
66. 1.Clinically tested, Pure White Essence boosts the
performance of other Pure White products
2 times more effective at improving skin tone
& dark spots over system alone
Pure White ESSENCE RESULTS
2. 92% of panelists felt that Essence made
their skin whiter in just 12 days
3. Compared to current Pure White
Essence is 38% more effective
at whitening
67. • SPF20, PA+++ provides additional protection to
vulnerable skin once melanin is reduced
• Increases moisture content of the
skin by 112%
• Fourth step of holistic whitening
MOISTURISER I
Normal to Dry
68. • SPF20, PA+++ provides additional protection
to vulnerable skin once melanin is reduced
• Contains botanical extracts and
micro-sponge particles for oil-control
• Fourth step of holistic whitening
MOISTURISER II
Normal to Oily
69. • A light textured nighttime creme
• Soothes and restores a fresh glow when
you awake
• Increases moisture content of the skin by
114%
CREME
All Skin Types
70. • Periodic treatments for your skin that supplement
your Pure White regimen
• Masque helps to exfoliate resulting in a healthy
complexion
• Spot Corrector diminishes spots
and freckles
MASK AND SPOT CORRECTOR
All Skin Types
*Existing formulas retained
75. 2. Connect them with information
SELLING
3 Steps to successful selling
• Importance of balancing melanin
• Connect the Pure White product
benefit to her skin concerns
• Share additional information of ARTISTRY
77. 1.Can people with sensitive skin use the new Pure
White, with the added fragrance and an increase
in SPF?
Common questions…………
The level of each ingredient in the products,
including fragrance and sunscreen, was selected to
be sure products would be well tolerated in use.
Our safety studies show that the products would not
cause person to develop allergies and non irritating.
However, some may have existing allergies to
cosmetic ingredients from exposure to products in
the past. Individuals will need to check the labels of
such ingredients.
78. 2. When can we see skin improvement?
Common questions…………
When you use the Pure White as a line, clinical
tests shown that you will see improvements in skin
transparency by 45% in 12 days. This will also
depend on how the skin is receptive to the Pure
White products.
79. 3. The previous Pure White line sold two types of
cleansers. Why the new Pure White only provide
one cleanser?
Common questions…………
New Pure White Cleanser has been developed for
all skin types. Testing was conducted for normal to
oily and dry skin. Test results proved that this
product is suitable for all skin types and meets the
needs of both.
80. 4. Although Pure White packages are made of
plastic, why do they feel heavy?
Common questions…………
The Pure White packages have a thicker walls to
provide better protection for the whitening formulas
than the thin wall package would provide.
81. 5. Will the colour of the Pure White Essence
change over time?
Common questions…………
Colour stability of the new Essence is much better
than the current Essence. However, there are many
natural ingredients in this Pure White Essence,
thus , there is a chance that the colour may change
overtime. Note that, research and tests have been
done to ensure efficacy is is not compromised even
with discoloration.
82. 6. Is Pure White suitable for men?
Common questions…………
Men can also receive benefits from Pure White for
skin whitening. Alternatively they can be use Pure
White along with Tolsom products
83. 8. Pure White Crème feels heavy on my skin
although it is very light texture.
Common questions…………
If Pure White Creme feels too rich and heavy on the
skin, please reduce the amount you are applying.
84. 10. What is the key focus in the holistic, balanced
approach?
Common questions…………
There are 3 main strategies – Prevent, Treat and
Protect. We use innovative technology for each
strategy.
85. 11. What is the difference between improvements in
skin tone and skin transparency?
Common questions…………
Skin tone – Colour of skin, darker to light. How
much your skin becomes lighter compared to your
starting point.
Skin transparency – Clarity. How much your skin
becomes more “clear” compared to your starting
point.
86. 12. What is the shelf life for the Pure White line?
Common questions…………
All Pure White products have a shelf life of 3 years
except Essence which has a 2 year shelf life.
The vision of Artistry
True Science, True Beauty. So what is it
The Artistry product works synergically with approved Nutrilite ingredients
With technology and renowed scientist to produce the unique Artistry product
New Pure White is your daily skincare partner for restoring your skin to natural white beauty
The products of Pure White has been developed by internal and External experts
Dr Di Qu has over 16 years of industry experience in formulation and product development. He holds 2 pending patents – one for skin whitening technology and another for pigment dispersion technology. Qualification – With a PHD in Chemical & Biochemical from the prstigious Rutgers University
Olivier van Doorne is President and Worldwide Creative Director for SelectNY. They are our image, packaging and design consultants for Artistry.
Beside that, Artistry R&D has a system to identify new functional ingredients.
C1. This cartoon shows the necessary steps.
C2. It starts from literature review,
C3. which leads to identifying useful botanicals.
C4. from there, we extract the useful components from the plant using both polar and non-polar solvents.
C5. Then we conduct further isolation steps,
C6. on the polar an non-polar fractions.
C7. Then the components are tested on a highly automated bio-assay system which detects hundreds of samples at a time. Each cell shown here has a different condition.
C8. When a component shows activity it is easily detected.
C9. A final decision on activity is made based on this test.
After having a formula, we conduct in-house in-vitro tests, such as
C1. the relationship of product pH and whitening efficacy
C2. tyrosinase inhibition test
C3. and whitening test on cultured skin model.
. These two photos show the results of in-vitro whitening test. As we can see the product treated sample on the right shows less pigment than a control sample on the left.
This slide shows an example of identifying new active ingredients.
C1. Each of the four ingredients shown here had previously been used individually.
C2. Then we put two scientists in a room to search for synergistic effects among those ingredients.
With new ingredients we can start to formulate a product. Formulation combines science and art. When you put 30 ingredients in one formula it requires many different tests.
C1. we need to investigate the chemical compatibility of those ingredients.
C2. to test for the desired texture,
C3. skin feel,
C4. develop fragrance.
C5. and conduct stability tests on chemical, physical and microbial properties to ensure they do not change too much over time.
After in-vitro tests, we conduct clinical studies for safety and efficacy claims. They are done
C1. in an independent testing lab
C2. on the Asian skin
C3. include all skin types
C4. self perceived sensitive skin
C5. clinically graded by dermatologists which include
C6. irritation and
C7. acnegenecity studies.
The formula is then examined in our pilot plant. The batch size of this tank is between the lab and production to determine how the product can be made most efficiently and consistently in the plant. It requires experienced chemical engineers to do the work properly. Flow properties, temperature, mix time, and order of addition are critical parameters to consider.
When the formula reaches our world class manufacturing plant, it is made by our experienced workers using computer controlled, high efficiency, and high quality manufacturing facility to ensure the ultimate quality of the product.
These two photos show the top view of the mix tanks in our cosmetic plant.
Quality control is a very important step of the production of Artistry products. Every raw material is carefully inspected before it is used in a production, and every product is carefully checked after each production to ensure it has good quality.
This photo shows a quality scientist inspecting incoming raw materials.
New Pure White is your daily skincare partner for restoring your skin to natural white beauty
Let us now look at the cross section of the skin
There are three main layers in the skin. Hypodermis, Epidermis and Dermis. Dermis is a layer which makes skin elastic and flexible. Fibers ,Collagen and Elastin are running through it.
Other layer Epidermis is what helps to provide the skin protective barrier.
The sweat glands highlighted helps to secrete sweat and toxins from our body
So, what causes melanin formation? Basically, there are four major causes, UV rays in the sunlight, genes, hormones, and inflammation.
C1. They act separately, or together, on the epidermal cells.
C2. The cells then produce cytokines or other signaling molecules such as MSH and send the chemicals to melanocytes.
C3. Upon receiving the signals melanocytes produce the enzyme tyrosinase
C4. which synthesize new melanin.
C5. Finally, the melanin is transferred to the epidermal cells and darkens the skin color.
Here is a little scientific background about the formation of melanin in the skin.
C1. We know that melanin is produced by the pigment cells called melanocytes.
C2. Melanocytes live at the dermal and epidermal junction. They produce melanin containing vesicles called melanosomes.
C3. Melanosoems transfer to keratinocytes to protect the skin from harmful UV rays.
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This cartoon illustrate the phenomenon.
C1. The sun sends out UV rays which act on the keratinocytes.
C2. The cells then produce signaling molecules, such as alpha-MSH,
C3. which stimulates the melanocytes to produce melanin.
C4. In severe cases, UV rays stimulate the melanocytes directly
C5. and cause proliferation of melanocytes.
C6. Dark spots form as the result.
<number>
Estrogen causes epidermal cells to release MSH (Melanocyte Stimulating Hormone)
This causes additional melanocytes to grow and triggers the melanocytes to release their stored melanosomes.
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1) Irritation causes the living cells to release a variety of chemical signals
2) The body responds with increased blood flow and “agents” that fight the irritating substances. This is the inflammation response.
3) As the skin heals some of the chemical messengers are misinterpreted by the melanocytes as a command to produce and release melanin.
4) A localized spot of darker color is formed or PIH
. So, let’s start with the concept of Pure White skin whitening.
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Let’s first look at alpha-MSH and see how it induces hyperpigmentation.
C1: UV rays or other factors act on the keratinocytes.
C2: The genes in those cells are activated
C3: and more MSH molecules are produced
C4: The MSH then bonds to the receptor on the melanocytes.
C5: This activates the genes in the melanocytes and
C6: more melanin is produced in the cells and
C7: transfers to the epidermal cells and darkens the skin.
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How does it actually work? From the previous slide we knew that bonding of MSH to the receptor stimulates the melanocytes to produce melanin.
C1: Now, if we stop or slow down the receptor bonding step, the genes in melanocytes will not be overly stimulated, and therefore less melanin is produced.
This slide illustrates the actions. We first block the signal receptor on the melanocyte so that less signals are received to produce melanin. Then, we control the transcription process to reduce the production of tyrosinase. Then, we inhibit the activity of tyrosinase so that less melanin is formed. Also, we can switch the melanin production process so that more light melanin, known as phaeomelanin, and less dark melanin, known as eumelanin, are produced. After that, we can inhibit the melanosome transfer process to slow down the transfer of melanin to the epidermal cells. Finally, in addition to all those actions, we also inhibit the melanin precursor polymerization process in the epidermal cells so that the skin will show less immediate darkening upon UV exposure. I am proud to say that we have identified ingredients for each of the mechanisms in our next generation Pure White products.
The whitening regimen is an holistic balance approach because all products work synergistically to prevent, treat and protect the skin from skin discloouration
All new Pure White products contains the Pure White Balancing Complex that prevents, treats and protects the skin from hyperpigmentation, ensuring a holistic, balanced approach to skin whitening
Aside from the effective brighteners found in the Pure White Balancing complex, the gentle, natural lighteners found in the new Artistry Pure White essence includes:
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For oily skin, our concern is with over production of skin oil.
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To control skin oil, we use the following two technologies in our products:
Microsponge particles to absorb surface oil, and
Zn or Cu PCAs to inhibit the sebaceous gland to produce less sebum.
The floral fragrance – found in all Pure White products – evokes a relaxing, comfortable, graceful feeling.
New Pure White is your daily skincare partner for restoring your skin to natural white beauty