Molecular Genetics

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Nathan Arnold

Tecnologia

Molecular Genetics
Understanding the Role of
Molecules in Inheritance

Tuesday, March 9, 2010

Master Objectives:

Tuesday, March 9, 2010

Master Objectives:

3.3.B.b Recognize that DNA codes for proteins,
which are expressed as the heritable
characteristics of an organism. (DOK: 1)

Tuesday, March 9, 2010

Master Objectives:

3.3.B.b Recognize that DNA codes for proteins,
which are expressed as the heritable
characteristics of an organism. (DOK: 1)

3.3.B.e Identify possible external causes (e.g.,
heat, radiation, certain chemicals) and effects
of DNA mutations (e.g., altered proteins
which may affect chemical reactions and
structural development). (DOK: 2)
Tuesday, March 9, 2010

DNA provides the CODE

Tuesday, March 9, 2010

DNA provides the CODE
The sequence of nitrogen bases
in DNA code for the building of protein

Tuesday, March 9, 2010

DNA provides the CODE
The sequence of nitrogen bases
in DNA code for the building of protein

The code (genes) are like a blueprint
for constructing enzymes and cell
parts

Tuesday, March 9, 2010

Each strand of DNA contains many
genes which each code for a
different protein product
Tuesday, March 9, 2010

Protein is made by linking
AMINO ACIDS together

Tuesday, March 9, 2010

Every 3 bases in DNA codes
for a speciﬁc amino acid

Tuesday, March 9, 2010

The sequence of amino acids
gives the protein its properties

Tuesday, March 9, 2010

Structural proteins and
enzymes are responsible
for ALL of our inherited
characteristics

Tuesday, March 9, 2010

Examples:

antibodies

Tuesday, March 9, 2010

Examples: keratin

antibodies

Tuesday, March 9, 2010

Examples: keratin

hemoglobin

antibodies

Tuesday, March 9, 2010

Examples: keratin

hemoglobin
actin and
myosin
antibodies

Tuesday, March 9, 2010

Examples: keratin

hemoglobin
actin and
myosin
antibodies
pepsin and
trypsin
Tuesday, March 9, 2010

The Big Picture
Central Dogma

Tuesday, March 9, 2010

The Big Picture

Protein Synthesis
Central Dogma

Tuesday, March 9, 2010

Mutations are changes
in the DNA that alter
protein synthesis.

Tuesday, March 9, 2010

All mutation requires is
a change in 1 base pair...

Tuesday, March 9, 2010

All mutation requires is
a change in 1 base pair...

Chemicals

Tuesday, March 9, 2010

All mutation requires is
a change in 1 base pair...

Chemicals

UV Radiation
Tuesday, March 9, 2010

All mutation requires is
a change in 1 base pair...

Nuclear Radiation

Chemicals

UV Radiation
Tuesday, March 9, 2010

All mutation requires is
a change in 1 base pair...

Nuclear Radiation
Mistakes
Chemicals by the Cell

UV Radiation
Tuesday, March 9, 2010

All mutation requires is
a change in 1 base pair...

Nuclear Radiation
Mistakes
Chemicals by the Cell

UV Radiation Carcinogens
Tuesday, March 9, 2010

"DNA makes RNA and RNA makes
proteins and proteins make us."
~Francis Crick

Tuesday, March 9, 2010

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Molecular Genetics

1. Molecular Genetics Understanding the Role of Molecules in Inheritance Tuesday, March 9, 2010

2. Tuesday, March 9, 2010

3. Master Objectives: Tuesday, March 9, 2010

4. Master Objectives: 3.3.B.b Recognize that DNA codes for proteins, which are expressed as the heritable characteristics of an organism. (DOK: 1) Tuesday, March 9, 2010

5. Master Objectives: 3.3.B.b Recognize that DNA codes for proteins, which are expressed as the heritable characteristics of an organism. (DOK: 1) 3.3.B.e Identify possible external causes (e.g., heat, radiation, certain chemicals) and effects of DNA mutations (e.g., altered proteins which may affect chemical reactions and structural development). (DOK: 2) Tuesday, March 9, 2010

6. Tuesday, March 9, 2010

7. DNA provides the CODE Tuesday, March 9, 2010

8. DNA provides the CODE The sequence of nitrogen bases in DNA code for the building of protein Tuesday, March 9, 2010

9. DNA provides the CODE The sequence of nitrogen bases in DNA code for the building of protein Tuesday, March 9, 2010

10. DNA provides the CODE The sequence of nitrogen bases in DNA code for the building of protein The code (genes) are like a blueprint for constructing enzymes and cell parts Tuesday, March 9, 2010

11. Each strand of DNA contains many genes which each code for a different protein product Tuesday, March 9, 2010

12. Each strand of DNA contains many genes which each code for a different protein product Tuesday, March 9, 2010

13. Protein is made by linking AMINO ACIDS together Tuesday, March 9, 2010

14. Protein is made by linking AMINO ACIDS together Tuesday, March 9, 2010

15. Every 3 bases in DNA codes for a speciﬁc amino acid Tuesday, March 9, 2010

16. Every 3 bases in DNA codes for a speciﬁc amino acid Tuesday, March 9, 2010

17. The sequence of amino acids gives the protein its properties Tuesday, March 9, 2010

18. The sequence of amino acids gives the protein its properties Tuesday, March 9, 2010

19. Structural proteins and enzymes are responsible for ALL of our inherited characteristics Tuesday, March 9, 2010

20. Examples: Tuesday, March 9, 2010

21. Examples: antibodies Tuesday, March 9, 2010

22. Examples: keratin antibodies Tuesday, March 9, 2010

23. Examples: keratin hemoglobin antibodies Tuesday, March 9, 2010

24. Examples: keratin hemoglobin actin and myosin antibodies Tuesday, March 9, 2010

25. Examples: keratin hemoglobin actin and myosin antibodies pepsin and trypsin Tuesday, March 9, 2010

26. The Big Picture Tuesday, March 9, 2010

27. The Big Picture Central Dogma Tuesday, March 9, 2010

28. The Big Picture Protein Synthesis Central Dogma Tuesday, March 9, 2010

29. The Big Picture Protein Synthesis Central Dogma Tuesday, March 9, 2010

30. Tuesday, March 9, 2010

31. Tuesday, March 9, 2010

32. Mutations are changes in the DNA that alter protein synthesis. Tuesday, March 9, 2010

33. All mutation requires is a change in 1 base pair... Tuesday, March 9, 2010

34. All mutation requires is a change in 1 base pair... Chemicals Tuesday, March 9, 2010

35. All mutation requires is a change in 1 base pair... Chemicals UV Radiation Tuesday, March 9, 2010

36. All mutation requires is a change in 1 base pair... Nuclear Radiation Chemicals UV Radiation Tuesday, March 9, 2010

37. All mutation requires is a change in 1 base pair... Nuclear Radiation Mistakes Chemicals by the Cell UV Radiation Tuesday, March 9, 2010

38. All mutation requires is a change in 1 base pair... Nuclear Radiation Mistakes Chemicals by the Cell UV Radiation Carcinogens Tuesday, March 9, 2010

39. "DNA makes RNA and RNA makes proteins and proteins make us." ~Francis Crick Tuesday, March 9, 2010

Molecular Genetics

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