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    © 2012 MedActive, LLC.
Four Brands Oral Care Redefined™
MedActive -



   MedActive redefines oral care by prioritizing dry mouth relief as a
   critical objective of daily oral hygiene.




   MedActive’s integration of continuous dry mouth relief into
   comprehensive oral care is based upon clinical recognition that
   salivary dysfunction adversely impacts oral and general health,
   especially for patients managing chronic illness.




                                 PAGE 1 OF 23
Causes of dry mouth and other
oral conditions:

                 •   Antibiotics                •   Anticholinergics     •   Antihypertensives
                 •   Diuretics                  •   Analgesics           •   Decongestants
   Medications   •   Muscle relaxers            •   Antipsychotics       •   Sedatives
                 •   Corticosteroids            •   Antihistamines       •   NSAIDS
                 •   Amphetamines               •   Antidepressants




     Medical     •   Cancer Chemotherapy & Radiation Therapy
                 •   Kidney Dialysis
   Treatments    •   Transplant Surgeries



                 •   Diabetes                   •   Anxiety              •   Hepatitis
                 •   COPD                       •   Lupus/Scleroderma    •   Sleep Disorder
     Health      •   Heart Disease              •   Pneumonia            •   GERD
    Condtions    •   Cancer                     •   Asthma               •   Obesity
                 •   High Blood Pressure        •   Allergies            •   Incontinence
                 •   Rheumatoid Arthritis       •   Sjögren’s Syndrome
                 •   Depression                 •   HIV/AIDS

                 •   Poor hygiene
    Lifestyle    •   Smoking
                 •   Drug & alcohol abuse
                 •   Infrequent dental visits

                          PAGE 2 OF 23
MedActive® Brands rely on multiple applications of
proprietary ingredients throughout the day. These
applications achieve unprecedented relief from dry
mouth discomfort.




     Repetitively enhancing saliva flow, with Spilanthes Extract and its unique “tingle”
     feature



     Repetitively moisturizing soft tissue, with ULTRAMULSION® and its extraordinary
     “mouthfeel” and flavor enhancement




     Repetitively lubricating and conditioning the mouth, with a mucoprotectant and
         2
     its distinct substantivity to soft tissue.




                                        PAGE 3 OF 23
Caries
                                                Immune
             Inflammation                        System
                                              Compromise




 Mucositis                                                  Bacterial
                                                           Overgrowth
                              Cascade
                              Effects of
                             Dry Mouth
                                                       Viral & Fungal
Stomatititis
                                                        Overgrowth




             Periodontitis                    Pathogenic
                                                Biofilm
                               Gingivitis




                               PAGE 4 OF 23
Dysphagia
                    Cancer                            Immuno-
                                                     compromise


      Bacteremia                                                  Kidney
                                                                  disease




Malnutrition
                                  Health                            Migration of
                                                                    biofilm into
                                Impacts of                          bloodstream
                                Dry Mouth
     Heart                                                         Ingestion of
    disease                                                       bacteria, virus
                                                                     & fungi

           Diminished
            quality of                                     Depression
               life
                                              Pulmonary
                             Stroke
                                              Infections




                                      PAGE 5 OF 23
MS,         Sjögren’s
                         Scleroderma                    Denture
                                         Syndrome
                           & Lupus                     Discomfort

             Arthritis                                              Hyper-
                                                                    tension


  Parkinson’s                                                             Allergies



Depression                                                                       Kidney
& Anxiety                                Patient                                 Dialysis
                                       Populations


 Obesity                                                                      Alzheimer's
                                                                              & Dementia


       Sleep
       Apnea                                                            COPD

                   Drug
                Dependency       Gastro-                     Diabetes
                                intestinal      Palliative
                                problems          Care




                                        PAGE 6 OF 23
Integration of Dry Mouth Management into Patient Centered
Care Pathways Reduces Costs

                                                     Nosocomial
                                                      infections

                           Increased                                         Regulatory
                          dental care                                           risk




              Longer & more
                                                                                          Litigative
                 frequent                    Downstream                                      risk
              hospitalizations
                                             Medical Costs



                    Empty bed                                                      Reduced
                      losses                                                        HVBP
                                                                                  Incentives



                                        Increased                   Increased
                                        care costs                  drug costs




                                                     PAGE 7 OF 23
Dry mouth leads to and exacerbates
the following conditions:




          • Oral thrush             • Gingivitis/Periodontitis
          • Sensitivity             • Bleeding gums
          • Sores & lesions         • Inflammation
          • Hoarsness               • Burning mouth
          • Caries                  • Throat irritation
                                    • Difficulty swallowing




                              PAGE 8 OF 23
Percentage of Adults who have had problems
involving the mouth




 “QuickStats: Percentage of Adults* Aged 18-64 Years Who Have Had Problems Involving the Mouth, by Race/Ethnicity and
 Type of Problem ---National Health Interview Survey, United States, 2008.” Centers for Disease Control and Prevention.
 Morbidity and Mortality Weekly Report (MMWR).
 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6022a7.htm?s_cid=mm6022a7_w

                                                       PAGE 9 OF 23
MedActive provides comprehensive oral care which
includes continuous oral relief for patient-centered
integrated care pathways.




 “ Taking the appropriate efforts to improve
     oral and dental care for nursing home
   residents could have a significant impact
      not only on quality of life for nursing
    facility residents, but also a meaningful
   impact on downstream medical costs for
     the health care system by preventing
   hospitalizations and death resulting from
  medical care needs arising out of poor oral
                  and dental care.
                                            ”

                                           PAGE 10 OF 23
Dentition problems can result
in malnutrition




   “ Patients with painful dentition eat less, and if the patient is demented at baseline,
       the communication of the painful condition is often missed by care providers.
     Dentition problems along with the normal loss of the sense of smell accompanied
    with aging can result in signficantly reduced caloric intakes. Malnutrition frequently
     leads to immunocompromise and this puts individuals at risk for a whole host of
      opportunistic infections such as urinary tract infections and pneumonia, both of
    which are common primary diagnoses for nursing home patients admitted to acute

                                                                                             ”
                                         care centers.




                                          PAGE 11 OF 23
MedActive protocol encourages and promotes
ongoing self-care and independence.




    Senior citizens fear moving into a
       nursing home and losing their
     independence more than death,
    according to a research study that
  examines the attitudes and anxieties of
      the nation’s elderly population.

  “Aging in Place in America,” commissioned by Clarity
                and The EAR Foundation                                   ”


                                                         PAGE 12 OF 23
FactsBrands
Four

          Approximately 300,000 cases of ventilator-associated pneumonia (VAP) are reported annually, associated
          with increased morbidity and mortality, and costs up to $50,000 per case.1



                              In a 2008 study in an acute care facility with 4 critical care units, the implementation of a q4
                              oral care protocol costing $21.35/day resulted in an annual savings of more than $7,722.1



          The January 2012 issue of the JADA reported that patients with diabetes were one third less likely to visit an
          emergency department or be hospitalized for the disease when regular dental care was received.2



          Undiagnosed dental and oral problems could be a leading cause of malnutrition in elderly people – the
          problem may be exacerbated by a failure of residential and nursing homes to ensure residents receive
          proper basic oral care. 3



          Patients on dialysis often feel thirsty, but are instructed to control their fluid intake. These patients are
          constantly looking for a way to relieve their dry mouth and satisfy their thirst.4



 1 Killer, Harriet S., RN, BSA, CIC, CPA & Tara Haines, RN, BSN. Simple & Cost-Effective Strategies to Reduce the Occurrence of Ventilator-Associated Pneumonia. Ocala

 Regional Medical Center, Ocala, FL. 2008.
 2   The Journal of the American Dental Association. January 1, 2012. Vol 143, No. 1, 20-30.
 3   Bad teeth cause malnutrition in elderly. BBC News Health. May 21, 1999.
 4The   National Kidney Foundation. http://www.kidney.org/.
                                                                                                                                                                     PAGE 13 OF 23
Physical Removal of Pathogenic Biofilm

Comprehensive
                                Inhibition of Bacterial Migration


                           Remineralization of Tooth Surfaces



                                     Saliva Enhancement
 Continuous
                                    Soft Tissue Conditioning


                                Ongoing Immune System Support



                PAGE 14 OF 23
The                        CONTINUUM™
Continuous, Comprehensive Oral Care & Relief




The Interactive Relationship of Saliva & Mucosal Soft Tissue Supports a Healthy Mouth




    MedActive’s Proprietary Formulation: Spilanthes Extract & ULTRAMULSION®
        Enhances saliva and coats/soothes the soft tissues of the mouth
                                      PAGE 15 OF 23
PAGE 7 OF 19 23
  PAGE 16 OF
Nighttime Care                       Daytime Relief




PROPHY TAPE®        Rinse          Gel      Spray       Lozenges
   (Floss)

                            PAGE 17 OF 23
Four Brands
Summary of the

    Physical removal of plaque biofilms


    Continuous enhancement of saliva flow


    Continuous cleansing of oral biofilm
    2


    Continuous conditioning of soft tissue


    Continuous remineralization of teeth


    Continuous relief of oral discomfort

                              PAGE 18 OF 23
Oral Professionals and Pharmacists Recognize
Medication-Induced Dry Mouth Risk




                        PAGE 19 OF 23
PAGE 20 OF 23
WhiteHill Oral Technologies
Stafford, TX




 • All MedActive Brands are proprietary patented technology

 • ULTRAMULSION® and Spilanthes Extract are exclusively licensed by WhiteHill to
   MedActive for healthcare

 • WhiteHill provides MedActive with:
           o Manufacturing (GMP)
           o Quality Control
           o Quality Assurance
           o Research & Development
           o FDA Label Claims Guidance




                                      PAGE 21 OF 23
Licensed Intellectual Property

  Pending U.S. Patent Applications:         Issued U.S. Patents:

               10/331,800                   5,711,936    6,609,527
               11/149,597                   5,057,310    6,575,176
               11/331,513                   6,138,314    6,907,889
               11/349,042                   6,086,373    6,916,880
               11/549,668                   6,545,077    7,017,591
               11/671,075




 Pending U.S. Trademark Applications:     Registered U.S. Trademark:
               HI-IMPACT™                          MedActive®
             feel it working™
            feel ‘m working™                    ULTRAMULSION®
            Patient-Friendly™                    PROPHY TAPE®
        Oral Relief CONTINNUM™
                                               SOFT ABRASIVES®
      PROPHYLAXIS ESSENTIALS™
   Clean, Lubricate, Moisten & Protect™
           Biofilm Targeting™
          Biofilm Management™
                                                                     PAGE 22 OF 23
Contact


          MedActive Oral Pharmaceuticals, LLC.

                     Headquarters:
                  8364 Forest Oaks Blvd.
                Spring Hill, FL 34606 U.S.A.
                   Phone: 352-293-2164
                     Fax: 352-835-7180




                   © 2011 MedActive, LLC.



                          PAGE 23 OF 23

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MedActive Oral Care for Dry Mouth Conditions

  • 1. © 2012 MedActive, LLC.
  • 2. Four Brands Oral Care Redefined™ MedActive - MedActive redefines oral care by prioritizing dry mouth relief as a critical objective of daily oral hygiene. MedActive’s integration of continuous dry mouth relief into comprehensive oral care is based upon clinical recognition that salivary dysfunction adversely impacts oral and general health, especially for patients managing chronic illness. PAGE 1 OF 23
  • 3. Causes of dry mouth and other oral conditions: • Antibiotics • Anticholinergics • Antihypertensives • Diuretics • Analgesics • Decongestants Medications • Muscle relaxers • Antipsychotics • Sedatives • Corticosteroids • Antihistamines • NSAIDS • Amphetamines • Antidepressants Medical • Cancer Chemotherapy & Radiation Therapy • Kidney Dialysis Treatments • Transplant Surgeries • Diabetes • Anxiety • Hepatitis • COPD • Lupus/Scleroderma • Sleep Disorder Health • Heart Disease • Pneumonia • GERD Condtions • Cancer • Asthma • Obesity • High Blood Pressure • Allergies • Incontinence • Rheumatoid Arthritis • Sjögren’s Syndrome • Depression • HIV/AIDS • Poor hygiene Lifestyle • Smoking • Drug & alcohol abuse • Infrequent dental visits PAGE 2 OF 23
  • 4. MedActive® Brands rely on multiple applications of proprietary ingredients throughout the day. These applications achieve unprecedented relief from dry mouth discomfort. Repetitively enhancing saliva flow, with Spilanthes Extract and its unique “tingle” feature Repetitively moisturizing soft tissue, with ULTRAMULSION® and its extraordinary “mouthfeel” and flavor enhancement Repetitively lubricating and conditioning the mouth, with a mucoprotectant and 2 its distinct substantivity to soft tissue. PAGE 3 OF 23
  • 5. Caries Immune Inflammation System Compromise Mucositis Bacterial Overgrowth Cascade Effects of Dry Mouth Viral & Fungal Stomatititis Overgrowth Periodontitis Pathogenic Biofilm Gingivitis PAGE 4 OF 23
  • 6. Dysphagia Cancer Immuno- compromise Bacteremia Kidney disease Malnutrition Health Migration of biofilm into Impacts of bloodstream Dry Mouth Heart Ingestion of disease bacteria, virus & fungi Diminished quality of Depression life Pulmonary Stroke Infections PAGE 5 OF 23
  • 7. MS, Sjögren’s Scleroderma Denture Syndrome & Lupus Discomfort Arthritis Hyper- tension Parkinson’s Allergies Depression Kidney & Anxiety Patient Dialysis Populations Obesity Alzheimer's & Dementia Sleep Apnea COPD Drug Dependency Gastro- Diabetes intestinal Palliative problems Care PAGE 6 OF 23
  • 8. Integration of Dry Mouth Management into Patient Centered Care Pathways Reduces Costs Nosocomial infections Increased Regulatory dental care risk Longer & more Litigative frequent Downstream risk hospitalizations Medical Costs Empty bed Reduced losses HVBP Incentives Increased Increased care costs drug costs PAGE 7 OF 23
  • 9. Dry mouth leads to and exacerbates the following conditions: • Oral thrush • Gingivitis/Periodontitis • Sensitivity • Bleeding gums • Sores & lesions • Inflammation • Hoarsness • Burning mouth • Caries • Throat irritation • Difficulty swallowing PAGE 8 OF 23
  • 10. Percentage of Adults who have had problems involving the mouth “QuickStats: Percentage of Adults* Aged 18-64 Years Who Have Had Problems Involving the Mouth, by Race/Ethnicity and Type of Problem ---National Health Interview Survey, United States, 2008.” Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report (MMWR). http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6022a7.htm?s_cid=mm6022a7_w PAGE 9 OF 23
  • 11. MedActive provides comprehensive oral care which includes continuous oral relief for patient-centered integrated care pathways. “ Taking the appropriate efforts to improve oral and dental care for nursing home residents could have a significant impact not only on quality of life for nursing facility residents, but also a meaningful impact on downstream medical costs for the health care system by preventing hospitalizations and death resulting from medical care needs arising out of poor oral and dental care. ” PAGE 10 OF 23
  • 12. Dentition problems can result in malnutrition “ Patients with painful dentition eat less, and if the patient is demented at baseline, the communication of the painful condition is often missed by care providers. Dentition problems along with the normal loss of the sense of smell accompanied with aging can result in signficantly reduced caloric intakes. Malnutrition frequently leads to immunocompromise and this puts individuals at risk for a whole host of opportunistic infections such as urinary tract infections and pneumonia, both of which are common primary diagnoses for nursing home patients admitted to acute ” care centers. PAGE 11 OF 23
  • 13. MedActive protocol encourages and promotes ongoing self-care and independence. Senior citizens fear moving into a nursing home and losing their independence more than death, according to a research study that examines the attitudes and anxieties of the nation’s elderly population. “Aging in Place in America,” commissioned by Clarity and The EAR Foundation ” PAGE 12 OF 23
  • 14. FactsBrands Four Approximately 300,000 cases of ventilator-associated pneumonia (VAP) are reported annually, associated with increased morbidity and mortality, and costs up to $50,000 per case.1 In a 2008 study in an acute care facility with 4 critical care units, the implementation of a q4 oral care protocol costing $21.35/day resulted in an annual savings of more than $7,722.1 The January 2012 issue of the JADA reported that patients with diabetes were one third less likely to visit an emergency department or be hospitalized for the disease when regular dental care was received.2 Undiagnosed dental and oral problems could be a leading cause of malnutrition in elderly people – the problem may be exacerbated by a failure of residential and nursing homes to ensure residents receive proper basic oral care. 3 Patients on dialysis often feel thirsty, but are instructed to control their fluid intake. These patients are constantly looking for a way to relieve their dry mouth and satisfy their thirst.4 1 Killer, Harriet S., RN, BSA, CIC, CPA & Tara Haines, RN, BSN. Simple & Cost-Effective Strategies to Reduce the Occurrence of Ventilator-Associated Pneumonia. Ocala Regional Medical Center, Ocala, FL. 2008. 2 The Journal of the American Dental Association. January 1, 2012. Vol 143, No. 1, 20-30. 3 Bad teeth cause malnutrition in elderly. BBC News Health. May 21, 1999. 4The National Kidney Foundation. http://www.kidney.org/. PAGE 13 OF 23
  • 15. Physical Removal of Pathogenic Biofilm Comprehensive Inhibition of Bacterial Migration Remineralization of Tooth Surfaces Saliva Enhancement Continuous Soft Tissue Conditioning Ongoing Immune System Support PAGE 14 OF 23
  • 16. The CONTINUUM™ Continuous, Comprehensive Oral Care & Relief The Interactive Relationship of Saliva & Mucosal Soft Tissue Supports a Healthy Mouth MedActive’s Proprietary Formulation: Spilanthes Extract & ULTRAMULSION® Enhances saliva and coats/soothes the soft tissues of the mouth PAGE 15 OF 23
  • 17. PAGE 7 OF 19 23 PAGE 16 OF
  • 18. Nighttime Care Daytime Relief PROPHY TAPE® Rinse Gel Spray Lozenges (Floss) PAGE 17 OF 23
  • 19. Four Brands Summary of the Physical removal of plaque biofilms Continuous enhancement of saliva flow Continuous cleansing of oral biofilm 2 Continuous conditioning of soft tissue Continuous remineralization of teeth Continuous relief of oral discomfort PAGE 18 OF 23
  • 20. Oral Professionals and Pharmacists Recognize Medication-Induced Dry Mouth Risk PAGE 19 OF 23
  • 22. WhiteHill Oral Technologies Stafford, TX • All MedActive Brands are proprietary patented technology • ULTRAMULSION® and Spilanthes Extract are exclusively licensed by WhiteHill to MedActive for healthcare • WhiteHill provides MedActive with: o Manufacturing (GMP) o Quality Control o Quality Assurance o Research & Development o FDA Label Claims Guidance PAGE 21 OF 23
  • 23. Licensed Intellectual Property Pending U.S. Patent Applications: Issued U.S. Patents: 10/331,800 5,711,936 6,609,527 11/149,597 5,057,310 6,575,176 11/331,513 6,138,314 6,907,889 11/349,042 6,086,373 6,916,880 11/549,668 6,545,077 7,017,591 11/671,075 Pending U.S. Trademark Applications: Registered U.S. Trademark: HI-IMPACT™ MedActive® feel it working™ feel ‘m working™ ULTRAMULSION® Patient-Friendly™ PROPHY TAPE® Oral Relief CONTINNUM™ SOFT ABRASIVES® PROPHYLAXIS ESSENTIALS™ Clean, Lubricate, Moisten & Protect™ Biofilm Targeting™ Biofilm Management™ PAGE 22 OF 23
  • 24. Contact MedActive Oral Pharmaceuticals, LLC. Headquarters: 8364 Forest Oaks Blvd. Spring Hill, FL 34606 U.S.A. Phone: 352-293-2164 Fax: 352-835-7180 © 2011 MedActive, LLC. PAGE 23 OF 23