1. Case #2
An Awesome Presentation Presented to You
by the Best Presenters in the Whole
Presentation World...
...Robert and Lauren!

2. Patient Information
● Female, 55 years old
● No history of health problems
● Marriage problems
● Recently won the lottery

3. Symptoms
● Fatigue
● Headaches
● Excessive salivation
● Nausea / Vomiting
● Diarrhea
● Vertigo
● Abdominal pain
● Weight loss

4. Physical Examination
● Swelling of eyelids
● Partial limb paralysis
● Hyperkeratosis of skin on palms & soles
● White banding on fingernails
● Muscle weakness

5. Lab Results
● Low levels of ATP production
● Unusually high levels of arsenic
● Abnormal levels of cell death
– Due to lack of energy

6. Our Theory – Arsenic Poisoning!

7. Patient's Symptoms vs. Arsenic Poisoning Symptoms
High levels of arsenic
headache dizziness
Falling body temperature
White banding on fingernails
diarrhea
vomiting
Abdominal pain
Muscle weakness
fatigue
vertigo
Excessive salivation
Hyperkeratosis of skin on palms & soles
Eyelid swelling
Limb paralysis
Weight loss
Low levels of atp production
Abnormal amount of cell death
Garlic odor on breath
Kidney failure
Progressive blindness
dementia

8. Arsenic Poisoning
● Organelle affected: mitochondria
● Inhibits pyruvate dehydrogenase
● Conversion of pyruvate to acetyl CoA
decreased
● Citric acid cycle activity decreased
● Production of ATP decreased
● Inhibits cellular glucose uptake and fatty
acid oxidation

9. How (we're guessing) It Happened
● Husband hated her as it was
● She won the lottery
● He wanted her money
● He poisoned her.
● ALL MEN ARE EVIL

10. How (we're guessing) It Happened
● Husband hated her as it was
● She won the lottery
● He wanted her money
● He poisoned her.
● ALL MEN ARE EVIL