This document discusses autoimmune disorders such as rheumatoid arthritis, osteoarthritis, and gouty arthritis. It provides information on their causes, symptoms, diagnosis, and treatment. Specifically:
1) Autoimmune disorders result from the immune system attacking the body's own tissues, causing inflammation and damage. They affect around 3.5% of people and are more common in women.
2) Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation of the joints. It often onset between ages 25-55 and can lead to joint destruction if left untreated.
3) Treatment involves reducing pain and inflammation using medications like NSAIDs, corticosteroids, and disease-modifying drugs. The
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Autoimmune disorders.RA, OA, Gout
1. Autoimmune Disorders:
Rheumatoid Arthritis, Osteoarthritis, &
Gouty Arthritis
Maria Carmela L. Domocmat, RN, MSN
Instructor, Curative and Rehabilitative Nursing Care II
School of Nursing
Northern Luzon Adventist College
2. Rheumatic Disorders
Comprise autoimmune and inflammatory
disorders
‘the primary crippling disease”
Inflammation of joint
Primary reason for work-related disability
Leading cause of disability among 65 yrs old
and above
Maria Carmela L. Domocmat, RN, MSN
3. What causes autoimmune disease?
http://www.medscape.com/content/2000/00/40/87/408750/art-mrc4856.lymp.fig2.gif
Certain variants or mutations in the MHC genes may
result in abnormal MHCDomocmat, RN, MSN
Maria Carmela L.
proteins
4. Reaction to Self
Occurs when the immune system sees “self”
antigens as “nonself”
may be due to genetic factors, infectious agents,
gender, and age
the autoimmune response results in tissue
damage
Some damage occurs in only one or a few organs, in
other cases it may be body-wide (systemic)
Maria Carmela L. Domocmat, RN, MSN
5. Reaction to Self
~ 3.5 % of people have autoimmune diseases
On average, women are 2.7 times more likely to
develop these diseases than men
most have no known cause or cure
treatment is aimed at controlling symptoms
Maria Carmela L. Domocmat, RN, MSN
6. Why does the immune system attack the body that
it’s supposed to protect?
failure to recognize some cells as “self”
in rheumatic fever, the streptococcus antigen is very similar to a
protein in heart tissue, so the body mistakenly identifies heart
tissues as foreign
cells seen as foreign are attacked and destroyed
may be only a few select cells or organs (organ-specific) – e.g.,
multiple sclerosis, juvenile diabetes, rheumatic fever
may be systemic - e.g., systemic lupus erythematosus, rheumatoid
arthritis
Maria Carmela L. Domocmat, RN, MSN
10. Rheumatoid Arthritis (RA)
chronic systemic autoimmune disease
- anti-self antibodies that react with the constant regions of other
antibodies (rheumatoid factor)
onset of disease occurs most often between the ages of
25-55
women are 3 times more likely to develop this than men
symptoms include weakness, fatigue, and joint pain
infections, hormones and genetic factors may be involved
X-ray shows severe arthritis
affecting the joints and
limiting mobility
Maria Carmela L. Domocmat, RN, MSN
11. Rheumatoid arthritis (RA) affects peripheral
joints and may cause destruction of both cartilage
and bone. The disease affects mainly individuals
carrying the DR4 variant of MHC genes.
Maria Carmela L. Domocmat, RN, MSN
16. ACR Clinical Classification
Criteria for Rheumatoid Arthritis
using history, physical examination, laboratory
and radiographic findings:
Maria Carmela L. Domocmat, RN, MSN
19. ACR Clinical Classification Criteria
for Juvenile Rheumatoid Arthritis
GENERAL CLASS
a. Persistent arthritis of at least six weeks duration
in one or more joints
b. Exclusion of other causes of arthritis (see list of
exclusions+)
onset subtypes-determined by manifestations
during the first six months of disease although
manifestations more closely resembling another
subtype may appear later
Maria Carmela L. Domocmat, RN, MSN
20. ACR Classification Criteria for
Determining Progression of
Rheumatoid Arthritis
*These criteria describe either spontaneous remission
or a state of drug-induced disease suppression.
29. Chemistries
normal
with the exception of a slight decrease in albumin
and increase in total protein reflecting the chronic
inflammatory process.
Renal and liver function should be checked prior
to instituting therapy.
Maria Carmela L. Domocmat, RN, MSN
30. Hematology
mild anemia with hematocrit values in the range of 30 - 34%
occurs in approximately 25 to 35% of patients
In most cases, the reduced red cell mass is caused by the anemia of chronic
disease, a normocytic-normochromic process characterized by a low concentration
of serum iron, a low serum iron-binding capacity, and a normal or increased serum
ferritin concentration.
occasionally true iron deficiency anemia can develop secondary to intercurrent
blood loss often from gastrointestinal (GI) bleeding due to NSAIDS.
Patients should be monitored closely for symptoms of GI bleeding and
consideration must also be given to other causes of GI blood loss such
as colonic lesions.
Maria Carmela L. Domocmat, RN, MSN
31. Hematology
white cell count platelet count
usually normal usually normal
can be mildly elevated but thrombocytosis
secondary to occurs in response to
inflammation. inflammation.
Drug reactions and
Felty's syndrome are rare
causes of leukopenia or
thrombocytopenia
Maria Carmela L. Domocmat, RN, MSN
33. Serology
(+) RF
Rheumatoid factors
are autoantibodies directed against IgG
A positive test for rheumatoid factor (RF)
pathognomonic of rheumatoid arthritis
Maria Carmela L. Domocmat, RN, MSN
34. Radiology
early in the disease
show nothing other than soft tissue swelling.
periarticular osteopenia may develop.
With progression of disease
narrowing of the joint space is caused by loss of
cartilage, and juxta-articular erosions appear, generally
at the point of attachment of the synovium.
end-stage disease
large cystic erosions of bone may be seen. Bony
proliferation may occur because of degenerative
changes that follow inflammation.
Maria Carmela L. Domocmat, RN, MSN
40. Typical visible changes
include ulnar deviation of
the fingers at the MCP
joints, hyperextension or
hyperflexion of the MCP
and PIP joints, flexion
contractures of the
elbows, and subluxation
of the carpal bones and
toes (cocked -up).
Maria Carmela L. Domocmat, RN, MSN
42. Rheumatoid Nodules
subcutaneous nodule
the most characteristic extra-articular lesion of the
disease.
occur in 20 to 30% of cases, almost exclusively in
seropositive patients.
located most commonly on the extensor surfaces of the
arms and elbows but are also prone to develop at
pressure points on the feet and knees.
Maria Carmela L. Domocmat, RN, MSN
43. Rheumatoid Nodules
http://images.rheumatology.org/vi
ewphoto.php?imageId=3011201
&albumId=75692
Maria Carmela L. Domocmat, RN, MSN
44. Rheumatoid Nodules
Rheumatoid nodules
commonly form near the
extensor surface of the
elbow. They can be fixed
to the underlying
periosteum or can be
freely mobile.
Maria Carmela L. Domocmat, RN, MSN
45. Caplan’s Syndrome
Presence of rheumatoid nodules in lungs
pneumococcus (noted in among coal miners and
asbestos workers)
http://images.rheumatology.
org/image_dir/album75692/
md_99-05-0096_1.tif.jpg
Maria Carmela L. Domocmat, RN, MSN
46. Cardiopulmonary Disease
There are several pulmonary manifestations of
rheumatoid arthritis,
including pleurisy with or without effusion,
intrapulmonary nodules,
rheumatoid pneumoconiosis (Caplan's syndrome),
diffuse interstitial fibrosis, and rarely,
bronchiolitis obliterans pneumothorax.
Maria Carmela L. Domocmat, RN, MSN
47. Cardiopulmonary Disease
On pulmonary function testing,
there commonly is a restrictive ventilatory defect with
reduced lung volumes and a decreased diffusing
capacity for carbon monoxide.
Although mostly asymptomatic, of greatest
concern is distinguishing these manifestations
from infection and tumor.
Pericarditis is the most common cardiac
manifestation.
Maria Carmela L. Domocmat, RN, MSN
48. Neurologic Disease
most common - is a mild, primarily sensory
peripheral neuropathy, usually more marked in the
lower extremities.
Entrapment neuropathies (e.g., carpal tunnel
syndrome and tarsal tunnel syndrome) sometimes
occur because of compression of a peripheral
nerve by inflamed edematous tissue.
Maria Carmela L. Domocmat, RN, MSN
49. Neurologic Disease
Cervical myelopathy secondary to atlantoaxial
subluxation is an uncommon but particularly
worrisome complication potentially causing
permanent, even fatal neurologic damage.
Maria Carmela L. Domocmat, RN, MSN
50. Felty's Syndrome
is characterized by
splenomegaly
leukopenia - predominantly granulocytopenia.
rare complication
Recurrent bacterial infections and chronic
refractory leg ulcers are the major complications.
Maria Carmela L. Domocmat, RN, MSN
51. Rheumatoid Vasculitis
most common clinical manifestations are small
digital infarcts along the nailbeds.
Maria Carmela L. Domocmat, RN, MSN
52. Sjogren's Syndrome
a chronic inflammatory disorder characterized by
lymphocytic infiltration of lacrimal and salivary
glands.
leads to impaired secretion of saliva and tears and
results in the sicca complex:
dry mouth (xerostomia)
dry eyes (keratoconjunctivitis sicca)
dry vagina (rare)
Maria Carmela L. Domocmat, RN, MSN
53. Criteria for Diagnosis of
Sjögren's Syndrome
Four or
more of
the
following
criteria
must be
present
Maria Carmela L. Domocmat, RN, MSN
54. Ocular Disease
Keratoconjunctivitis of Sjogren's syndrome is the
most common ocular manifestation of rheumatoid
arthritis.
Sicca (dry eyes) is a common complaint.
Episcleritis occurs occasionally and is manifested
by mild pain and intense redness of the affected
eye.
Scleritis and corneal ulcerations are rare but more
serious problems.
Maria Carmela L. Domocmat, RN, MSN
57. Disability is higher among patients with
rheumatoid arthritis with 60% being unable to
work 10 years after the onset of their disease.
Recent studies have demonstrated an increased
mortality in rheumatoid patients.
Median life expectancy was shortened an average
of 7 years for men and 3 years for women
compared to control populations.
Maria Carmela L. Domocmat, RN, MSN
58. Patients at higher risk for shortened survival are
those with
systemic extra-articular involvement,
low functional capacity,
low socioeconomic status,
low education, and
prednisone use.
Maria Carmela L. Domocmat, RN, MSN
59. ACR Guidelines for Medical
Management of Rheumatoid
Arthritis
(updated April, 2002)
63. The goal of treatment now aims toward
achieving the
lowest possible level of arthritis disease activity
and remission if possible,
the minimization of joint damage, and
enhancing physical function and quality of life.
Maria Carmela L. Domocmat, RN, MSN
64. Reduce pain and inflammation
Protect Articular surface
› Reduction of joint stress
Maintain function
› ROM exercises
› Physical and occupational therapy
Surgical intervention
Maria Carmela L. Domocmat, RN, MSN
68. NSAIDs and corticosteroids
have a short onset of action while DMARDs can
take several weeks or months to demonstrate a
clinical effect
Maria Carmela L. Domocmat, RN, MSN
70. NSAIDs
major effect - reduce acute inflammation thereby
decreasing pain and improving function.
have mild to moderate analgesic properties
independent of their anti-inflammatory effect.
Note: these drugs alone do not change the course
of the disease of rheumatoid arthritis or prevent
joint destruction.
Maria Carmela L. Domocmat, RN, MSN
72. Aspirin - oldest drug of the non-steroidal class
but because of its high rate of GI toxicity, a narrow
window between toxic and anti-inflammatory serum
levels, and the inconvenience of multiple daily doses,
aspirin's use as the initial choice of drug therapy
has largely been replaced by other NSAIDs.
Maria Carmela L. Domocmat, RN, MSN
75. Drugs for Prevention NSAID-
Induced Ulcers
If NSAID-induced ulcers are identified, the
following steps have been suggested:
Switch to alternative pain relievers.
proton-pump inhibitors (PPIs).
misoprostol or Arthrotec.
L-arginine
If cannot change drugs, then should use lowest
NSAID dose possible
Maria Carmela L. Domocmat, RN, MSN
76. Drugs for Prevention NSAID-
Induced Ulcers
proton-pump inhibitors (PPIs).
Can reduce NSAID-ulcer rates by as much as 80%
compared with no treatment.
omeprazole (Prilosec)
esomeprazole (Nexium)
lansoprazole (Prevacid),
rabeprazole (Aciphex),
pantoprozole (Protonix).
Maria Carmela L. Domocmat, RN, MSN
77. Drugs for Prevention NSAID-
Induced Ulcers
Try misoprostol or Arthrotec.
If other agents are inappropriate, misoprostol protects against
the major intestinal toxicity of NSAIDs.
the first drug approved for preventing NSAID-induced ulcers.
It is equally or even more effective than some of the PPIs, but it
does not heal existing ulcers and has more side effects than
PPIs. Patients tend to stop using it.
Arthrotec - a combination of an ulcer protective
agent called misoprostol and the NSAID
diclofenac.
Maria Carmela L. Domocmat, RN, MSN
78. L-arginine supplement
an amino acid found in health stores
may help protect against damage from NSAIDs.
an alternative agent
not government regulated and more research is
needed to confirm its benefits.
Maria Carmela L. Domocmat, RN, MSN
79. Topical NSAIDs
delivered in gels, creams, or patches are proving
to reduce arthritic pain and pose less of a risk for
gastrointestinal complications associated with
oral NSAIDs.
diclofenac (Pennsaid, Oxa Sat)
eltenac, ibuprofen, or ketoprofen.
Maria Carmela L. Domocmat, RN, MSN
81. NSAIDS: COX-2 inhibitor
includes COX-2 inhibitors
also effective in controlling inflammation.
Only one of these agents is currently available in
the United States (celecoxib, Celebrex®) while
additional compounds are available in other
countries (etoricoxib, Arcoxia®; lumiracoxib,
Prexige®).
Maria Carmela L. Domocmat, RN, MSN
83. COX-2 inhibitors
designed to decrease the gastrointestinal risk of
NSAIDS,
but concerns of possible increases in
cardiovascular risk with these agents has led to
the withdrawal of two of these drugs from the
market (rofecoxib, Vioxx®; valdecoxib, Bextra®).
Maria Carmela L. Domocmat, RN, MSN
85. Corticosteroids
anti-inflammatory & immunoregulatory activity.
PO, IV, IM or can be injected directly into the joint.
useful in early disease as temporary adjunctive
therapy while waiting for DMARDs to exert their
antiinflammatory effects.
Maria Carmela L. Domocmat, RN, MSN
87. Corticosteroids
also useful as chronic adjunctive therapy in
patients with severe disease that is not well
controlled on NSAIDs and DMARDs.
Weight gain and a cushingoid appearance
(increased fat deposition around the face, redness
of the cheeks, development of a “buffalo hump”
over the neck) is a frequent problem and source of
patient complaints
Maria Carmela L. Domocmat, RN, MSN
89. Prevent osteoporosis due to steroid
use
adequate calcium and vitamin D supplementation
Bisphosphonates
alendronate (Fosamax®)
risedronate (Actonel®)
ibandronate (Boniva®)
Patients with and without osteoporosis risk factors
on low dose prednisone should undergo bone
densitometry (DEXA Scan) to assess fracture risk.
Maria Carmela L. Domocmat, RN, MSN
90. Intra-articular corticosteroids
(e.g., triamcinolone or
methylprednisolone and others)
are effective for controlling a local
flare in a joint without changing the
overall drug regimen.
Maria Carmela L. Domocmat, RN, MSN
93. Disease Modifying Anti-rheumatic
Drugs (DMARDs)
Can alter the disease course and improve
radiographic outcomes.
DMARDs have an effect upon rheumatoid arthritis
that is different and may be more delayed in onset
than either NSAIDs or corticosteroids.
when the diagnosis of rheumatoid arthritis is
confirmed, DMARD agents should be started.
Maria Carmela L. Domocmat, RN, MSN
95. DMARDs
B cell Depleting Agents
rituximab (Rituxan®)
Interleukin-1 (IL-1) Receptor Antagonist Therapy
anakinra (Kineret®)
Intramuscular Gold
Other Immunomodulatory and Cytotoxic agents—
azathioprine (Imuran®),
cyclophosphamide, and
cyclosporine A(Neoral®, Sandimmune®)
Maria Carmela L. Domocmat, RN, MSN
96. Methotrexate
the first-line DMARD agent
Has rapid onset of action at therapeutic doses (6-
8 weeks)
good efficacy
favorable toxicity profile
ease of administration
and relatively low cost.
Maria Carmela L. Domocmat, RN, MSN
98. Hydroxychloroquine
an antimalarial drug
relatively safe and well-tolerated agent for the
treatment of rheumatoid arthritis.
have limited ability to prevent joint damage on
their own, their use should probably be limited to
patients with very mild and nonerosive disease.
Maria Carmela L. Domocmat, RN, MSN
99. Hydroxychloroquine
is sometimes combined with methotrexate for
additive benefits for signs and symptoms or as
part of a regimen of “triple therapy” with
methotrexate and sulfasalazine.
Maria Carmela L. Domocmat, RN, MSN
100. Sulfasalazine
Azulfidine®
effectiveness - somewhat less than
that methotrexate,
reduce signs and symptoms and
slow radiographic damage.
given in conjunction with
methotrexate and
hydroxychloroquine as part of a
regimen of “triple therapy”
Maria Carmela L. Domocmat, RN, MSN
101. Leflunomide (Arava®)
efficacy is similar to methotrexate in terms of signs
and symptoms
viable alternative - failed or are intolerant to
methotrexate.
Maria Carmela L. Domocmat, RN, MSN
102. Tumor necrosis factor (TNF)
inhibitors
Tumor necrosis factor alpha (TNF)
is a pro-inflammatory cytokine produced by
macrophages and lymphocytes.
found in large quantities in the rheumatoid joint and is
produced locally in the joint by synovial macrophages
and lymphocytes infiltrating the joint synovium.
TNF is one of the critical cytokines that mediate joint
damage and destruction due to its activities on many
cells in the joint as well as effects on other organs and
body systems.
Maria Carmela L. Domocmat, RN, MSN
103. TNF antagonists
first of the biological DMARDS to be approved for
the treatment of RA and
have also been referred to as biological
response modifiers or “biologics” to
differentiate them from other DMARDS such as
methotrexate, leflunomide, or sulfasalazine.
Maria Carmela L. Domocmat, RN, MSN
104. TNFs or Biological Response
Modifiers (BRMs)
Etanercept (Enbrel®)
Infliximab(Remicade®)
Adalimumab (Humira®)
Maria Carmela L. Domocmat, RN, MSN
105. Etanercept (Enbrel®)
Etanercept is effective in reducing the signs and
symptoms of RA, as well as in slowing or halting
radiographic damage, when used either as
monotherapy or in combination with methotrexate.
Maria Carmela L. Domocmat, RN, MSN
106. Infliximab(Remicade®)
Infliximab, in combination with methotrexate, is
approved for the treatment of RA, and for the
treatment of psoriatic arthritis, and ankylosing
spondylitis, as well as psoriasis and Crohn’s
disease.
Maria Carmela L. Domocmat, RN, MSN
107. Adalimumab (Humira®)
Adalimumab is a fully human anti-TNF monoclonal
antibody with high specificity for TNF.
Maria Carmela L. Domocmat, RN, MSN
108. Anakinra (Kineret™)
a human recombinant IL-1 receptor antagonist (hu
rIL-1ra)
can be used alone or in combination with
DMARDs other than TNF blocking agents
(Etanercept, Infliximab, Adalimumab).
Maria Carmela L. Domocmat, RN, MSN
109. T-cell Costimulatory blockade
Abatacept (Orencia®)
first of a class of agents known as T-cell
costimulatory blockers.
interfere with the interactions between antigen-
presenting cells and T lymphocytes and affect
early stages in the pathogenic cascade of events
in rheumatoid arthritis.
Maria Carmela L. Domocmat, RN, MSN
110. Intramuscular Gold
Myochrysine® and Solganal®
IM
have been replaced by
Methotrexate and other DMARDS
as the preferred agents to treat RA.
rarely used now due to their
numerous side effects and
monitoring requirements, their
limited efficacy, and very slow
onset of action.
Maria Carmela L. Domocmat, RN, MSN
112. Alternative treatments
glucosamine sulfate
chondroitin sulfateare
are dietary supplements usually taken in pill form that
are thought to protect and possibly help repair
cartilage cells.
Maria Carmela L. Domocmat, RN, MSN
114. Chronic pain r/t inflammation and swelling from
pressure on surrounding tissues, joint deformity
and joint destruction
Teach about meds
Promote comfort with nonpharmacologic measures
Manage stiffness
Promote sleep and rest
Maria Carmela L. Domocmat, RN, MSN
117. Promote sleep and rest
Encourage to sleep at least 8 hrs at night, take
daily naps
Promote a quiet envt
Provide warm beverages before retiring to sleep
Administer hypnotics or relaxants as prescribed
Maria Carmela L. Domocmat, RN, MSN
119. Reduction of joint stress
Because obesity stresses the musculoskeletal
system, ideal body weight should be achieved and
maintained.
Rest, in general, is an important feature of
management.
When the joints are actively inflamed, vigorous
activity should be avoided because of the danger
of intensifying joint inflammation or causing
traumatic injury to structures weakened by
inflammation.
Maria Carmela L. Domocmat, RN, MSN
120. Readiness for enhanced self-care r/t complex
medication schedules, high risk of S/E of meds,
health maintenance, and self-care
Promote balanced diet
Promote decision-making
Promote hope
Promote coping
Maria Carmela L. Domocmat, RN, MSN
121. Self-care
Use china or heavy plastic cup with handle
which is easier to manipulate rather than
styrofoam or paper cup which may bend or
collapse
When fine motor activities become impossible –
use larger joints or body surfaces
Ex: use palm of hand to press the toothpaste to
toothbrush rather than the fingers
Use devices – long-handed brushes to brush hair or
dressing sticks for facilitite wearing of pants
Maria Carmela L. Domocmat, RN, MSN
122. Reduction of joint stress
urge to maintain a modest level of activity to
prevent joint laxity and muscular atrophy.
Splinting of acutely inflamed joints, particularly at
night and the use of walking aids (canes, walkers)
are all effective means of reducing stress on
specific joints.
Maria Carmela L. Domocmat, RN, MSN
123. Assistive devices
Computer Keyboard Aid
Arthritic's Pen
Maria Carmela L. Domocmat, RN, MSN
124. Phone & Cup Holder with
Hook and Loop Strap
Maria Carmela L. Domocmat, RN, MSN
125. Arthritis in your hands
causes your finger joints
and knuckles to become
stiff and sometimes
painful and swollen.
Protect your hands by
avoiding pushing, pulling
and twisting motions.
Avoid making a tight fist
or pinching objects tightly.
Maria Carmela L. Domocmat, RN, MSN
126. Instead, use a grasp that
aligns your knuckles
evenly along the handle
of the tool or utensil.
This makes grasping the
tool more comfortable
and requires less effort to
use the tool.
For instance, a built-up
handle made of foam can
make it easier for you to
grasp your toothbrush.
Maria Carmela L. Domocmat, RN, MSN
127. For tasks that require you to
pinch objects tightly, look for
assistive devices that can help
you hold the object with less
force.
For instance, using a special
key holder may help you turn
keys more comfortably without
putting strain on your hand.
This type of holder aligns your
knuckles evenly along the
handle of the tool or utensil,
allowing you to use a larger
grip to turn the key.
Maria Carmela L. Domocmat, RN, MSN
128. Use assistive devices to
help you open jars. This
spares your fingers from
the twisting motion
required to open a jar.
Maria Carmela L. Domocmat, RN, MSN
129. To protect your finger joints,
avoid tightly pinching with
your fingers.
For example, use a button
aid to help you grasp and
fasten buttons on your
clothes. Choose clothes with
easy-to-close fasteners,
such as zippers, large
buttons or hooks.
Maria Carmela L. Domocmat, RN, MSN
130. Promote balanced diet
Good oral hygiene b4 and after meals
Small, frequent feedings
High-caloric snacks
If with xerostamia – moisten foods, extra fluids with
meals
Eliminate spicy or acidic foods
Sit upright to eat
Take all meds with food and full glass of water – to
ameliorate GI distress
Use assistive device if with stiffness
Maria Carmela L. Domocmat, RN, MSN
131. Promote decision-making
Exercise healthy control over the disease
Client should be able to verbalize cause of illness
Educate the client
Increase participation in decision-making
allow as many choices as possible
Decide on own ADL
Maria Carmela L. Domocmat, RN, MSN
132. Promote hope
Avoid false reassurance
Help set realistic goals
Praise for accomplishments (no matter how
small)
Active listening
Be sensitive to changes in mind and affect
Maria Carmela L. Domocmat, RN, MSN
133. Promote coping
The client would be able to integrate disease
into the demands of daily living
Sign that the client has healthy approach
strategies
Seek out info and assistance
Find strength through spiritual support
Verbalize feelings and concerns
Set goals
Express positive thoughts
Maintain realistic independence
Maria Carmela L. Domocmat, RN, MSN
134. Signs of less adaptive strategies
Avoidance strategies – ex: denial
Excessive sleeping
Other passive behaviors
Depression
Maria Carmela L. Domocmat, RN, MSN
136. Management of Fatigue:
For muscle atrophy – aggressive PT to
strengthen muscle and prevent further atrophy
Maria Carmela L. Domocmat, RN, MSN
137. Management of Fatigue
Principles of energy conservation
Pacing activities- do not plan too much activity for one
day
Allow rest periods
Set priorities – determine which activities are most
important and do them first
Obtain assistance when needed – delegate
responsibilities
balance activity and rest
Plan ahead to prevent last minute rushing and stress
Learn own activity tolerance and do not exceed it
Maria Carmela L. Domocmat, RN, MSN
139. Enhance body image
Body image may be affected by both the disease
process and drug therapy
Ulnar deviation, swan-neck deformity, boutonnière
deformity, rheumatoid nodules
Steroid side effect – cushingoid syndrome
Determine client’s perception of the changes
and impact of reaction of the SO
Most impt Ix – communicate acceptance of the
client ; establish and maintain trusting
relationship to encourage the client to express
feelings
Maria Carmela L. Domocmat, RN, MSN
140. Let the client wear own clothes rather than the
hosp gown, brush own hair, use make-up if
desired
Use colored hair accessories , nail polish,
perfume
Maria Carmela L. Domocmat, RN, MSN
143. Tendon transfer and osteotomy
Nodules or benign bony tumors (exostoses) –
surgically removed and flexion contractures
surgically relieved
Osteotomies
Excision or cutting through bones
Maria Carmela L. Domocmat, RN, MSN
145. Synovectomy
ordinarily not recommended for patients with
rheumatoid arthritis, primarily because relief is
only transient.
synovectomy of the wrist - an exception
recommended if intense synovitis is persistent despite
medical treatment over 6 to 12 months.
Persistent synovitis involving the dorsal compartments
of the wrist can lead to extensor tendon sheath rupture
resulting in severe disability of hand function.
Maria Carmela L. Domocmat, RN, MSN
148. Arthrodesis
Operation that produce bony fusion of joint
used for clients with bone loss after joint
infection , tumors, musculoskeletal trauma,
paralysis
Immobilize the joint but eliminate some
discomfort or arthritic process
Ankle - most common
Maria Carmela L. Domocmat, RN, MSN
149. Joint arthroplasty or replacement
particularly of the knee, hip, wrist, and elbow, are highly
successful.
Arthroplasty of the metacarpophalangeal (knuckle)
joints also can reduce pain and improve function.
Maria Carmela L. Domocmat, RN, MSN
153. Surgical intervention
Other operations include
release of nerve entrapments (e.g., carpal tunnel
syndrome)
arthroscopic procedures
removal of a symptomatic rheumatoid nodule. -
occasionally
Maria Carmela L. Domocmat, RN, MSN
154. Complementary/ Alternative
therapies
Pain relief – hypnosis, acupuncture, magnet
Good nutrition
Omega-3 fatty acids
Found in coldwater fish (salmon, sea bass, tuna)
May help reduce inflam
But amount needed is impractical to human consumption
Fish oil capsules
Maria Carmela L. Domocmat, RN, MSN
155. Complementary/ Alternative
therapies
Antioxidant vitamins (A,C, E) to help maintain normal
function of the immune system
Trace elements for joint health
Zinc, Selenium, Copper, Iron
Maria Carmela L. Domocmat, RN, MSN
156.
157. Osteoarthritis
associated with the
aging process and
can affect any joint.
The cartilage of the
affected joint is
gradually worn
down, eventually
causing bone to rub
against bone. Bony
spurs develop on
the unprotected
bones, causing pain
and inflammation.
Maria Carmela L. Domocmat, RN, MSN
160. Osteoarthritis is a deterioration of cartilage and
overgrowth of bone often due to "wear and tear."
Rheumatoid arthritis is the inflammation of a
joint's connective tissues, such as the synovial
membranes, which leads to the destruction of
the joint's cartilage.
Maria Carmela L. Domocmat, RN, MSN
161. Known as the “wear-and-tear” kind of arthritis
a chronic condition characterized by the
breakdown of the joint’s cartilage. Cartilage is the
part of the joint that cushions the ends of the
bones and allows easy movement of joints. The
breakdown of cartilage causes the bones to rub
against each other, causing stiffness, pain and
loss of movement in the joint.
Maria Carmela L. Domocmat, RN, MSN
162. AKA
degenerative joint disease,
ostoarthrosis,
hypertrophic arthritis
degenerative arthritis.
Maria Carmela L. Domocmat, RN, MSN
163. stages of osteoarthritis
Cartilage loses elasticity and is more easily
damaged by injury or use.
Wear of cartilage causes changes to underlying
bone. The bone thickens and cysts may occur
under the cartilage. Bony growths, called spurs or
osteophytes, develop near the end of the bone at
the affected joint.
Maria Carmela L. Domocmat, RN, MSN
164. stages of osteoarthritis
Bits of bone or cartilage float loosely in the joint
space.
The joint lining, or the synovium, becomes
inflamed due to cartilage breakdown causing
cytokines (inflammation proteins) and enzymes
that damage cartilage further.
Maria Carmela L. Domocmat, RN, MSN
165. The main problem in
knee OA is degeneration
of the articular cartilage.
Articular cartilage is the
smooth lining that covers
the ends of bones where
they meet to form the
joint. The cartilage gives
the knee joint freedom of
movement by decreasing
friction.
Maria Carmela L. Domocmat, RN, MSN
166. The articular cartilage is
kept slippery by joint fluid
made by the joint lining
(the synovial membrane).
The fluid, called synovial
fluid, is contained in a soft
tissue enclosure around
synovial joints called
the joint capsule.
Maria Carmela L. Domocmat, RN, MSN
167. An important substance
present in articular
cartilage and synovial
fluid is called hyaluronic
acid. Hyaluronic acid
helps joints collect and
hold water, improving
lubrication and reducing
friction. It also acts by
allowing cells to move
and work within the joint.
Maria Carmela L. Domocmat, RN, MSN
168. When the articular
cartilage degenerates, or
wears away, the bone
underneath is uncovered
and rubs against bone.
Small outgrowths called
bone spurs,
or osteophytes, may form
in the joint.
Maria Carmela L. Domocmat, RN, MSN
169. Changes in the cartilage and bones of the joint
can lead to pain, stiffness and use limitations.
Deterioration of cartilage can:
Affect the shape and makeup of the joint so it doesn’t
function smoothly. - limp when walk or have trouble
going up and down stairs.
Cause fragments of bone and cartilage to float in joint fluid
causing irritation and pain.
Cause bony spurs, called osteophytes, to develop near
the ends of bones
Mean the joint fluid doesn’t have enough hyaluronan,
which affects the joint’s ability to absorb shock.
Maria Carmela L. Domocmat, RN, MSN
171. Causes and Risk factors
there is no single known cause of osteoarthritis
(OA),
there are several risk factors that should be
considered
Age
Obesity
Injury or Overuse
Genetics or Heredity
Muscle Weakness
Other Diseases and Types of Arthritis
Maria Carmela L. Domocmat, RN, MSN
174. Acetaminophen
Tylenol, Anacin-3, Panadal, Phenaphen,
Valadol, and others)
for mild to moderate osteoarthritis.
usually the first choice
Maria Carmela L. Domocmat, RN, MSN
175. Nonsteroidal anti-inflammatory
drugs (NSAIDs)
for moderate to severe arthritic pain.
OTC NSAIDs
Prescription NSAIDs include
Maria Carmela L. Domocmat, RN, MSN
176. Drugs for Prevention NSAID-
Induced Ulcers
If NSAID-induced ulcers are identified switch to
alternative pain relievers.
Maria Carmela L. Domocmat, RN, MSN
177. Topical NSAIDs
$63.07
Maria Carmela L. Domocmat, RN, MSN
178. Capsaicin (Zostrix)
is an ointment prepared from the active
ingredient in hot chili peppers that has been
helpful for relieving painful areas in other
disorders.
Maria Carmela L. Domocmat, RN, MSN
180. Tramadol (Ultram)
is a pain reliever that has some properties that
are similar to narcotics.
not as addictive, however, and may be an
alternative for patients who do not respond to
NSAIDs or less potent agents.
Maria Carmela L. Domocmat, RN, MSN
182. Narcotic pain relievers
oxycodone, oxymorphone, or morphine
may be necessary for severe pain that does not
respond to less potent pain relievers.
Maria Carmela L. Domocmat, RN, MSN
187. Gouty arthritis
is a disease characterized by an abnormal
metabolism of uric acid, resulting in an excess of
uric acid in the tissues and blood causing
inflammation
People with gout either produce too much uric
acid, or more commonly, their bodies have a
problem in removing it.
AKA
gout
the disease of kings
the king of diseases
Maria Carmela L. Domocmat, RN, MSN
189. Gouty arthritis
Primary
Inherited X-lined trait
Caused by several inborn errors of purine metabolism
Uric acid- is the end-product of purine metabolism; excreted
in urine
Production of uric acid exceeds the excretion
capability of kidneys
Sodium urate is deposited in the synovium and other
tissues which results in inflammation
Males, 30’s and 40’s
Maria Carmela L. Domocmat, RN, MSN
190. Gouty arthritis
Secondary
Hyperuricemia
Excessive uric acid in blood casued by anoterh disease
Affects all ages
Renal insufficiency
Diuretic therapy
Multiple myeloma
Carcinomas
Causes:
decreased normal excretion of uric acid and other waste
products
Increased production of uric acid
Maria Carmela L. Domocmat, RN, MSN
191. Four Stages Of Gouty Arthritis
Asymptomatic Hyperuricemia
Acute Gout / Acute Gouty Arthritis
Interval / Intercritical
Chronic Tophaceous Gout
Maria Carmela L. Domocmat, RN, MSN
192. Four Stages Of Gouty Arthritis
Asymptomatic Hyperuricemia:
Asypmptomatic but with elevated blood uric acid
levels
Serum uric acid level (mg/dl) Incidence of gout
>9.0 7.0-8.9
7.0-8.9 0.5-0.37
<7.0 0.1%
Maria Carmela L. Domocmat, RN, MSN
193. Four Stages Of Gouty Arthritis
Acute Gout / Acute Gouty Arthritis
hyperuricemia has caused deposits of uric acid
crystals in joint spaces, leading to gouty attacks.
Excruciating pain and inflammation of one or more
joints – esp metatarsophalangeal joints of the great
toe (podagra)
Increased ESR, WBC
Maria Carmela L. Domocmat, RN, MSN
197. Four Stages Of Gouty Arthritis
Interval / Intercritical
the periods between acute gouty attacks – may be
months or years after the 1st attack
Asymptomatic period
No abnormality in joints
Chronic Tophaceous Gout:
the disease has caused permanent damage
Deposits or urate crytals under skin and within major
organs (i.e., urate kidney stone formation)
Maria Carmela L. Domocmat, RN, MSN
198. Tophi
Tophi – deposits of sodium urate crystals
May occur anywhere; common in outer ear
http://www.hopkins-arthritis.org/images/gout_fig7.gif
Maria Carmela L. Domocmat, RN, MSN
207. Management
Drug therapy
acute gouty arthritis – inflammation subsides
spontaneously within 3 to 5 days
But if cannot tolerate pain
Colchicine (Colsalide, Novocolchicine) and NSAIDs
Taken for 4-7 days
(NSAIDs) -Indomethacin (Indocin), ibuprofen (Advil),
and naproxen (Aleve), celecoxib (Celebrex)
painkillers such as codeine, hydrocodone,
and oxycodone
Corticosteroids
Maria Carmela L. Domocmat, RN, MSN
208. Management
Drug therapy
Chronic or repeated acute episodes
Allopurinol (Zyloprim)
A xanthine oxidase inhibitor – prevents conversion of xanthine
to uric acid
Probenecid (Benemid, Benuryl)
Uricosuric drug – promotes excretion of excess uric acid
drink at least 2 liters of fluid a day while taking this medication
(to help prevent uric acid kidney stones from forming).
Combination drug
Probenecid and Colchicine (ColBenemid)
Note: avoid aspirin – it inactivates the drug
Maria Carmela L. Domocmat, RN, MSN
210. Febuxostat (Uloric)
first new medication developed specifically for the
control of gout in over 40 years.
Decreases formation of uric acid by the body and is a
very reliable way to lower the blood uric acid level.
can be used in patients with mild to moderate kidney
impairment.
should not be taken with 6-mercaptopurine (6-MP), or
azathioprine.
http://www.emedicinehealth.com/gout/page7_em.htm#Medications
Maria Carmela L. Domocmat, RN, MSN
212. Management
Diet therapy
Avoid alcohol, anchovies, sardines, oils, herring,
organ meat (liver, kidney, and sweetbreads), legumes
(dried beans and peas), gravies, mushrooms,
spinach, asparagus, cauliflower, consommé, and
baking or brewer's yeast.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/
Maria Carmela L. Domocmat, RN, MSN
213. Limit meat
Avoid fatty foods such as salad dressings, ice
cream, and fried foods.
Eat enough carbohydrates.
If losing weight, lose it slowly. Quick weight loss
may cause uric acid kidney stones to form.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/
Maria Carmela L. Domocmat, RN, MSN
215. Avoid all forms of aspirin and diuretics – may
precipitate attack
Excessive physical or emotional stress- can
exacerbate disease
Maria Carmela L. Domocmat, RN, MSN
216. Prevention of kidney stone
formation
Increase fluid intake – prevent stone formation
Dilute urine and prevent sediment formation
Alkaline ash diet
Citrus fruits, juices, milk and certain dairy products
Uric acid is more soluble in high pH urine – less likely
to form urinary stones
Maria Carmela L. Domocmat, RN, MSN