1. AMINOFLAVONES: A POTENTIAL AhR-DIRECTED BREAST CANCER TREATMENT Edward A. Sausville, M.D., Ph.D University of Maryland Marlene and Stewart Greenebaum Cancer Center
6. ANTITUMOR ACTIVITY OF AMINOFLAVONE AGAINST MCF-7 BREAST TUMOR XENOGRAFTS Loaiza-Perez et al, Mol Cancer Ther. 3:715, 2004
7. AMINOFLAVONE INDUCES CYP1A1 ACTIVITY IN AF-SENSITIVE MCF-7 CELLS BUT NOT IN RESISTANT CELLS Loaiza-Perez et al, Mol Cancer Ther. 3:715, 2004
8. AMINOFLAVONE INDUCES BINDING TO XRE SEQUENCES OF CYP1A1 IN MCF-7 CELLS Loaiza-Perez et al, Mol Cancer Ther. 3:715, 2004
9. AMINOFLAVONE INDUCES TRANSLOCATION OF THE AHR TO THE NUCLEUS IN AF-SENSITIVE MCF-7 CELLS Loaiza-Perez et al, Mol Cancer Ther. 3:715, 2004
10. GENERATION OF G-H2AX FOCI IN MCF-7 CELLS TREATED WITH AMINOFLAVONE Meng et al Cancer Res 65: 5337, 2005
11. 2 SO 3 Me AFP 464 NSC 710464 AF NSC 686288 Sensitive breast cancer cell AhR Insensitive breast cancer cell nucleus AhR: ligand Translocation to nucleus CYP1A1 Induction Covalent binding Reactive intermediate DNA adducts Single strand breaks Cell death ER Cell survival AhR Hsp 90 PROPOSED MODE OF ACTION OF AMINOFLAVONE
14. Expression of ERa in MDA-MB-231 Restores Sensitivity to AF AhR ER α ER α & AhR ER α /AhR/DAPI MDA-MB-231/ ER
15. COMBINATION OF AF WITH ER ANTAGONISTS SHOW INCREASEDANTI-PROLIFERATIVE EFFECT
16.
17. ACKNOWLEDGEMENTS ANGELIKA BURGER PHILLIP SHELTON AVERELL GNATT ANGELA BRODIE “ The Role of Aryl Hydrocarbon Receptor and Cross Talk with Estrogen Receptor in the Response of Breast Cancer Cells to the NovelAntitumor Agent Aminoflavone” Susan G. Komen for the Cure
