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open content and
                                 the commons

                                          kaitlin thaney
                           program manager, science at creative commons
                                sherbrooke, quebec - 11 march 2010


                                This presentation is licensed under the CreativeCommons-Attribution-3.0 license.

Thursday, March 11, 2010
make sharing easy, legal and scalable

                           integrated approach

             building part of the infrastructure for
                       knowledge sharing

Thursday, March 11, 2010
knowledge?

                               journal articles
                                     data
                                  ontologies
                                 annotations
                                grey literature
                           plasmids and stem cells

Thursday, March 11, 2010
(1) the “paradigm shift”

  (2) access ...
      (content) (research tools) (data)

  (3) technical / semantic



Thursday, March 11, 2010
1.
                   the “paradigm shift”
             it’s no longer about the container.




Thursday, March 11, 2010
scientific revolutions occur when a
              sufficient body of data accumulates to
                overthrow the dominant theories
                     we use to frame reality,

                           ... a so-called paradigm shift

                                                - thomas kuhn
Thursday, March 11, 2010
Thursday, March 11, 2010
media company response:
    adjust the physical media
       force the cd format

           ignore that people...
            like to make mixes.




Thursday, March 11, 2010
facing the same
                                   shift
                           for education, science



Thursday, March 11, 2010
scholarship entrenched in idea of
                  transmitting knowledge via paper

          mentality reflected even in the way we
                    describe “papers”

                  static, one-dimensional documents


Thursday, March 11, 2010
information sharing is at the root of
             scholarship and science

               the system of print publishing is a
             system of communicating knowledge

                 then came the move to digital ...


Thursday, March 11, 2010
in the digital world, “papers” can
                       become living, breathing works

                      no longer static PDF documents

               linking to data sets, other relevant
               papers, information, plasmids, genes


Thursday, March 11, 2010
oldest scientific
                               journal
                             published in
                               english-
                           speaking world

                                1665


Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
need to change the way we think of
                       scholarly publishing,
                      of knowledge sharing

                                paradigm shift

                           begin thinking of “papers” as
                            containers of knowledge

Thursday, March 11, 2010
the container is still the paper




              what’s changed is how we use it
Thursday, March 11, 2010
Thursday, March 11, 2010
2.
                           access is step one

                     content needs to be legally and
                         technically accessible



Thursday, March 11, 2010
indexing, translation, redistribution: disallowed




Thursday, March 11, 2010
“ By open access to the literature, we mean its
                       free availability on the public internet,
                      permitting users to read, download, copy,
                 distribute, print, search, or link to the full texts of
                  the articles, crawl them for indexing, pass them as
                 data to software, or use them for any other lawful
                      purpose, without financial, legal or technical
                 barriers other than those inseparable from gaining
                              access to the internet itself.”

                           Image from the Public Library of Science, licensed to the public, under
                                                        CC-BY-3.0



Thursday, March 11, 2010
“The only constraint on reproduction and
                 distribution, and the only role for copyright in this
                 domain, should be to give authors control over the
                     integrity of their work and the right to be
                      properly acknowledged and cited.”




Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
legal
                           implementation




Thursday, March 11, 2010
Open Access journals




                           >1000 journals under CC

                             image from the public library of science
                             licensed to the public under CC-BY 3.0


Thursday, March 11, 2010
... what about the
                                physical
                                materials?




Thursday, March 11, 2010
non-digital.




Thursday, March 11, 2010
non-digital.




Thursday, March 11, 2010
non-digital.




Thursday, March 11, 2010
ideally ...

                       contact author, obtain material,
                            recreate experiment

                 build on the existing work, publish

                               and repeat ...

Thursday, March 11, 2010
the reality ...
                materials difficult to find, fulfill, lack
                             resources

           reagents and assays often re-invented
                  or reverse engineered

           locked in contracts, bureaucracy,
       deliberate withholding, “club mentality”
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
solves the access problem via
                            contract
                     UBMTA        (standardized material
                                 transfer agreements, or
                                         MTAs)
                           SLA


                    SCMTA
                                  standard icons, CC
                                 methodology, metadata


Thursday, March 11, 2010
Thursday, March 11, 2010
build offer through simple set of choices
                          similar way to license chooser




Thursday, March 11, 2010
scientist




                                lawyer




                                         machine




Thursday, March 11, 2010
Thursday, March 11, 2010
and scaling ...




Thursday, March 11, 2010
access to data

            the data “rights” conundrum...


Thursday, March 11, 2010
legal implications

                           in short, it’s complicated.



Thursday, March 11, 2010
©
                           “creative expression”
Thursday, March 11, 2010
is it creative?




Thursday, March 11, 2010
is it creative?




Thursday, March 11, 2010
is it creative?




Thursday, March 11, 2010
category errors




Thursday, March 11, 2010
the problem of...
                              Non-Commercial


                              for data


Thursday, March 11, 2010
Non-Commercial


                           what’s a commercial use
                              of the data web?

Thursday, March 11, 2010
the problem of...
                             Share Alike


                              for data


Thursday, March 11, 2010
1854
Thursday, March 11, 2010
issue of license proliferation

         whatever you do to the least of the
      databases, you do to the integrated system

                             (the most restrictive wins)

                      risk for unintended consequences

Thursday, March 11, 2010
the problem of...
                              Attribution


                              for data


Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
the problem of...
                             any license

                              for data


Thursday, March 11, 2010
national law / jurisdiction-based
                        hurdles

                                sui generis,
                           “sweat of the brow”
                             Crown copyright
                              “level of skill”

       how internat’l data sharing efforts
                 are affected?
Thursday, March 11, 2010
attribution vs. citation

     which one applies? which is best fit?
           what’s the difference?


             “credit where credit is due”
Thursday, March 11, 2010
attribution:
                                 (legal entity)

         “triggered by making of a copy”
               does it apply to facts?
      how to attribute? (papers, ontologies, data)

                           “in a manner specified by ...”
                                attribution stacking

Thursday, March 11, 2010
citation:
                           (gentle(wo)man’s club)

                               legal requirement?
                                interoperability?
                           credit where credit is due
                           entrenched scientific norm


Thursday, March 11, 2010
we shouldn’t use the law to make it
              hard to do the wrong thing ...




Thursday, March 11, 2010
need for a legally accurate and
                                    simple solution

           reducing or eliminating the need to make the
                  distinction of what’s protected

        requires modular, standards based approach
                          to licensing


Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
... must promote legal predictability and certainty.

                           ... must be easy to use and understand.

 ... must impose the lowest possible transaction costs on
                          users.

 full text:
 http://sciencecommons.org/projects/publishing/open-access-data-protocol/




Thursday, March 11, 2010
norms approach

                           set of principles (not license)

           open, accessible, interoperable

                       create legal zones of certainty

Thursday, March 11, 2010
calls for data providers to waive all rights
     necessary for data extraction and re-use

              requires provider place no additional
                obligations (like share-alike) to limit
                          downstream use

          request behavior (like attribution) through
                 norms and terms of use

Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
3.
                           technical considerations

                   (semantics, annotation, standards)



Thursday, March 11, 2010
“read 189,000
                             papers” is not
                           the ideal answer.



Thursday, March 11, 2010
DRD1, 1812      adenylate cyclase activation
                           ADRB2, 154      adenylate cyclase activation
                           ADRB2, 154      arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway
                           DRD1IP, 50632   dopamine receptor signaling pathway
                           DRD1, 1812      dopamine receptor, adenylate cyclase activating pathway
                           DRD2, 1813      dopamine receptor, adenylate cyclase inhibiting pathway
                           GRM7, 2917      G-protein coupled receptor protein signaling pathway
                           GNG3, 2785      G-protein coupled receptor protein signaling pathway
                           GNG12, 55970    G-protein coupled receptor protein signaling pathway
                           DRD2, 1813      G-protein coupled receptor protein signaling pathway
                           ADRB2, 154      G-protein coupled receptor protein signaling pathway
                           CALM3, 808      G-protein coupled receptor protein signaling pathway
                           HTR2A, 3356     G-protein coupled receptor protein signaling pathway
                           DRD1, 1812      G-protein signaling, coupled to cyclic nucleotide second messenger
                           SSTR5, 6755     G-protein signaling, coupled to cyclic nucleotide second messenger
                           MTNR1A, 4543    G-protein signaling, coupled to cyclic nucleotide second messenger
                           CNR2, 1269      G-protein signaling, coupled to cyclic nucleotide second messenger
                           HTR6, 3362      G-protein signaling, coupled to cyclic nucleotide second messenger
                           GRIK2, 2898     glutamate signaling pathway
                           GRIN1, 2902     glutamate signaling pathway
                           GRIN2A, 2903    glutamate signaling pathway
                           GRIN2B, 2904    glutamate signaling pathway
                           ADAM10, 102     integrin-mediated signaling pathway
                           GRM7, 2917      negative regulation of adenylate cyclase activity
                           LRP1, 4035      negative regulation of Wnt receptor signaling pathway
                           ADAM10, 102     Notch receptor processing
                           ASCL1, 429      Notch signaling pathway
                           HTR2A, 3356     serotonin receptor signaling pathway
                           ADRB2, 154      transmembrane receptor protein tyrosine kinase activation (dimerization)
                           PTPRG, 5793     transmembrane receptor protein tyrosine kinase signaling pathway
                           EPHA4, 2043     transmembrane receptor protein tyrosine kinase signaling pathway
                           NRTN, 4902      transmembrane receptor protein tyrosine kinase signaling pathway
                           CTNND1, 1500    Wnt receptor signaling pathway
                           `




Thursday, March 11, 2010
technical



Thursday, March 11, 2010
semantic
  agreement
    is hard.

Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
espresso
                     coffee
                                cafe
                                       kopi
                                                cafezinho

            latte                      koffee

                              mocha             americano

Thursday, March 11, 2010
“choice” or interoperability.
                               (pick one)




Thursday, March 11, 2010
converge on common names

                               “coffee”


                               “cafe”              coffee

                               “kopi”      http://ontology.foo.org/1234567




Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
better answers through better formats:


                                                                                    Mesh: Pyramidal Neurons
select ?gene_name ?process_name
where                                                                               Pubmed: Journal Articles
{ PropertyValue(?pubmed_record, ?p, mesh:D017966)
    PropertyValue(?article, sc:identified_by_pmid , ?pubmed_record)
    PropertyValue(?gene_record, sc:describes_gene_or_gene_product_mentioned_by, ?article)
    SubClassOf(?protein, some(ro:has_function, some(ro:realized_as, ?process)))
    SubClassOf(?process, or(go:GO_0007166, some(ro:part_of, go:GO_0007166))
                                                                                     Entrez Gene: Genes
    SubClassOf(?protein, some(sc:is_protein_gene_product_of_dna_described_by,?gene_record))
    Annotation(?gene_record,rdfs:label,{?gene_name})


}
    Annotation(?process,rdfs:label,?process_name)
                                                                                     GO: Signal Transduction



Thursday, March 11, 2010
DRD1, 1812      adenylate cyclase activation
                           ADRB2, 154      adenylate cyclase activation
                           ADRB2, 154      arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway
                           DRD1IP, 50632   dopamine receptor signaling pathway
                           DRD1, 1812      dopamine receptor, adenylate cyclase activating pathway
                           DRD2, 1813      dopamine receptor, adenylate cyclase inhibiting pathway
                           GRM7, 2917      G-protein coupled receptor protein signaling pathway
                           GNG3, 2785      G-protein coupled receptor protein signaling pathway
                           GNG12, 55970    G-protein coupled receptor protein signaling pathway
                           DRD2, 1813      G-protein coupled receptor protein signaling pathway
                           ADRB2, 154      G-protein coupled receptor protein signaling pathway
                           CALM3, 808      G-protein coupled receptor protein signaling pathway
                           HTR2A, 3356     G-protein coupled receptor protein signaling pathway
                           DRD1, 1812      G-protein signaling, coupled to cyclic nucleotide second messenger
                           SSTR5, 6755     G-protein signaling, coupled to cyclic nucleotide second messenger
                           MTNR1A, 4543    G-protein signaling, coupled to cyclic nucleotide second messenger
                           CNR2, 1269      G-protein signaling, coupled to cyclic nucleotide second messenger
                           HTR6, 3362      G-protein signaling, coupled to cyclic nucleotide second messenger
                           GRIK2, 2898     glutamate signaling pathway
                           GRIN1, 2902     glutamate signaling pathway
                           GRIN2A, 2903    glutamate signaling pathway
                           GRIN2B, 2904    glutamate signaling pathway
                           ADAM10, 102     integrin-mediated signaling pathway
                           GRM7, 2917      negative regulation of adenylate cyclase activity
                           LRP1, 4035      negative regulation of Wnt receptor signaling pathway
                           ADAM10, 102     Notch receptor processing
                           ASCL1, 429      Notch signaling pathway
                           HTR2A, 3356     serotonin receptor signaling pathway
                           ADRB2, 154      transmembrane receptor protein tyrosine kinase activation (dimerization)
                           PTPRG, 5793     transmembrane receptor protein tyrosine kinase signaling pathway
                           EPHA4, 2043     transmembrane receptor protein tyrosine kinase signaling pathway
                           NRTN, 4902      transmembrane receptor protein tyrosine kinase signaling pathway
                           CTNND1, 1500    Wnt receptor signaling pathway
                           `




Thursday, March 11, 2010
turn ugly query code into a link
               http://hcls1.csail.mit.edu:8890/sparql/?query=prefix%20go%3A%20%3Chttp%3A%2F%2Fpurl.org%2Fobo%2Fowl%2FGO%23%3E
               %0Aprefix%20rdfs%3A%20%3Chttp%3A%2F%2Fwww.w3.org%2F2000%2F01%2Frdf-schema%23%3E%0Aprefix%20owl%3A
               %20%3Chttp%3A%2F%2Fwww.w3.org%2F2002%2F07%2Fowl%23%3E%0Aprefix%20mesh%3A%20%3Chttp%3A%2F%2Fpurl.org
               %2Fcommons%2Frecord%2Fmesh%2F%3E%0Aprefix%20sc%3A%20%3Chttp%3A%2F%2Fpurl.org%2Fscience%2Fowl
               %2Fsciencecommons%2F%3E%0Aprefix%20ro%3A%20%3Chttp%3A%2F%2Fwww.obofoundry.org%2Fro%2Fro.owl%23%3E%0A
               %0Aselect%20%3Fgenename%20%3Fprocessname%0Awhere%0A%7B%20%20graph%20%3Chttp%3A%2F%2Fpurl.org
               %2Fcommons%2Fhcls%2Fpubmesh%3E%0A%20%20%20%20%20%7B%20%3Fpaper%20%3Fp%20mesh%3AD017966%20.%0A
               %20%20%20%20%20%20%20%3Farticle%20sc%3Aidentified_by_pmid%20%3Fpaper.%0A%20%20%20%20%20%20%20%3Fgene
               %20sc%3Adescribes_gene_or_gene_product_mentioned_by%20%3Farticle.%0A%20%20%20%20%20%7D%0A%20%20%20graph
               %20%3Chttp%3A%2F%2Fpurl.org%2Fcommons%2Fhcls%2Fgoa%3E%0A%20%20%20%20%20%7B%20%3Fprotein%20rdfs
               %3AsubClassOf%20%3Fres.%0A%20%20%20%20%20%20%20%3Fres%20owl%3AonProperty%20ro%3Ahas_function.%0A
               %20%20%20%20%20%20%20%3Fres%20owl%3AsomeValuesFrom%20%3Fres2.%0A
               %20%20%20%20%20%20%20%3Fres2%20owl%3AonProperty%20ro%3Arealized_as.%0A
               %20%20%20%20%20%20%20%3Fres2%20owl%3AsomeValuesFrom%20%3Fprocess.%0A%20%20%20graph%20%3Chttp%3A%2F
               %2Fpurl.org%2Fcommons%2Fhcls%2F20070416%2Fclassrelations%3E%0A%20%20%20%20%20%7B%7B%3Fprocess%20%3Chttp
               %3A%2F%2Fpurl.org%2Fobo%2Fowl%2Fobo%23part_of%3E%20go%3AGO_0007166%7D%0A%20%20%20%20%20%20%20union
               %0A%20%20%20%20%20%20%7B%3Fprocess%20rdfs%3AsubClassOf%20go%3AGO_0007166%20%7D%7D%0A
               %20%20%20%20%20%20%20%3Fprotein%20rdfs%3AsubClassOf%20%3Fparent.%0A%20%20%20%20%20%20%20%3Fparent
               %20owl%3AequivalentClass%20%3Fres3.%0A%20%20%20%20%20%20%20%3Fres3%20owl%3AhasValue%20%3Fgene.%0A
               %20%20%20%20%20%20%7D%0A%20%20%20graph%20%3Chttp%3A%2F%2Fpurl.org%2Fcommons%2Fhcls%2Fgene%3E%0A
               %20%20%20%20%20%7B%20%3Fgene%20rdfs%3Alabel%20%3Fgenename%20%7D%0A%20%20%20graph%20%3Chttp%3A
               %2F%2Fpurl.org%2Fcommons%2Fhcls%2F20070416%3E%0A%20%20%20%20%20%7B%20%3Fprocess%20rdfs%3Alabel
               %20%3Fprocessname%7D%0A%7D&format=&maxrows=50




Thursday, March 11, 2010
Thursday, March 11, 2010
Thursday, March 11, 2010
one man’s observation is another
           man’s closed book or flight of
                      fancy.

                           - willard van orman quine



Thursday, March 11, 2010
data without structure and annotation is a
                      lost opportunity.

                           work towards maximum reuse of
                             information, interoperability

        support recombination and reconfiguration
        into computer models, queryable by search
                        engine

                           treat knowledge as public good
Thursday, March 11, 2010
resist the temptation to treat
                                     as property

      embrace the potential to treat instead
            as a network resource



Thursday, March 11, 2010
thank you.

                           kaitlin@creativecommons.org
                                 sciencecommons.org
                                creativecommons.org
                              slideshare.net/kaythaney




Thursday, March 11, 2010

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Open Content and the Commons

  • 1. open content and the commons kaitlin thaney program manager, science at creative commons sherbrooke, quebec - 11 march 2010 This presentation is licensed under the CreativeCommons-Attribution-3.0 license. Thursday, March 11, 2010
  • 2. make sharing easy, legal and scalable integrated approach building part of the infrastructure for knowledge sharing Thursday, March 11, 2010
  • 3. knowledge? journal articles data ontologies annotations grey literature plasmids and stem cells Thursday, March 11, 2010
  • 4. (1) the “paradigm shift” (2) access ... (content) (research tools) (data) (3) technical / semantic Thursday, March 11, 2010
  • 5. 1. the “paradigm shift” it’s no longer about the container. Thursday, March 11, 2010
  • 6. scientific revolutions occur when a sufficient body of data accumulates to overthrow the dominant theories we use to frame reality, ... a so-called paradigm shift - thomas kuhn Thursday, March 11, 2010
  • 8. media company response: adjust the physical media force the cd format ignore that people... like to make mixes. Thursday, March 11, 2010
  • 9. facing the same shift for education, science Thursday, March 11, 2010
  • 10. scholarship entrenched in idea of transmitting knowledge via paper mentality reflected even in the way we describe “papers” static, one-dimensional documents Thursday, March 11, 2010
  • 11. information sharing is at the root of scholarship and science the system of print publishing is a system of communicating knowledge then came the move to digital ... Thursday, March 11, 2010
  • 12. in the digital world, “papers” can become living, breathing works no longer static PDF documents linking to data sets, other relevant papers, information, plasmids, genes Thursday, March 11, 2010
  • 13. oldest scientific journal published in english- speaking world 1665 Thursday, March 11, 2010
  • 17. need to change the way we think of scholarly publishing, of knowledge sharing paradigm shift begin thinking of “papers” as containers of knowledge Thursday, March 11, 2010
  • 18. the container is still the paper what’s changed is how we use it Thursday, March 11, 2010
  • 20. 2. access is step one content needs to be legally and technically accessible Thursday, March 11, 2010
  • 21. indexing, translation, redistribution: disallowed Thursday, March 11, 2010
  • 22. “ By open access to the literature, we mean its free availability on the public internet, permitting users to read, download, copy, distribute, print, search, or link to the full texts of the articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal or technical barriers other than those inseparable from gaining access to the internet itself.” Image from the Public Library of Science, licensed to the public, under CC-BY-3.0 Thursday, March 11, 2010
  • 23. “The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited.” Thursday, March 11, 2010
  • 28. legal implementation Thursday, March 11, 2010
  • 29. Open Access journals >1000 journals under CC image from the public library of science licensed to the public under CC-BY 3.0 Thursday, March 11, 2010
  • 30. ... what about the physical materials? Thursday, March 11, 2010
  • 34. ideally ... contact author, obtain material, recreate experiment build on the existing work, publish and repeat ... Thursday, March 11, 2010
  • 35. the reality ... materials difficult to find, fulfill, lack resources reagents and assays often re-invented or reverse engineered locked in contracts, bureaucracy, deliberate withholding, “club mentality” Thursday, March 11, 2010
  • 38. solves the access problem via contract UBMTA (standardized material transfer agreements, or MTAs) SLA SCMTA standard icons, CC methodology, metadata Thursday, March 11, 2010
  • 40. build offer through simple set of choices similar way to license chooser Thursday, March 11, 2010
  • 41. scientist lawyer machine Thursday, March 11, 2010
  • 43. and scaling ... Thursday, March 11, 2010
  • 44. access to data the data “rights” conundrum... Thursday, March 11, 2010
  • 45. legal implications in short, it’s complicated. Thursday, March 11, 2010
  • 46. © “creative expression” Thursday, March 11, 2010
  • 47. is it creative? Thursday, March 11, 2010
  • 48. is it creative? Thursday, March 11, 2010
  • 49. is it creative? Thursday, March 11, 2010
  • 51. the problem of... Non-Commercial for data Thursday, March 11, 2010
  • 52. Non-Commercial what’s a commercial use of the data web? Thursday, March 11, 2010
  • 53. the problem of... Share Alike for data Thursday, March 11, 2010
  • 55. issue of license proliferation whatever you do to the least of the databases, you do to the integrated system (the most restrictive wins) risk for unintended consequences Thursday, March 11, 2010
  • 56. the problem of... Attribution for data Thursday, March 11, 2010
  • 59. the problem of... any license for data Thursday, March 11, 2010
  • 60. national law / jurisdiction-based hurdles sui generis, “sweat of the brow” Crown copyright “level of skill” how internat’l data sharing efforts are affected? Thursday, March 11, 2010
  • 61. attribution vs. citation which one applies? which is best fit? what’s the difference? “credit where credit is due” Thursday, March 11, 2010
  • 62. attribution: (legal entity) “triggered by making of a copy” does it apply to facts? how to attribute? (papers, ontologies, data) “in a manner specified by ...” attribution stacking Thursday, March 11, 2010
  • 63. citation: (gentle(wo)man’s club) legal requirement? interoperability? credit where credit is due entrenched scientific norm Thursday, March 11, 2010
  • 64. we shouldn’t use the law to make it hard to do the wrong thing ... Thursday, March 11, 2010
  • 65. need for a legally accurate and simple solution reducing or eliminating the need to make the distinction of what’s protected requires modular, standards based approach to licensing Thursday, March 11, 2010
  • 70. ... must promote legal predictability and certainty. ... must be easy to use and understand. ... must impose the lowest possible transaction costs on users. full text: http://sciencecommons.org/projects/publishing/open-access-data-protocol/ Thursday, March 11, 2010
  • 71. norms approach set of principles (not license) open, accessible, interoperable create legal zones of certainty Thursday, March 11, 2010
  • 72. calls for data providers to waive all rights necessary for data extraction and re-use requires provider place no additional obligations (like share-alike) to limit downstream use request behavior (like attribution) through norms and terms of use Thursday, March 11, 2010
  • 78. 3. technical considerations (semantics, annotation, standards) Thursday, March 11, 2010
  • 79. “read 189,000 papers” is not the ideal answer. Thursday, March 11, 2010
  • 80. DRD1, 1812 adenylate cyclase activation ADRB2, 154 adenylate cyclase activation ADRB2, 154 arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway DRD1IP, 50632 dopamine receptor signaling pathway DRD1, 1812 dopamine receptor, adenylate cyclase activating pathway DRD2, 1813 dopamine receptor, adenylate cyclase inhibiting pathway GRM7, 2917 G-protein coupled receptor protein signaling pathway GNG3, 2785 G-protein coupled receptor protein signaling pathway GNG12, 55970 G-protein coupled receptor protein signaling pathway DRD2, 1813 G-protein coupled receptor protein signaling pathway ADRB2, 154 G-protein coupled receptor protein signaling pathway CALM3, 808 G-protein coupled receptor protein signaling pathway HTR2A, 3356 G-protein coupled receptor protein signaling pathway DRD1, 1812 G-protein signaling, coupled to cyclic nucleotide second messenger SSTR5, 6755 G-protein signaling, coupled to cyclic nucleotide second messenger MTNR1A, 4543 G-protein signaling, coupled to cyclic nucleotide second messenger CNR2, 1269 G-protein signaling, coupled to cyclic nucleotide second messenger HTR6, 3362 G-protein signaling, coupled to cyclic nucleotide second messenger GRIK2, 2898 glutamate signaling pathway GRIN1, 2902 glutamate signaling pathway GRIN2A, 2903 glutamate signaling pathway GRIN2B, 2904 glutamate signaling pathway ADAM10, 102 integrin-mediated signaling pathway GRM7, 2917 negative regulation of adenylate cyclase activity LRP1, 4035 negative regulation of Wnt receptor signaling pathway ADAM10, 102 Notch receptor processing ASCL1, 429 Notch signaling pathway HTR2A, 3356 serotonin receptor signaling pathway ADRB2, 154 transmembrane receptor protein tyrosine kinase activation (dimerization) PTPRG, 5793 transmembrane receptor protein tyrosine kinase signaling pathway EPHA4, 2043 transmembrane receptor protein tyrosine kinase signaling pathway NRTN, 4902 transmembrane receptor protein tyrosine kinase signaling pathway CTNND1, 1500 Wnt receptor signaling pathway ` Thursday, March 11, 2010
  • 82. semantic agreement is hard. Thursday, March 11, 2010
  • 85. espresso coffee cafe kopi cafezinho latte koffee mocha americano Thursday, March 11, 2010
  • 86. “choice” or interoperability. (pick one) Thursday, March 11, 2010
  • 87. converge on common names “coffee” “cafe” coffee “kopi” http://ontology.foo.org/1234567 Thursday, March 11, 2010
  • 91. better answers through better formats: Mesh: Pyramidal Neurons select ?gene_name ?process_name where Pubmed: Journal Articles { PropertyValue(?pubmed_record, ?p, mesh:D017966) PropertyValue(?article, sc:identified_by_pmid , ?pubmed_record) PropertyValue(?gene_record, sc:describes_gene_or_gene_product_mentioned_by, ?article) SubClassOf(?protein, some(ro:has_function, some(ro:realized_as, ?process))) SubClassOf(?process, or(go:GO_0007166, some(ro:part_of, go:GO_0007166)) Entrez Gene: Genes SubClassOf(?protein, some(sc:is_protein_gene_product_of_dna_described_by,?gene_record)) Annotation(?gene_record,rdfs:label,{?gene_name}) } Annotation(?process,rdfs:label,?process_name) GO: Signal Transduction Thursday, March 11, 2010
  • 92. DRD1, 1812 adenylate cyclase activation ADRB2, 154 adenylate cyclase activation ADRB2, 154 arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway DRD1IP, 50632 dopamine receptor signaling pathway DRD1, 1812 dopamine receptor, adenylate cyclase activating pathway DRD2, 1813 dopamine receptor, adenylate cyclase inhibiting pathway GRM7, 2917 G-protein coupled receptor protein signaling pathway GNG3, 2785 G-protein coupled receptor protein signaling pathway GNG12, 55970 G-protein coupled receptor protein signaling pathway DRD2, 1813 G-protein coupled receptor protein signaling pathway ADRB2, 154 G-protein coupled receptor protein signaling pathway CALM3, 808 G-protein coupled receptor protein signaling pathway HTR2A, 3356 G-protein coupled receptor protein signaling pathway DRD1, 1812 G-protein signaling, coupled to cyclic nucleotide second messenger SSTR5, 6755 G-protein signaling, coupled to cyclic nucleotide second messenger MTNR1A, 4543 G-protein signaling, coupled to cyclic nucleotide second messenger CNR2, 1269 G-protein signaling, coupled to cyclic nucleotide second messenger HTR6, 3362 G-protein signaling, coupled to cyclic nucleotide second messenger GRIK2, 2898 glutamate signaling pathway GRIN1, 2902 glutamate signaling pathway GRIN2A, 2903 glutamate signaling pathway GRIN2B, 2904 glutamate signaling pathway ADAM10, 102 integrin-mediated signaling pathway GRM7, 2917 negative regulation of adenylate cyclase activity LRP1, 4035 negative regulation of Wnt receptor signaling pathway ADAM10, 102 Notch receptor processing ASCL1, 429 Notch signaling pathway HTR2A, 3356 serotonin receptor signaling pathway ADRB2, 154 transmembrane receptor protein tyrosine kinase activation (dimerization) PTPRG, 5793 transmembrane receptor protein tyrosine kinase signaling pathway EPHA4, 2043 transmembrane receptor protein tyrosine kinase signaling pathway NRTN, 4902 transmembrane receptor protein tyrosine kinase signaling pathway CTNND1, 1500 Wnt receptor signaling pathway ` Thursday, March 11, 2010
  • 93. turn ugly query code into a link http://hcls1.csail.mit.edu:8890/sparql/?query=prefix%20go%3A%20%3Chttp%3A%2F%2Fpurl.org%2Fobo%2Fowl%2FGO%23%3E %0Aprefix%20rdfs%3A%20%3Chttp%3A%2F%2Fwww.w3.org%2F2000%2F01%2Frdf-schema%23%3E%0Aprefix%20owl%3A %20%3Chttp%3A%2F%2Fwww.w3.org%2F2002%2F07%2Fowl%23%3E%0Aprefix%20mesh%3A%20%3Chttp%3A%2F%2Fpurl.org %2Fcommons%2Frecord%2Fmesh%2F%3E%0Aprefix%20sc%3A%20%3Chttp%3A%2F%2Fpurl.org%2Fscience%2Fowl %2Fsciencecommons%2F%3E%0Aprefix%20ro%3A%20%3Chttp%3A%2F%2Fwww.obofoundry.org%2Fro%2Fro.owl%23%3E%0A %0Aselect%20%3Fgenename%20%3Fprocessname%0Awhere%0A%7B%20%20graph%20%3Chttp%3A%2F%2Fpurl.org %2Fcommons%2Fhcls%2Fpubmesh%3E%0A%20%20%20%20%20%7B%20%3Fpaper%20%3Fp%20mesh%3AD017966%20.%0A %20%20%20%20%20%20%20%3Farticle%20sc%3Aidentified_by_pmid%20%3Fpaper.%0A%20%20%20%20%20%20%20%3Fgene %20sc%3Adescribes_gene_or_gene_product_mentioned_by%20%3Farticle.%0A%20%20%20%20%20%7D%0A%20%20%20graph %20%3Chttp%3A%2F%2Fpurl.org%2Fcommons%2Fhcls%2Fgoa%3E%0A%20%20%20%20%20%7B%20%3Fprotein%20rdfs %3AsubClassOf%20%3Fres.%0A%20%20%20%20%20%20%20%3Fres%20owl%3AonProperty%20ro%3Ahas_function.%0A %20%20%20%20%20%20%20%3Fres%20owl%3AsomeValuesFrom%20%3Fres2.%0A %20%20%20%20%20%20%20%3Fres2%20owl%3AonProperty%20ro%3Arealized_as.%0A %20%20%20%20%20%20%20%3Fres2%20owl%3AsomeValuesFrom%20%3Fprocess.%0A%20%20%20graph%20%3Chttp%3A%2F %2Fpurl.org%2Fcommons%2Fhcls%2F20070416%2Fclassrelations%3E%0A%20%20%20%20%20%7B%7B%3Fprocess%20%3Chttp %3A%2F%2Fpurl.org%2Fobo%2Fowl%2Fobo%23part_of%3E%20go%3AGO_0007166%7D%0A%20%20%20%20%20%20%20union %0A%20%20%20%20%20%20%7B%3Fprocess%20rdfs%3AsubClassOf%20go%3AGO_0007166%20%7D%7D%0A %20%20%20%20%20%20%20%3Fprotein%20rdfs%3AsubClassOf%20%3Fparent.%0A%20%20%20%20%20%20%20%3Fparent %20owl%3AequivalentClass%20%3Fres3.%0A%20%20%20%20%20%20%20%3Fres3%20owl%3AhasValue%20%3Fgene.%0A %20%20%20%20%20%20%7D%0A%20%20%20graph%20%3Chttp%3A%2F%2Fpurl.org%2Fcommons%2Fhcls%2Fgene%3E%0A %20%20%20%20%20%7B%20%3Fgene%20rdfs%3Alabel%20%3Fgenename%20%7D%0A%20%20%20graph%20%3Chttp%3A %2F%2Fpurl.org%2Fcommons%2Fhcls%2F20070416%3E%0A%20%20%20%20%20%7B%20%3Fprocess%20rdfs%3Alabel %20%3Fprocessname%7D%0A%7D&format=&maxrows=50 Thursday, March 11, 2010
  • 96. one man’s observation is another man’s closed book or flight of fancy. - willard van orman quine Thursday, March 11, 2010
  • 97. data without structure and annotation is a lost opportunity. work towards maximum reuse of information, interoperability support recombination and reconfiguration into computer models, queryable by search engine treat knowledge as public good Thursday, March 11, 2010
  • 98. resist the temptation to treat as property embrace the potential to treat instead as a network resource Thursday, March 11, 2010
  • 99. thank you. kaitlin@creativecommons.org sciencecommons.org creativecommons.org slideshare.net/kaythaney Thursday, March 11, 2010