Polychlorinated Biphenyls

1. PCBs – Polychlorinated Biphenyls Juliann Chen Laura Stachel

12. Levels of PCB 1.9 ppm Bottom-feeding and game fish ( EPA, 1992) 20 ppm Fish near hazardous waste sites ( ATSDR, 2000) <20 ppb Background levels in human serum (1980s) 1-2 ppm Human adipose tissue 40-100 ppb Human breast milk 40-100 ppb Recreational fishers

17. Reproductive Effects Animal and Human studies

24. Human Development Birth Weight and Gestational Age

27. Increase 72 Wisconsin fish eaters Smith Decrease 179 Netherlands Pantandin No change 912 North Carolina background Rogan No change Lake Ontario fisheaters Lonky Decrease 200 Occupational exposure Taylor Decrease 241 Michigan fish eaters Jacobson Birthweight number Location Study

28. Neurodevelopment Overview

30. Neurodevelopmental Tests Ribas-Fito et al. 2001

31. Neurodevelopment Yusho and Yu-Cheng experience

34. Mean Difference in Full Mental Scales – Taiwan

35. Neurodevelopment Fish consumption studies

39. Neurodevelopment General population

44. Schantz et al. 2003 Dutch cohort (cont)

48. Ribas-Fito et al. 2001

50. Schantz et al. 2003

51. Prop 65 and PCB Should salmon carry warning labels? Should breast milk?

53. Primary source of exposure - diet Courtesy of the BC Salmon Farmers Association

54. FDA allowable tolerance limits 0.2 Finished animal feed for food producing animals (except feed concentrates, feed supplements, and feed premixes) 3 Red meat 0.2 Infant and junior foods 0.3 Eggs 3 Poultry 1.5 Cow Milk / Dairy (fat) 2 Fish (fat) Concentration (ppm) Commodity

62. Breastfeeding and PCB Human development

67. Levels in breast milk ATSDR, 2000

69. PCBs Other health effects