ImaBioteh provides a MALDI imaging solution as a fast and robust tool for ADME and pharmacokinetics

1. Mass spectrometry Imaging (MSI) An innovative platform for drug and metabolites study www.imabiotech.com Imagine your next innovations

2. Introduction IMABIOTECH is a leading French company providing CRO, biotechs and pharmaceutical groups with innovative Mass spectrometry imaging (MSI), customized services and products. IMABIOTECH is a spin-off of University of Lille, and in 2008, founded with Professor SALZET and Professor FOURNIER to bring expertise in the field of MSI www.imabiotech.com Imagine your next innovations

4. Combine molecular and spatial information in early stage of drug discovery

5. Fast study of ADME and pharmacokinetics www.imabiotech.com Imagine your next innovations

6. MSI Technique MSI : in vitro/ex vivo imaging technique which detects surface molecules of histological tissue sections More than thousands simultaneously detected molecules such as drugs, metabolites , lipids and proteins www.imabiotech.com Imagine your next innovations

8. Biomolecules or drugs/Metabolites

9. Large scope of simultaneous detection of elements and molecules (Atom to proteins)

10. Fast compared to labeling approaches (HIC, autoradiography)

11. Detailed images

12. Resolution : 500nm - 100μm

13. Sensitivity ng/g

14. Whole body, cells, organsA label free method www.imabiotech.com Imagine your next innovations

16. Contrast agent evaluation

17. Chemicals detection

18. Iron, Lithium of potassium detection

19. Peptides or lipids www.imabiotech.com Imagine your next innovations Optical image of Kidney Drug localization 2 hours post dose 6 hours post dose Control T0

21. Co-localization of drugs and metabolites (defined by their exact masses)

22. Research of unknown metabolites

23. Assess Administration and Formulation

24. Nanoparticles localization and Drug delivery systems studies

25. Whole body or organs studies (Brain, Heart, Liver, Kidney, Bones, Muscles… ) Whole mouse body Drug distribution Metabolites distribution www.imabiotech.com Imagine your next innovations

27. Oncology

28. CNS diseases

29. Infectious diseases

30. Ophthalmology

31. Gastroenterology

32. Pulmonary

33. Cardiology…Intestinal Disease CNS disease Ophthalmology Cardiology Pulmonary Oncology www.imabiotech.com Imagine your next innovations

35. No radioactive and no labeling are required

36. MSI technique discriminates the localization of drugs and metabolites

37. Expertise in MSI www.imabiotech.com Imagine your next innovations

39. ImaBiotech Performs :

40. More than 40 images within in a week

41. Organs and whole-body MS imaging

42. For each molecules injected (>0,2 mg/kg; 0-70KDa)

43. Distribution of drug and metabolites within 2 week

44. And pharmacokinetics within 4 weeks www.imabiotech.com Imagine your next innovations

45. For further information visit our website www.imabiotech.comor contactstauber.jonathan@imabiotech.com www.imabiotech.com Imagine your next innovations