5. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
6. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration Zerbib J et al. PLoS One. 2009 Oct 5;4(10):e7341.
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16. Vitamin E and Age-Related Macular Degeneration in a Randomized Trial of Women Christen WG & al. Ophthalmology. 2010 Jun;117(6):1163-8. Epub 2010 Feb 13.
18. Association of diabetes with age-related macular degeneration in the EUREYE study Topouzis F & al. Br J Ophthalmol. 2009 Aug;93(8):1037-41. AMD No diabetes n (%) Diabetes n (%) Total No AMD 1954 (87.0) 292 (13.0) 2246 AMD grade 1 1491 (86.6) 231 (13.4) 1722 AMD grade 2 430 (89.6) 50 (10.4) 480 AMD grade 3 100 (86.2) 16 (13.8) 116 Late AMD 131 (82.9) 27 (17.1) 158 Total 4106 (87.0) 616 (13.1) 4722
19. Association of diabetes with age-related macular degeneration in the EUREYE study † Adjusted for age and sex. ‡ Adjusted for age, sex, smoking, education, BMI, alcohol consumption, cardiovascular disease, aspirin use, systolic blood pressure, alpha-tocopherol ratio, vitamin C and lutein. Topouzis F & al. Br J Ophthalmol. 2009 Aug;93(8):1037-41. OR* (95% CI)† OR* (95% CI)‡ AMD grade 1 1.03 1.04 n = 1552 [0.77 to 1.38] [0.76 to 1.40] p = 0.8 p = 0.8 AMD grade 2 0.75 0.75 n = 430 [0.54 to 1.06] [0.54 to 1.04] p = 0.1 p = 0.1 AMD grade 3 1.09 1.14 n = 108 [0.69 to 1.75] [0.77 to 1.71] p = 0.7 p = 0.5 Geographic atrophy 1.08 1.07 n = 38 [0.31 to 3.70] [0.28 to 4.04] p = 0.9 p = 0.9 Neovascular AMD 1.75 1.81 n = 95 [1.11 to 2.76] [1.10 to 2.98] p = 0.016 p = 0.02
21. Risk of advanced age-related macular degeneration after cataract surgery in the Age-Related Eye Disease Study: AREDS report 25. Ophthalmology. 2009 Feb;116(2):297-303. Epub 2008 Dec 16. 2009
Vers de nouvelles pistes et de nouveaux traitements ?
CT hetero. A risque augmenté de DMLA
Dans les populations sans autre facteurs de risque, heterozygte CT augmente le risque de DMLA, surtout exsudativce
DMLA et rétinopathie diabétique sont les deux patjologies les plus fréquentes dans les pays développés Peu de données sur un éventuel lien entre les deux Peu d’association entre DMLA et RD Or un lien semble exister, uniquement pour les formes exsudatives
Association significative entre diabéte et néovaisseaux choroidiens Mais pas avec formes précoces et atrophie gféographique NV et atrophie resulteraient donc de mécanismes différents
The results from the Cox proportional hazards models used to examine AREDS data show little evidence of a detrimental effect of cataract surgery on progression to advanced AMD. Use of the Cox regression model allows us to take advantage of a unique feature of AREDS, the ability to examine the effect of important covariates, including time-dependent covariates, on progression to late AMD. Results from the Cox models are not statistically significant and there are no consistent trends among models, with point estimates for risk of neovascular AMD in the harmful direction for the matched pair analyses and in the protective direction for the logistic regression analyses. For GA results, all models had point estimates in the direction of protection, suggesting that it is unlikely that there is any risk of cataract extraction on the development of GA. The absence of any consistent pattern in the direction of harm across models reinforces the conclusion that AREDS data provide little evidence that cataract surgery increases the risk of progression to late AMD.
