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Renal Cell
Carcinoma
with Hepatic Metastasis
Introduction
Underlying Disease:
Renal Cell Carcinoma
- Most common type of cancer
- Carcinoma โ€œKarkinosโ€ meaning crab forming
cancer.
Secondary Disease:
-Hepatic Metastasis
-Pneumonia
-Severe Fatty Liver
Introduction
Etiology:
๏‚› Smoking
๏‚› Obesity
๏‚› Hypertension
Pathophysiology:
2 forms of RCC
๏‚› Hereditary
๏‚› Sporadic
Methodology
Patient Finding
Gathering of Data
Analysis and
Interpretation
Evaluation and
Implication
Recommendation
Subjective
Case: RCC with Hepatic Metastasis
Subject: Mr. Levi O. Fernandez
Age: 58 yrs. old
Civil Status: Married, with 3 sons
Occupation: Former Electrical
Engineer in Japan
Subjective
๏‚› Prior to his diagnosis, he experiences
difficulty in urinating, fever, malaise, night
sweats and hypertension.
๏‚› He loves eating salty foods, softdrinks and
sweets.
๏‚› The foods he doesnโ€™t like are pork and
alcoholic beverages in relation to his
religion as an Adventist.
Objective
Table 1. Quantitative analysis of his 24-hour food recall
Meal No. of
exchanges
CHO (g) PRO (g) FATS (g) ENERGY (kcal)
Rice 10 230 20 - 1000
Meat
Low fat 1 - 8 1 41
Medium fat 1 - 8 6 86
Veg. A 2 3 - - 6
Coffee (free
food)
3 - - - -
TOTAL - 233 36 7 1133
Objective
๏‚› Nutrient Adequacy =
Actual Nutrient Intake/Recommended
Nutrient Intake *100
Protein = 36/60(100)
= 60%
Energy = 1133/2320(100)
= 49%
Objective
Food group Recommended servings Actual intake Variance
grains 6-11 6 0-5
vegetables 3-5 2 1-3
fruits 2-4 0 2-4
dairy 2-3 0 2-3
Meat/poultry/fish 2-3 2 0-1
Fats, oils and sweets Use sparingly 5 -
Table 2. Qualitative analysis of his 24-hour food recall
Assessment
๏‚› Anthropometric
Patientโ€™s Height and Weight
Pt. Ht. = 5โ€™7
= 67 inches
= 67 inches x 2.54 cm
= 170.18 cm or 1.70 m
Pt. Wt. = 73 kg
Assessment
Desirable Body Weight
DBW = 170.18- 100
= 70.18
= 70.18-7.018 (10% of 70.18)
=63.162 or 63 kg
Assessment
Body Mass Index
BMI = wt. (kg)/ ht. (m)ยฒ
= 73 kg/ 2.9
= 25.21
Assessment
Total Energy Allowance
TEA = Activity x DBW
= 35.0 (light) x 63 kg
= 2205 kcal
Assessment
๏‚› Biochemical
Clinical Chemistry Laboratory Findings/Result Reference Range Implication
- LDL Cholesterol 4.41 <4.07 HIGH
- Creatinine 135.2 umol/L 53.0-115.0 HIGH
- CHOLE-HDL Ratio 8.28 <4.40 HIGH
Table 3. Significant Laboratory Findings on Blood
Chemistry
HEMATOLOGY Laboratory Findings/Result Reference Range Implication
WBC COUNT 12.20 10^9/L 5.0-10.0 HIGH
Segmenters 0.83% 0.45-0.65 HIGH
Lymphocytes 0.17% 0.20-0.35 LOW
Table 4. Significant Laboratory Findings on Hematology
Urinalysis Laboratory Findings/Result Reference Range Implication
Physical examination
- Color Brown red Yellow
- Transparency cloudy Clear
- Reaction Acidic ACIDIC
Chemical Examination
- Nitrite Positive NEGATIVE BACTERIURIA
Table 5. Significant Laboratory Findings on Urinalysis
Sonography:
Radiological Test:
Final Histophatologic Diagnosis
Kidney, Radical nephrectomy (left):
RENAL CELL CARCINOMA, CLEAR CELL TYPE, FUHRMAN GRADE 2, 8.4
CM IN WIDEST TUMOR DIMENSION.
RENAL CAPSULAR INVASION AND LYMPHOVASCULAR SPACE INVASION
ARE PRESENT.
Plan
๏‚› Diet Rx: 2520kcal; C445; P38; F79
2000 mg Na
1600 mg K (41 mEq)
500 mg P (39 mEq)
1200 Ca(60 mEq)
1500 ml fluid
HBV - 2/3 (25.2)
LBV - 1/3 (12.6)
Food group # of
exchanges
Pro Na K Ca P Fluid Cho Fat
Milk
A.powder
ยฝ 4 80 200 180 125 0.3 6 5
Meat ยพ 26 - - - - - - -
Lean Meat
(V-A)
1 - 30 200 15 70 31.0 - 1
Fish
(V-A)
1 ยฝ - 45 300 22.5 105 46.5 - 1.5
Egg (V-C) ยพ - 82.5 71.25 37.5 86 33.75 - 4.5
Total - 30 237.5 771.25 255 386 111.55 6 12
Food group # of
exchanges
Pro Na K Ca P Fluid Cho Fat
Veg. B1 2 0.6 16 220 60 20 60 3 -
Rice 6 12 - - - - - 118 -
A 4 - 8 240 60 140 300 - -
B 1 - 230 60 20 35 10 - -
Total - 12.6 254 1520 140 195 370 121 -
Total 3 & 4 - 42.6 492 1292 395 581 482 127 12
Food group # of
exchanges
Pro Na K Ca P Fluid Cho Fat
Fruits 3 0 - - - - - - -
A 2 0.8 6 240 20 20 95 20 -
B 1 0.2 2 60 5 5 42 10 -
Sugar 63.6 - - - - - - 384 -
Total - 1.0 8 300 25 25 137 414 -
445 (prescribed)
127 (milk and vegetable and rice)
318 /5 = 63.6 or 64
Food group # of
exchanges
Pro Na K Ca P Fluid Cho Fat
Fat - - - - - - - - -
A 8 0.5 320 16.0 8.0 8.0 8.0 - 4.0
B ยฝ - 9 22.0 4.0 10.0 9.0 - 2.5
Free foods 4 - - - - - - - 20
Total 3,4,5 and
6
44.1 829 1630 432 624 636 541 74.5
Fat milk 5
Meat 12
17 โ€“ 79 = 62 / 5 = 12.4 or 12
Fluid rx = 1500 ml
Inherent 636 ml
864 ml (additional oral fluid)
Na rx = 2000 mg/day
Inherent 829 mg
1171 mg/day (additional oral)
1200 โ€“ 432 = 768 = 1 tablet
Intervention
Medical
๏‚› Omeprazole, to maintain healing of erosive esophagitis
๏‚› Vit. B complex, to treatment To Prevent Vitamin Deficiency Medications
Inherited Disease Marked by Excretion of Sulfur in Urine Medications
๏‚› Paracetamol, Taken as required for relief of mild-to-moderate pain or fever.
๏‚› Clonidine, treat high blood pressure
๏‚› Tramadol, treat moderate to severe pain
๏‚› Tranexamic acid, used to control unwanted bleeding
๏‚› Ceftriaxone, given before certain types of surgery to prevent infections that may
develop after the operation
๏‚› Centrum silver , For Multivitamins and minerals deficiency
๏‚› Neobloc, H TN & chronic angina pectoris.
Intervention
Diet
๏‚› Maintain A Healthy Body Weight
๏‚› Eating more vegetables and fruit
๏‚› Potassium and sodium restriction
๏‚› fluid
๏‚› Low calorie diet
Evaluation
๏‚› To check if the patient will follow the
dietary plan, there should be a regular
visit and report about the progress of his
condition. Regular checkup in his
physician is also recommended to have
an update about his health status.
The End.

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Renal Cell Carcinoma with hepatic metastasis

  • 2. Introduction Underlying Disease: Renal Cell Carcinoma - Most common type of cancer - Carcinoma โ€œKarkinosโ€ meaning crab forming cancer. Secondary Disease: -Hepatic Metastasis -Pneumonia -Severe Fatty Liver
  • 3. Introduction Etiology: ๏‚› Smoking ๏‚› Obesity ๏‚› Hypertension Pathophysiology: 2 forms of RCC ๏‚› Hereditary ๏‚› Sporadic
  • 4.
  • 5. Methodology Patient Finding Gathering of Data Analysis and Interpretation Evaluation and Implication Recommendation
  • 6. Subjective Case: RCC with Hepatic Metastasis Subject: Mr. Levi O. Fernandez Age: 58 yrs. old Civil Status: Married, with 3 sons Occupation: Former Electrical Engineer in Japan
  • 7. Subjective ๏‚› Prior to his diagnosis, he experiences difficulty in urinating, fever, malaise, night sweats and hypertension. ๏‚› He loves eating salty foods, softdrinks and sweets. ๏‚› The foods he doesnโ€™t like are pork and alcoholic beverages in relation to his religion as an Adventist.
  • 8. Objective Table 1. Quantitative analysis of his 24-hour food recall Meal No. of exchanges CHO (g) PRO (g) FATS (g) ENERGY (kcal) Rice 10 230 20 - 1000 Meat Low fat 1 - 8 1 41 Medium fat 1 - 8 6 86 Veg. A 2 3 - - 6 Coffee (free food) 3 - - - - TOTAL - 233 36 7 1133
  • 9. Objective ๏‚› Nutrient Adequacy = Actual Nutrient Intake/Recommended Nutrient Intake *100 Protein = 36/60(100) = 60% Energy = 1133/2320(100) = 49%
  • 10. Objective Food group Recommended servings Actual intake Variance grains 6-11 6 0-5 vegetables 3-5 2 1-3 fruits 2-4 0 2-4 dairy 2-3 0 2-3 Meat/poultry/fish 2-3 2 0-1 Fats, oils and sweets Use sparingly 5 - Table 2. Qualitative analysis of his 24-hour food recall
  • 11. Assessment ๏‚› Anthropometric Patientโ€™s Height and Weight Pt. Ht. = 5โ€™7 = 67 inches = 67 inches x 2.54 cm = 170.18 cm or 1.70 m Pt. Wt. = 73 kg
  • 12. Assessment Desirable Body Weight DBW = 170.18- 100 = 70.18 = 70.18-7.018 (10% of 70.18) =63.162 or 63 kg
  • 13. Assessment Body Mass Index BMI = wt. (kg)/ ht. (m)ยฒ = 73 kg/ 2.9 = 25.21
  • 14. Assessment Total Energy Allowance TEA = Activity x DBW = 35.0 (light) x 63 kg = 2205 kcal
  • 15. Assessment ๏‚› Biochemical Clinical Chemistry Laboratory Findings/Result Reference Range Implication - LDL Cholesterol 4.41 <4.07 HIGH - Creatinine 135.2 umol/L 53.0-115.0 HIGH - CHOLE-HDL Ratio 8.28 <4.40 HIGH Table 3. Significant Laboratory Findings on Blood Chemistry
  • 16. HEMATOLOGY Laboratory Findings/Result Reference Range Implication WBC COUNT 12.20 10^9/L 5.0-10.0 HIGH Segmenters 0.83% 0.45-0.65 HIGH Lymphocytes 0.17% 0.20-0.35 LOW Table 4. Significant Laboratory Findings on Hematology
  • 17. Urinalysis Laboratory Findings/Result Reference Range Implication Physical examination - Color Brown red Yellow - Transparency cloudy Clear - Reaction Acidic ACIDIC Chemical Examination - Nitrite Positive NEGATIVE BACTERIURIA Table 5. Significant Laboratory Findings on Urinalysis
  • 20. Final Histophatologic Diagnosis Kidney, Radical nephrectomy (left): RENAL CELL CARCINOMA, CLEAR CELL TYPE, FUHRMAN GRADE 2, 8.4 CM IN WIDEST TUMOR DIMENSION. RENAL CAPSULAR INVASION AND LYMPHOVASCULAR SPACE INVASION ARE PRESENT.
  • 21. Plan ๏‚› Diet Rx: 2520kcal; C445; P38; F79 2000 mg Na 1600 mg K (41 mEq) 500 mg P (39 mEq) 1200 Ca(60 mEq) 1500 ml fluid HBV - 2/3 (25.2) LBV - 1/3 (12.6)
  • 22. Food group # of exchanges Pro Na K Ca P Fluid Cho Fat Milk A.powder ยฝ 4 80 200 180 125 0.3 6 5 Meat ยพ 26 - - - - - - - Lean Meat (V-A) 1 - 30 200 15 70 31.0 - 1 Fish (V-A) 1 ยฝ - 45 300 22.5 105 46.5 - 1.5 Egg (V-C) ยพ - 82.5 71.25 37.5 86 33.75 - 4.5 Total - 30 237.5 771.25 255 386 111.55 6 12
  • 23. Food group # of exchanges Pro Na K Ca P Fluid Cho Fat Veg. B1 2 0.6 16 220 60 20 60 3 - Rice 6 12 - - - - - 118 - A 4 - 8 240 60 140 300 - - B 1 - 230 60 20 35 10 - - Total - 12.6 254 1520 140 195 370 121 - Total 3 & 4 - 42.6 492 1292 395 581 482 127 12
  • 24. Food group # of exchanges Pro Na K Ca P Fluid Cho Fat Fruits 3 0 - - - - - - - A 2 0.8 6 240 20 20 95 20 - B 1 0.2 2 60 5 5 42 10 - Sugar 63.6 - - - - - - 384 - Total - 1.0 8 300 25 25 137 414 - 445 (prescribed) 127 (milk and vegetable and rice) 318 /5 = 63.6 or 64
  • 25. Food group # of exchanges Pro Na K Ca P Fluid Cho Fat Fat - - - - - - - - - A 8 0.5 320 16.0 8.0 8.0 8.0 - 4.0 B ยฝ - 9 22.0 4.0 10.0 9.0 - 2.5 Free foods 4 - - - - - - - 20 Total 3,4,5 and 6 44.1 829 1630 432 624 636 541 74.5 Fat milk 5 Meat 12 17 โ€“ 79 = 62 / 5 = 12.4 or 12
  • 26. Fluid rx = 1500 ml Inherent 636 ml 864 ml (additional oral fluid) Na rx = 2000 mg/day Inherent 829 mg 1171 mg/day (additional oral) 1200 โ€“ 432 = 768 = 1 tablet
  • 27. Intervention Medical ๏‚› Omeprazole, to maintain healing of erosive esophagitis ๏‚› Vit. B complex, to treatment To Prevent Vitamin Deficiency Medications Inherited Disease Marked by Excretion of Sulfur in Urine Medications ๏‚› Paracetamol, Taken as required for relief of mild-to-moderate pain or fever. ๏‚› Clonidine, treat high blood pressure ๏‚› Tramadol, treat moderate to severe pain ๏‚› Tranexamic acid, used to control unwanted bleeding ๏‚› Ceftriaxone, given before certain types of surgery to prevent infections that may develop after the operation ๏‚› Centrum silver , For Multivitamins and minerals deficiency ๏‚› Neobloc, H TN & chronic angina pectoris.
  • 28. Intervention Diet ๏‚› Maintain A Healthy Body Weight ๏‚› Eating more vegetables and fruit ๏‚› Potassium and sodium restriction ๏‚› fluid ๏‚› Low calorie diet
  • 29. Evaluation ๏‚› To check if the patient will follow the dietary plan, there should be a regular visit and report about the progress of his condition. Regular checkup in his physician is also recommended to have an update about his health status.