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Medical Nutrition Therapy in CRF Dr. B. K. Iyer
Terms to know CRD CRI CRF ESRD Chronic renal disease is a patho-physiologic process with multiple causes, resulting in the inevitable decrease of nephron number and function. Chronic renal insufficiency (CRI) is the term for patients with mild-to-moderate renal impairment, those whose GFR falls at 30-70 cc/min.  Chronic renal failure Is characterized by progressive destruction of renal mass with irreversible loss of nephrons over a period of at least months to many years.  End-stage renal disease is a stage of total or nearly total and permanent kidney failure to render patient permanently dependent upon RRT
Terms to know ,[object Object],GFR RRT Glomerular filtration rate (GFR) progressively decreases with nephron loss. Renal Replacement Therapy (dialysis  or transplantation) Uraemia Is the clinical and laboratory syndrome, reflecting dysfunction of all organ systems as a result of untreated or undertreated renal failure
Pathophysiology
Chronic renal disease - causes ,[object Object],[object Object]
Chronic renal disease - causes ,[object Object]
History of diabetic nephropathy
Chronic renal disease - path ,[object Object],[object Object]
Renal compensation ,[object Object],[object Object]
Renal manifestations ,[object Object],[object Object]
Renal stages ,[object Object],[object Object]
Renal stages
GFR upto 50% ,[object Object],[object Object]
GFR upto 30% ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
GFR < 30% ,[object Object]
GFR < 10% ,[object Object]
Uremic syndrome
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal problems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Uraemia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical abnormalities
Renal problem spillovers ,[object Object],[object Object],[object Object],[object Object],[object Object]
Fluid and electrolyte disturbances ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Sodium Potassium Calcium Phosphorus pH
Hyperkalaemia ,[object Object],[object Object],[object Object],[object Object]
Metabolic acidosis ,[object Object],[object Object],[object Object]
Volume expansion ,[object Object],[object Object],[object Object],[object Object]
Endocrine metabolic disturbance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Phosphate retention ,[object Object],[object Object],[object Object]
Neuromuscular disturbances ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular and  pulmonary disturbances ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dermatologic disturbances ,[object Object],[object Object]
Gastointestinal disturbances  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hematologic and inmunologic disturbances ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physical Examination
Physical examination ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment  MNT
Delaying or halting progression of CRF ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treating pathologic manifestations of CRF with oral alkali supplementation  Metabolic acidosis with loop diuretics or ultrafiltration Fluid overload with calcitriol or vitamin D analogs. Hyper-parathyroidism with calcium supplements +/- calcitriol  Hypo- calcemia with dietary phosphate binders and dietary phosphate restriction  Hyper-phosphatemia with erythropoietin  Anemia
Timely planning for chronic renal replacement therapy ,[object Object],[object Object],[object Object],[object Object]
Renal Replacement Therapies  ,[object Object],[object Object],[object Object],[object Object]
Protein Replacement Therapies  ,[object Object],[object Object],[object Object]
Protein Replacement Therapies  ,[object Object],[object Object],[object Object]
Protein Replacement Therapies  ,[object Object],[object Object],[object Object],[object Object]
Maintenance dialysis ,[object Object],[object Object],[object Object],[object Object]
Haemodialysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Haemodialysis ,[object Object],[object Object],[object Object],[object Object]
Haemodialysis
Haemodialysis
Haemodialysis
Haemodialysis
Haemofiltration ,[object Object],[object Object],[object Object]
Peritoneal dialysis ,[object Object],[object Object],[object Object]
Peritoneal dialysis ,[object Object],[object Object],[object Object],[object Object]
CAPD – Continuous Ambulatory Peritoneal dialysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MNT In ESRD
CKD: Nutritional Management ,[object Object],[object Object],[object Object],[object Object],[object Object]
Therapy concerns
MNT concerns Individualized [~1000 mg/day] Individualized [~1000 mg/day] Individualized [based on serum level] Calcium  (mg/d) Individualized 500-750 + urine output  (1000 if anuric) Unrestricted Fluid  (ml/d) Individualized ~ 40 Individualized Potassium  (mg/kg IBW) 2000-4000 2000-3000 1000-3000 Sodium  (mg/d) <17 indiv <17 indiv 8-12 indiv Phosphorus 30-35 30-35 30-35 Energy  (kcal/kg IBW) 1.2-1.5 1.1-1.4 0.6-1.0 Protein  [g/kg/day] CAPD or CCPD Haemo dialysis CKD Nutrients
ESRD: Dietary protein & energy requirements   ,[object Object],[object Object],[object Object],[object Object],[object Object]
ESRD: Nutritional Management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ESRD: Nutritional Management ,[object Object],[object Object],[object Object],[object Object]
Interdialytic Weight Gain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Monitor Patient Status ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Monitor Patient Status ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment  In HD MNT
Typical Hemodialysis diet ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MNT in HD: Protein ,[object Object],[object Object],[object Object],[object Object],NKF K/DOQI practice guidelines. Am J Kid Dis 2000;35(suppl):S40-S41, Cited in Byham-Gray, p. 45-46
MNT in HD: Energy ,[object Object],[object Object],[object Object],NKF K/DOQI practice guidelines. Am J Kid Dis 2000;35(suppl):S40-S41, Cited in Byham-Gray, p. 46
Treatment  In PD MNT
PERITONEAL DIALYSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MNT for PD: Energy & proteins  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Peritoneal dialysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Background basics  MNT
What are AGEs? ,[object Object],[object Object]
What are AGEs? ,[object Object],[object Object],[object Object]
What are AGEs? ,[object Object],[object Object],[object Object]
Measuring proteins in the body ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Osmosis ,[object Object],[object Object],[object Object],[object Object]
Diffusion ,[object Object]
Colloid Osmotic Pressure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Colloid Osmotic Pressure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Osmolality ,[object Object],[object Object],[object Object],[object Object],[object Object]
Isotonic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hypertonic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hypotonic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Isotonic Fluid Imbalance ,[object Object],[object Object],[object Object],[object Object],[object Object]
Concepts Related to Fluid Volume Deficit ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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MNT in chronic renal failure

  • 1. Medical Nutrition Therapy in CRF Dr. B. K. Iyer
  • 2. Terms to know CRD CRI CRF ESRD Chronic renal disease is a patho-physiologic process with multiple causes, resulting in the inevitable decrease of nephron number and function. Chronic renal insufficiency (CRI) is the term for patients with mild-to-moderate renal impairment, those whose GFR falls at 30-70 cc/min. Chronic renal failure Is characterized by progressive destruction of renal mass with irreversible loss of nephrons over a period of at least months to many years. End-stage renal disease is a stage of total or nearly total and permanent kidney failure to render patient permanently dependent upon RRT
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  • 38. Treating pathologic manifestations of CRF with oral alkali supplementation Metabolic acidosis with loop diuretics or ultrafiltration Fluid overload with calcitriol or vitamin D analogs. Hyper-parathyroidism with calcium supplements +/- calcitriol Hypo- calcemia with dietary phosphate binders and dietary phosphate restriction Hyper-phosphatemia with erythropoietin Anemia
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  • 58. MNT concerns Individualized [~1000 mg/day] Individualized [~1000 mg/day] Individualized [based on serum level] Calcium (mg/d) Individualized 500-750 + urine output (1000 if anuric) Unrestricted Fluid (ml/d) Individualized ~ 40 Individualized Potassium (mg/kg IBW) 2000-4000 2000-3000 1000-3000 Sodium (mg/d) <17 indiv <17 indiv 8-12 indiv Phosphorus 30-35 30-35 30-35 Energy (kcal/kg IBW) 1.2-1.5 1.1-1.4 0.6-1.0 Protein [g/kg/day] CAPD or CCPD Haemo dialysis CKD Nutrients
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  • 65. Treatment In HD MNT
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  • 69. Treatment In PD MNT
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