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C:\documents and settings\administrator\桌面\20100607 nephrotic syndrome
1.
Department of pediatrics
The first affiliated hospital Sun Yat Sen University Sun Liangzhong ( 孙良忠 ) [email_address] Nephrotic Syndrome
2.
3.
4.
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a Basement membrane
b Epithelial cell c Endothelial cell d Mesangial cell Glomerular filtration barrier
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Glomerular filtration
barrier a Basement membrane b Epithelial cell c Endothelial cell d Mesangial cell
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8.
aperture barrier Endothelium
slit diaphragm
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10.
Charge-selective barrier Endothelium
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13.
Nonselective proteinuria
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15.
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17.
18.
Mild Moderate Mesangial
proliferative glomerulonephritis
19.
Focal segmental glomerulosclerosis
(FSGS)
20.
membranous nephrosis (MN)
21.
Membranoprliferative glomerulonephritis
22.
Pathological patterns of
INS in children and adults
23.
Pathophysiology Pathogenetic factor
glomerular permeability↑ massive proteinuria Hypoproteinemia lipoproteins synthesis ↑ hyperlipidemia Plasma oncotic pressure↓ Intravascular volume ↓ RAA(aldosterone)↑ ADH↑ Water sodium retention Edema Fluid Interstitial space Lipoprotein lipase ↓
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Thank You
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