This document summarizes a panel discussion on start-ups and innovation national policies that took place in Tel Aviv, Israel in May 2010. The panel was moderated by Dr. Gilead Fortuna and included participants from Israel, Hungary, Finland, the Netherlands, Czech Republic, and the United Kingdom. They discussed questions around basic infrastructure and advanced support for innovation, whether innovation policy should be tailored per country or follow best practices, and how to balance systematic systems with disruptive technologies. The panel then took questions from all participants and closed with final remarks.