This document discusses how clinical nutrition can be an essential adjunct to successful manual therapy. It notes that many chiropractors, osteopaths, and other manual therapists recommend nutritional supplements from Igennus Healthcare, particularly their EPA supplements, to support conditions like CFS/ME, neurodevelopmental disorders, and inflammation. The document emphasizes that inflammation is a key driver of pain and many modern illnesses, and that restoring the balance of omega-6 to omega-3 fatty acids can help reduce unnecessary inflammation and support conditions commonly treated with manual therapy. It encourages manual therapists to consider nutritional counseling and anti-inflammatory supplements as a way to improve client health outcomes.
2. • Igennus Healthcare Nutrition are a clinical nutrition
specialist providing bespoke support for inflammatory
conditions
• You don’t need to be a nutrition specialist to make a
difference to your client’s health!
• Igennus has established relationships with over 50
chiropractors, osteopaths, acupuncturists,
reflexologists, massage therapists, personal trainers
and fitness instructors…….
3. CFS/ME/FMS
• Dr Raymond Perrin (PhD) osteopath, neuroscientist and
pioneer of The ‘Perrin Technique’
• The Perrin Technique is a unique lymphatic drainage
technique that treats CFS – all Perrin CFS patients are
recommended to take 1-2g of Igennus EPA
• Igennus collaborates with 96 ‘Perrin Practitioners’ who
use this protocol successfully
4. Neurodevelopmental disorders
• Robin Pauc – neurologist and chiropractor, founder of the UK
renowned Tinsley House Clinic for childhood developmental
disorders
• Robin Pauc regularly recommends Igennus’ products as an
addition to his treatment programmes:
• ADHD
• Autism
• Asperger's
• Dyslexia
• Dyspraxia
5. • Igennus EPA used by Dave Scott U.S. triathlete and six-time Ironman
Triathlon World Champion
• Numerous personal trainers use Igennus’ products over generic oils as part
of their sports nutrition package - clients get better results:
Modulates inflammation
Immunity support
Cardiovascular support
Joint and bone support
Reduced oxidative stress
Supports energy requirements
Supports lean muscle mass/fat burn
Supports recovery time and performance
Our biggest practitioner accounts are manual/physical
therapists NOT nutrition specialists….
6. Why do they choose us?
Premium quality ingredients
Scientifically proven formulations
Niche therapeutic target
Highly specialised
Expert support team
Highest purity and lowest contaminants
They really work!
7. • Accident
• Injury
• Illness
• Stress
• Tension
• Posture issues
• Muscle spasm
• Over-exertion
All result in nerve and muscle damage = short/long term reduced mobility,
pain and subsequent secondary issues
But most importantly the science……..
Top reason to see a manual therapist:
PAIN!
Pain due to:
8. • Pain = inflammation = pain – signal that damage is present and protects
against worsening
• Process of inflammation must be tightly regulated in the body. If not,
can lead to unnecessary inflammation and exacerbate pre-existing
issues or initiate new ones otherwise non-problematic
• Unnecessary inflammation / inability to switch off inflammation =
chronic pain and reduced mobility
• PLUS very high risk of inflammation ‘spreading’ systemically = increased
risk of inflammatory disease
9. Managing pain
• Medication – but like fighting an Australian bush fire with oil - if
you use enough may put out the flame in the short term but long
term MUCH worse
• Many pharmaceuticals also have potentially detrimental side
effects (i.e. COX-2 inhibitors)
• Manual therapy addresses the muscle and nerve issues and
restores function to the body to reduce pain and promote mobility
• But without addressing the route cause of unnecessary
inflammation leads to long term issues and numerous secondary
problems
10. What is inflammation?
– the normal response of a tissue to injury
– triggered by a number of causes including infection, invading
pathogens (such as bacteria or viruses), trauma or compromised blood
flow
– desirable defence mechanism with undesirable side effects
– normal inflammatory response has an on/off switch
– in chronic inflammation there are issues with down-regulating signals
11. The key to regulating inflammation is through the
modulation of eicosanoids:
• Pro-inflammatory eicosanoids drive the immune and inflammatory
processes
• Anti-inflammatory eicosanoids act to end the process
• Overproduction of pro-inflammatory products or reduced
production of anti-inflammatory products can result in continued
production of inflammatory products – the hallmark of silent
inflammation
12. Regulating eicosanoids through diet
• Eicosanoids are derived from a group of polyunsaturated fats
known as omega-6 and omega-3
• The ratio of omega-6 to omega-3 in the diet influences the type
of eicosanoid produced
• The ratio of omega-6 to omega-3 is commonly associated with
health status
• The ratio of KEY omega-6 and omega-3 fats AA and EPA gives us a
direct indication of inflammatory health
13. • The AA to EPA ratio is an indication of the balance between pro-
inflammatory and anti-inflammatory eicosanoids
• High AA and low EPA levels will drive the inflammatory response and the
subsequent failure to resolve inflammation may increase susceptibility to
the development of chronic, low-grade, inflammation-based diseases
AA to EPA ratio - biomarker of inflammatory status
14. 0 % 4% 8% 12%
Omega-3 index* - biomarker of cardiovascular health
Desirable OptimalUndesirable
*Harris & Von Schacky, 2004
15. The role of diet and lifestyle in modulating inflammation
• Triggers from chronic altered diet and psycho-emotional stress
negatively influence the resolution step of the inflammatory
response
• Failure to resolve inflammation increases susceptibility to the
development of chronic, low-grade, inflammation-based
diseases due to the constant activation of both the HPA-axis
and innate immune system (Bosma-den Boer et al., 2012)
16. Resoleomics - the process of inflammation resolutionInflammatoryresponse
Initiation Resolution Termination
PGE2
LTB4
Eicosanoid switch Stop signal
Time
Pro-inflammatory reduced
Anti-inflammatory increased
Bosma-den Boer MM, van Wetten ML, Pruimboom L: Chronic inflammatory diseases are stimulated by current lifestyle:
how diet, stress levels and medication prevent our body from recovering. Nutrition & metabolism 2012, 9:32
17. •Oily fish via diet in decline
•A major 1st world dietary
deficiency
•Supplementation of food
necessary – milk, spreads
Omegas in food
Omegas in dietary
Supplements
Omegas in
medicines
Omega-3 transition to medicine
18. Increasing health problems relating to weight issues
Flock MR, Rogers CJ, Prabhu KS, Kris-Etherton PM: Immunometabolic role of long-
chain omega-3 fatty acids in obesity-induced inflammation. Diabetes/metabolism
research and reviews 2013, 29:431-445.
Makki K, Froguel P, Wolowczuk I: Adipose Tissue in Obesity-Related Inflammation
and Insulin Resistance: Cells, Cytokines, and Chemokines. ISRN inflammation 2013,
2013:139239.
Titos E, Claria J: Omega-3-derived mediators counteract obesity-induced adipose
tissue inflammation. Prostaglandins & other lipid mediators 2013, 107:77-84.
White PJ, Marette A: Is omega-3 key to unlocking inflammation in obesity?
Diabetologia 2006, 49:1999-2001.
White PJ, Marette A: Potential role of omega-3-derived resolution mediators in
metabolic inflammation. Immunology and cell biology 2014, 92:324-330.
19. Omega-3 and bone health
Mangano KM, Sahni S, Kerstetter JE, Kenny AM, Hannan MT: Polyunsaturated fatty
acids and their relation with bone and muscle health in adults. Current
osteoporosis reports 2013, 11:203-212.
McMahon MS: Beneficial effect of omega-3 fatty acids on bone metabolism.
Orthopedics 2012, 35:735-736.
Rousseau JH, Kleppinger A, Kenny AM: Self-reported dietary intake of omega-3
fatty acids and association with bone and lower extremity function. Journal of the
American Geriatrics Society 2009, 57:1781-1788.
Saidenberg Kermanac'h N, Bessis N, Cohen-Solal M, De Vernejoul MC, Boissier MC:
Osteoprotegerin and inflammation. European cytokine network 2002, 13:144-153.
20. Inflammation, omega-3 and rheumatoid arthritis
Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, Dent CM, Otterness
IG, Harwood JL, Caterson B: Pathologic indicators of degradation and inflammation
in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.
Arthritis and rheumatism 2002, 46:1544-1553.
Sperling RI: Dietary omega-3 fatty acids: effects on lipid mediators of inflammation
and rheumatoid arthritis. Rheumatic diseases clinics of North America 1991,
17:373-389.
Lee YH, Bae SC, Song GG: Omega-3 polyunsaturated fatty acids and the treatment
of rheumatoid arthritis: a meta-analysis. Archives of medical research 2012,
43:356-362.
21. Omega-3 and pain
Maroon JC, Bost JW: Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for
discogenic pain. Surgical neurology 2006, 65:326-331.
22. • AA and EPA contents of cell membranes can be altered through
oral administration of omega-3 EPA
• Increasing EPA levels results in a changed pattern of production of
eicosanoids
• Changing the fatty acid composition of cell membranes also affects
immune function and pathways
– changes in membrane structure
– cell signalling
– gene expression of cells and products involved in the inflammatory
cascade and pain signalling
23. • As health practitioners, you are perfectly placed to guide patients
toward natural co-therapies
• Route of inflammation may not just be due to pain/injury issue,
as consultation/client history may reveal:
• High stress
• Fatigue
• Neurological disorder
• Poor diet and lifestyle
• CVD
• Low mood
• Inflammation is a key driver of a myriad of diseases/conditions
26. Thus, addressing high levels of inflammation by restoring
AA to EPA ratio and increasing the omega-3 index will
reduce:
Pain
Fatigue
Stress
Risk of modern illness
27. Measuring inflammation and tracking progress
• Blood spot fatty acid profiling
Omega-6 to omega-3 ratio
AA to EPA ratio
Omega-3 index
• Knowing a client’s baseline omega-3 index allows effective dosing to
increase omega-3 index and reduce the AA to EPA ratio
Omega-3 index Dose required Body weight Minimum dose
Base line Target (mg/kg) (kg) (g)
3 8 0.0222 89 1.98
4 8 0.0172 89 1.53
6 8 0.0072 89 0.64
28. So remember!
You don’t need to be a nutrition specialist to
make a difference to your clients’ health
Our biggest practitioner accounts are manual
therapists NOT nutrition specialists….
29. Expertly formulated EPA supplements to suit all ages and needs
Scientifically proven co-therapies to support long term health
Technical support from MSc Nutrition Specialists
Literature and personalised support for your clients
Fatty acid blood profiling service allows a bespoke and effective
supplementation regime
30. Practitioner Scheme benefits:
A personalised referral code (i.e. SMITH25)
Highest commission on direct orders
Best discount for your clients
Free 1-2-1 training with our highly qualified nutrition team
Free promotional materials for your clients
Free profile feature on our website
Over 45% profit on trade orders
Instant 30 days free credit
PLUS additional 20% off your first trade order (effective profit
up to 57%)
32. References
Bosma-den Boer MM, van Wetten ML, Pruimboom L: Chronic inflammatory diseases are
stimulated by current lifestyle: how diet, stress levels and medication prevent our body from
recovering. Nutrition & metabolism 2012, 9:32.
Flock MR, Skulas-Ray AC, Harris WS, Etherton TD, Fleming JA, Kris-Etherton PM: Determinants of
erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response
randomized controlled trial. Journal of the American Heart Association 2013, 2:e000513.
Harris WS, Von Schacky C: The Omega-3 Index: a new risk factor for death from coronary heart
disease? Preventive medicine 2004, 39:212-220.
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Inflammation is a key player in bone resorption Role for omega-3 in reducing bone and muscle loss with ageing and reduce fracture risk, higher BMD in omega-3 users
Lee = high doses (2.7g) reduces NSAID intake
Our results mirror other controlled studies that compared ibuprofen and omega-3 EFAs demonstrating equivalent effect in reducing arthritic pain. Omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group.