This document discusses reducing waste in pharmaceutical manufacturing through green chemistry solutions. It presents a case study where a company called Newreka was able to reduce the E-Factor, a measure of waste generation, by 90% for an anti-retroviral drug by implementing green chemistry processes. This included recycling aqueous and solvent streams, improving yields, replacing hazardous solvents, and decreasing fresh water usage. The solutions improved economics, environmental impact, and safety while enhancing product quality. The document also outlines opportunities for green chemistry in industries like pharmaceuticals that produce large volumes and waste.

1. RECYCLE SOLUTIONS Reduce E-Factor for Pharma Intermediates by 90% Nitesh H. Mehta Founder Director Newreka Green Synth Technologies Pvt. Ltd. Mumbai, India [email_address]

4. This is the only World that exists. We keep hearing: GC in Real World Practice, Real World Case Studies of GC, GC implementation in Real World, etc….. There is no other world. Then why specifically say “Real World” ?? Real World ?? Roadblocks in Implementation of GC

8. Industrial A bigger cause (beyond us) Green = + Chemistry Green Chemistry Commercialized or Commercially viable + Quality of Air, Water & Soil impacted at ground level Concept of Industrial Green Chemistry

11. Founders Team of Technocrats from IIT Bombay passionate about Nature Foundation Principles of Green Chemistry, Green Engineering & Enviropreneurship Knowledge Base & Over 40,000 experiments conducted by Experience a dedicated team of 50 Chemists & Chemical Engineers. Service Customized & Sustainable Solutions to reduce E-FACTOR * * E-FACTOR = kgs waste generated per kg product Newreka as an Enviropreneur

13. Solvent & Water contribute more than 90% of the Reaction Mass Source Data: ACS GCI Pharmaceutical Roundtable benchmarking exercise 2007 Average composition of Effluents will be similar. Recycle of Water & Solvent can take care of 90% of problem. Average Composition of Reaction Mass

14. SOURCE: REACTION MEDIUM EXTRACTION MEDIUM After Process AQUEOUS STREAM SOLVENT STREAM (acidic, neutral, or alkaline) Raw Finished Organic Inorganic Materials Product Impurities Impurities Effluent Streams in Chemical Industry

15. AQUEOUS STREAMS SOLVENT STREAMS (acidic, neutral, alkaline) Raw Finished Organic Inorganic Materials Product Impurities Impurities selectively removed “ RCat TM ” (customized proprietary catalytic formulation for Recycle @ Source) selectively & effectively removes undesired org. & inorg. impurities such that the streams can be recycled back in the process. Concept behind our Recycle Solutions

16. Industry Pharmaceutical Customer One of the fastest growing Pharma Company in India Product Anti – Retroviral (or Anti – Aids) Drug Application prevents transfer of virus from mother to child Our Context Enable our customer to supply drug to patients at affordable price so that our next generation is not contaminated with the virus Convert entire API/Drug synthesis Green Case Study

17. CONVENTIONAL SYNTHETIC CHEMISTRY PROCESS E-Factor 67 61 42 4 Effluent 4020 TPA 3660 TPA 1680 TPA 240 TPA Total = 9600 TPA (for 60TPA plant) (32,000 kgs per day) GREEN CHEMISTRY SOLUTION BY NEWREKA E-Factor 6 6 1 4 Effluent 360 TPA 360 TPA 60 TPA 240 TPA Total = 1020 TPA Case Study: Reducing E-Factor & Improving Yield Stage III Chlorination Stage IV Reduction Stage V Stage II Nitration Stage I Diazo. & Hydrolysis Stage VI Stage II Nitration Stage III Chlorination Stage IV Reduction Stage I Diazo & Hydrolysis Stage VI Stage V

18. CONVENTIONAL SYNTHETIC CHEMISTRY PROCESS Th. Yield 1.01 1.41 1.12 0.826 = Overall Yield 1.317 Yield 0.80 0.53 1.05 0.73 = Actual Yield 0.325 (25% of Th.) GREEN CHEMISTRY BASED PROCESS Th. Yield 1.01 1.41 1.12 0.826 Yield 0.95 1.38 1.10 0.79 = Actual Yield 1.140 (86% of Th.) 250% Improvement in Yield Case Study: Improving Yield & Reducing E-Factor Stage III Chlorination Stage IV Reduction Stage V Stage II Nitration Stage I Diazo. & Hydrolysis Stage VI Stage II Nitration Stage III Chlorination Stage IV Reduction Stage I Diazo & Hydrolysis Stage VI Stage V

26. Thank You & Wish all of You a “ Greener Future” from Team Newreka