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Future Health
     Decision Support for
Professionals . Patients . Policy


                             Bart De Moor
        ESAT-SCD-SISTA, ESAT-PSI, CUO, ITEC

                WeBBT - 03/05/2011 Brussels
Associated research groups
• bioinformatics & machine
                                  • bioinformatics & computer science
  learning
                                  • education
• biomedical data processing
                                  • linguistics
• digital signal processing for
  audio & telecom                 • statistics


• Fac. Engineering                               • K.U.Leuven
  Dept. ESAT - K.U.Leuven                        campus Kortrijk

                                                 • medical imaging
• user experience
  research                                       • Fac. Engineering
                                                   Dept. ESAT
• Fac. Social Sciences                             K.U.Leuven
  K.U.Leuven
Structure department




                       Scientific
                       Committee

                       Research
                       Managers
Mission statement
 create lasting and positive impact on society through IT innovation

 improve quality and cost effectiveness in health care through
  computational research and IT development

Health Decision Support for Professionals . Patients . Policy

 • Dialogue with health care stakeholders

 • Demand-driven & interdisciplinary

 • Economical & societal valorization

   reference center for computational research in health care
Societal trends
              Ageing
                                      60plus   age related &
                  Flanders 2012
                                               chronic diseases
                                               rise

                   challenge: reconcile quality with costs


              Patient empowerment  P4 Medicine
                  •   Personalized
                  •   Preventive
                  •   Predictive
                  •   Participatory

                   challenge: patient-centric &
                  personalized health care
Technological trends
    IT + internet            Monitoring &             Biomedical
   performance &            smart systems            technologies
   pervasiveness
                          • Variety of imaging
                          modalities
            Moore’s Law   • Multichannel,
                         Wireless, Mobile &
             computing
                 power    Real-Time

                                                 Carlson’s law 
                                                 $1000 personal genome


broadband capacity &                                 Biobank
pervasiveness
 data access and
sharing
Challenge: data tsunami

            interpretability               complexity

                                                              # data, e.g. genetic



                 analysis bottleneck




                                                           Price per data point, e.g
                                                             sequenced base pair




IT to the rescue!
IT, mathematical engineering and software design

 fully exploit the opportunities created by advancing technologies
Research focus: Health Decision Support

data:      clinical, biomedical, imaging,
           omics, health insurance data,         •     IT & software design
           medical knowledge …                   •     data processing & mining
                                                 •     data integration & visualization
                  exploit data for more          •     user experience & e-learning
                   effective medicine
  Clinical

                 patient-centred care for                to extract appropriate
                  empowered patients                          information
  Patient

                   smart & data-driven               to transfer this information to
                health care system policies                      the user:
  Policy                                              professional, patient and policy
                                                                   maker


decision support             to enable better health care
Research focus
Clinical Decision Support                             Patient   Policy
                                                        DS       DS
•   interpretation of wide range of data
•   demand-driven, user-centred, with future vision
Research focus
Clinical   Patient Decision Support                      Policy DS
  DS
                                   ‘online’         •   data mining to
                                   telemonitoring       identify best
                                                        practices, …




                                                    •   hospital logistics
                       ‘patient empowerment’:
                       e.g. disease management
                       for patients with chronic
                       diseases using new media
Research focus: positioning
                                               Translational


                          5-10 years ahead of
                              deployment



       Health Care        Health Decision                      Fundamental
       Information           Support                            Biomedical
         Systems                                                 Research

                           Clinical Decision
          Invoicing             Support                         Pathogenesis

         PACS/CWS          Patient Decision                     Biomarkers
                               Support
       Health Insurance                                         Target/Drug
         (e.g. RIZIV)       Policy Decision                      Discovery
                                Support
Research focus: track record
                                         in silico
                                         drug
                                         discovery      image quantification
data handling & mining
for clinical genetics



                             medical image computing

social interest software
                                                          home monitoring for
                             (e-)learning solutions       epilepsy detection



vision software & hardware                  Theraplay: ergotherapeutic game
Research focus: track record
• 17 PI, 25 postdocs, 88 PhD students
• ~ 270 publications /year
• ~ € 5 million external financing /year
• ~ 15 PhDs /year
• ~ 40 patents
• 5 spin-offs launched since 2005
Interaction within IBBT
Interaction with stakeholders
        key to accessible and efficient health care = dialogue
            between research, technology and health care
                                  research
                      universities & research centres
            strategic research centers: IBBT, imec, VIB, VITO
                                     …


                                                     technology providers
                                                        & core facilities
health care stakeholders        dialogue
                                                           industry
        patients
                                                       supercomputing
        hospitals                IBBT
                                                    medical imaging center
         doctors             Future Health
                                                         usability lab
    health insurance
                                                 sequencing (Genomics Core)
   health care policy
                                                              …
            …
Conclusion
                                       improve health care quality and
Trends                                              cost effectiveness



                                 Decision Support for
                            Professionals . Patients . Policy

                          exploit data for more       • Dialogue
                           effective medicine
             Clinical
                                                      • Demand-driven
                         patient-centred care for
                          empowered patients
             Patient                                  • User-centred
                           smart & data-driven
              Policy    health care system policies   • Future vision
Future Health Department

 www.kuleuven.be/ibbt
Towards evidence-based and personalized
  medicine
                                                                                         IBBT Future Health
              high

                                                                               personalized
 access to                                                               (based on people like me)
  patient
information
                                                          evidence-based
                                                       (based on population)


                         evidence
                                           clinician
                          based
                                          consensus


                       trial and error

                          individual
                     clinical knowledge
                       and experience

              low

                      low                                                                high
                                          access to clinical knowledge
                                             (e.g. diagnostic tools)

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Inge Thijs - Future Health

  • 1. Future Health Decision Support for Professionals . Patients . Policy Bart De Moor ESAT-SCD-SISTA, ESAT-PSI, CUO, ITEC WeBBT - 03/05/2011 Brussels
  • 2. Associated research groups • bioinformatics & machine • bioinformatics & computer science learning • education • biomedical data processing • linguistics • digital signal processing for audio & telecom • statistics • Fac. Engineering • K.U.Leuven Dept. ESAT - K.U.Leuven campus Kortrijk • medical imaging • user experience research • Fac. Engineering Dept. ESAT • Fac. Social Sciences K.U.Leuven K.U.Leuven
  • 3. Structure department Scientific Committee Research Managers
  • 4. Mission statement  create lasting and positive impact on society through IT innovation  improve quality and cost effectiveness in health care through computational research and IT development Health Decision Support for Professionals . Patients . Policy • Dialogue with health care stakeholders • Demand-driven & interdisciplinary • Economical & societal valorization reference center for computational research in health care
  • 5. Societal trends Ageing 60plus age related & Flanders 2012 chronic diseases rise  challenge: reconcile quality with costs Patient empowerment  P4 Medicine • Personalized • Preventive • Predictive • Participatory  challenge: patient-centric & personalized health care
  • 6. Technological trends IT + internet Monitoring & Biomedical performance & smart systems technologies pervasiveness • Variety of imaging modalities Moore’s Law • Multichannel,  Wireless, Mobile & computing power Real-Time Carlson’s law  $1000 personal genome broadband capacity & Biobank pervasiveness  data access and sharing
  • 7. Challenge: data tsunami interpretability complexity # data, e.g. genetic analysis bottleneck Price per data point, e.g sequenced base pair IT to the rescue! IT, mathematical engineering and software design  fully exploit the opportunities created by advancing technologies
  • 8. Research focus: Health Decision Support data: clinical, biomedical, imaging, omics, health insurance data, • IT & software design medical knowledge … • data processing & mining • data integration & visualization exploit data for more • user experience & e-learning effective medicine Clinical patient-centred care for to extract appropriate empowered patients information Patient smart & data-driven to transfer this information to health care system policies the user: Policy professional, patient and policy maker decision support to enable better health care
  • 9. Research focus Clinical Decision Support Patient Policy DS DS • interpretation of wide range of data • demand-driven, user-centred, with future vision
  • 10. Research focus Clinical Patient Decision Support Policy DS DS ‘online’ • data mining to telemonitoring identify best practices, … • hospital logistics ‘patient empowerment’: e.g. disease management for patients with chronic diseases using new media
  • 11. Research focus: positioning Translational 5-10 years ahead of deployment Health Care Health Decision Fundamental Information Support Biomedical Systems Research Clinical Decision Invoicing Support Pathogenesis PACS/CWS Patient Decision Biomarkers Support Health Insurance Target/Drug (e.g. RIZIV) Policy Decision Discovery Support
  • 12. Research focus: track record in silico drug discovery image quantification data handling & mining for clinical genetics medical image computing social interest software home monitoring for (e-)learning solutions epilepsy detection vision software & hardware Theraplay: ergotherapeutic game
  • 13. Research focus: track record • 17 PI, 25 postdocs, 88 PhD students • ~ 270 publications /year • ~ € 5 million external financing /year • ~ 15 PhDs /year • ~ 40 patents • 5 spin-offs launched since 2005
  • 15. Interaction with stakeholders key to accessible and efficient health care = dialogue between research, technology and health care research universities & research centres strategic research centers: IBBT, imec, VIB, VITO … technology providers & core facilities health care stakeholders dialogue industry patients supercomputing hospitals IBBT medical imaging center doctors Future Health usability lab health insurance sequencing (Genomics Core) health care policy … …
  • 16. Conclusion improve health care quality and Trends cost effectiveness Decision Support for Professionals . Patients . Policy exploit data for more • Dialogue effective medicine Clinical • Demand-driven patient-centred care for empowered patients Patient • User-centred smart & data-driven Policy health care system policies • Future vision
  • 17. Future Health Department www.kuleuven.be/ibbt
  • 18.
  • 19. Towards evidence-based and personalized medicine IBBT Future Health high personalized access to (based on people like me) patient information evidence-based (based on population) evidence clinician based consensus trial and error individual clinical knowledge and experience low low high access to clinical knowledge (e.g. diagnostic tools)