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Quantitative analysis of ultrasound images  of the preterm brain Ewout Vansteenkiste IBBT-Medisip/IPI-UGENT Friday Food 25/01/2008
Outline [Source: William Lawson,  A new Orchard and Garden , 1648, Londen ] quantitative image analysis medical ultrasound speckle-reduction in  ultrasound 2D echo/3D MRI registration white matter classification 1/24 texture-classification psycho-physics segmentation registration white matter segmentation ventricle segmentation segmentation carotid
Quantitative image analysis 2/24 tumor = “white dot” in the image size = “small”, “average” Qualitative  analysis : in words   2.25 cm² Both experts  measure  the tumor Using the same segmentation algorithm Quantitative   analysis: through measuring
Medical ultrasound 3/24 SPECKLE probe electric current Pi ëzo-electric  cristal pulsing Tissue structures/transitions skin
White matter damage = Periventricular Leukomalacia (PVL) grey matter: what we think with white matter: highways of the brain ventricles: cavities regulating brain fluid 4/24 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],mild severe
White matter damage diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],pros:  - non-invasive/safe   - portable - real-time imaging - relatively cheap contras: - poor image quality - diagnosis = subjective 5/24 “ flaring” normal severe mild flaring
Problem = subjectivity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],6/24
Tissue  texture  classification (1) -  Texture : no unique definition. Description: regular, irregular, stochastic  pattern present in most natural scenes: -  Texture parameters : mathematical measures expressing texture characteristics 7/24 ,[object Object],- Important for ultrasound:  tissue   structure  is manifested as  speckle texture
Example texture parameters: co-occurrence matrices wood cloth 8/24 Contrast = 100 Entropy = 0.78 Contrast = 60 Entropy = 0.34 pathological benign Contrast = 70 Entropy = 0.44 Contrast = 130 Entropy = 0.64 255 0 255 0 2D co-occurrence matrix
Tissue texture  classification  (2) 9/24 length width length width length width ? ?
Tissue texture classification (3) Quantitative analysis = precision 92.5%   = sensitivity 88 % Qualitative analysis  = precision 75%   = sensitivity 70% 10/24 patholigical non-pathological 140 pati e nts ,[object Object],[object Object],[object Object],[object Object],Compensation algorithm ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bayes classifier KNN classifier classifier combination - pathological - non-pathological Normalization LDA classifier
Outline [Source: William Lawson,  A new Orchard and Garden , 1648, Londen ] Quantitative image analysis medical ultrasound Texture classification white matter classification 11/24
Flare segmentation and area estimation 12/24 sensitivity 98% Validation? Initial texture-  Basd segmen- Tation map -Morfological  closing -Gradient -Opening by Reconstruction expert existing new Expert delineation: subjective? 2D US 3D MRI registration
Multimodal image registration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Magnetic Resonance Scanner ,[object Object],[object Object],[object Object],13/24 + 2D high-resolution - low image quality
Multimodal 2D ultrasound to 3D MRI registration initialization Mutuel  Information Metric Regular Step Gradient Descent Rigid  Transformation Trilinear  Interpolation result  14/24
Validation registration = “CAVE” + segmentation 15/24 Registration algorithm flaring segmentation MRI-flaring expert
Segmentation extended: ventricles + carotid enlarged ventricles indicative for PVL 3D reconstruction 2D seg- mentation 16/24 Bifurcation of the  carotid: atherosclerosis  3D reconstruction [Source = Glor, 2004] 2D seg- mentation
Outline [Source: William Lawson,  A new Orchard and Garden , 1648, Londen ] quantitative image analysis medical ultrasound Texture-classification segmentation registration 2D echo/3D MRI registration white matter classificaton 17/24 white matter segmentation ventricle segmentation segmentation carothid
Psychovisual experiments SUBJECTS dummy? physicians? Experts? METHODOLOGY 18/24 STIMULI
Image degradations ,[object Object],[object Object],19/24 blur noise artefacts
Test room implementation examples (1) © Cedric Marchessoux - BARCO 20/24
Set-up experiment: filtering of ultrasound images ,[object Object],[object Object],[object Object],[bron: Pizurica, 2002] 21/24 original filtered
methodology + results ,[object Object],[object Object],[object Object],22/24 speckle reduction rejected ! Les suited for diagnosis  degree of filtering 0  1  2  3  4
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],23/24 Improved, early  quantitative detection of PVL sensitivity: 70%  98% + ultrasound more sensitive than MRI
and remember… The more questions you now ask,  the less time we have to eat… 24/24

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20080125 Friday Food

  • 1. Quantitative analysis of ultrasound images of the preterm brain Ewout Vansteenkiste IBBT-Medisip/IPI-UGENT Friday Food 25/01/2008
  • 2. Outline [Source: William Lawson, A new Orchard and Garden , 1648, Londen ] quantitative image analysis medical ultrasound speckle-reduction in ultrasound 2D echo/3D MRI registration white matter classification 1/24 texture-classification psycho-physics segmentation registration white matter segmentation ventricle segmentation segmentation carotid
  • 3. Quantitative image analysis 2/24 tumor = “white dot” in the image size = “small”, “average” Qualitative analysis : in words 2.25 cm² Both experts measure the tumor Using the same segmentation algorithm Quantitative analysis: through measuring
  • 4. Medical ultrasound 3/24 SPECKLE probe electric current Pi ëzo-electric cristal pulsing Tissue structures/transitions skin
  • 5.
  • 6.
  • 7.
  • 8.
  • 9. Example texture parameters: co-occurrence matrices wood cloth 8/24 Contrast = 100 Entropy = 0.78 Contrast = 60 Entropy = 0.34 pathological benign Contrast = 70 Entropy = 0.44 Contrast = 130 Entropy = 0.64 255 0 255 0 2D co-occurrence matrix
  • 10. Tissue texture classification (2) 9/24 length width length width length width ? ?
  • 11.
  • 12. Outline [Source: William Lawson, A new Orchard and Garden , 1648, Londen ] Quantitative image analysis medical ultrasound Texture classification white matter classification 11/24
  • 13. Flare segmentation and area estimation 12/24 sensitivity 98% Validation? Initial texture- Basd segmen- Tation map -Morfological closing -Gradient -Opening by Reconstruction expert existing new Expert delineation: subjective? 2D US 3D MRI registration
  • 14.
  • 15. Multimodal 2D ultrasound to 3D MRI registration initialization Mutuel Information Metric Regular Step Gradient Descent Rigid Transformation Trilinear Interpolation result 14/24
  • 16. Validation registration = “CAVE” + segmentation 15/24 Registration algorithm flaring segmentation MRI-flaring expert
  • 17. Segmentation extended: ventricles + carotid enlarged ventricles indicative for PVL 3D reconstruction 2D seg- mentation 16/24 Bifurcation of the carotid: atherosclerosis 3D reconstruction [Source = Glor, 2004] 2D seg- mentation
  • 18. Outline [Source: William Lawson, A new Orchard and Garden , 1648, Londen ] quantitative image analysis medical ultrasound Texture-classification segmentation registration 2D echo/3D MRI registration white matter classificaton 17/24 white matter segmentation ventricle segmentation segmentation carothid
  • 19. Psychovisual experiments SUBJECTS dummy? physicians? Experts? METHODOLOGY 18/24 STIMULI
  • 20.
  • 21. Test room implementation examples (1) © Cedric Marchessoux - BARCO 20/24
  • 22.
  • 23.
  • 24.
  • 25. and remember… The more questions you now ask, the less time we have to eat… 24/24