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Organização: Pró-Reitoria de Pesquisa - USP

Workshop de Capacitação em
Escrita Científica

Módulo 5
Prof. Dr. Valtencir Zucolotto
Laboratório de Nanomedicina e Nanotoxicologia
Instituto de Física de São Carlos, USP
USP, 2012
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Workshop Outline
Modulo 1: O Gênero Literário
Seções de Um Artigo Científico
Módulo 2: Estrutura 1: Abstract
Módulo 3: Estrutura 2: Introduction
Módulo 4: Estrutura 3: Results and Discussion, Conclusion
Módulo 5: Estilo
Linguagem 1: Especificidade, Complexidade e Ambiguidade
Módulo 6: Linguagem 2: Redundâncias, Ação no Verbo, Fluidez de
Texto, Ritmo de Escrita
Módulo 7: Linguagem 3: Plain English, Escrever em Inglês, Preposições
Módulo 8: Linguagem 4: Topic Sentences, Cover Letters, Final Remarks

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Módulo 5
- Estilo
- Linguagem 1:
Especificidade, Complexidade e Ambiguidade

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Scientific Writing Style

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

Define the abbreviation in parentheses the
first time you use it:
Green Fluorescent Protein (GFP)

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

Use Abbreviations / acronyms with discretion

Ex: Use of combined 5-PAS and BTR3 increased the
OP toxicity for MD14+ cells

??????

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

Words “day’, “week”, “month” and “year” are not
abbreviated.

Except in the case of footnotes, tables and captions, spell out
all months with or without a specific day :

Ex: Data were collected in January, 2000.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

U.S. citizens;
U.K. football team
(Adjectives)
or
“The citizens from United States….”
“The football team of United Kingdom….”
(nouns)

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

Units of measure are abbreviated : 2 mm.; 10 min.
In a non-measurable context: "we measured length in
millimeters"

OBS: Never add an "s" to the measure unit.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

Latin abbreviations:
- i.e., id est (that is),
- e.g., exempli gratia (for example),
- etc. (so on),
- vs (versus),
- et al., et alli, and others,
- via (road),
- in situ (in a place)

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Abbreviations

Controversy: Some authors agree that a period is used
only if the last letter of the abbreviation is not the last
letter of the word:

Ex.: Prof. , Vol. 1, p. 23-25 , 2nd ed. , et al. , etc.
Dr , Mr , Ms , vs

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Numerals
A good reference material may be found at:

The ACS Style Guide, Dodd, J. S., Ed;
American Chemical Society, Washington, DC, 2006

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Numerals
Use a space between the number and the unit:

6 min, 0.3 g, 80 mL, etc.

Exception: %, $ and °
50%, $400, 180° (Obs: 90 °C, 180 °F).

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
What Tense to use?

Use past tense for sentences concerning your findings.

Ex: This study was aimed at investigating.. (The study)

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
What Tense to use?

Present forms preferable in
Conclusion Section

Present and even Future Tenses may be used!!

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Active / Passive Voices
Passive voice almost always requires more words than
Active voice:

ACTIVE: “the melting processing consumed
polymeric material at a higher rate..” (10 words)
PASSIVE: “Polymeric material was consumed by the
melting process at a higher rate..” (12 words)

Mathews, JR and and Mathews RW, Successful Scientific Writing, Cambridge University
Press; 3 edition 2007)
Dodd, J. S., Ed. The ACS Style Guide; American Chemical Society: Washington,
DC, 1986.).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
First vs Third Person
Sometimes first person may be used to
emphasize important information

Our research group has investigated….
We have demonstrated that….

Avoid: “we believe”, “we feel”, “we can see”
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Formal Language

Avoid
nowadays
on the contrary

(up) until now

www.nanomedicina.com.br

Better
presently, currently
in contrast
to date

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Language I

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Lets face it, English is a stupid language.
There is no egg in the eggplant.
No ham in the hamburger.
And neither pine nor apple in the pineapple.
English muffins were not invented in England.
French fries were not invented in France.

http://www.gray-area.org/Research/Ambig/#HEAD
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Specificity
The efficient writing is specific

“Novel strategies have been proposed to overcome the
limitations regarding diseases diagnosis.”

Too general!!

www.nanomedicina.com.br

What were the strategies?
What are the limitations?
What are the diseases?

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Specificity

The use of carbon nanotubes-based biosensors
has been proposed to overcome the poor selectivity
exhibited by conventional systems used for cancer
detection.

Better !!

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Specificity

Carbon nanotubes-based biosensors exhibit high
selectivity for cancer detection.

Efficient Scientific Writing!!

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
The right emphasis on details

Possible ways of emphasizing details:

Repetition, wording, illustration and placement

Source: Michael Alley The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
The right emphasis on Details

1. Repetition

Title, abstract, discussion and conclusions ??

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
The right emphasis on Details
2. Wording
Stress the most important details in a sentence!!

Ex: High levels of the protein were found in the blood
samples from patients with hemorrhagic infections.

What is the most important detail?
The protein, the levels or the infection?

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
The right emphasis on Details
Unexpected high levels of a protein were found in the
blood samples from patients with hemorrhagic infections.

High levels of a very specific S100 family protein were
found in the blood samples from patients with
hemorrhagic infections.

High levels of a specific protein were found in the blood
samples from examined patients. This may be the cause
of the hemorrhagic infection.
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Complexity: Sentences
A huge problem: Long Sentences
The mechanical analyses had been carried out using
stress-strain measurements and indicated that the
copper-based alloys are more resistant than the silverbased ones, which may be due to the fabrication process
used for each composite material, since the copper
alloys had been produced via casting, whereas the silver
composites had been fabricated via reactive extrusion
under high pressures, controlled atmosphere, and at
temperatures ranging from 300 – 400 °C.
????????
Too long!,
Too wordy!
Too many ideas in a single sentence!!
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Complexity: Sentences
Streamlining it:
First half of the sentence:
The mechanical analyses had been carried out
using…..

Second half :
.............................................................................

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Complexity: Sentences
M5P2 IEEE T.E.C.

The proposed memetic algorithm that combines search by an ES [44] on
the upper level and nonlinear local optimizations to handle complex
nonlinear equality constraints and to realize a Lamarckian learning
principle is a promising concept for general design optimization problems
in which a large number of nonlinear model equations and constraints as
well as discrete design decisions and possibly discontinuous value
functions are present, well beyond the domain of chemical engineering.
While the selection of the representation as well as of the mutation and
recombination operators is of course problem specific and has to be
modified for different applications, and the use of other local solvers may
also require small changes to the algorithm, the general principle can be
transferred to any similar problem, and significant gains in computational
performance and robustness (probability of finding the best as well as most
of the local optima) can be expected.
Urselmann, et al., IEEE Transactions on Evolutionary Computation, 15, 2011, 659

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Stacking of Passive Voice

A new methodology for protein purification
is presented. Isolation techniques using
HPLC are discussed. The amount of
protein purified in each cycle is revealed.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Stacking of Passive Voice

This study describes a new methodology for
protein purification using novel techniques based
on HPLC experiments. Each purification cycle
provided a total amount of 1.2 mg of protein.

Better!!
Active voice is straightforward

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity
Words/phrases with more than one
meaning

Chickens are ready to eat
????

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity
Word Choice:

Be careful with:
as, only

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity
Word Choice:

“Tissue temperature increased as the
particles released the phytotherapics”

????
The word “as” may be interpreted as “because” or “while”

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity

“Tissue temperature increased because the
particles released the phytotherapics”
Better

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity

Only I tested the device yesterday
I only tested the device yesterday
I tested only the device yesterday

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity

“ In low water temperatures and high toxicity levels of
oil, we tested how well the microorganisms survived”

Better: “We tested how well the microorganisms
survived in low water temperatures and high toxicity
levels of oil”
Extracted from: Michael Alley The Craft of Scientific Writing,
3rd edition (Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity

“The train left the station crowded and dirty.”

Better: “The train was crowded and dirty when it left the station”

www.1-language.com/eslquizzes/ambiguoussentences.htm
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity
Unclear Pronoun

Since the platform has a support system
connected to the equipment, it was mounted
inside the lab.

What was mounted inside the lab????
It = The platform or the support system??
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Ambiguity

Exercises at:
http://www.writing.engr.psu.edu/handbo
ok/exercises/exercise4.html

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Sources
-Michael Alley. The Craft of Scientific Writing, 3rd edition (SpringerVerlag, 1996).

Mathews, JR and and Mathews RW, Successful Scientific Writing, Cambridge
University Press; 3 edition 2007)
Dodd, J. S., Ed. The ACS Style Guide; American Chemical Society:
Washington, DC, 1986.).
Brawand et al., Nature, 2011, 478, 343
Urselmann, et al., IEEE Transactions on Evolutionary Computation, 15, 2011, 659
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Muito Obrigado
Valtencir Zucolotto
zuco@ifsc.usp.br
www.nanomedicinna.com.br
www.lnn.ifsc.usp.br

www.twitter.com/Nanomedicina
Instituto de Física de São Carlos - USP
www.twitter.com/escreverartigos
www.twitter.com/writingpapers

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Organização: Pró-Reitoria de Pesquisa - USP

Workshop de Capacitação em
Escrita Científica

Módulo 6
Prof. Dr. Valtencir Zucolotto
Laboratório de Nanomedicina e Nanotoxicologia
Instituto de Física de São Carlos, USP
USP, 2012
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Workshop Outline
Modulo 1: O Gênero Literário
Seções de Um Artigo Científico
Módulo 2: Estrutura 1: Abstract
Módulo 3: Estrutura 2: Introduction
Módulo 4: Estrutura 3: Results and Discussion, Conclusion
Módulo 5: Estilo
Linguagem 1: Especificidade, Complexidade e Ambiguidade
Módulo 6: Linguagem 2: Redundâncias, Ação no Verbo, Fluidez de
Texto, Ritmo de Escrita
Módulo 7: Linguagem 3: Plain English, Escrever em Inglês, Preposições
Módulo 8: Linguagem 4: Topic Sentences, Cover Letters, Final Remarks

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Módulo 6
Linguagem 2:
Redundâncias, Ação no Verbo, Fluidez da
Escrita, Ritmo de Escrita

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Language II

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Redundancies

During the data collection phase of the study, all
experimental measurements were performed in a
period of time of 3 months. All the obtained results
were further analyzed and possible errors were
completely eliminated.

Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Redundancies

Better:
During the data collection, all measurements were
performed in 3 months. The results were further
analyzed and possible errors were eliminated.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Redundancies

Best:
All measurements were performed in 3 months.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Redundancies

Efficient Scientific Writing:

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Redundancies
Common redundancies from Non-Native Speakers

Alternative choices
Basic fundamentals
Completely eliminate
Currently underway
Empty space
Introduced a new
Mix together
Never before

Period of time
Separate entities
Still persists
Quite unique
Very similar
Join together
Completely full

Obtained Results
Definitely proved
Exactly true
First of all

Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Strong Nouns
Strong nouns provide a “visual image” to the reader.

A short list of abstract nouns:
Ability, approach, capability, concept, environment,
factor, nature, parameter,….

Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Action in the verb

Não-Nativos tendem a “Substantivar”
os Verbos

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Strong Verbs
Replace verb phrases by the correspondent strong verb

Weak verb phrase
Made the arrangement for
Made the decision
Made the measurement of
Performed the development of

www.nanomedicina.com.br

Strong Verb
Arranged
Decided
Measured
Developed

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Action in the verb

“A continuous improvement in patient´s condition
was observed”

Better:
“Patient´s condition improved”

Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Action in the verb

Administration of dopamine produced a decrease
in the frequency of convulsions

Better:
Administration of dopamine decreased convulsions
frequency

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Action in the verb

The new phytotherapics exert their action by
blocking the cells communications.

Better:
The
new
phytotherapics
communications.

www.nanomedicina.com.br

block

cells

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
A Clear and Effective Writing is made of Smooth
Transitions between Ideas, Sentences, Paragraphs

Problem: Complementary ideas disconnected and/or
placed far way from each other.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow

The level of the proteins found in the blood samples
is similar to that observed by other researchers. Due to its
ability to form complexes with DNA and RNA, such proteins
had been extensively investigated by a number of research
groups, including the group from Harvard, which estimated
that the normal level of the protein in blood should be
around 1 mg/dL.

????

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow

Better:

The level of the proteins found in the blood
samples was 1 mg/dL, which is similar to that
observed by Harvard´s group.

The word which brings the ideas closer to
each other!

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Transitional words within a sentence

1) Reason:
Because, since, due to,….

Example: The size of the nanoparticles was ca. 5 nm
because of the synthetic route employed.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Transitional words within a sentence

2) Consequence:
therefore, as a consequence,….

Example: The enzymes showed a high specificity to
pesticides, therefore allowing its use in biosensors.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Transitional words within a sentence

3) Concession:
Although, even though, ….

Example: Although individual residues in the repeatedsequence blocks in the core have diverged, the
patterns of amino acids are identical.

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Smooth Transition between sentences

1) Continuation: Movement of ideas in the same
direction:
Examples:
Also;
Moreover;
first, second…;
In addition;
……..

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Smooth Transition between sentences

2) Pause:

Examples:
For example;
In other words;
…….

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Smooth Transition between sentences

3) Reversal: Movement of ideas reverses direction.

Examples:
However;
In contrast;
On the other hand;
Conversely;
Contrarily;

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Smooth Transition between sentences

4) Conclusion:

Examples:
In summary
Concluding
…….

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Rhythm

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Sentence Openers: Rhythm
DNA sensing has been considered a powerful tool to diagnose cancer. Cancer
diagnosis is usually not straightforward due to a large number of pathologies
variations as well as to the very low amount of DNA molecules expressed in the
beginning of disease. Sensors capable of detecting specific types of tumoral
cells may represent a breakthrough in medicine. This paper describes the
development of special sensors for cancer detection. The sensors comprise
immobilized antibodies that recognizes specific types of proteins produced by
cancer cell. The sensor systems were produced using different immobilization
strategies. The results show that different types of cancer cells can be detected
at very low limits of detection. The experiments were carried out in triplicate.
The systems we developed will be evaluated in clinical trials in a few months.
Many medicine areas will benefit from our new technologies.

????
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Vary sentence openers
Topic of Sentence
Time of action
Location of action
Manner of action
Subordinate action
Reason for action

Subject
Prepositional Phrase
Prepositional Phrase
Adverb
Dependent Clause
Infinitive Phrase

Source: Michael Alley. The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
adverb

Recently, DNA sensors….

dependent clause

Although cancer diagnosis is not
straightforward ,….

infinitive phrase

To optimize the systems….

subject-verb

The results show that….

prepositional phrase

In a few months, the systems will
be….

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Recently, DNA sensing has been considered a powerful tool to diagnose cancer.
Although cancer diagnosis is not straightforward, due to a large number of
pathologies variations, this strategy may be very efficient for some cancer
types. Sensors capable of detecting specific types of tumoral cells may
represent a breakthrough in medicine. In this paper we describe the
development of special sensors for cancer detection. The sensors comprise
immobilized antibodies that recognizes specific types of proteins produced by
cancer cell. To optimize the systems, the sensor were produced using different
immobilization strategies. The results show that different types of cancer cells
can be detected at very low limits of detection. The experiments were carried
out in triplicate. In a few months, the systems will be evaluated in clinical
trials in a few months. Since highly sensitivity and specificity were achieved by
the sensors, clinical areas may benefit from our new technologies.

Rhythm !!!!
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Flow
Rewrite the following Abstract improving rhytm
The development of new antimicrobial peptides (AMPs) has arisen as a novel,
promising strategy to overcome the effects of antibiotic resistance developed
by several pathogens. The efficient design and development of such
biomolecules, however, requires an understanding of the mechanisms of
interactions between the peptides and cell membrane. In this study we
examined the interactions of the cationic antimicrobial peptide dermaseptin 01
with three membrane systems. The membrane systems had been
investigated in the form of Langmuir monolayers. The degree of interaction of
DS 01with the different biomembrane models was quantified from equilibrium
and dynamic liquid-air interface parameters, such as: minimum molecular
area and dilatational elasticity modulus. The interaction between DS 01 and
the zwitterionic phospholipid, as well as with the LRE-La monolayers were
very weak at low peptide concentrations, whereas with negatively charged
phospholipids the interactions were stronger. The latter is in agreement with
previous literature for vesicles and planar lipid bilayers, and with the greater
activity of AMPs against bacterial membranes, as compared to mammalian
cell membranes.
www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Sources
-Michael Alley. The Craft of Scientific Writing, 3rd edition
(Springer-Verlag, 1996).

Science Research Writing for Non-Native Speakers of English, Hilary
Glasman-Deal, Imperial College Press, 2009
Mathews, JR and and Mathews RW, Successful Scientific Writing,
Cambridge University Press; 3 edition 2007)

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br
Muito Obrigado
Valtencir Zucolotto
zuco@ifsc.usp.br
www.nanomedicina.com.br
www.lnn.ifsc.usp.br
www.twitter.com/Nanomedicina
Instituto de Física de São Carlos - USP
www.twitter.com/escreverartigos
www.twitter.com/writingpapers

www.nanomedicina.com.br

Prof. Dr. Valtencir Zucolotto
zuco@ifsc.usp.br

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Workshops escrita modulos_5_6

  • 1. Organização: Pró-Reitoria de Pesquisa - USP Workshop de Capacitação em Escrita Científica Módulo 5 Prof. Dr. Valtencir Zucolotto Laboratório de Nanomedicina e Nanotoxicologia Instituto de Física de São Carlos, USP USP, 2012 www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 2. Workshop Outline Modulo 1: O Gênero Literário Seções de Um Artigo Científico Módulo 2: Estrutura 1: Abstract Módulo 3: Estrutura 2: Introduction Módulo 4: Estrutura 3: Results and Discussion, Conclusion Módulo 5: Estilo Linguagem 1: Especificidade, Complexidade e Ambiguidade Módulo 6: Linguagem 2: Redundâncias, Ação no Verbo, Fluidez de Texto, Ritmo de Escrita Módulo 7: Linguagem 3: Plain English, Escrever em Inglês, Preposições Módulo 8: Linguagem 4: Topic Sentences, Cover Letters, Final Remarks www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 3. Módulo 5 - Estilo - Linguagem 1: Especificidade, Complexidade e Ambiguidade www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 4. Scientific Writing Style www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 5. Abbreviations Define the abbreviation in parentheses the first time you use it: Green Fluorescent Protein (GFP) www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 6. Abbreviations Use Abbreviations / acronyms with discretion Ex: Use of combined 5-PAS and BTR3 increased the OP toxicity for MD14+ cells ?????? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 7. Abbreviations Words “day’, “week”, “month” and “year” are not abbreviated. Except in the case of footnotes, tables and captions, spell out all months with or without a specific day : Ex: Data were collected in January, 2000. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 8. Abbreviations U.S. citizens; U.K. football team (Adjectives) or “The citizens from United States….” “The football team of United Kingdom….” (nouns) www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 9. Abbreviations Units of measure are abbreviated : 2 mm.; 10 min. In a non-measurable context: "we measured length in millimeters" OBS: Never add an "s" to the measure unit. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 10. Abbreviations Latin abbreviations: - i.e., id est (that is), - e.g., exempli gratia (for example), - etc. (so on), - vs (versus), - et al., et alli, and others, - via (road), - in situ (in a place) www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 11. Abbreviations Controversy: Some authors agree that a period is used only if the last letter of the abbreviation is not the last letter of the word: Ex.: Prof. , Vol. 1, p. 23-25 , 2nd ed. , et al. , etc. Dr , Mr , Ms , vs www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 12. Numerals A good reference material may be found at: The ACS Style Guide, Dodd, J. S., Ed; American Chemical Society, Washington, DC, 2006 www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 13. Numerals Use a space between the number and the unit: 6 min, 0.3 g, 80 mL, etc. Exception: %, $ and ° 50%, $400, 180° (Obs: 90 °C, 180 °F). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 14. What Tense to use? Use past tense for sentences concerning your findings. Ex: This study was aimed at investigating.. (The study) www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 15. What Tense to use? Present forms preferable in Conclusion Section Present and even Future Tenses may be used!! www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 16. Active / Passive Voices Passive voice almost always requires more words than Active voice: ACTIVE: “the melting processing consumed polymeric material at a higher rate..” (10 words) PASSIVE: “Polymeric material was consumed by the melting process at a higher rate..” (12 words) Mathews, JR and and Mathews RW, Successful Scientific Writing, Cambridge University Press; 3 edition 2007) Dodd, J. S., Ed. The ACS Style Guide; American Chemical Society: Washington, DC, 1986.). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 17. First vs Third Person Sometimes first person may be used to emphasize important information Our research group has investigated…. We have demonstrated that…. Avoid: “we believe”, “we feel”, “we can see” www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 18. Formal Language Avoid nowadays on the contrary (up) until now www.nanomedicina.com.br Better presently, currently in contrast to date Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 19. Language I www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 20. Lets face it, English is a stupid language. There is no egg in the eggplant. No ham in the hamburger. And neither pine nor apple in the pineapple. English muffins were not invented in England. French fries were not invented in France. http://www.gray-area.org/Research/Ambig/#HEAD www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 21. Specificity The efficient writing is specific “Novel strategies have been proposed to overcome the limitations regarding diseases diagnosis.” Too general!! www.nanomedicina.com.br What were the strategies? What are the limitations? What are the diseases? Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 22. Specificity The use of carbon nanotubes-based biosensors has been proposed to overcome the poor selectivity exhibited by conventional systems used for cancer detection. Better !! www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 23. Specificity Carbon nanotubes-based biosensors exhibit high selectivity for cancer detection. Efficient Scientific Writing!! www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 24. The right emphasis on details Possible ways of emphasizing details: Repetition, wording, illustration and placement Source: Michael Alley The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 25. The right emphasis on Details 1. Repetition Title, abstract, discussion and conclusions ?? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 26. The right emphasis on Details 2. Wording Stress the most important details in a sentence!! Ex: High levels of the protein were found in the blood samples from patients with hemorrhagic infections. What is the most important detail? The protein, the levels or the infection? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 27. The right emphasis on Details Unexpected high levels of a protein were found in the blood samples from patients with hemorrhagic infections. High levels of a very specific S100 family protein were found in the blood samples from patients with hemorrhagic infections. High levels of a specific protein were found in the blood samples from examined patients. This may be the cause of the hemorrhagic infection. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 28. Complexity: Sentences A huge problem: Long Sentences The mechanical analyses had been carried out using stress-strain measurements and indicated that the copper-based alloys are more resistant than the silverbased ones, which may be due to the fabrication process used for each composite material, since the copper alloys had been produced via casting, whereas the silver composites had been fabricated via reactive extrusion under high pressures, controlled atmosphere, and at temperatures ranging from 300 – 400 °C. ???????? Too long!, Too wordy! Too many ideas in a single sentence!! www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 29. Complexity: Sentences Streamlining it: First half of the sentence: The mechanical analyses had been carried out using….. Second half : ............................................................................. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 30. Complexity: Sentences M5P2 IEEE T.E.C. The proposed memetic algorithm that combines search by an ES [44] on the upper level and nonlinear local optimizations to handle complex nonlinear equality constraints and to realize a Lamarckian learning principle is a promising concept for general design optimization problems in which a large number of nonlinear model equations and constraints as well as discrete design decisions and possibly discontinuous value functions are present, well beyond the domain of chemical engineering. While the selection of the representation as well as of the mutation and recombination operators is of course problem specific and has to be modified for different applications, and the use of other local solvers may also require small changes to the algorithm, the general principle can be transferred to any similar problem, and significant gains in computational performance and robustness (probability of finding the best as well as most of the local optima) can be expected. Urselmann, et al., IEEE Transactions on Evolutionary Computation, 15, 2011, 659 www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 31. Stacking of Passive Voice A new methodology for protein purification is presented. Isolation techniques using HPLC are discussed. The amount of protein purified in each cycle is revealed. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 32. Stacking of Passive Voice This study describes a new methodology for protein purification using novel techniques based on HPLC experiments. Each purification cycle provided a total amount of 1.2 mg of protein. Better!! Active voice is straightforward www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 33. Ambiguity Words/phrases with more than one meaning Chickens are ready to eat ???? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 34. Ambiguity Word Choice: Be careful with: as, only www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 35. Ambiguity Word Choice: “Tissue temperature increased as the particles released the phytotherapics” ???? The word “as” may be interpreted as “because” or “while” www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 36. Ambiguity “Tissue temperature increased because the particles released the phytotherapics” Better www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 37. Ambiguity Only I tested the device yesterday I only tested the device yesterday I tested only the device yesterday www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 38. Ambiguity “ In low water temperatures and high toxicity levels of oil, we tested how well the microorganisms survived” Better: “We tested how well the microorganisms survived in low water temperatures and high toxicity levels of oil” Extracted from: Michael Alley The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 39. Ambiguity “The train left the station crowded and dirty.” Better: “The train was crowded and dirty when it left the station” www.1-language.com/eslquizzes/ambiguoussentences.htm www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 40. Ambiguity Unclear Pronoun Since the platform has a support system connected to the equipment, it was mounted inside the lab. What was mounted inside the lab???? It = The platform or the support system?? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 42. Sources -Michael Alley. The Craft of Scientific Writing, 3rd edition (SpringerVerlag, 1996). Mathews, JR and and Mathews RW, Successful Scientific Writing, Cambridge University Press; 3 edition 2007) Dodd, J. S., Ed. The ACS Style Guide; American Chemical Society: Washington, DC, 1986.). Brawand et al., Nature, 2011, 478, 343 Urselmann, et al., IEEE Transactions on Evolutionary Computation, 15, 2011, 659 www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 43. Muito Obrigado Valtencir Zucolotto zuco@ifsc.usp.br www.nanomedicinna.com.br www.lnn.ifsc.usp.br www.twitter.com/Nanomedicina Instituto de Física de São Carlos - USP www.twitter.com/escreverartigos www.twitter.com/writingpapers www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 44. Organização: Pró-Reitoria de Pesquisa - USP Workshop de Capacitação em Escrita Científica Módulo 6 Prof. Dr. Valtencir Zucolotto Laboratório de Nanomedicina e Nanotoxicologia Instituto de Física de São Carlos, USP USP, 2012 www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 45. Workshop Outline Modulo 1: O Gênero Literário Seções de Um Artigo Científico Módulo 2: Estrutura 1: Abstract Módulo 3: Estrutura 2: Introduction Módulo 4: Estrutura 3: Results and Discussion, Conclusion Módulo 5: Estilo Linguagem 1: Especificidade, Complexidade e Ambiguidade Módulo 6: Linguagem 2: Redundâncias, Ação no Verbo, Fluidez de Texto, Ritmo de Escrita Módulo 7: Linguagem 3: Plain English, Escrever em Inglês, Preposições Módulo 8: Linguagem 4: Topic Sentences, Cover Letters, Final Remarks www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 46. Módulo 6 Linguagem 2: Redundâncias, Ação no Verbo, Fluidez da Escrita, Ritmo de Escrita www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 47. Language II www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 48. Redundancies During the data collection phase of the study, all experimental measurements were performed in a period of time of 3 months. All the obtained results were further analyzed and possible errors were completely eliminated. Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 49. Redundancies Better: During the data collection, all measurements were performed in 3 months. The results were further analyzed and possible errors were eliminated. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 50. Redundancies Best: All measurements were performed in 3 months. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 52. Redundancies Common redundancies from Non-Native Speakers Alternative choices Basic fundamentals Completely eliminate Currently underway Empty space Introduced a new Mix together Never before Period of time Separate entities Still persists Quite unique Very similar Join together Completely full Obtained Results Definitely proved Exactly true First of all Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 53. Strong Nouns Strong nouns provide a “visual image” to the reader. A short list of abstract nouns: Ability, approach, capability, concept, environment, factor, nature, parameter,…. Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 54. Action in the verb Não-Nativos tendem a “Substantivar” os Verbos www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 55. Strong Verbs Replace verb phrases by the correspondent strong verb Weak verb phrase Made the arrangement for Made the decision Made the measurement of Performed the development of www.nanomedicina.com.br Strong Verb Arranged Decided Measured Developed Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 56. Action in the verb “A continuous improvement in patient´s condition was observed” Better: “Patient´s condition improved” Adapted from Michael Alley. The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 57. Action in the verb Administration of dopamine produced a decrease in the frequency of convulsions Better: Administration of dopamine decreased convulsions frequency www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 58. Action in the verb The new phytotherapics exert their action by blocking the cells communications. Better: The new phytotherapics communications. www.nanomedicina.com.br block cells Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 59. Flow A Clear and Effective Writing is made of Smooth Transitions between Ideas, Sentences, Paragraphs Problem: Complementary ideas disconnected and/or placed far way from each other. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 60. Flow The level of the proteins found in the blood samples is similar to that observed by other researchers. Due to its ability to form complexes with DNA and RNA, such proteins had been extensively investigated by a number of research groups, including the group from Harvard, which estimated that the normal level of the protein in blood should be around 1 mg/dL. ???? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 61. Flow Better: The level of the proteins found in the blood samples was 1 mg/dL, which is similar to that observed by Harvard´s group. The word which brings the ideas closer to each other! www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 62. Flow Transitional words within a sentence 1) Reason: Because, since, due to,…. Example: The size of the nanoparticles was ca. 5 nm because of the synthetic route employed. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 63. Flow Transitional words within a sentence 2) Consequence: therefore, as a consequence,…. Example: The enzymes showed a high specificity to pesticides, therefore allowing its use in biosensors. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 64. Flow Transitional words within a sentence 3) Concession: Although, even though, …. Example: Although individual residues in the repeatedsequence blocks in the core have diverged, the patterns of amino acids are identical. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 65. Flow Smooth Transition between sentences 1) Continuation: Movement of ideas in the same direction: Examples: Also; Moreover; first, second…; In addition; …….. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 66. Flow Smooth Transition between sentences 2) Pause: Examples: For example; In other words; ……. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 67. Flow Smooth Transition between sentences 3) Reversal: Movement of ideas reverses direction. Examples: However; In contrast; On the other hand; Conversely; Contrarily; www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 68. Flow Smooth Transition between sentences 4) Conclusion: Examples: In summary Concluding ……. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 70. Flow Sentence Openers: Rhythm DNA sensing has been considered a powerful tool to diagnose cancer. Cancer diagnosis is usually not straightforward due to a large number of pathologies variations as well as to the very low amount of DNA molecules expressed in the beginning of disease. Sensors capable of detecting specific types of tumoral cells may represent a breakthrough in medicine. This paper describes the development of special sensors for cancer detection. The sensors comprise immobilized antibodies that recognizes specific types of proteins produced by cancer cell. The sensor systems were produced using different immobilization strategies. The results show that different types of cancer cells can be detected at very low limits of detection. The experiments were carried out in triplicate. The systems we developed will be evaluated in clinical trials in a few months. Many medicine areas will benefit from our new technologies. ???? www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 71. Flow Vary sentence openers Topic of Sentence Time of action Location of action Manner of action Subordinate action Reason for action Subject Prepositional Phrase Prepositional Phrase Adverb Dependent Clause Infinitive Phrase Source: Michael Alley. The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 72. Flow adverb Recently, DNA sensors…. dependent clause Although cancer diagnosis is not straightforward ,…. infinitive phrase To optimize the systems…. subject-verb The results show that…. prepositional phrase In a few months, the systems will be…. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 73. Flow Recently, DNA sensing has been considered a powerful tool to diagnose cancer. Although cancer diagnosis is not straightforward, due to a large number of pathologies variations, this strategy may be very efficient for some cancer types. Sensors capable of detecting specific types of tumoral cells may represent a breakthrough in medicine. In this paper we describe the development of special sensors for cancer detection. The sensors comprise immobilized antibodies that recognizes specific types of proteins produced by cancer cell. To optimize the systems, the sensor were produced using different immobilization strategies. The results show that different types of cancer cells can be detected at very low limits of detection. The experiments were carried out in triplicate. In a few months, the systems will be evaluated in clinical trials in a few months. Since highly sensitivity and specificity were achieved by the sensors, clinical areas may benefit from our new technologies. Rhythm !!!! www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 74. Flow Rewrite the following Abstract improving rhytm The development of new antimicrobial peptides (AMPs) has arisen as a novel, promising strategy to overcome the effects of antibiotic resistance developed by several pathogens. The efficient design and development of such biomolecules, however, requires an understanding of the mechanisms of interactions between the peptides and cell membrane. In this study we examined the interactions of the cationic antimicrobial peptide dermaseptin 01 with three membrane systems. The membrane systems had been investigated in the form of Langmuir monolayers. The degree of interaction of DS 01with the different biomembrane models was quantified from equilibrium and dynamic liquid-air interface parameters, such as: minimum molecular area and dilatational elasticity modulus. The interaction between DS 01 and the zwitterionic phospholipid, as well as with the LRE-La monolayers were very weak at low peptide concentrations, whereas with negatively charged phospholipids the interactions were stronger. The latter is in agreement with previous literature for vesicles and planar lipid bilayers, and with the greater activity of AMPs against bacterial membranes, as compared to mammalian cell membranes. www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 75. Sources -Michael Alley. The Craft of Scientific Writing, 3rd edition (Springer-Verlag, 1996). Science Research Writing for Non-Native Speakers of English, Hilary Glasman-Deal, Imperial College Press, 2009 Mathews, JR and and Mathews RW, Successful Scientific Writing, Cambridge University Press; 3 edition 2007) www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br
  • 76. Muito Obrigado Valtencir Zucolotto zuco@ifsc.usp.br www.nanomedicina.com.br www.lnn.ifsc.usp.br www.twitter.com/Nanomedicina Instituto de Física de São Carlos - USP www.twitter.com/escreverartigos www.twitter.com/writingpapers www.nanomedicina.com.br Prof. Dr. Valtencir Zucolotto zuco@ifsc.usp.br