1. Fatigue causing Human Herpes Virus 6
(HHV-6): A Viral Co-infection of Chronic
Lyme Disease

2. And Its Link to Chronic Fatigue Syndrome, Fibromyalgia, Fatigue, and Cancer
HHV-6, a human herpes virus, was first reported in 1986 and is now considered among the most
prevalent of human herpes viruses. It comes in two variants HHV-6A and -6B, and though similar, there
areclear differences in their epidemiology and pathogenicity.
HHV-6B is acquired in early childhood (often in daycare centers) and is responsible for infecting up to
90% of most populations during infancy. HHV-6A behaves quite differently as it is generally not seen
until adulthood. Both versions of the virus can be found in saliva and are presumably spread this way as
well.
Immunocompromised patients including those who have received new organs, bone marrow, or HIV
positive have the greatest risk for severe HHV-6 complications and chronic Lyme disease patients.
How Does HHV-6 Work?
HHV-6 attacks diverse types of cells including CD 4 lymphocytes, natural killers, oligodedrocytes, CD 8s,
and microglials. The difficulty with treating HHV-6 is the fact that it is not only immune suppressive, but
it also can activate other viruses in the body. When HHV-6 is dormant, it can be found in the salivary
glands, kidneys, or brain.
CFS, Fibromyalgia, and Autoimmune
Disease Symptoms Linked to HHV-6
HHV-6 has been linked to idiopathic illness Chronic Fatigue Syndrome (CFS). It was observed in one
study that 30 percent of CFS patients tested positive for HHV-6 and after a series of follow-up tests, it
was discovered that an additional 20-40 percent were also positive after initially showing no trace of the
virus. The obvious association between HHV-6 and CFS reaffirms a much broader link between infection
and chronic disease.
One study suggests that a "smoldering" central nervous system (CNS) infection may play a role in
conditions that plague millions of Americans. A doctor at Jikei University Medical School in Tokyo
identified a novel human herpes virus-6 (HHV-6) protein, “present in Chronic Fatigue Syndrome (CFS)
that is a likely contributor to the psychological symptoms that are so often associated with the disorder.
It was also found that 71 percent of Chronic Fatigue Symptom patients had antibody SITH-1. What is so
remarkable about this discovery is that 53 percent of depression and 76 percent of bipolar disorder
sufferers have the SITH-1 antibody.
HHV-6 is one of the infections found invirtually all Chronic Lyme Disease patients – a chief contributor to
fatigue and other neurological symptoms. Antibiotics do not affect this or other herpetic viruses.

3. HHV-6 as a Potential Causative to
Chronic Lyme Disease, Parkinson’s, and
Alzheimer’s
Neurodegenerative diseases such as Alzheimer's, Parkinson’s, and Multiple Sclerosis (MS) increasingly
appear to be catalyzed, at least in some cases, by viral infections. Tied to many neurologic problems
including encephalitis and mesial temporal lobe epilepsy is neurotropic virus HHV-6.
Nevertheless, HHV-6’s route into the central nervous system remains inconclusive. However, among
various brain regions examined, the highest frequency of HHV-6 DNA can be routinely identified in the
olfactory bulb/tract region. While further tests must be conducted, the olfactory pathway does seem
likely as at least one pathway for HHV-6 to move into the CNS.
HHV-6 Infection: Its Role in One Child’s
Acute Lymphoblastic Leukemia
Evidence continues to mount that suggests viral infections could play a major causative role in some
childhood leukemia. In one recent case, a child’s acute lymphoblastic leukemia came only two months
after an HHV-6 infection was detected.
HHV-6 Attacks p53 giving rise to cancers
Protein p53 is a critical component of cell cycle regulation. Naturally, it also serves as the body’s
premiere tumor suppressor – a major player in helping the body prevent cancer growth.
How does p53 work?
When DNA damage is detected by p53, the protein snaps into action. It’s typically low levels rise quickly
to initiate effective measure to protect the body by binding to sites in the genome and halting cell
division completely, until the damage can be repaired. Should the damage have progressed too far for
repair, p53 then triggers apoptosis, queuing cell self-destruction, thus ending the problem in the
immediate.

4. HHV-6 Viral Co-infection of Chronic
Lyme Disease: Immunity and Cancer
Implications
HHV-6 infection has been shown to be a regular perpetrator in altering regulatory influences in cell
proliferation. The more research that is done, the more support is gained for the contention that viral
infections exert significant stress in such regard.
Envita’s Fully Engages Chronic Lyme
Disease Complex and Its Dangerous
HHV-6 Co-infection
Envita clinical experience in testing chronic Lyme disease patients shows many have activated forms of
co-infection viruses such as HHV-6. That means that many Lyme sufferers are likely carriers of this
infection as well as others. Biofilm communities and immunodeficiencies could make HHV-6 and other
virus actively replicate.
Envita advanced diagnostic tools are capable of testing for a variety of infections like HHV-6, and
examine whether it is a causative factor for other maladies, such as Chronic Fatigue Syndrome. We
utilize the most effective therapies from around the world to modulate and boost immune function in
patients suffering with HHV-6 or those who are immunocompromised and at risk of contracting it.
References:
• Abel-Haq, N.M. and Asmar BI. Human herpesvirus 6 (HHV-6) infection. Indian J. Pediatr. 2004
Jan; 71(1): 89-96
• Secchiero, Paola, et al. HHV-6 Infection in Immunocompromised Patients. Infections in
Medicine.2005; 22(3).
• Wisconsin Viral Research Group, Ltd. wisconsinlab.com
• Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD, (citations for the
above)
• http://www.medicalnewstoday.com/releases/112548.php this source to site

5. • Seror E, DeVillartay P, Leverger G, Lenoir G. SourceService de pédiatriegénérale, hôpital Necker-
Enfants-Malades, AP-HP, 149, rue de Sèvres, 75743 Paris cedex 15, France
• Dr. David Bell in 2008 on research by Dr. L. Flammand to citation Source Laboratory of
Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
• Journal of the American Society of Hematology citations for above