1. Drug Development Research in
Preclinical Imaging Centre (PRIME)
Prof. dr. Otto C. Boerman

2. RTM: Radboud Translational Medicine
from molecule to man
Discovery Screening preclinical testing Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands

3. RTM: Radboud Translational Medicine
from molecule to man
Discovery Screening preclinical testing Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands

4. PRIME: Preclinical Imaging Centre
microSPECT
Radboud University Nijmegen Medical Centre, The Netherlands

5. From human imaging to small animal imaging

6. From human imaging to small animal imaging
Mouse Human
Uptake of 123I-IBF
by D2 receptors
Neurology Dopamine w/ 99mTc-TRODAT
99m
Tc-MIBI
Cardiovascular Stress 99mTc-MIBI
[99mTc] Minigastrin
Oncology Renal Cell Carcinoma
*functional imaging

7. Radboud University Nijmegen Medical Centre, The Netherlands

8. Radboud University Nijmegen Medical Centre, The Netherlands

9. Radboud University Nijmegen Medical Centre, The Netherlands

10. Radboud University Nijmegen Medical Centre, The Netherlands

11. Radboud University Nijmegen Medical Centre, The Netherlands

12. PRIME
Preclinical Imaging Centre
microSPECT
PET imaging in PRIME
Radboud University Nijmegen Medical Centre, The Netherlands

13. Annihilation
Radboud University Nijmegen Medical Centre, The Netherlands

14. FDG-PET: imaging cancer
Normal FDG-PET Metastasized Melanoma

15. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

16. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment 1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

17. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment 1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

18. microPET/CT scanner
Radboud University Nijmegen Medical Centre, The Netherlands

19. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day
Radboud University Nijmegen Medical Center, The Netherlands

20. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day 1 day
Radboud University Nijmegen Medical Center, The Netherlands

21. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day 1 day 3 days
Radboud University Nijmegen Medical Center, The Netherlands

22. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day 1 day 3 days 7 days
Radboud University Nijmegen Medical Center, The Netherlands

23. PRIME
Preclinical Imaging Centre
microSPECT
SPECT imaging in PRIME
Radboud University Nijmegen Medical Centre, The Netherlands

24. Small animal SPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands

25. Radboud University Nijmegen Medical Centre, The Netherlands
25

26. microSPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands

27. Imaging transplated islets of Langerhans
Diabetes type 1: autoimmune destruction of insulin producing beta cells
Islet transplantation is a promising treatment for patients with type1 diabetes
AIM: Non-invasive in vivo determination of beta cell mass after islet transplantation.
In-111-DTPA-
Exendin
islets
Radboud University Nijmegen Medical Centre, The Netherlands

28. Imaging transplated islets of Langerhans
Radboud University Nijmegen Medical Centre, The Netherlands

29. Imaging transplated islets of Langerhans
2D
3W
In-111-Exendin
6W
8W
11W
Radboud University Nijmegen Medical Centre, The Netherlands

30. PRIME
Preclinical Imaging Centre
microSPECT
Intravital fluorescence imaging in PRIME
Radboud University Nijmegen Medical Centre, The Netherlands

31. Multi-photon fluorescence microscopy
Radboud University Nijmegen Medical Centre, The Netherlands

32. Multi-photon fluorescence microscopy
Monitoring of tumor development using the dorsal skinfold chamber model
Radboud University Nijmegen Medical Centre, The Netherlands

33. Multi-photon fluorescence microscopy
Tumor cells
Extracellular
matrix, collagen,
muscle fibers
Fat cells, nerves
Blood vessels,
immune cells
Radboud University Nijmegen Medical Centre, The Netherlands

34. Multi-photon fluorescence microscopy
Tumor cells
Extracellular matrix,
collagen, muscle fibers
Fat cells, nerves
Blood vessels, immune
cells
Radboud University Nijmegen Medical Centre, The Netherlands

35. Immunofluorescence Guided Surgery
Radboud University Nijmegen Medical Center, The Netherlands

36. Immunofluorescence Guided Surgery
Radboud University Nijmegen Medical Center, The Netherlands

37. Multi-modality Imaging
Fluorescence imaging
MRI
PET
Multiphoton imaging
Radboud University Nijmegen Medical Centre, The Netherlands

38. Drug development Research
Hoffmann La Roche
Novartis
Sanofi
Fuji Biotechnology
Future Chemistry
Immunomedics Inc.
Synaffix
Wilex
Milabs
Radboud University Nijmegen Medical Centre, The Netherlands