The document discusses how established organizations can get stuck operating within existing paradigms and assumptions, similar to the character Wile E. Coyote in the Roadrunner cartoons. It suggests organizations need more "roadrunner thinking" by questioning assumptions and trying new approaches. Some ways to shift paradigms mentioned include starting with the desired end instead of existing processes, changing the frame of reference, doing the opposite of the obvious, and finding people who don't know the existing paradigms. Breaking paradigms in organizational, market, and industry assumptions can enable major growth for established companies.