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Prof: Gabriel Gomila
  Stud: Mina Moeini




                       1
   inorganic semiconductor nanocrystals
   generally composed of atoms
   can be made to emit fluorescent light in the ultraviolet
    to infrared spectrum just by varying their size
   the larger the QD, the longer the wavelength of the
    emission




                                                               2
   Prostate cancer (The cancer cells spread to other parts
    of the body)
         • Computer tomography (CT) ,poor soft-tissue
           contrast resolution
         • Magnetic resonance image (MRI), better soft-
           tissue resolution
         • Radionuclide imaging (RNI), improved
           specificity for cancer
         • Positron emission tomography (PET),3D image
   labour intensive, time consuming, expensive and don’t
    have multiplexing capability

                                                              3
   Multifunctional nanoparticle probes based on
    semiconductor QDs for cancer cell imaging in living
    animals.
   Encapsulating luminescent QDs with an ABC triblock
    copolymer and linking amphiphilic polymer to tumor
    targeting ligands and drug delivery functionalities.
   Core shell CdS/ZnS QDs are protected by a
    coordinating ligand, trinoctylphosphine oxide (TOPO),
    and an amphiphilic polymer coating.
   High-quality , high levels of brightness, large
    absorption coefficients , more surface areas .

                                                        4
BICONJUGATED QDS   MEDICAL IMAGE PATENT




                                          5
   human prostate cancer growing in nude mice indicate
    that the QD probes accumulate at tumors both by the
    enhanced permeability and retention of tumor sites
    and by antibody binding to cancer .
   auto fluorescence background(a) clearly shows the
    whole animal and the tumor site (d).




                                                          6
   QDs are highly toxic to cells under UV illumination.
   surface ligands and coatings are slowly degraded in
    body fluids.
   QDs with a stable polymer coating are essentially
    nontoxic to cells.
   polymer protection layer is so stable that the QD core
    would not be exposed to the outside environment.
   polymer-encapsulated QDs, chemical or enzymatic
    degradation of the semiconductor cores is unlikely to
    occur.
   polymer protected QDs might be cleared from the
    body by slows filtration and through the kidney

                                                             7

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Transcriptiion Qds

  • 1. Prof: Gabriel Gomila Stud: Mina Moeini 1
  • 2. inorganic semiconductor nanocrystals  generally composed of atoms  can be made to emit fluorescent light in the ultraviolet to infrared spectrum just by varying their size  the larger the QD, the longer the wavelength of the emission 2
  • 3. Prostate cancer (The cancer cells spread to other parts of the body) • Computer tomography (CT) ,poor soft-tissue contrast resolution • Magnetic resonance image (MRI), better soft- tissue resolution • Radionuclide imaging (RNI), improved specificity for cancer • Positron emission tomography (PET),3D image  labour intensive, time consuming, expensive and don’t have multiplexing capability 3
  • 4. Multifunctional nanoparticle probes based on semiconductor QDs for cancer cell imaging in living animals.  Encapsulating luminescent QDs with an ABC triblock copolymer and linking amphiphilic polymer to tumor targeting ligands and drug delivery functionalities.  Core shell CdS/ZnS QDs are protected by a coordinating ligand, trinoctylphosphine oxide (TOPO), and an amphiphilic polymer coating.  High-quality , high levels of brightness, large absorption coefficients , more surface areas . 4
  • 5. BICONJUGATED QDS MEDICAL IMAGE PATENT 5
  • 6. human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced permeability and retention of tumor sites and by antibody binding to cancer .  auto fluorescence background(a) clearly shows the whole animal and the tumor site (d). 6
  • 7. QDs are highly toxic to cells under UV illumination.  surface ligands and coatings are slowly degraded in body fluids.  QDs with a stable polymer coating are essentially nontoxic to cells.  polymer protection layer is so stable that the QD core would not be exposed to the outside environment.  polymer-encapsulated QDs, chemical or enzymatic degradation of the semiconductor cores is unlikely to occur.  polymer protected QDs might be cleared from the body by slows filtration and through the kidney 7