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An overview




5/7/2009                          1
                 Sushant Satyal
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           Sushant Satyal
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           Sushant Satyal
Normal brain function requires

    an
    orderly, organized, coordinate
    d discharge of electrical
    impulses.

    Electrical impulses enable the

    brain to communicate with the
    spinal cord, nerves, and
    muscles as well as within itself.

      Seizures may result when the

      brain's electrical activity is
      disrupted.
5/7/2009                                                 4
                                        Sushant Satyal
Classified as involving parts of the brain


     Involving a small part of the brain: Focal


     Involving the whole part of the brain: Generalized


     Focal Seizures can be simple or complex


     Also classified in terms of body affected




5/7/2009                                                           5
                                                  Sushant Satyal
Whole body affected : Generalized


     Small part or side of the body affected: Focal


     Symptom may vary depending on what parts of brain

     are involved.

     Some Seizures may hard to notice as they consist of

     staring spells

     May cause loss of awareness and shaking of body



5/7/2009                                                         6
                                                Sushant Satyal
A sudden, involuntary, time-limited alteration in

     behavior,        motor          activity,     autonomic
     function, consciousness, or sensation, accompanied by an
     abnormal electrical discharge in the brain.


     Seizure (medicine), sudden attack or spasm, as in epilepsy

     or a similar disorder. Seizures differ with the type of
     condition    and      may     consist    of     loss    of
     consciousness, convulsive jerking of parts of the
     body, emotional explosions, or periods of mental
     confusion.
5/7/2009                                                           7
                                                  Sushant Satyal
An electroencephalogram (an EEG) is a

     recording of the brain's electrical activity.
     The procedure is simple and painless.
     About 20 small adhesive electrodes are
     placed on the scalp, and the brain's activity
     is recorded under normal conditions. Then
     the person is exposed to various stimuli,
     such as bright or flashing lights, to try to
     provoke a seizure. During a seizure,
     electrical activity in the brain accelerates,
     producing a jagged wave pattern. Such
     recordings of brain waves help identify a
     seizure disorder. Different types of seizures
     have different wave patterns.




5/7/2009                                                              8
                                                     Sushant Satyal
Primary generalized seizure:
A.
       Begins with a widespread electrical discharge
       Involves both sides of the brain at once
       Hereditary factors are important


           Partial Seizure:
B.
       Begins with an electrical discharge in one limited area of the
        brain
       Related to head injury, brain infection, stroke, or tumor



5/7/2009                                                                 9
                                                        Sushant Satyal
Types of Primary generalized seizure

      1. Absence seizures:

           ▪   Brief episodes of staring

           ▪   Absence seizures are considered complex absence

               seizures

           ▪   Include a change in muscle activity


5/7/2009                                                              10
                                                     Sushant Satyal
▪   Most common movement are eye blinks

           ▪   Complex absence seizures are often more than 10

               seconds long

           ▪   Usually begin between ages 4 and 14

           ▪   no warning before a seizure, and the person is

               completely alert immediately afterward

5/7/2009                                                                 11
                                                        Sushant Satyal
▪   Other movements include slight tasting movements of

               the mouth, hand movements such as rubbing the fingers

               together ,etc

           ▪   Children who get them usually have normal development

               and intelligence

           ▪   70% of cases, absence seizures stop by age 18

5/7/2009                                                                  12
                                                         Sushant Satyal
2. Atypical absence seizure:

           ▪   Atypical (a-TIP-i-kul) means unusual or not typical

           ▪   Person will stare but often is somewhat responsive

           ▪   Eye blinking or slight jerking movements of the lips may

               occur




5/7/2009                                                                    13
                                                           Sushant Satyal
▪    Hard to distinguish from the person's usual behavior,

                especially in those with cognitive impairment

           ▪ Generally begins at the age of 6

           ▪    Most of the children affected have below-average

               intelligence



5/7/2009                                                                    14
                                                           Sushant Satyal
▪ Other types of seizures that are difficult to control

           ▪ Seizures usually continue till adulthood

           ▪ Daydreaming and inattentiveness can mimic these

             seizures

           ▪ Diagnosis can be difficult if the behavior during seizures is

             similar to the child's usual behavior

5/7/2009                                                                     15
                                                            Sushant Satyal
3. Monoclonic seizures:

           ▪   Very brief jerks, last only for 2 to 3 sec

           ▪   seizures usually cause abnormal movements on both

               sides of the body at the same time

           ▪   Myoquot; means muscle and quot;clonusquot; (KLOH-nus) means

               rapidly alternating contraction and relaxation

5/7/2009                                                                     16
                                                            Sushant Satyal
▪   Seizures usually begin in childhood, but the seizures can

               occur at any age

           ▪   Seizures occur in reflex epilepsies, triggered by flashing

               lights or other things in the environment

           ▪   Syndromes usually can be diagnosed on the basis of the

               medical history and often EEG patterns

5/7/2009                                                                     17
                                                            Sushant Satyal
4. Atonic Seizures:

           ▪   Atonicquot; (a-TON-ik) means quot;without tone

           ▪   In an atonic seizure, muscles suddenly lose strength

           ▪   Eyelids may droop, the head may nod, and the person

               may drop things and often falls to the ground

           ▪   Also known as quot;drop attacksquot; or quot;drop seizures

5/7/2009                                                                   18
                                                          Sushant Satyal
▪ The person usually remains conscious

           ▪ Another name for this type of seizure is “akinetic”

           ▪ (A-kin-ET-ik), which means quot;without movement“

           ▪ Seizures often begin in childhood

           ▪ Often last into adulthood

           ▪ People with atonic seizures are injured when they fall

5/7/2009                                                                    19
                                                           Sushant Satyal
▪ Seizures may cause people to fall when they're standing

            often have tonic seizures rather than atonic seizures

           ▪ Syndromes usually can be diagnosed on the basis of the

            medical history and often EEG patterns




5/7/2009                                                                  20
                                                         Sushant Satyal
5. Tonic Seizures:

           ▪   Usually last less than 20 sec

           ▪   In such seizures, the tone is greatly increased and the

               body, arms, or legs make sudden stiffening movements

           ▪   Consciousness is usually preserved

           ▪   Seizures most often occur during sleep

5/7/2009                                                                    21
                                                           Sushant Satyal
▪   Usually involve all or most of the brain, affecting both

               sides of the body

           ▪   Common in people who have the epilepsy syndrome

               called Lennox-Gastaut syndrome

           ▪   Seizures in Lennox-Gastaut syndrome may become more

               difficult to control over time

5/7/2009                                                                     22
                                                            Sushant Satyal
6. Clonic seizures:

           ▪   Seizures consist of rhythmic jerking movements of the

               arms and legs

           ▪   Length vary according to the case

           ▪   Clonusquot;   (KLOH-nus)     means      rapidly        alternating

               contraction and relaxation of a muscle


5/7/2009                                                                        23
                                                             Sushant Satyal
▪   Movements cannot be stopped by restraining or

               repositioning the arms or legs

           ▪   These seizures are rarely found

           ▪   Common are tonic-clonic seizures, in which the jerking is

               preceded by stiffening (the quot;tonicquot; part)



5/7/2009                                                                    24
                                                           Sushant Satyal
▪   Sometimes tonic-clonic seizures start with jerking alone

           ▪   These are called clonic-tonic-clonic seizures

           ▪   Occur at various ages, including in newborns

           ▪   Brief and infrequent clonic seizures in infants usually

               disappear within very short period



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                                                           Sushant Satyal
▪   Occasionally quot;jitterinessquot; in a young infant can be

               mistaken for a clonic seizure

           ▪   Children with neurological impairments with repetitive

               movements that could be mistaken for clonic seizures

           ▪   The EEG pattern will change during a seizure, so video-

               EEG is very useful for diagnosis

5/7/2009                                                                 26
                                                        Sushant Satyal
7. Tonic-clonic seizures:

           ▪   Normally last for 2 to 3 min

           ▪   More than 5 min calls for immediate medical help

           ▪   Seizure that lasts more than 30 minutes indicate

               convulsion

           ▪   Person loses consciousness and falls to the floor

5/7/2009                                                                    27
                                                           Sushant Satyal
▪   Tongue or cheek may be bitten, so bloody saliva may

               come from the mouth

           ▪   Person may turn a bit blue in the face

           ▪   After the tonic phase comes the clonic phase

           ▪   Arms and usually the legs begin to jerk rapidly and

               rhythmically

5/7/2009                                                                  28
                                                         Sushant Satyal
▪   Bending and relaxing at the elbows, hips, and knees

           ▪   After a few minutes, the jerking slows and stops

           ▪   Bladder or bowel control sometimes is lost as the body

               relaxes

           ▪   Consciousness returns slowly, and the person may be

               drowsy, confused, agitated, or depressed

5/7/2009                                                                   29
                                                          Sushant Satyal
▪   They affect both children and adults

           ▪   Children who have had a single tonic-clonic seizure, the

               risk that they will have more seizures

           ▪   Some children will outgrow their epilepsy

           ▪   Tonic-clonic seizures can be controlled by seizure

               medicines

5/7/2009                                                                    30
                                                           Sushant Satyal
▪   Patients who are seizure-free for a year or two while

               taking seizure medicine will stay seizure-free

           ▪   Medicine can be stopped gradually

           ▪   Patients with no epilepsy wave in EEG can stay free with

               any medication

           ▪   People who faint sometimes may develop tonic or clonic

               seizure
5/7/2009                                                                    31
                                                           Sushant Satyal
Types of Partial seizures
     1. Simple partial seizures:

           ▪   Different from person to person, depending on the part

               of the brain where they begin

           ▪   One thing they all have in common is that the person

               remains alert and can remember what happens

           ▪   Usually last for less than 2 min

5/7/2009                                                                32
                                                       Sushant Satyal
▪          Doctors often divide simple partial seizures into
                      categories depending on the type of symptoms the
                      person experiences
               i.      Motor seizures
               ii.     Sensory seizures
               iii.    Autonomic seizures
               iv.     Psychic seizures

           ▪          Anyone can get these seizures

           ▪          People     who      have   had   a   head   injury,           brain

                      infection, stroke, or brain tumor likely to get them

5/7/2009                                                                                    33
                                                                   Sushant Satyal
▪   These seizures often can be controlled by seizure

               medicines

           ▪   Medical disorders such as, stomach disorders or a

               pinched nerve can cause some similar symptoms

           ▪   Some symptoms (such as déja vu) are experienced by

               almost everyone at some time

5/7/2009                                                                34
                                                       Sushant Satyal
2. Complex Partial Seizures:

           ▪   Usually last between 30 seconds and 2 minutes

           ▪   Afterward, the person may be tired or confused for

               about 15 minutes and may not be fully normal for hours

           ▪   Seizures usually start in a small area of the temporal lobe

               or frontal lobe of the brain


5/7/2009                                                                     35
                                                           Sushant Satyal
▪   Quickly involve other areas of the brain that affect

               alertness and awareness

           ▪   These seizures (usually ones beginning in the temporal

               lobe) start with a simple partial seizure

           ▪   Also called an aura, this warning seizure often includes

               an odd feeling in the stomach

5/7/2009                                                                    36
                                                           Sushant Satyal
▪   Person loses awareness and stares blankly

           ▪   Most people move their mouth, pick at the air or their

               clothing, or perform other purposeless actions

           ▪   These movements are called quot;automatismsquot;

           ▪   Less often, people may repeat words or phrases, laugh,

               scream, or cry

5/7/2009                                                                    37
                                                           Sushant Satyal
▪   Some people do things during these seizures that can be

               dangerous or embarrassing

           ▪   People need to take precautions in advance

           ▪   Complex partial seizures starting in the frontal lobe tend

               to be shorter than the ones from the temporal lobe

           ▪   Some complex partial seizures turn into secondarily

               generalized seizures
5/7/2009                                                                    38
                                                          Sushant Satyal
▪   people     who     have     had      a    head   injury,          brain

               infection, stroke, or brain tumor are more likely to get

               seizures

           ▪   If medication is not effective, some can be eliminated by

               epilepsy surgery

           ▪   Complex     partial       seizures       sometimes       resemble

               daydreaming or absence sezuires
5/7/2009                                                                                 39
                                                                Sushant Satyal
Secondarily generalized seizures:
      3.

           ▪    Start in one limited area of the brain

           ▪    Can also spread throughout the brain becoming

                generalized

           ▪    Convulsive phase of these seizures usually lasts no more

                than a few minutes

           ▪    Preceding partial seizure is usually not very long

5/7/2009                                                                     40
                                                            Sushant Satyal
▪   Happen when a burst of electrical activity in a limited

               area (the partial seizure) spreads throughout the brain

           ▪   Seizures occur in more than 30% of people with partial

               epilepsy

           ▪   Can affect people of all ages who have partial seizures

           ▪   Seizures of this kind can be controlled with medication

5/7/2009                                                                   41
                                                          Sushant Satyal
▪   Seizures of this kind can be controlled with medication

           ▪   If not controlled with medication, surgery is another

               option

           ▪   Easily diagnosed through EEG or MRI tests




5/7/2009                                                                    42
                                                           Sushant Satyal
7%
                       7%
                                       34%   Simple partial
           15%                               Other generalized
                                             Partial unknown
                                             Absence
                 17%
                                             Myoclonic
                                 20%
                                             Unclassified




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                                             Sushant Satyal
Change in consciousness, so that you can't remember



     some period of time

     Change       in     emotion,    like   unexplainable



     fear, panic, joy, or laughter

     Change in sensation of the skin, usually spreading



     over the arm, leg, or trunk
5/7/2009                                                      44
                                             Sushant Satyal
Changes in vision, including flashing lights, or (rarely)



     hallucinations (seeing things that aren't there)

     Loss of muscle control and falling, often very suddenly


     Muscle movement such as twitching that might



     spread up an arm or leg

5/7/2009                                                          45
                                                 Sushant Satyal
Muscle movement such as twitching that might



     spread up an arm or leg

      Muscle tension/tightening that causes twisting of the


     body, head, arms or leg

     Tasting a bitter or metallic flavor



5/7/2009                                                        46
                                               Sushant Satyal
Beginning State:

       This stage can be said as warning or aura
       Sometimes an individual may not be aware of such aura
       In middle stage this aura is followed by other symptoms
       It may be considered as simple partial seizure


     Middle State:

       People have aura in beginning, the aura may convert into
        convulsion
       For those who don’t have aura, the seizure may continue as
        complex partial seizure
5/7/2009                                                                  47
                                                         Sushant Satyal
End state:


       This state represents a transition from seizure back to

           normal state

       Also referred as the “Post-ictal period”

       Signifies recovery period of brain

       May last from a second to minutes to hours


5/7/2009                                                              48
                                                     Sushant Satyal
 If a person has a convulsion, the level of awareness gradually

           improves during the post-ictal period, much like a person

           waking up from anesthesia after an operation




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                                                          Sushant Satyal
 Emotional
     Early seizure symptoms:

                                           ▪ Fear/Panic
       Sensory/ thoughts
                                           ▪ Pleasant feeling
           ▪   Déjà vu
                                          Physical
           ▪   Jamais vu
                                           ▪
           ▪                                   Dizziness
               Smell
                                           ▪   Headache
           ▪   Sound
                                           ▪   Lightheadedness
           ▪   Taste
                                           ▪   Nausea
           ▪   Visual loss or blurring
                                           ▪   Numbness
           ▪   Racing thoughts
                                          No Warnings
           ▪   Stomach feelings
           ▪                               ▪ Sometimes seizures come with
               Strange feelings
           ▪                                 no warnings
               Tingling feeling

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                                                          Sushant Satyal
 Emotional:
     Middle Seizure Symptoms :

                                           ▪ Fear/Panic
       Sensory/ thoughts
           ▪   Black out
                                          Physical:
           ▪   Confusion
                                           ▪ Chewing movements
           ▪   Deafness/Sounds
                                           ▪ Convulsion
           ▪   Electric Shock Feeling
                                           ▪ Eyes rolling up
           ▪   Loss of consciousness
                                           ▪ Falling down
           ▪   Smell
                                           ▪ Foot stomping
           ▪   Spacing out
                                           ▪ Hand waving
           ▪   Out of body experience
                                           ▪ Inability to move
           ▪   Visual loss or blurring


5/7/2009                                                         51
                                                Sushant Satyal
•   Incontinence
           ▪    Staring
           ▪   Stiffening
           ▪   Swallowing
           ▪   Sweating
           ▪   Teeth clenching/grind
           ▪   Tongue biting
           ▪   Tremors
           ▪   Twitching movement
           ▪   Breathing difficulty
           ▪   Heart racing




5/7/2009                                                52
                                       Sushant Satyal
 Physical
     Post-ical state:

                                          ▪   Bruising
       Thought
                                          ▪   Difficulty talking
           ▪ Memory loss
                                          ▪   Injuries
           ▪ Writing Difficulty           ▪   Sleeping
                                          ▪   Exhaustion
       Emotional
                                          ▪   Headache
           ▪   Confusion                  ▪   Nausea
           ▪   Depression and Sadness     ▪   Pain
           ▪                              ▪
               Fear                           Thirst
           ▪                              ▪
               Frustration                    Weakness
                                          ▪
           ▪                                  Urge to
               Shame/ Embarrassment
                                              urinate/defecate


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                                                     Sushant Satyal
Causes                   Examples
                            •Heatstroke
High fever
                            •Infections
                            •Abscess
Brain infections
                            •AIDS
                            •Malaria
                            •Meningitis
                            •Rabies
                            •Syphilis
                            •Tetanus
                            •Toxoplasmosis
                            •Viral encephalitis



5/7/2009                                                           54
                                                  Sushant Satyal
Causes                                 Examples

                                          •High blood levels of sugar or sodium
  Metabolic disorders
                                          •Kidney or liver failure
                                          •Low blood levels of sugar, calcium,
                                          magnesium, or sodium
                                          •Underactive parathyroid gland
                                          •Vitamin B6 deficiency (in newborns)

                                          •Abnormal heart rhythms
  Inadequate oxygen supply to the brain
                                          •Carbon monoxide poisoning
                                          •Near drowning
                                          •Near suffocation
                                          •Stroke
                                          •Vasculiti


5/7/2009                                                                          55
                                                                 Sushant Satyal
Causes                                   Examples
                                           •Brain tumor
Structural damage to the brain
                                           •Head injury
                                           •Hydrocephalus
                                           •Intracranial hemorrhage
                                           •Stroke

                                           •Birth defect
Abnormalities present or occurring at
                                           •Hereditary metabolic disorders, such as
birth
                                           Tay-Sachs disease or phenylketonuria
                                           •Injury during birth

                                           •Eclampsia
luid accumulation in the brain (cerebral
                                           •Hypertensive encephalopathy
edema)




5/7/2009                                                                              56
                                                                 Sushant Satyal
Drug              Use                 Possible side-effects
Acetazolamide     Absence seizures when       Kidney stones and
                  other anticonvulsants are   chemical imbalance in
                  ineffective                 blood
Carbamazepine     Generalized seizures        A low white blood cell
                  Partial seizures            count (granulocytopenia),
                                              production of too few
                                              blood cells (aplastic
                                              anemia, which can be fatal
                                              disorder), a low platelet
                                              count (thrombocytopenia),
                                              digestive upset, inability to
                                              articulate words, lethargy,
                                              dizziness, and visual
                                              disturbances

5/7/2009                                                                      57
                                                       Sushant Satyal
Drugs        Uses                       Possible side-effects
Clonazepam   Atonic seizures Atypical   Drowsiness, abnormal
             absence seizures           behavior, loss of
             Infantile spasms           coordination, and lost
             Myo clonic seizures        effectiveness of the drug
                                        after 1 to 6 months
Divalproex   Absence seizures           Nausea, vomiting,
             Febrile seizures           abdominal pain, diarrhea,
             Generalized tonic-clonic   temporary drowsiness,
             seizures                   dizziness, shaking
             Infantile spasms           (tremor), reversible hair
             Juvenile myoclonic         loss, weight gain, and liver
             epilepsy                   damage
             Myoclonic seizures


5/7/2009                                                               58
                                                 Sushant Satyal
Drugs              Uses                 Possible side-effects
Ethosuximide       Absence seizures             Nausea, lethargy,
                                                dizziness, a low white
                                                blood cell count and a low
                                                red blood cell count
Felbamate          Atypical absence seizures,   Headache, fatigue, liver
                   Partial seizures             failure, and, rarely, aplastic
                                                anemia (which can be
                                                fatal)
Fosphenytoin       Status Epilepticus           Loss of coordination,
                                                drowsiness, headache,
                                                rash, and tingling
                                                sensations


5/7/2009                                                                         59
                                                          Sushant Satyal
Drugs         Uses                   Possible side-effects
Gabapentin    Partial seizures       Drowsiness, dizziness,
                                     weight gain, and headache
                                     In children, aggressive
                                     behavior, mood swings,
                                     and hyperactivity

Lamotrigine   Generalized seizures   Nausea, vomiting,
              Partial seizures       indigestion, headache,
                                     drowsiness, dizziness,
                                     insomnia, fatigue, loss of
                                     coordination, double
                                     vision, tremor, rash, and
                                     abnormal menstrual
                                     periods

5/7/2009                                                          60
                                              Sushant Satyal
Drugs           Uses                 Possible side-effects
Levetiracetam   Juvenile myoclonic   Dizziness, weakness,
                epilepsy             fatigue, loss of
                Myoclonic seizures   coordination, changes in
                Partial seizures     mood and behavior, and
                                     increased risk of infection
Oxcarbazepine   Partial seizures     Headache, abdominal
                                     pain, double vision,
                                     drowsiness, dizziness,
                                     fatigue, nausea, low
                                     sodium levels in the blood,
                                     and a low white blood cell
                                     count



5/7/2009                                                           61
                                              Sushant Satyal
Drugs        Uses                        Possible side-effects
Topiramate   Atypical absence seizures   Confusion, reduced
             Partial seizures            concentration, difficulty
             Primarily generalized       finding words, fatigue, loss
             tonic-clonic seizures       of appetite and weight,
                                         numbness or tingling,
                                         reduced sweating, and
                                         kidney stones
Valproate    Absence seizures            Nausea, vomiting,
             Febrile seizures            abdominal pain, diarrhea,
             Generalized tonic-clonic    weight gain, reversible hair
             seizures                    loss, temporary
             Infantile spasms            drowsiness, shaking
             Juvenile myoclonic          (tremor), and, rarely, liver
             epilepsy                    damage

5/7/2009                                                                62
                                                  Sushant Satyal
Stay with the person until recovery or you have


     professional medical help

     Monitor pulse ,rate of breathing, and blood pressure


     Do not give the person anything by mouth until


     convulsions have stopped and the person is fully

     awake and alert
5/7/2009                                                        63
                                               Sushant Satyal
Do not move the person unless he or she is in danger



     or near something hazardous

     Do not place anything including your fingers between


     the person’s teeth. You can break person’s teeth, if

     you do so.

5/7/2009                                                         64
                                                Sushant Satyal
The doctor will perform a physical examination and ask
    questions to help understand the cause of the seizures,
    such as:

     Are there any risk factors ( such as recent head


     injury)?

     Did it occur or start on one side of the body?


     Did the person remain awake and aware during


     seizure?

     How long the seizure last?




5/7/2009                                                                       65
                                                              Sushant Satyal
How often do the seizures happen?



     Was there any aura of the seizures?



     Were there any other symptoms present (visual


     changes, abnormal smells)?




5/7/2009                                                    66
                                           Sushant Satyal
The following tests may be performed:

  Blood tests

  Ct scan or MRI of the brain

 EEG
 Lumbar puncture




5/7/2009                                                 67
                                        Sushant Satyal
People with uncontrolled seizures should not drive.


     Drinking should be avoided


     Medicines should be taken regularly


     Avoid activities such as climbing to high


     places, biking, and swimming

     Use of sharp instruments such as knife should be avoided


5/7/2009                                                           68
                                                  Sushant Satyal
Seizure is life threatening disease



     No specific way to prevent seizures



     But it is curable if instruction are followed


     Good habits may help to control seizures





5/7/2009                                                              69
                                                     Sushant Satyal
Sleep deprivation, and poor diet must be avoided



     Good sleep habits, stress reduction, proper



     exercise, and sound nutrition may help

     Use helmets to avoid head injury



     Have faith in yourself, and seizure is curable!!



5/7/2009                                                           70
                                                  Sushant Satyal
5/7/2009                    71
           Sushant Satyal

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Seizure Disorder

  • 1. An overview 5/7/2009 1 Sushant Satyal
  • 4. Normal brain function requires  an orderly, organized, coordinate d discharge of electrical impulses. Electrical impulses enable the  brain to communicate with the spinal cord, nerves, and muscles as well as within itself. Seizures may result when the  brain's electrical activity is disrupted. 5/7/2009 4 Sushant Satyal
  • 5. Classified as involving parts of the brain  Involving a small part of the brain: Focal  Involving the whole part of the brain: Generalized  Focal Seizures can be simple or complex  Also classified in terms of body affected  5/7/2009 5 Sushant Satyal
  • 6. Whole body affected : Generalized  Small part or side of the body affected: Focal  Symptom may vary depending on what parts of brain  are involved. Some Seizures may hard to notice as they consist of  staring spells May cause loss of awareness and shaking of body  5/7/2009 6 Sushant Satyal
  • 7. A sudden, involuntary, time-limited alteration in  behavior, motor activity, autonomic function, consciousness, or sensation, accompanied by an abnormal electrical discharge in the brain. Seizure (medicine), sudden attack or spasm, as in epilepsy  or a similar disorder. Seizures differ with the type of condition and may consist of loss of consciousness, convulsive jerking of parts of the body, emotional explosions, or periods of mental confusion. 5/7/2009 7 Sushant Satyal
  • 8. An electroencephalogram (an EEG) is a  recording of the brain's electrical activity. The procedure is simple and painless. About 20 small adhesive electrodes are placed on the scalp, and the brain's activity is recorded under normal conditions. Then the person is exposed to various stimuli, such as bright or flashing lights, to try to provoke a seizure. During a seizure, electrical activity in the brain accelerates, producing a jagged wave pattern. Such recordings of brain waves help identify a seizure disorder. Different types of seizures have different wave patterns. 5/7/2009 8 Sushant Satyal
  • 9. Primary generalized seizure: A.  Begins with a widespread electrical discharge  Involves both sides of the brain at once  Hereditary factors are important Partial Seizure: B.  Begins with an electrical discharge in one limited area of the brain  Related to head injury, brain infection, stroke, or tumor 5/7/2009 9 Sushant Satyal
  • 10. Types of Primary generalized seizure 1. Absence seizures: ▪ Brief episodes of staring ▪ Absence seizures are considered complex absence seizures ▪ Include a change in muscle activity 5/7/2009 10 Sushant Satyal
  • 11. Most common movement are eye blinks ▪ Complex absence seizures are often more than 10 seconds long ▪ Usually begin between ages 4 and 14 ▪ no warning before a seizure, and the person is completely alert immediately afterward 5/7/2009 11 Sushant Satyal
  • 12. Other movements include slight tasting movements of the mouth, hand movements such as rubbing the fingers together ,etc ▪ Children who get them usually have normal development and intelligence ▪ 70% of cases, absence seizures stop by age 18 5/7/2009 12 Sushant Satyal
  • 13. 2. Atypical absence seizure: ▪ Atypical (a-TIP-i-kul) means unusual or not typical ▪ Person will stare but often is somewhat responsive ▪ Eye blinking or slight jerking movements of the lips may occur 5/7/2009 13 Sushant Satyal
  • 14. Hard to distinguish from the person's usual behavior, especially in those with cognitive impairment ▪ Generally begins at the age of 6 ▪ Most of the children affected have below-average intelligence 5/7/2009 14 Sushant Satyal
  • 15. ▪ Other types of seizures that are difficult to control ▪ Seizures usually continue till adulthood ▪ Daydreaming and inattentiveness can mimic these seizures ▪ Diagnosis can be difficult if the behavior during seizures is similar to the child's usual behavior 5/7/2009 15 Sushant Satyal
  • 16. 3. Monoclonic seizures: ▪ Very brief jerks, last only for 2 to 3 sec ▪ seizures usually cause abnormal movements on both sides of the body at the same time ▪ Myoquot; means muscle and quot;clonusquot; (KLOH-nus) means rapidly alternating contraction and relaxation 5/7/2009 16 Sushant Satyal
  • 17. Seizures usually begin in childhood, but the seizures can occur at any age ▪ Seizures occur in reflex epilepsies, triggered by flashing lights or other things in the environment ▪ Syndromes usually can be diagnosed on the basis of the medical history and often EEG patterns 5/7/2009 17 Sushant Satyal
  • 18. 4. Atonic Seizures: ▪ Atonicquot; (a-TON-ik) means quot;without tone ▪ In an atonic seizure, muscles suddenly lose strength ▪ Eyelids may droop, the head may nod, and the person may drop things and often falls to the ground ▪ Also known as quot;drop attacksquot; or quot;drop seizures 5/7/2009 18 Sushant Satyal
  • 19. ▪ The person usually remains conscious ▪ Another name for this type of seizure is “akinetic” ▪ (A-kin-ET-ik), which means quot;without movement“ ▪ Seizures often begin in childhood ▪ Often last into adulthood ▪ People with atonic seizures are injured when they fall 5/7/2009 19 Sushant Satyal
  • 20. ▪ Seizures may cause people to fall when they're standing often have tonic seizures rather than atonic seizures ▪ Syndromes usually can be diagnosed on the basis of the medical history and often EEG patterns 5/7/2009 20 Sushant Satyal
  • 21. 5. Tonic Seizures: ▪ Usually last less than 20 sec ▪ In such seizures, the tone is greatly increased and the body, arms, or legs make sudden stiffening movements ▪ Consciousness is usually preserved ▪ Seizures most often occur during sleep 5/7/2009 21 Sushant Satyal
  • 22. Usually involve all or most of the brain, affecting both sides of the body ▪ Common in people who have the epilepsy syndrome called Lennox-Gastaut syndrome ▪ Seizures in Lennox-Gastaut syndrome may become more difficult to control over time 5/7/2009 22 Sushant Satyal
  • 23. 6. Clonic seizures: ▪ Seizures consist of rhythmic jerking movements of the arms and legs ▪ Length vary according to the case ▪ Clonusquot; (KLOH-nus) means rapidly alternating contraction and relaxation of a muscle 5/7/2009 23 Sushant Satyal
  • 24. Movements cannot be stopped by restraining or repositioning the arms or legs ▪ These seizures are rarely found ▪ Common are tonic-clonic seizures, in which the jerking is preceded by stiffening (the quot;tonicquot; part) 5/7/2009 24 Sushant Satyal
  • 25. Sometimes tonic-clonic seizures start with jerking alone ▪ These are called clonic-tonic-clonic seizures ▪ Occur at various ages, including in newborns ▪ Brief and infrequent clonic seizures in infants usually disappear within very short period 5/7/2009 25 Sushant Satyal
  • 26. Occasionally quot;jitterinessquot; in a young infant can be mistaken for a clonic seizure ▪ Children with neurological impairments with repetitive movements that could be mistaken for clonic seizures ▪ The EEG pattern will change during a seizure, so video- EEG is very useful for diagnosis 5/7/2009 26 Sushant Satyal
  • 27. 7. Tonic-clonic seizures: ▪ Normally last for 2 to 3 min ▪ More than 5 min calls for immediate medical help ▪ Seizure that lasts more than 30 minutes indicate convulsion ▪ Person loses consciousness and falls to the floor 5/7/2009 27 Sushant Satyal
  • 28. Tongue or cheek may be bitten, so bloody saliva may come from the mouth ▪ Person may turn a bit blue in the face ▪ After the tonic phase comes the clonic phase ▪ Arms and usually the legs begin to jerk rapidly and rhythmically 5/7/2009 28 Sushant Satyal
  • 29. Bending and relaxing at the elbows, hips, and knees ▪ After a few minutes, the jerking slows and stops ▪ Bladder or bowel control sometimes is lost as the body relaxes ▪ Consciousness returns slowly, and the person may be drowsy, confused, agitated, or depressed 5/7/2009 29 Sushant Satyal
  • 30. They affect both children and adults ▪ Children who have had a single tonic-clonic seizure, the risk that they will have more seizures ▪ Some children will outgrow their epilepsy ▪ Tonic-clonic seizures can be controlled by seizure medicines 5/7/2009 30 Sushant Satyal
  • 31. Patients who are seizure-free for a year or two while taking seizure medicine will stay seizure-free ▪ Medicine can be stopped gradually ▪ Patients with no epilepsy wave in EEG can stay free with any medication ▪ People who faint sometimes may develop tonic or clonic seizure 5/7/2009 31 Sushant Satyal
  • 32. Types of Partial seizures 1. Simple partial seizures: ▪ Different from person to person, depending on the part of the brain where they begin ▪ One thing they all have in common is that the person remains alert and can remember what happens ▪ Usually last for less than 2 min 5/7/2009 32 Sushant Satyal
  • 33. Doctors often divide simple partial seizures into categories depending on the type of symptoms the person experiences i. Motor seizures ii. Sensory seizures iii. Autonomic seizures iv. Psychic seizures ▪ Anyone can get these seizures ▪ People who have had a head injury, brain infection, stroke, or brain tumor likely to get them 5/7/2009 33 Sushant Satyal
  • 34. These seizures often can be controlled by seizure medicines ▪ Medical disorders such as, stomach disorders or a pinched nerve can cause some similar symptoms ▪ Some symptoms (such as déja vu) are experienced by almost everyone at some time 5/7/2009 34 Sushant Satyal
  • 35. 2. Complex Partial Seizures: ▪ Usually last between 30 seconds and 2 minutes ▪ Afterward, the person may be tired or confused for about 15 minutes and may not be fully normal for hours ▪ Seizures usually start in a small area of the temporal lobe or frontal lobe of the brain 5/7/2009 35 Sushant Satyal
  • 36. Quickly involve other areas of the brain that affect alertness and awareness ▪ These seizures (usually ones beginning in the temporal lobe) start with a simple partial seizure ▪ Also called an aura, this warning seizure often includes an odd feeling in the stomach 5/7/2009 36 Sushant Satyal
  • 37. Person loses awareness and stares blankly ▪ Most people move their mouth, pick at the air or their clothing, or perform other purposeless actions ▪ These movements are called quot;automatismsquot; ▪ Less often, people may repeat words or phrases, laugh, scream, or cry 5/7/2009 37 Sushant Satyal
  • 38. Some people do things during these seizures that can be dangerous or embarrassing ▪ People need to take precautions in advance ▪ Complex partial seizures starting in the frontal lobe tend to be shorter than the ones from the temporal lobe ▪ Some complex partial seizures turn into secondarily generalized seizures 5/7/2009 38 Sushant Satyal
  • 39. people who have had a head injury, brain infection, stroke, or brain tumor are more likely to get seizures ▪ If medication is not effective, some can be eliminated by epilepsy surgery ▪ Complex partial seizures sometimes resemble daydreaming or absence sezuires 5/7/2009 39 Sushant Satyal
  • 40. Secondarily generalized seizures: 3. ▪ Start in one limited area of the brain ▪ Can also spread throughout the brain becoming generalized ▪ Convulsive phase of these seizures usually lasts no more than a few minutes ▪ Preceding partial seizure is usually not very long 5/7/2009 40 Sushant Satyal
  • 41. Happen when a burst of electrical activity in a limited area (the partial seizure) spreads throughout the brain ▪ Seizures occur in more than 30% of people with partial epilepsy ▪ Can affect people of all ages who have partial seizures ▪ Seizures of this kind can be controlled with medication 5/7/2009 41 Sushant Satyal
  • 42. Seizures of this kind can be controlled with medication ▪ If not controlled with medication, surgery is another option ▪ Easily diagnosed through EEG or MRI tests 5/7/2009 42 Sushant Satyal
  • 43. 7% 7% 34% Simple partial 15% Other generalized Partial unknown Absence 17% Myoclonic 20% Unclassified 5/7/2009 43 Sushant Satyal
  • 44. Change in consciousness, so that you can't remember  some period of time Change in emotion, like unexplainable  fear, panic, joy, or laughter Change in sensation of the skin, usually spreading  over the arm, leg, or trunk 5/7/2009 44 Sushant Satyal
  • 45. Changes in vision, including flashing lights, or (rarely)  hallucinations (seeing things that aren't there) Loss of muscle control and falling, often very suddenly  Muscle movement such as twitching that might  spread up an arm or leg 5/7/2009 45 Sushant Satyal
  • 46. Muscle movement such as twitching that might  spread up an arm or leg Muscle tension/tightening that causes twisting of the  body, head, arms or leg Tasting a bitter or metallic flavor  5/7/2009 46 Sushant Satyal
  • 47. Beginning State:   This stage can be said as warning or aura  Sometimes an individual may not be aware of such aura  In middle stage this aura is followed by other symptoms  It may be considered as simple partial seizure Middle State:   People have aura in beginning, the aura may convert into convulsion  For those who don’t have aura, the seizure may continue as complex partial seizure 5/7/2009 47 Sushant Satyal
  • 48. End state:   This state represents a transition from seizure back to normal state  Also referred as the “Post-ictal period”  Signifies recovery period of brain  May last from a second to minutes to hours 5/7/2009 48 Sushant Satyal
  • 49.  If a person has a convulsion, the level of awareness gradually improves during the post-ictal period, much like a person waking up from anesthesia after an operation 5/7/2009 49 Sushant Satyal
  • 50.  Emotional Early seizure symptoms:  ▪ Fear/Panic  Sensory/ thoughts ▪ Pleasant feeling ▪ Déjà vu  Physical ▪ Jamais vu ▪ ▪ Dizziness Smell ▪ Headache ▪ Sound ▪ Lightheadedness ▪ Taste ▪ Nausea ▪ Visual loss or blurring ▪ Numbness ▪ Racing thoughts  No Warnings ▪ Stomach feelings ▪ ▪ Sometimes seizures come with Strange feelings ▪ no warnings Tingling feeling 5/7/2009 50 Sushant Satyal
  • 51.  Emotional: Middle Seizure Symptoms :  ▪ Fear/Panic  Sensory/ thoughts ▪ Black out  Physical: ▪ Confusion ▪ Chewing movements ▪ Deafness/Sounds ▪ Convulsion ▪ Electric Shock Feeling ▪ Eyes rolling up ▪ Loss of consciousness ▪ Falling down ▪ Smell ▪ Foot stomping ▪ Spacing out ▪ Hand waving ▪ Out of body experience ▪ Inability to move ▪ Visual loss or blurring 5/7/2009 51 Sushant Satyal
  • 52. Incontinence ▪ Staring ▪ Stiffening ▪ Swallowing ▪ Sweating ▪ Teeth clenching/grind ▪ Tongue biting ▪ Tremors ▪ Twitching movement ▪ Breathing difficulty ▪ Heart racing 5/7/2009 52 Sushant Satyal
  • 53.  Physical Post-ical state:  ▪ Bruising  Thought ▪ Difficulty talking ▪ Memory loss ▪ Injuries ▪ Writing Difficulty ▪ Sleeping ▪ Exhaustion  Emotional ▪ Headache ▪ Confusion ▪ Nausea ▪ Depression and Sadness ▪ Pain ▪ ▪ Fear Thirst ▪ ▪ Frustration Weakness ▪ ▪ Urge to Shame/ Embarrassment urinate/defecate 5/7/2009 53 Sushant Satyal
  • 54. Causes Examples •Heatstroke High fever •Infections •Abscess Brain infections •AIDS •Malaria •Meningitis •Rabies •Syphilis •Tetanus •Toxoplasmosis •Viral encephalitis 5/7/2009 54 Sushant Satyal
  • 55. Causes Examples •High blood levels of sugar or sodium Metabolic disorders •Kidney or liver failure •Low blood levels of sugar, calcium, magnesium, or sodium •Underactive parathyroid gland •Vitamin B6 deficiency (in newborns) •Abnormal heart rhythms Inadequate oxygen supply to the brain •Carbon monoxide poisoning •Near drowning •Near suffocation •Stroke •Vasculiti 5/7/2009 55 Sushant Satyal
  • 56. Causes Examples •Brain tumor Structural damage to the brain •Head injury •Hydrocephalus •Intracranial hemorrhage •Stroke •Birth defect Abnormalities present or occurring at •Hereditary metabolic disorders, such as birth Tay-Sachs disease or phenylketonuria •Injury during birth •Eclampsia luid accumulation in the brain (cerebral •Hypertensive encephalopathy edema) 5/7/2009 56 Sushant Satyal
  • 57. Drug Use Possible side-effects Acetazolamide Absence seizures when Kidney stones and other anticonvulsants are chemical imbalance in ineffective blood Carbamazepine Generalized seizures A low white blood cell Partial seizures count (granulocytopenia), production of too few blood cells (aplastic anemia, which can be fatal disorder), a low platelet count (thrombocytopenia), digestive upset, inability to articulate words, lethargy, dizziness, and visual disturbances 5/7/2009 57 Sushant Satyal
  • 58. Drugs Uses Possible side-effects Clonazepam Atonic seizures Atypical Drowsiness, abnormal absence seizures behavior, loss of Infantile spasms coordination, and lost Myo clonic seizures effectiveness of the drug after 1 to 6 months Divalproex Absence seizures Nausea, vomiting, Febrile seizures abdominal pain, diarrhea, Generalized tonic-clonic temporary drowsiness, seizures dizziness, shaking Infantile spasms (tremor), reversible hair Juvenile myoclonic loss, weight gain, and liver epilepsy damage Myoclonic seizures 5/7/2009 58 Sushant Satyal
  • 59. Drugs Uses Possible side-effects Ethosuximide Absence seizures Nausea, lethargy, dizziness, a low white blood cell count and a low red blood cell count Felbamate Atypical absence seizures, Headache, fatigue, liver Partial seizures failure, and, rarely, aplastic anemia (which can be fatal) Fosphenytoin Status Epilepticus Loss of coordination, drowsiness, headache, rash, and tingling sensations 5/7/2009 59 Sushant Satyal
  • 60. Drugs Uses Possible side-effects Gabapentin Partial seizures Drowsiness, dizziness, weight gain, and headache In children, aggressive behavior, mood swings, and hyperactivity Lamotrigine Generalized seizures Nausea, vomiting, Partial seizures indigestion, headache, drowsiness, dizziness, insomnia, fatigue, loss of coordination, double vision, tremor, rash, and abnormal menstrual periods 5/7/2009 60 Sushant Satyal
  • 61. Drugs Uses Possible side-effects Levetiracetam Juvenile myoclonic Dizziness, weakness, epilepsy fatigue, loss of Myoclonic seizures coordination, changes in Partial seizures mood and behavior, and increased risk of infection Oxcarbazepine Partial seizures Headache, abdominal pain, double vision, drowsiness, dizziness, fatigue, nausea, low sodium levels in the blood, and a low white blood cell count 5/7/2009 61 Sushant Satyal
  • 62. Drugs Uses Possible side-effects Topiramate Atypical absence seizures Confusion, reduced Partial seizures concentration, difficulty Primarily generalized finding words, fatigue, loss tonic-clonic seizures of appetite and weight, numbness or tingling, reduced sweating, and kidney stones Valproate Absence seizures Nausea, vomiting, Febrile seizures abdominal pain, diarrhea, Generalized tonic-clonic weight gain, reversible hair seizures loss, temporary Infantile spasms drowsiness, shaking Juvenile myoclonic (tremor), and, rarely, liver epilepsy damage 5/7/2009 62 Sushant Satyal
  • 63. Stay with the person until recovery or you have  professional medical help Monitor pulse ,rate of breathing, and blood pressure  Do not give the person anything by mouth until  convulsions have stopped and the person is fully awake and alert 5/7/2009 63 Sushant Satyal
  • 64. Do not move the person unless he or she is in danger  or near something hazardous Do not place anything including your fingers between  the person’s teeth. You can break person’s teeth, if you do so. 5/7/2009 64 Sushant Satyal
  • 65. The doctor will perform a physical examination and ask questions to help understand the cause of the seizures, such as: Are there any risk factors ( such as recent head  injury)? Did it occur or start on one side of the body?  Did the person remain awake and aware during  seizure? How long the seizure last?  5/7/2009 65 Sushant Satyal
  • 66. How often do the seizures happen?  Was there any aura of the seizures?  Were there any other symptoms present (visual  changes, abnormal smells)? 5/7/2009 66 Sushant Satyal
  • 67. The following tests may be performed: Blood tests  Ct scan or MRI of the brain   EEG  Lumbar puncture 5/7/2009 67 Sushant Satyal
  • 68. People with uncontrolled seizures should not drive.  Drinking should be avoided  Medicines should be taken regularly  Avoid activities such as climbing to high  places, biking, and swimming Use of sharp instruments such as knife should be avoided  5/7/2009 68 Sushant Satyal
  • 69. Seizure is life threatening disease  No specific way to prevent seizures  But it is curable if instruction are followed  Good habits may help to control seizures  5/7/2009 69 Sushant Satyal
  • 70. Sleep deprivation, and poor diet must be avoided  Good sleep habits, stress reduction, proper  exercise, and sound nutrition may help Use helmets to avoid head injury  Have faith in yourself, and seizure is curable!!  5/7/2009 70 Sushant Satyal
  • 71. 5/7/2009 71 Sushant Satyal