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Graph Analysis of Brain
Networks—Measures and
         Tools

                   Speaker : Jimmy Lu
                   Advisor : Hsing Mei

         Web Computing Laboratory(WECO Lab)
 Computer Science and Information Engineering Department
                 Fu Jen Catholic University
Steps of Graph Analysis
 Define the network nodes. (EEG, MEG, MRI, DTI,
  etc.)
 Estimate a continuous measure of association
  between nodes
 Generate an association matrix, a binary adjacency
  matrix or undirected graph.
 Calculate the network parameters of interest in
  this graphical model of a brain network


                    WECO Lab, CSIE dept., FJU
2010/6/2                                        2
                     http://www.weco.net
Steps of generate structural and functional brain networks

                              WECO Lab, CSIE dept., FJU
2010/6/2                                                                3
                               http://www.weco.net
Computational modeling of structural and functional brain netowrks

                                   WECO Lab, CSIE dept., FJU
2010/6/2                                                                   4
                                    http://www.weco.net
Illustrative anatomical, functional, effective connectivity networks

                                   WECO Lab, CSIE dept., FJU
2010/6/2                                                                      5
                                    http://www.weco.net
Network measures

           WECO Lab, CSIE dept., FJU
2010/6/2                               6
            http://www.weco.net
Measures of network topology

                WECO Lab, CSIE dept., FJU
2010/6/2                                    7
                 http://www.weco.net
Construction of brain networks

                 WECO Lab, CSIE dept., FJU
2010/6/2                                     8
                  http://www.weco.net
Graph analysis tools
 Brain connectivity toolbox (BCT)
      A toolbox of Matlab
      Contributor: Olaf Sporns, Mikail Rubinov, Rolf Kotter,
       Patric Hagmann
      Define functions for analyzing complex graph (ex:
       degree, shortest path, etc.)
      The functions are the collection of many research
       results
      The web site also provide some useful information. (ex:
       connectivity datasets, tools for visualization, etc.)
      Open source. We can define our own measures.
                         WECO Lab, CSIE dept., FJU
2010/6/2                                               9
                          http://www.weco.net
http://www.brain-connectivity-toolbox.net

                      WECO Lab, CSIE dept., FJU
2010/6/2                                               10
                       http://www.weco.net
Reference
 [1] Ed Bullmore, Olaf Sporns, “Complex brain networks: graph
  theoretical analysis of structural and functional systems”, Nature
  Reviews Neuroscience 10, 186-198 (March 2009)
 [2] Mikail Rubinov, Olaf Sporns, “Complex network measures of brain
  connectivity: uses and interpretations”, NeuroImage (2009)




                           WECO Lab, CSIE dept., FJU
2010/6/2                                                     11
                            http://www.weco.net

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Graph Analysis of Brain Networks - Measures and Tools

  • 1. Graph Analysis of Brain Networks—Measures and Tools Speaker : Jimmy Lu Advisor : Hsing Mei Web Computing Laboratory(WECO Lab) Computer Science and Information Engineering Department Fu Jen Catholic University
  • 2. Steps of Graph Analysis  Define the network nodes. (EEG, MEG, MRI, DTI, etc.)  Estimate a continuous measure of association between nodes  Generate an association matrix, a binary adjacency matrix or undirected graph.  Calculate the network parameters of interest in this graphical model of a brain network WECO Lab, CSIE dept., FJU 2010/6/2 2 http://www.weco.net
  • 3. Steps of generate structural and functional brain networks WECO Lab, CSIE dept., FJU 2010/6/2 3 http://www.weco.net
  • 4. Computational modeling of structural and functional brain netowrks WECO Lab, CSIE dept., FJU 2010/6/2 4 http://www.weco.net
  • 5. Illustrative anatomical, functional, effective connectivity networks WECO Lab, CSIE dept., FJU 2010/6/2 5 http://www.weco.net
  • 6. Network measures WECO Lab, CSIE dept., FJU 2010/6/2 6 http://www.weco.net
  • 7. Measures of network topology WECO Lab, CSIE dept., FJU 2010/6/2 7 http://www.weco.net
  • 8. Construction of brain networks WECO Lab, CSIE dept., FJU 2010/6/2 8 http://www.weco.net
  • 9. Graph analysis tools  Brain connectivity toolbox (BCT)  A toolbox of Matlab  Contributor: Olaf Sporns, Mikail Rubinov, Rolf Kotter, Patric Hagmann  Define functions for analyzing complex graph (ex: degree, shortest path, etc.)  The functions are the collection of many research results  The web site also provide some useful information. (ex: connectivity datasets, tools for visualization, etc.)  Open source. We can define our own measures. WECO Lab, CSIE dept., FJU 2010/6/2 9 http://www.weco.net
  • 10. http://www.brain-connectivity-toolbox.net WECO Lab, CSIE dept., FJU 2010/6/2 10 http://www.weco.net
  • 11. Reference  [1] Ed Bullmore, Olaf Sporns, “Complex brain networks: graph theoretical analysis of structural and functional systems”, Nature Reviews Neuroscience 10, 186-198 (March 2009)  [2] Mikail Rubinov, Olaf Sporns, “Complex network measures of brain connectivity: uses and interpretations”, NeuroImage (2009) WECO Lab, CSIE dept., FJU 2010/6/2 11 http://www.weco.net