13. ~ 2.4 hours ( + 2 h) Technical failure X X No CCE colonoscopy CCE incomplete colonoscopy ~ 2.2 hours ( + 1.5 h)
14.
15. SYSTEMATIC REVIEW: 2006-2009 Significant polyp ( > 6 mm/>3) 16 13 87 0 64 6 13 22 199 Full/ abstr. Eliakim et al. (2006) full Schoofs et al. (2006) full Van Gossum et al. (2009) full Sieg et al. (2009) full Gay et al. (2009) full Pilz et al. (2008) Abstr. Spada et al. (2009) Abstr. Sacher-Huvelin et al. (2009) Abstr. Total Patients included 84 36 320 36 126 59 40 105 806 Polyp any size 36 25 212 11 67 28 20 - 399 Multi-centre Yes No Yes No No No No Yes l
16. CCE: POLYP ANY SIZE 71% (61-76%) I 2 : 12.9% Sensitivity 75% (66-83%) I 2 : 53% Specificity
17. CCE: > 6 mm polyp or > 3 polyp 68% (56-79%) I 2 : 60% Sensitivity 82% (77-85%) I 2 : 9% Specificity
18. Sensitivity for > 6 mm polyps Level bowel prep Good-excellent Poor-fair
19.
20. CCE: CANCER Pooled sensitivity (95% CI) 76% (58-94%) Colonoscopy Van Gossum et al. (2009) Sieg et al. (2009) Spada et al. (2009) Total Cancer CCE 19 1 1 21 Cancer Capsule 14 1 1 16
21. Additional Information on Misses of Adenocarcinoma by PillCam Site Referral AdenoK by OC Capsule finding PillCam cleansing Comments Italy Hematochezia 40 mm, left < 6mm, right < 6mm, sigm. Fair “ Inadequate preparation precluding the visualization of colonic mucosa” Italy Hematochezia > 10 mm, left No finding Poor “ Inadequate preparation precluding the visualization of colonic mucosa” Italy Hematochezia > 10 mm, left No finding Poor No comments Spain CRC 40 mm, rectum 2 x < 6mm, sigm Good K was located in rectum. Capsule stopped working at the sigmoid (at 07.52h) Lyon CRC Pedunculated 8-9 mm, sigm. 6 x < 6mm: 1-right 2-left 2-sigmoid 1-rectum Good No comments
24. Lieberman D, Moravec M, Holub J, et al. Gastroenterology 2008;135:1100-5. Rex DK, Overhiser AJ, Chen SC, et al. Am J Gastroenterol 2009;104:149-53. Pickhardt PJ, Choi JR, Hwang I, et al. N Engl J Med 2003; 349: 2191-2200. Kim DH, Pickhardt PJ, Taylor AJ, et al. N Engl J Med 2007;357:1403-12.