Benefits & Risks in Research Involving Human Particpants
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Benefits & Risks in Research Involving Human Particpants
- 1. Benefits & Risks in Research Involving Human Particpants Ghaiath M. A. Hussein MBBS, MHSc. (Bioethics)
- 10. Nazi Experiments
- 11. 2. Pressure: Low oxygen pressure as happened with the Nazi experiments when high altitude experiments where performed to test how long pilots would survive after being ejected from their planes.
- 13. 3. Heat: Heat stroke; Burn; Exhaustion 4.Noise: High noise may lead to impairment or loss of hearing 5. Light: Dim light may affect the vision
- 15. 2. Preventive: New vaccines e.g. Salk polio vaccine when a lump of a live polio vaccine given to children and most of them eventually developed polio.
- 25. Minimization of Risk -Adequate facilities ,procedures and personnel for dealing with emergencies . -Arrangement made for monitoring and detecting adverse out comes . -All trials should be reviewed by a Data Safety Monitoring Board (DSMB). -All potential toxins, mutagens or teratogens used should be justified. -The National Committee for Atomic Energy should completed risk assessment for the use of the radiation and radioactive substances .
Editor's Notes
- These Nazi experiments included hypothermia experiments depicted in this slide whereby prisoners were submerged in a tank filled with cold water. The goal of this type of these experiments was to determine how long German pilots, who had to parachute into the cold north sea, would survive.
- High altitude experiments were performed to test how long pilots would survive after being ejected from their planes. Prisoners were put into low-pressure tanks with little oxygen. Many of those who did not die immediately were put under water until they died. Autopsies followed. .