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Reflections on Medicine, Computer Science,
and Clinical Informatics
Geoff Rutledge, MD, PhD
Cofounder and CMIO
16,000 Physicians. No waiting room.
Medicine, Computer Science, and Clinical
Informatics

 Intro and background

 What is Biomedical Informatics?

 Career paths in Biomedical Informatics

 Lessons from Academia and Industry

 HealthTap University




                        Slide 3
My Path to Academic Informatics

 Undergrad and Med School
 - math physics computer science, then biology,
   biochemistry and medicine
 - A med school with a strong clinical tradition (McGill)

 Clinical medicine
 - Internal Medicine residency, practice of Emergency
   Medicine at community hospitals
 - Clinical faculty at UCSD and Stanford

 Informatics
 - Stanford program in Medical Information Sciences
 - Faculty at Harvard Medical School
                         Slide 4
What is Biomedical Informatics?
Components of NLM Informatics Training Programs:
   •Bioinformatics and/or computational biology

   •Translational informatics and clinical research

   •Structural informatics (imaging)

   •Clinical informatics

   •Public health informatics




                                   Slide 5
Biomedical Informatics

                          Biomedical Informatics Methods, Techniques,
Basic Research            and Theories




                                    Imaging       Clinical         Public Health
                   Bioinformatics   Informatics   Informatics      Informatics
Applied Research



                    Molecular and
                    Cellular        Tissues and      Individuals     Populations
                    Processes       Organs           (Patients)      And Society

                                    Slide 6                             From E.H. Shortliffe
Biomedical Informatics Research Areas

                   Biomedical                                 Biomedical
                   Knowledge                                  Data


                                            Biomedical
                                            Research
Machine learning                            Planning &                     Real-time acquisition
                            Knowledge                       Data
Text interpretation                         Data Analysis                  Imaging
                            Acquisition                     Acquisition
Knowledge engineering                                                      Speech/language/text
                                                                           Specialized input devices




                    Knowledge               Inferencing           Data
                    Base                    System                Base




              Information                     Treatment      Human                        Image
 Model                          Diagnosis                                  Teaching
              Retrieval                       Planning       Interface                    Generation
 Dev.
<domain name> Informatics

The practice of informatics, most generally, requires
  the presence of two components:

      (1) A set of skills and methodologic tools derived from
        knowledge of the basic informational and computing
        sciences; and

      (2) Knowledge, experience, and activity in one or more
        application domains. The coexistence of, and interactions
        between, these key components gives meaning and
        significance to informatics as a field

      (Friedman, ACMI)




                            Slide 8
Clinical Informatics

 My motivation:
  - Improve processes and outcomes of clinical care, using
    automation



 There are many paths and career options to
 accomplish this




                         Slide 9
Career Paths in Biomedical Informatics

 Academic
  - Research, teaching, administration
 Health-system operational roles
  - EG CIO, CMIO, or director for information technology
  - Digital library management
 Corporate research and development
  - For profit and non profit organizations
 Business opportunities
  - From startups to mid size to mega corporations
     • Biotechnology/pharmaceutical companies
     • Medical/hospital information system companies
     • Online/mobile
         - Interactive Health

                                Slide 10
What I Learned in Academia

 Creating a credible research agenda while in a full time clinical
 faculty role is “challenging”
  -   A research career requires dedicated time for gestation
        •     Spend that time with a very smart group of researchers
  -   The right mentor can make all the difference


 Research opportunities/awards come easily to those who
 have all their ducks lined up
  -   Right   training
  -   Right   institution
  -   Right   mentors/advisors
  -   Right   preliminary/foundational research


 Your measure of success is publications
  -   Having high impact is good
  -   But productivity is measured by quantity
  -   Closely linked to future success in funding


                                                                       Slide 11
What I wish I had figured out sooner

 How to pick your research topic
  - First, pick your ideal next job
     • Where is it?
     • Who will interview you for that job?
     • Who will be in the audience at your job talk?

  - Make sure your job talk will be compelling for the people
    in that audience
     • If the results of your research are not interesting to your
       next employer, then you picked the wrong employer (or the
       wrong research)




                           Slide 12
My Path to Industry:


 Internet Startups
  -   The potential of the Internet for health was obvious 20 years ago
  -   Healtheon was an early entrant in Internet health
  -   Wellsphere pursued a model of wellness, and consumer health
      information for the healthy


 HealthTap
  - Now 2 years old, has led the new era in Interactive
    Health
  - The power of mobile




                                 Slide 13
Moving From Academia to Industry
 A well capitalized small company is an incredible
 opportunity
      • An early phase company will change it’s business plan and
        objectives with some regularity
      • You can redefine yourself regularly (you have to adapt)
      • Seize opportunities as they arise

 Starting your own company is hard
 -   Requires a team effort, and knowledge of the hurdles
 -   It’s best to be either naïve or brilliant
 -   Success often depends on timing

 What I wish I had learned sooner
 - Business is business, retain your perspective
 - Diversify
      • Your personal stake in the business is already huge, maintain
        perspective (diversify)
                               Slide 14
Observations On Working in Industry

  Take time to figure out how the business works

  Trust and respect are earned
   -   It is lethal to expect special treatment based on your credentials or prior
       accomplishments

  Be kind, respectful, and helpful to your colleagues

  Put the company’s needs first
   -   Position everything you do as essential to the pursuit of company goals

  Don’t ignore corporate politics
   -   Make yourself helpful/indispensible to others
   -   Figure out who is threatened by you – make them your advocate (and be aware
       you could be blindsided)

  Be flexible: Consider opportunities that involve work outside your areas of
  expertise/experience
   -   Especially if there is no one better equipped to figure it out than you, and even
       more so if it is important to the future of the business

                                      Slide 15
Mission
Measurably prolong the life expectancy
of humankind and improve people’s quality
of life by enabling immediate access to the
best health experts and their knowledge
anytime, anywhere
Get in touch with
         your health
What Patients Do


      consumers go online



      health searches/month
      (Google)



      fastest growing mobile category
But it’s Not Helpful
What’s missing?
Physicians




Specialties




States
of doctor visits are questions and answers
The 1st Mobile Health Platform
Publications
HealthTap’s Consumer Health Ontology


Interprets what people ask
  •   Best answers
  •   Relevant specialists
  •   Related publications
  •   Similar topics
Consumer Health Vocabulary

A few of the observed spellings of “hemorrhoid”

 hemorrhoid     hemoriod       hemorrhoids
 hemeroid       hemmroids      hemorroid
 hemeroids      hemorhoids     hemorroides
 hemmerhoids    hemoride       hemorroids
 hemmoroid      hemoroid       hemroIds
 hemmoroids     hemoroids      hemroids
 hemmorroids    hemorrhoid     hemrroId
 hemmroid       hemorrhoidal   hemorrhoidopexy
How It Works
HealthTap
              University

Interact with and help real
patients

Discover what patients mean
when they ask questions

Learn from highly experienced,
expert clinicians
What HTU Students Say
HealthTap
              University


To sign up to HealthTap
University, send an email to:

geoff@healthtap.com
HealthTap
The Future Is Finally Here
but not evenly distributed

 Imagine a world in which most doctors are
 available and accessible online

 And every interaction that is more efficient when
 done electronically is available online
Have Fun!

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Geoff what is_medical_informatics_oct2012

  • 1. Reflections on Medicine, Computer Science, and Clinical Informatics Geoff Rutledge, MD, PhD Cofounder and CMIO
  • 2. 16,000 Physicians. No waiting room.
  • 3. Medicine, Computer Science, and Clinical Informatics Intro and background What is Biomedical Informatics? Career paths in Biomedical Informatics Lessons from Academia and Industry HealthTap University Slide 3
  • 4. My Path to Academic Informatics Undergrad and Med School - math physics computer science, then biology, biochemistry and medicine - A med school with a strong clinical tradition (McGill) Clinical medicine - Internal Medicine residency, practice of Emergency Medicine at community hospitals - Clinical faculty at UCSD and Stanford Informatics - Stanford program in Medical Information Sciences - Faculty at Harvard Medical School Slide 4
  • 5. What is Biomedical Informatics? Components of NLM Informatics Training Programs: •Bioinformatics and/or computational biology •Translational informatics and clinical research •Structural informatics (imaging) •Clinical informatics •Public health informatics Slide 5
  • 6. Biomedical Informatics Biomedical Informatics Methods, Techniques, Basic Research and Theories Imaging Clinical Public Health Bioinformatics Informatics Informatics Informatics Applied Research Molecular and Cellular Tissues and Individuals Populations Processes Organs (Patients) And Society Slide 6 From E.H. Shortliffe
  • 7. Biomedical Informatics Research Areas Biomedical Biomedical Knowledge Data Biomedical Research Machine learning Planning & Real-time acquisition Knowledge Data Text interpretation Data Analysis Imaging Acquisition Acquisition Knowledge engineering Speech/language/text Specialized input devices Knowledge Inferencing Data Base System Base Information Treatment Human Image Model Diagnosis Teaching Retrieval Planning Interface Generation Dev.
  • 8. <domain name> Informatics The practice of informatics, most generally, requires the presence of two components: (1) A set of skills and methodologic tools derived from knowledge of the basic informational and computing sciences; and (2) Knowledge, experience, and activity in one or more application domains. The coexistence of, and interactions between, these key components gives meaning and significance to informatics as a field (Friedman, ACMI) Slide 8
  • 9. Clinical Informatics My motivation: - Improve processes and outcomes of clinical care, using automation There are many paths and career options to accomplish this Slide 9
  • 10. Career Paths in Biomedical Informatics Academic - Research, teaching, administration Health-system operational roles - EG CIO, CMIO, or director for information technology - Digital library management Corporate research and development - For profit and non profit organizations Business opportunities - From startups to mid size to mega corporations • Biotechnology/pharmaceutical companies • Medical/hospital information system companies • Online/mobile - Interactive Health Slide 10
  • 11. What I Learned in Academia Creating a credible research agenda while in a full time clinical faculty role is “challenging” - A research career requires dedicated time for gestation • Spend that time with a very smart group of researchers - The right mentor can make all the difference Research opportunities/awards come easily to those who have all their ducks lined up - Right training - Right institution - Right mentors/advisors - Right preliminary/foundational research Your measure of success is publications - Having high impact is good - But productivity is measured by quantity - Closely linked to future success in funding Slide 11
  • 12. What I wish I had figured out sooner How to pick your research topic - First, pick your ideal next job • Where is it? • Who will interview you for that job? • Who will be in the audience at your job talk? - Make sure your job talk will be compelling for the people in that audience • If the results of your research are not interesting to your next employer, then you picked the wrong employer (or the wrong research) Slide 12
  • 13. My Path to Industry: Internet Startups - The potential of the Internet for health was obvious 20 years ago - Healtheon was an early entrant in Internet health - Wellsphere pursued a model of wellness, and consumer health information for the healthy HealthTap - Now 2 years old, has led the new era in Interactive Health - The power of mobile Slide 13
  • 14. Moving From Academia to Industry A well capitalized small company is an incredible opportunity • An early phase company will change it’s business plan and objectives with some regularity • You can redefine yourself regularly (you have to adapt) • Seize opportunities as they arise Starting your own company is hard - Requires a team effort, and knowledge of the hurdles - It’s best to be either naïve or brilliant - Success often depends on timing What I wish I had learned sooner - Business is business, retain your perspective - Diversify • Your personal stake in the business is already huge, maintain perspective (diversify) Slide 14
  • 15. Observations On Working in Industry Take time to figure out how the business works Trust and respect are earned - It is lethal to expect special treatment based on your credentials or prior accomplishments Be kind, respectful, and helpful to your colleagues Put the company’s needs first - Position everything you do as essential to the pursuit of company goals Don’t ignore corporate politics - Make yourself helpful/indispensible to others - Figure out who is threatened by you – make them your advocate (and be aware you could be blindsided) Be flexible: Consider opportunities that involve work outside your areas of expertise/experience - Especially if there is no one better equipped to figure it out than you, and even more so if it is important to the future of the business Slide 15
  • 16. Mission Measurably prolong the life expectancy of humankind and improve people’s quality of life by enabling immediate access to the best health experts and their knowledge anytime, anywhere
  • 17. Get in touch with your health
  • 18. What Patients Do consumers go online health searches/month (Google) fastest growing mobile category
  • 19. But it’s Not Helpful
  • 21.
  • 23. of doctor visits are questions and answers
  • 24. The 1st Mobile Health Platform
  • 25.
  • 27.
  • 28. HealthTap’s Consumer Health Ontology Interprets what people ask • Best answers • Relevant specialists • Related publications • Similar topics
  • 29. Consumer Health Vocabulary A few of the observed spellings of “hemorrhoid” hemorrhoid hemoriod hemorrhoids hemeroid hemmroids hemorroid hemeroids hemorhoids hemorroides hemmerhoids hemoride hemorroids hemmoroid hemoroid hemroIds hemmoroids hemoroids hemroids hemmorroids hemorrhoid hemrroId hemmroid hemorrhoidal hemorrhoidopexy
  • 31. HealthTap University Interact with and help real patients Discover what patients mean when they ask questions Learn from highly experienced, expert clinicians
  • 33. HealthTap University To sign up to HealthTap University, send an email to: geoff@healthtap.com
  • 35. The Future Is Finally Here but not evenly distributed Imagine a world in which most doctors are available and accessible online And every interaction that is more efficient when done electronically is available online

Notas do Editor

  1. Health care/clinical informaticsPrinciples and methods affecting direct patient care, and informational support for healthcare consumersBioinformatics and/or computational biologyPrinciples and methods to support basic research in genomics, proteomics, cheminformatics, systems biology, and simulation/modeling of biological systemsClinical research and translational informaticsPrinciples and methods for “bench to bedside” translational research, genome-phenome relationships, pharmacogenomics, drug discovery, clinical trialsPublic health informaticsPrinciples and methods to build public health infrastructure
  2. When at home in the middle of the nightWhile walking on the streetWhile waiting for the elevatorFrom the comfort of your seatOn the bus or trainAsk a question anytime, anywhere … even while attending a panel at the Medicine-X conference
  3. For the first time ever, doctors are systematically reviewing and judging the opinions of other experts. Doctors on HealthTap provide a new answer to a question, or “Agree” with an existing answer. Patients see which answers other doctors agree with (and which they don’t)
  4. Empowered patients want to discover the latest advances from the research literatureMedical experts publish clinically relevant articles, but in language that is impenetrable to most patientsHealthTap enables both plain language summaries of medical publications, and discussions among patients and experts on the meaning and implications of published studies
  5. Consumers on HealthTap find experts:By DocScore,By “Known for” topics,By the answers they give,By publications,By distanceConsumers can request answers from specific physiciansIncluding images in their questions,And their health history
  6. HealthTap has built the world’s largest and most complete consumer health ontology. The ontology enables understanding of consumer language: Find the most relevant similar questionsSelect the most relevant specialists for each questionIdentify and organize the health topics of greatest interest to experts and consumers