Induciton of a myasthenic-like syndrome in mice by injecting a large quantitiy of immunoglobulin G from MG patients
Induciton of a myasthenic-like syndrome in mice by injecting a large quantitiy of immunoglobulin G from MG patients Top photo shows a rabbit with "floppy" ears after an injection of receptor antigens. Bottom shows the same rabbit after receiving edrophonium. http://www.aneuroa.org/html/c20html/1970_1979.htm
Induciton of a myasthenic-like syndrome in mice by injecting a large quantitiy of immunoglobulin G from MG patients
Onset from mild to maximal weakness is less than 36 months in 83% of patients
Lambert-Eaton myasthenic syndrome (LEMS) is a rare condition in which weakness results from an abnormality of acetylcholine (ACh) release at the neuromuscular junction. Recent work demonstrates that LEMS results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal.
Positive RNS test features Decrement in CMAP amplitude Size: More than 10% in reduction in CMAP amplitude Measure from 1st to 4th or 5th potential in train Smallest CMAP is often 2nd or 3rd potential in train Post-exercise exhaustion Exercising muscle briefly before testing exacerbates decremental response Occurs rapidly after initial stimulation Post-tetanic potentiation Reduction in decrement in minutes after exercise Occurs after post-exercise exhaustion
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