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The Results of neo-adjuvant intra-arterial [ 131 I]lipiodol in liver resection and transplantation for HCC B. Launois, J.L. Raoul, L.A. Veilhan, B. Meunier, K. Boudjema, M. S. Metcalfe, G.J. Maddern Departments of Surgery University of Rennes (France) University of Adelaide (Australia) Bucharest (Romania) 9-11 April, 2003

Surgery for HCC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Injection of [ 131 I]Lipiodol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IA injection of [ 131 I] lipiodol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pre-operative [ 131 I] lipiodol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

Study design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Patients ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tumours ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Surgery ,[object Object],[object Object],[object Object],[object Object],[object Object]

Results: efficacy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tolerance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Patients 1 January 1987- 1 August 1999 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Etiology of Cirrhosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Three groups ,[object Object],[object Object],[object Object]

Group Characteristics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Characteristics of 38 liver transplants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Protocol of IA injection of [ 131 I] lipiodol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Morbidity post- [ 131 I] lipiodol injection in 20 patients ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Evaluation of response to [ 131 I] lipiodol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Efficacy of [ 131 I] lipiodol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Efficacy by alpha-fetoprotein ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pathology of 51 liver transplants for HCC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pathology of 51 LT for HCC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Delay of Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object]

Post-operative course ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Months Overall survival of 52 liver transplant patients

months Liver transplant survival by tumour diameter <30mm 30-50mm >50mm

Survival of liver transplants with and without vascular invasion months No vascular invasion Vascular invasion

months Survival of liver transplants by experimental groups No lipiodol incidental lipiodol

Cumulative survival of 52 patients ,[object Object],[object Object],[object Object],[object Object],[object Object]

Characteristics of recurrences ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusions ,[object Object],[object Object],[object Object]

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