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بسم الله الرحمن الرحيم
M anagement of   c holangiocarcinoma   Mansoura Experience Egypt ,[object Object]
CHOLANGIOCARCINOMA Is the second most frequent malignant tumor of the liver after hepatocelular carcinoma, with incidence at autopsy ranges from 0.01 to 0.05%
[object Object],[object Object]
EPIDEMIOLOGICAL AND RISK FACTOR ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLASSIFICATION OF CHOLANGIOCARCINOMA   ,[object Object],[object Object],[object Object],[object Object]
Hilar ccc classified into 4 Types   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Lygidakis 1989
MANAGMENT ,[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object]
 
Left hepatectomy, segment one resection Portal. V. I.V.C. R.hepatic A.
CCC supra duodenal dissection
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mansoura Experience ( E G Y P T) Gastroenterology Center ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
PRESENTATION 385 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EVALUATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cholangio carcinoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MRCP of young patients with  C.C.C
MRCP. Shows Hilar chalangio carcinoma CCC
 
 
Resectability ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CENTRAL CHOLANGIOCARCINOMA     216  ,[object Object],[object Object]
Operative photo : stent inside the common hepatic duct of  C.C.C
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CRITERIA FOR UNRESECTABILTY
Cholangio carcinoma in cirrhotic liver
 
WHAT ABOUT NON RESECTABLE C.C.C. 170 PATIENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of NON RESECTABLE C.C.C.  (170  PATIENTS ) ,[object Object],[object Object],[object Object],[object Object],[object Object]
SURGICAL TREATMENT   (46   patients with C.C.C.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
INDICATION LOCALIZED RESECTION ,[object Object],[object Object],[object Object],[object Object]
 
Operative photo loclaised resection in cirrhotic liver
RA RP LD CHD GB Localized resection  of C.C.C
Post operativ cholangiography after resection of central cholangiocarcinoma double hapaticojejunostomy(arrows)
INDICATION OF L. HEPATECTOMY ,[object Object],[object Object],[object Object]
 
Operative photo of  C.C.C (atrophic left lob)
 
Portography (obstruction of the left portal vein)
Operative cholangiogram
CCC supra duodenal dissection  Segment 1 abscess CCC portahepatis dissection
Left hepatectomy, segment one resection Cut surface after left hepatectomy (catheters inside 3 ducts)
1 2 3 4
Papillematosis of the left hepatic duct
 
Left hepatectomy + segment I for C.C.C
 
Left hepatectomy for C.C.C in cirrhotic liver
Post operative cholangiogram right hepatico jujnostomy after left hepatectomy for C.C.C
Post operative cholangiogram after left hepatectomy
Cholangogram after left hepatectomy for hillar chalongio carcinoma Right hepatico jejunostomy (arrow)  CCC
INDICATION OF RIGHT HEPATICTOMY ,[object Object],[object Object],[object Object]
 
 
 
Hepatic Vein Dissection
 
Dessection of Rt Hepatic Vein Rt H V Occlusion 15  S
1  2 3 4
One week . Postoperative Chalangiogrphy ( left hepaticojejunostomy)
Post operative cholangiogram after right hepatectomy for C.C.C
Postoperative Complication ,[object Object],[object Object],[object Object],[object Object],[object Object]
postoperative complication Total  BDR.  (20)   BDR+L.R . (26) Internal haemonhage 2 - 2  (4.3) Wound infection 4 2  (10) 2  (7.6) Multiple organfailure 1 - 1  (3.8) Pulmonary infarction 1 1  (5) - Total No. with comp. 13  4  (20) 9  (34.6) continue
Hospital Mortality 5 (10.8) Causes   No. % Hepatic cell failure 3  6.6 Gastro intestinal bleeding 1 2.1 Multple organ failure 1 2.1
LATE COMPLICATION   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RECURRENCE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Surgery for recurrent CCC anastomotic
Surgery for recurrent CCC
CCC
15 months after resection of C.C.C Recurrent stricture (1),  Balloon inside stric.(2), After dilatation(3) 1 2 3
LATE MORTALITY 24 (57.2%) ,[object Object],[object Object],[object Object],[object Object],[object Object]
SURVIVAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
INTRA HEPATIC CHOLANGIOCARCINOMA ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 
PTC for pripheral cholangiocarcinoma
Time of survival (months) Survival probability
Time of survival (months) ( P= 0.017) Survival probability
Time of survival (months) (P= 0.041) Survival   probability
Time of survival (months) ( P= 0.049 ) Survival   probability
Survival   probability Time of survival (months) ( P= 0.25)
[object Object]

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