hashimoto thyroiditis is common in cancer patients We include the clinical psychological and graphological correlation

1. HASHIMOTO AND CANCER CLINICAL - PSYCHOLOGICAL
GRAPHOLOGICAL CORRELATION REVISION OF 202 PATIENTS
FRANCESCO MATOZZA MD, ADRIANA ORTIZ ,
1-Introduction:
Hashimoto Thyroiditis is an autoimmune disease which mostly affects women in an
approximated ratio 9:1 relationship with men.
Statistically the disease appears especially in 3rd, 4th and 5th decade of the life and can
be associated with other autoimmune disease like rheumatoid arthritis, diabetes, arthritis,
vitíligo , pernicious anaemia, endometriosis, psoriasis, etc
The most frequent symptoms are: fatigue and excessive drowsiness, intolerance to cold,
dry skin, dry and fragile hair, fragility of nails, pallor of skin, increased weight,
constipation, apathy and indifference, depression, sleep disorders, memory loss, attention
and lack of concentration.
Psychologically these patients appear to present a chronic emotional blockage which,
in the presence of other stress factors such as bereavement, marital or work-related
difficulties etc., endangers a negative mental attitude which activates the endocrine and
nervous system; this in turn alters the Immune System.
.
Clinical forms:
A) Sub clinical Hypothyroidism: T3 and T4, normal, TSH normal
Increase TPA and/or TGA.
B) Clinical Hypothyroidism:
Diminution of T3 and T4, increase TSH,
Increase TGA, and PTO.
Treatment Clinical Hypothyroidism: levotyroxine
2-Objective of the study:
The objective of the study is to evaluate if a relationship between cancer and Hashimoto
Thyroiditis exists; using handwriting analyses, personality profiles of the patients and
correlating them with clinical and laboratory studies.

2. 3-Material and Methods:
202 patients were included in this multicentric and multidisciplinary study of which: 162
patients (22-76 years of age) present Thyroiditis Hashimoto and cancer and 40 patients of
the same age group with Thyroiditis Hashimoto without cancer
20%
TH
TH y cancer
80%
The oncological patients were in different stages of the disease. And they were evaluated
from the point of view: clinical, radiological, graphological and laboratory tests
including, T3, T4, TSH, TPO, and TGA. The patients without cancer were evaluated by
the same means as the patients with cancer.
Distribution of the tumours

3. Hashimoto Thyroiditis Psychological aspects
Low self-esteem, Emotional instability,Affective disorders
Difficulty in recognizing their own affective needs
Depression ,Fear of any form of affirmation
Insecurity ,Rigidity,Perfectionism ,Self exigent
THE PATIENTS WITH HASHIMOTO THYROIDITIS:
Insatiable need for affection and addiction to work
Self-punitive ,Tendency to bradypsychia,Uni-polar depression
Excessive anticipatory preoccupation, Difficulty with confronting feelings of
aggressiveness.
It is important to state that the present of these personality traits is not a cause of
developing the disease.
Graphological findings
1) Direction. Falling lines or foxtails.
2) Pressure: irregular in all aspects.
3) Dimension: Narrow between letters, Inhibited and suspended.
4) Twisted and broken forms, especially in ascenders and descenders with spasmodic writing.
5) Trembling strokes, closed or congested. Tremors Hard to see with the naked eye.
6) Meaningless and unnecessary dots.
7) Strokes rigid in part or total. Squaring.
8) Angular handwriting.
9) Fireplace.
10) Triangular movements, especially in the ovals.

4. 11) Jagged -edged on two sides.
12) Middle zone always with extras, mainly ovals.
13) Movement direction: regressive and/or mixed.
14) Letters and/or Word endings missing or suspended.
15) Wide starting stroke comes from lower zone to the left.
16) Paraph circles.
17) Stroke that crosses out signature for no reason.
18) Lower zone crossed out with paraph for no reason.
) Angular paraph to the left.
PSYCHOTHERAPEUTIC TREATMENT
Of the psychotherapeutic treatments currently used most are psychoanalytic and of a
mental-behavioural nature.
Psychoanalysis reveals that these patients find difficulty in recognizing and addressing
their own aggressiveness and employs techniques which allow the liberation of their
repressed impulses.
From a more general point of view the controlled liberation of the repressed aggressive
emotional impulses is due to favour, considering that due to the frequent resistance that
can occur in the psychosomatic patients.
PROPOSED THERAPEUTIC FRAME: The therapeutic frame that we use considers
mental aspects as much as behavioural. This approach seeks to:
1- Identify the pessimistic thoughts and self-punishing feelings, confronting them with
constructive and positive alternatives grounded in reality.
2- To increase their social awareness of others in order to suppress the tendency in being
solely concentrated on themselves and their problems.

5. 3- To help patients identify factors in their lives which cause stress and to help them
organize their time and plan activities that are pleasurable.
4- Prioritizing personal development and to connect them with their own feelings.
5- To introduce the patient to exercises and muscle relaxation.
6- In highlighting the disease to the patient, it enables them to face up to difficult
situations
7- In enabling the patient to express fear and anxiety, it will promote resolution of any
real problems.
8- If a patient suffers body-image problems, we try to analyse and identify the distortion
in their own self-perception.
General conclusion:
The patients with Hashimoto Thyroiditis have the same personality profile of cancer
patients, namely Type C personality traits although vary graph logically in the intensity
of the observed variables. This personality is independent of the type of tumour, age, sex,
social status.
The evolution of the Hashimoto Thyroiditis is the following one:
1- Hashimoto Thyroiditis ------------------- Hashimoto Thyroiditis
2- Hashimoto Thyroiditis ------------ Another one autoimmune, AR, Psoriasis
3- Hashimoto Thyroiditis ------------- uterine fibroma. Ovarian cyst.
Breast dysplasia
4- Hashimoto Thyroiditis ---------------- ------- Malignant tumours (breast, ovarian,
Lung, colorectal, prostate, lymphoma etc
Clinical implications:
Women with Hashimoto Thyroiditis would have to take gynaecological and radiological
examinations like mammography, mammary Ultrasound, trans-vaginal US and
colposcopy at least once per year, since statistically they are more likely to develop
benign or malignant gynaecological disease due to the dysfunction of the immunological
system.

6. Patients with uterine fibrome, ovarian cyst and breast dysplasia should have exam T3,
T4, TSH, PT and ATG to exclude hashimoto thyroiditis.
The psycho diagnosis, handwriting analysis and the psychological treatment would be
indicated in patients with hashimoto thyroiditis with or without cancer
References
REFERENCES HASHIMOTO THYROIDITIS AND CANCER
1-Saitoh T, Matsushima T, Saito Y, Yamane A, Yokohoma A, Irisawa H, Handa H,
Tsukamoto N, Karasawa M, Kojima M, Nojima Y, Murakami H.
Hodgkin lymphoma presenting with various immunologic abnormalities, including
autoimmune hepatitis, Hashimoto's thyroiditis, autoimmune hemolytic anemia, and
immune thrombocytopenia.
Clin Lymphoma Myeloma. 2008 Feb; 8(1):62-4.
PMID: 18501091 [Pub Med - indexed for MEDLINE]
2-Troch M, Woehrer S, Streubel B, Weissel M, Hoffmann M, Müllauer L, Chott A,
Raderer M.
Chronic autoimmune thyroiditis (Hashimoto's thyroiditis) in patients with MALT
lymphoma.
Ann Oncol. 2008 Jul; 19(7):1336-9. Epub 2008 Mar 11.
PMID: 18334510 [Pub Med - indexed for MEDLINE]
3-Mellemkjaer L, Pfeiffer RM, Engels EA, Gridley G, Wheeler W, Hemminki K, Olsen
JH, Dreyer L, Linet MS, Goldin LR, Landgren O.
Autoimmune disease in individuals and close family members and susceptibility to non-
Hodgkin's lymphoma.
Arthritis Rheum. 2008 Mar; 58(3):657-66.
PMID: 18311836 [Pub Med - indexed for MEDLINE]
4-Cizmić M, Ignjatović M, Cerović S, Ajdinović B.
[Coexistence of Hashimoto's thyroiditis and papillary thyroidal carcinoma with papillary
carcinoma of thyreoglossal duct]
Vojnosanit Pregl. 2007 Oct; 64(10):714-8. Serbian.
PMID: 18041575 [Pub Med - indexed for MEDLINE]
5Costanzo M, Caruso LA, Testa R, Marziani A, Cannizzaro MA.
[Hashimoto thyroiditis. Possible cause or consequence of a malignant thyroid tumor]
Ann Ital Chir. 2006 Nov-Dec; 77(6):469-71. Italian.
PMID: 17343229 [Pub Med - indexed for MEDLINE]
6-Fierabracci P, Pinchera A, Campani D, Pollina LE, Giustarini E, Giani C.
Association between breast cancer and autoimmune thyroid disorders: no increase of
lymphocytic infiltrates in breast malignant tissues.
J Endocrinol Invest. 2006 Mar; 29(3):248-51.
PMID: 16682839 [Pub Med - indexed for MEDLINE]

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16-HANDWRITING ANALYSIS IN CANCER PATIENTS
Francesco Matozza M.D.-Consultant Oncologist, Rawson and Rivadavia Hospitals ,
Buenos Aires Prof. Adriana Ortiz–Consultant graphologist, Handwriting expert. ...
www.salutedonna.it/handwriting_analysis_in_cancer_patients.htm - 14k -
17 britishgraphology.org - The British Institute of graphology...
- Francesco Matozza quot;Handwriting Analysis and Cancerquot; Pat Church quot;How
Graphology Can Provide Extra Insight in Counsellingquot; Dor Gauthier quot;Dr Werner Wolffquot;
...
www.britishgraphology.org/magazine.htm - 37k -
18IPOS progr def A4_3-fare correz.qxp
Handwriting analysis in cancer patients. -. Oritz A, Matozza FS, Levy D ( Argentina). P
83. Somatic complaints and mental exposures. in Haematology/ Oncology: ...
www.ipos2006.it/IPOS_programme.pdf -
19 IMPORTANCIA DE ESTUDIOS GRAFOLOGICOS
Adriana Ortiz, es Licenciada en Grafología. Dr. Francesco Matozza, doctorado en
Medicina y Cirugía Universidad de Bologna. ...
www.farmasalute.it/speciali/prevenzionetumori/ESTUDIOSGRAFOLOGICOS.pdf
20-L’ IMPIEGO DELLA GRAFOLOGIA NEL TRATTAMENTO E FOLLOW UP
DEI ...
Dr. Francesco MATOZZA - M.N.52472 ... Vice Direttrice del dipartimento di
grafologia scientifica del “Centro Argentino de ...
www.farmasalute.it/speciali/prevenzionetumori/ESTUDIOSGRAFOLOGICOS2.pdf -

8. Adriana Ortiz is consultant graphologist and Vice Director of Centro Argentino de
Investigaciones Grafopatológicas. Buenos Aires Argentinaadrianaortizb@hotmail.com
Francesco Matozza M:D:medical oncologist and radiologist. Buenos Aires-Argentina
Frankmatozza@libero.it

9. 20%
TH
TH y cancer
80%