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Vizbi Takeaway 2012 - visualising biological data




 Vizbi Takeaway 2012
   Visualising biological data - highlights




      Photo: avlxyz - http://www.flickr.com/photos/avlxyz/3786955645/
Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                         Visualising biological data
                                 6 - 8 March 2012       EMBL Heidelberg

                        300 participants, 80 posters, 25 talks, 12 tutorials




     Photos: francisrowland / SéanO / Siemar | Flickr
Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                        Takeaway menu

                       • Juri Pärn - The curse of n-dimensions
                       • Ingvar Lagerstedt - The power of images
                       • Martijn van Iersel - Pathway visualisation & WikiPathways
                       • Glen van Ginkel - Principles of data visualisation
                       • Francis Rowland - UX design for data visualisation
                       • Benedetta Baldi - Data visualisation technology for biologists




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                             The curse of n-dimensions
                               Juri Pärn EMBL-EBI External Services


                                             One dimension...


                       1




                       2




                       3



Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                             The curse of n-dimensions
                                            Two dimensions...

                               1                           2




                               3                           4




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




        The curse of
        n-dimensions...
        Three dimensions...




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




        The curse of
        n-dimensions...
        Three dimensions...




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




        The curse of
        n-dimensions...
        Three dimensions...




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




        The curse of
        n-dimensions...
        Three dimensions...




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                              The curse of n-dimensions


                       • With every new dimension, it gets worse
                       • The diagonal grows slowly but steadily with
                       • For dimension = 100 the diagonal is
                       • Important to keep in mind for clustering, as many
                         clustering algorithms use euclidian distance
                       • Points tend to cluster along dimensions, not across
                         dimensions
                       • Possible solution for clustering
                         - dimension reduction
                         - using another distant function, e.g.




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                             The curse of n-dimensions
                                               an example...




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                   The power of images
                                        Ingvar Lagerstedt PDBe



                                How do you read a paper?

                          •   Title
                          •   Author
                          •   Abstract
                          •   Images/Tables
                          •   Legends for images/table
                          •   Conclusions
                          •   Methods/Body of text




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                               Using images effectively

                       • What do you want to show?
                       • Highlight/simplify
                         - remove details that are not relevant to the point
                           you want to make
                       • We are not all layout designers
                         - use professional help
                         - I tend to cram in far to much detail
                       • Publishers often charge per image
                         - encourages composite images




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                        Example from Nature Structural
                             & Molecular Biology




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                              Colouring

                       • Use limited number of colours
                         - Horror example with 250+ colour based keys
                         - Think hard if you really need more than say 5-6
                           colours
                       • Use soft colours for large areas
                         - It is fine to use strong colours for features/lines
                           etc., but they tend to be tiring if used excessively
                       • Think about the colour blind




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                       Designing a new file format (RNA)

                        • Many existing competing compact formats
                        • Wanted a new community based
                        • Everyone likes XML
                          • parsers are free
                        • Except
                          • There was 30 X bloat
                          • Details were left ambiguous
                          • Each group produced slightly different versions
                          • Hardly anyone can cope with reading other
                            groups version




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                       Pathway Visualization & WikiPathways
                            Martijn van Iersel Saez-Rodriguez Group




                                       http://www.wikipathways.org

Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                      Editing pathways




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                        Pathways
                                        Genes       90
                                                     90
                                                    5


                                                    26
                                                     26
                                                    15
                                                     1



Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                   Systems Biology Graphical Notation (SBGN)

                                                                 Macro
                        Simple                      Catalysis
                                                                molecule




                                     Clone




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                               LibSBGN
                       Reference                    Rend. Ext.
                                    PathVisio                    SBGN-ED




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                           Principles & Resource sharing
                                           Glen van Ginkel PDBe



                           Cross-Origin Resource Sharing (CORS)


                                   Domain A         XMLHttpRequest       Domain B
                           http://domaina.example                    http://domainb.foo




                                       http://www.w3.org/TR/cors/

                       https://developer.mozilla.org/en/HTTP_access_control




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                 Graphics & visualisation

                       • Graphics used to form a sign system:
                          - Each mark (point, line, or area) represents a
                            data element
                          - Visualisation is about choosing visual variables
                            to encode relationships between data elements
                                - difference, similarity, order, proportion
                                - only position supports all relationships
                       • Huge range of alternative visual encodings for
                         data
                          - find images that express and effectively
                            convey the information


                            Prof Jessie Kennedy (Institute for Informatics & Digital Innovation)




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                                     Encoding schemes




                       Adapted from Mackinlay J (1986) Automating the design of graphical presentations of relational information.




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                       Accuracy of Quantitative Perceptual Tasks




                             Cleveland, W.S. & McGill, R. Science 229, 828–833
                             (1985).




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                        Mapping data types to encoding




                       Mackinlay J (1986) Automating the design of graphical presentations of relational information.




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                                    Colour


                       “Colour used poorly is worse than no colour at all”
                       - Edward Tufte


                            • “Above all, do no harm”
                            • colour can cause the wrong information to stand
                              out and
                            • make meaningful information difficult to see.




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                             Brewer Palettes

                       Brewer palettes (colorbrewer.org) provide a range of palettes based on
                       HSV model which make life easier for us….


                                  Avoid the use of hue to encode quantitative variables


                               QUALITATIVE              SEQUENTIAL           DIVERGING




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                        UX design for data visualisation
                           Francis Rowland EMBL-EBI External Services




                   Biologists                                      Data viz
                                                                   experts




             Data visualisation
                sweet spot


                                               Designers

Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                           Biologists
                       Tell the story of your research
                       through data visualisation


                           Data visualisation experts
                       Integrate analysis & visualisation


                           Designers
                       Apply design principles and expertise




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                       Data visualisation technology for biologists
                             Benedetta Baldi Computational Neurobiology




                           autoFill

Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data


                  Simulation                                 Animation




                                                     Eric
                                                    Keller




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data



                   autoFill                 http://autofill.grahamj.com/




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                             Questions?




                                                          Drew Berry
Monday, 2 April 2012
Vizbi Takeaway 2012 - visualising biological data




                                                       Thanks to...


                       Scientific Organisers:
                       Seán O’Donoghue CSIRO and Garvan Institute, Australia
                       James Procter University of Dundee, UK


                       Conference Organiser:
                       Anja Maria Kröffges EMBL Heidelberg, Germany




                       Continue the discussion on the EBI Interfaces mailing list:
                       http://listserver.ebi.ac.uk/mailman/listinfo/interfaces



Monday, 2 April 2012

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Vizbi 2012 Takeaway

  • 1. Vizbi Takeaway 2012 - visualising biological data Vizbi Takeaway 2012 Visualising biological data - highlights Photo: avlxyz - http://www.flickr.com/photos/avlxyz/3786955645/ Monday, 2 April 2012
  • 2. Vizbi Takeaway 2012 - visualising biological data Visualising biological data 6 - 8 March 2012 EMBL Heidelberg 300 participants, 80 posters, 25 talks, 12 tutorials Photos: francisrowland / SéanO / Siemar | Flickr Monday, 2 April 2012
  • 3. Vizbi Takeaway 2012 - visualising biological data Takeaway menu • Juri Pärn - The curse of n-dimensions • Ingvar Lagerstedt - The power of images • Martijn van Iersel - Pathway visualisation & WikiPathways • Glen van Ginkel - Principles of data visualisation • Francis Rowland - UX design for data visualisation • Benedetta Baldi - Data visualisation technology for biologists Monday, 2 April 2012
  • 4. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions Juri Pärn EMBL-EBI External Services One dimension... 1 2 3 Monday, 2 April 2012
  • 5. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions Two dimensions... 1 2 3 4 Monday, 2 April 2012
  • 6. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions... Three dimensions... Monday, 2 April 2012
  • 7. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions... Three dimensions... Monday, 2 April 2012
  • 8. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions... Three dimensions... Monday, 2 April 2012
  • 9. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions... Three dimensions... Monday, 2 April 2012
  • 10. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions • With every new dimension, it gets worse • The diagonal grows slowly but steadily with • For dimension = 100 the diagonal is • Important to keep in mind for clustering, as many clustering algorithms use euclidian distance • Points tend to cluster along dimensions, not across dimensions • Possible solution for clustering - dimension reduction - using another distant function, e.g. Monday, 2 April 2012
  • 11. Vizbi Takeaway 2012 - visualising biological data The curse of n-dimensions an example... Monday, 2 April 2012
  • 12. Vizbi Takeaway 2012 - visualising biological data The power of images Ingvar Lagerstedt PDBe How do you read a paper? • Title • Author • Abstract • Images/Tables • Legends for images/table • Conclusions • Methods/Body of text Monday, 2 April 2012
  • 13. Vizbi Takeaway 2012 - visualising biological data Using images effectively • What do you want to show? • Highlight/simplify - remove details that are not relevant to the point you want to make • We are not all layout designers - use professional help - I tend to cram in far to much detail • Publishers often charge per image - encourages composite images Monday, 2 April 2012
  • 14. Vizbi Takeaway 2012 - visualising biological data Example from Nature Structural & Molecular Biology Monday, 2 April 2012
  • 15. Vizbi Takeaway 2012 - visualising biological data Colouring • Use limited number of colours - Horror example with 250+ colour based keys - Think hard if you really need more than say 5-6 colours • Use soft colours for large areas - It is fine to use strong colours for features/lines etc., but they tend to be tiring if used excessively • Think about the colour blind Monday, 2 April 2012
  • 16. Vizbi Takeaway 2012 - visualising biological data Designing a new file format (RNA) • Many existing competing compact formats • Wanted a new community based • Everyone likes XML • parsers are free • Except • There was 30 X bloat • Details were left ambiguous • Each group produced slightly different versions • Hardly anyone can cope with reading other groups version Monday, 2 April 2012
  • 17. Vizbi Takeaway 2012 - visualising biological data Pathway Visualization & WikiPathways Martijn van Iersel Saez-Rodriguez Group http://www.wikipathways.org Monday, 2 April 2012
  • 18. Vizbi Takeaway 2012 - visualising biological data Editing pathways Monday, 2 April 2012
  • 19. Vizbi Takeaway 2012 - visualising biological data Pathways Genes 90 90 5 26 26 15 1 Monday, 2 April 2012
  • 20. Vizbi Takeaway 2012 - visualising biological data Systems Biology Graphical Notation (SBGN) Macro Simple Catalysis molecule Clone Monday, 2 April 2012
  • 21. Vizbi Takeaway 2012 - visualising biological data LibSBGN Reference Rend. Ext. PathVisio SBGN-ED Monday, 2 April 2012
  • 22. Vizbi Takeaway 2012 - visualising biological data Principles & Resource sharing Glen van Ginkel PDBe Cross-Origin Resource Sharing (CORS) Domain A XMLHttpRequest Domain B http://domaina.example http://domainb.foo http://www.w3.org/TR/cors/ https://developer.mozilla.org/en/HTTP_access_control Monday, 2 April 2012
  • 23. Vizbi Takeaway 2012 - visualising biological data Graphics & visualisation • Graphics used to form a sign system: - Each mark (point, line, or area) represents a data element - Visualisation is about choosing visual variables to encode relationships between data elements - difference, similarity, order, proportion - only position supports all relationships • Huge range of alternative visual encodings for data - find images that express and effectively convey the information Prof Jessie Kennedy (Institute for Informatics & Digital Innovation) Monday, 2 April 2012
  • 24. Vizbi Takeaway 2012 - visualising biological data Encoding schemes Adapted from Mackinlay J (1986) Automating the design of graphical presentations of relational information. Monday, 2 April 2012
  • 25. Vizbi Takeaway 2012 - visualising biological data Accuracy of Quantitative Perceptual Tasks Cleveland, W.S. & McGill, R. Science 229, 828–833 (1985). Monday, 2 April 2012
  • 26. Vizbi Takeaway 2012 - visualising biological data Mapping data types to encoding Mackinlay J (1986) Automating the design of graphical presentations of relational information. Monday, 2 April 2012
  • 27. Vizbi Takeaway 2012 - visualising biological data Colour “Colour used poorly is worse than no colour at all” - Edward Tufte • “Above all, do no harm” • colour can cause the wrong information to stand out and • make meaningful information difficult to see. Monday, 2 April 2012
  • 28. Vizbi Takeaway 2012 - visualising biological data Brewer Palettes Brewer palettes (colorbrewer.org) provide a range of palettes based on HSV model which make life easier for us…. Avoid the use of hue to encode quantitative variables QUALITATIVE SEQUENTIAL DIVERGING Monday, 2 April 2012
  • 29. Vizbi Takeaway 2012 - visualising biological data UX design for data visualisation Francis Rowland EMBL-EBI External Services Biologists Data viz experts Data visualisation sweet spot Designers Monday, 2 April 2012
  • 30. Vizbi Takeaway 2012 - visualising biological data Biologists Tell the story of your research through data visualisation Data visualisation experts Integrate analysis & visualisation Designers Apply design principles and expertise Monday, 2 April 2012
  • 31. Vizbi Takeaway 2012 - visualising biological data Data visualisation technology for biologists Benedetta Baldi Computational Neurobiology autoFill Monday, 2 April 2012
  • 32. Vizbi Takeaway 2012 - visualising biological data Simulation Animation Eric Keller Monday, 2 April 2012
  • 33. Vizbi Takeaway 2012 - visualising biological data autoFill http://autofill.grahamj.com/ Monday, 2 April 2012
  • 34. Vizbi Takeaway 2012 - visualising biological data Monday, 2 April 2012
  • 35. Vizbi Takeaway 2012 - visualising biological data Questions? Drew Berry Monday, 2 April 2012
  • 36. Vizbi Takeaway 2012 - visualising biological data Thanks to... Scientific Organisers: Seán O’Donoghue CSIRO and Garvan Institute, Australia James Procter University of Dundee, UK Conference Organiser: Anja Maria Kröffges EMBL Heidelberg, Germany Continue the discussion on the EBI Interfaces mailing list: http://listserver.ebi.ac.uk/mailman/listinfo/interfaces Monday, 2 April 2012