16. Event-free survival and overall survival according to response at 2 cycles on the basis of PET (n = 90) PET– (n = 54) PET+ (n = 36) Probability of EFS p < 0.0001 Years after randomisation Event-free survival p = 0.006 median f/u: 2 years Overall survival 100 100 0 1 2 3 0 1 2 3 Years after randomisation probability of OS 80 60 40 20 0 80 60 40 20 0 Haioun C, et al. Blood 2005; 106(4): 1376–81 PET– (n = 54) PET+ (n = 36) PPV 50 % NPV 74 % Accuracy 68.5%
17. =1g/cm 3 (Bq/g) Activité injectée Poids du corps C* totale = (Bq/g) Activité mesurée Volume du foyer C* tissulaire = C* tissulaire C* totale SUV = Si distribution homogène, SUV = 1 SUV= Ci*( ) dose/poids
18.
19. SUV-based Assessment versus Visual Analysis SUV and EFS : Optimal cut-off point of SUVmax reduction: 65.7% (ROC analysis) Lin C, Itti E. JNM 2007; 48:1626-32. PPV 81.3% NPV 75.0% Accuracy 76.1%
20. Visual Analysis versus SUV-based Assessment Months After Randomization > 65.7% 65.7% SUV max Reduction P < .0001 Probability of EFS (%) Visual Analysis PET (-) PET (+) P = .009 n=34 n=58 n=76 n=16 Linh C, Itti E. JNM 2007; 48:1626-32.
21.
22. Moskowitz et al., Blood 108: Abstract 532, 2006 MSKCC 01-142-DLBCL: Risk Adapted Therapy Transplant-eligible, CS IIX, III or IV age-adjusted IPI 1, 2, or 3 Risk Factors