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Meiosis
You have body cells and gametes


                       DNA in these
                       cells is passed on
                       to offspring


                       DNA in these
                       cells is NOT
                       passed on to
                       offspring
You have body cells and gametes


                       DNA in these
                       cells is passed on
                       to offspring


                       DNA in these
                       cells is NOT
                       passed on to
                       offspring
Ploidy: Number of sets of
chromosomes in a cell
   Haploid (n)-- one set chromosomes
   Diploid (2n)-- two sets
    chromosomes
   Most plant and animal adults are
    diploid (2n)
   Eggs and sperm are haploid (n)
Your cells have autosomes and
sex chromosomes
Summary of chromosome
characteristics
   Diploid set for humans; 2n = 46
   Autosomes - homologous
    chromosomes, one from each
    parent (humans = 22 sets of 2)
   Sex chromosomes (humans have 1
    set of 2)
     Female-sex chromosomes are
      homologous (XX)
     Male-sex chromosomes are non-
      homologous (XY)
Mitosis
   The nucleus divides to form 2 nuclei
     Prophase
     Metaphase
     Anaphase
     Telophase

   Cytokinesis – the cytoplasm of the
    cell is divided in half and the cell
    membrane grows to enclose each
    cell
Asexual (vegetative)
reproduction
   A form of duplication using only mitosis.
   Example,
       a new plant grows out of the root or
       a shoot from an existing plant.
   Produces only genetically identical offspring
    since all divisions are by mitosis.
       Offspring called clones meaning that each is an
        exact copy of the original organism
       Method of reproduction is rapid and effective
       Since the offspring are identical, there is no
        mechanism for introducing diversity
Meiosis

2 divisions of the nucleus
   Meiosis I
   Meiosis II


A form of cell division that halves the
number of chromosomes when
forming specialized reproductive
cells, such as gametes or spores
Formation of Diploid & Haploid Cells

     Mitosis                       Meiosis
          2n                            2n



     2n        2n              n                 n


                           n        n        n       n
2 diploid cells produced

                           4 haploid cells produced
Sexual Reproduction
   Formation of new individual by a combination of two
    haploid sex cells (gametes).
   Gametes for fertilization usually come from separate
    parents
       Female- produces an egg
       Male - produces sperm
   The new individual is called a zygote, with two sets
    of chromosomes (diploid).
   Meiosis is a process to convert a diploid cell to a
    haploid gamete, and cause a change in the genetic
    information to increase diversity in the offspring.
What is Meiosis I?
   Chromosomes in a diploid cell re-
    segregate, producing four haploid
    daughter cells.

       It is this step in meiosis that
       generates genetic diversity!
Prophase I
                homologous chromosomes
                 pair, a step unique to meiosis
                Chromosomal condensation
                 allows these to be viewed in
                 the microscope.
                Note that there are 2
                 chromosomes and 4
                 chromatids, with one
                 chromosome coming from
                 each parent.
Metaphase I
                 Paired chromosomes (four
                  chromatids) align at the
                  equator
                 The orientation is random,
                  with either parental
                  homologue on a side.
                 This means that there is a
                  50-50 chance for the
                  daughter cells to get either
                  the mother's or father's
                  homologue for each
                  chromosome.
Anaphase I
                Paired chromosomes
                 separate.
                Chromosomes, each
                 with two chromatids,
                 move to separate
                 poles.
                Each of the daughter
                 cells is now haploid (23
                 chromosomes)
Telophase I
                 Nuclear envelopes may
                  reform, or the cell may
                  quickly start meiosis II.
Cytokinesis
                 Analogous to mitosis
                  where two complete
                  daughter cells form.
Meiosis I
Meiosis II
   chromatids of each chromosome are
    no longer identical because of
    recombination.
   chromatids separate from one
    another
Meiosis II
Comparing Meiosis & Mitosis
   Chromosome behavior
       Mitosis: Homologous chromosomes independent
       Meiosis: Homologous chromosomes pair forming
        bivalents until anaphase I
   Chromosome number- reduction in meiosis
       Mitosis- identical daughter cells
       Meiosis- daughter cells haploid
   Genetic identity of progeny:
       Mitosis: identical daughter cells
       Meiosis: daughter cells have new assortment of
        parental chromosomes
       Meiosis: chromatids not identical, crossing over
Meiotic Errors
   Nondisjunction- homologues don't separate
    in meiosis 1
       Usually embryo lethal
       Trisomy 21, exception leading to Downs syndrome
       Sex chromosomes
            Turner syndrome: monosomy X
            Klinefelter syndrome: XXY
   Translocation and deletion: transfer of a
    piece of one chromosome to another or loss
    of fragment of a chromosome.

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Meiosis

  • 2. You have body cells and gametes DNA in these cells is passed on to offspring DNA in these cells is NOT passed on to offspring
  • 3. You have body cells and gametes DNA in these cells is passed on to offspring DNA in these cells is NOT passed on to offspring
  • 4. Ploidy: Number of sets of chromosomes in a cell  Haploid (n)-- one set chromosomes  Diploid (2n)-- two sets chromosomes  Most plant and animal adults are diploid (2n)  Eggs and sperm are haploid (n)
  • 5. Your cells have autosomes and sex chromosomes
  • 6. Summary of chromosome characteristics  Diploid set for humans; 2n = 46  Autosomes - homologous chromosomes, one from each parent (humans = 22 sets of 2)  Sex chromosomes (humans have 1 set of 2)  Female-sex chromosomes are homologous (XX)  Male-sex chromosomes are non- homologous (XY)
  • 7. Mitosis  The nucleus divides to form 2 nuclei  Prophase  Metaphase  Anaphase  Telophase  Cytokinesis – the cytoplasm of the cell is divided in half and the cell membrane grows to enclose each cell
  • 8. Asexual (vegetative) reproduction  A form of duplication using only mitosis.  Example,  a new plant grows out of the root or  a shoot from an existing plant.  Produces only genetically identical offspring since all divisions are by mitosis.  Offspring called clones meaning that each is an exact copy of the original organism  Method of reproduction is rapid and effective  Since the offspring are identical, there is no mechanism for introducing diversity
  • 9. Meiosis 2 divisions of the nucleus  Meiosis I  Meiosis II A form of cell division that halves the number of chromosomes when forming specialized reproductive cells, such as gametes or spores
  • 10. Formation of Diploid & Haploid Cells Mitosis Meiosis 2n 2n 2n 2n n n n n n n 2 diploid cells produced 4 haploid cells produced
  • 11. Sexual Reproduction  Formation of new individual by a combination of two haploid sex cells (gametes).  Gametes for fertilization usually come from separate parents  Female- produces an egg  Male - produces sperm  The new individual is called a zygote, with two sets of chromosomes (diploid).  Meiosis is a process to convert a diploid cell to a haploid gamete, and cause a change in the genetic information to increase diversity in the offspring.
  • 12. What is Meiosis I?  Chromosomes in a diploid cell re- segregate, producing four haploid daughter cells. It is this step in meiosis that generates genetic diversity!
  • 13. Prophase I  homologous chromosomes pair, a step unique to meiosis  Chromosomal condensation allows these to be viewed in the microscope.  Note that there are 2 chromosomes and 4 chromatids, with one chromosome coming from each parent.
  • 14. Metaphase I  Paired chromosomes (four chromatids) align at the equator  The orientation is random, with either parental homologue on a side.  This means that there is a 50-50 chance for the daughter cells to get either the mother's or father's homologue for each chromosome.
  • 15. Anaphase I  Paired chromosomes separate.  Chromosomes, each with two chromatids, move to separate poles.  Each of the daughter cells is now haploid (23 chromosomes)
  • 16. Telophase I  Nuclear envelopes may reform, or the cell may quickly start meiosis II.
  • 17. Cytokinesis  Analogous to mitosis where two complete daughter cells form.
  • 19. Meiosis II  chromatids of each chromosome are no longer identical because of recombination.  chromatids separate from one another
  • 21. Comparing Meiosis & Mitosis  Chromosome behavior  Mitosis: Homologous chromosomes independent  Meiosis: Homologous chromosomes pair forming bivalents until anaphase I  Chromosome number- reduction in meiosis  Mitosis- identical daughter cells  Meiosis- daughter cells haploid  Genetic identity of progeny:  Mitosis: identical daughter cells  Meiosis: daughter cells have new assortment of parental chromosomes  Meiosis: chromatids not identical, crossing over
  • 22. Meiotic Errors  Nondisjunction- homologues don't separate in meiosis 1  Usually embryo lethal  Trisomy 21, exception leading to Downs syndrome  Sex chromosomes  Turner syndrome: monosomy X  Klinefelter syndrome: XXY  Translocation and deletion: transfer of a piece of one chromosome to another or loss of fragment of a chromosome.