What is the emkaBATH4 system? Integrated and compact solution for studying the contractile properties of isolated tissue: aortic rings trachea papillary muscles atrium uterus ... The intelligent setup that takes care of technical details so you can concentrate on your data! http://isolated-organ.emka.fr/

1. emkaBATH4
tissue bath system
smart tools – swift services – sharp research
www.emka.fr

2. 1 - what is the emkaBATH4 system?
APPLICATIONS
SYSTEM OVERVIEW
2 - how does it work?
AUTOMATION
STAND-ALONE USE OR SOFTWARE CONTROL
DATA ACQUISITION
STIMULATION
3 - why use it?

3. what is the emkaBATH4 system?
integrated and compact solution for studying the
contractile properties of isolated tissue
aortic rings
trachea
papillary muscles
atrium
uterus
...

4. what is the emkaBATH4 system?
all-in-one mainframe
• 4 baths with transducers & amplifiers
• bath temperatures adjusted and controlled
electronically
• automated bath filling/emptying
• automated tissue tensioning with motors
smart tools – swift services – sharp research
www.emka.fr

5. what is the emkaBATH4 system?
integrated hardware
• pump for pushing perfusate to baths
• emptying pump for drawing perfusate
from the baths
smart tools – swift services – sharp research
www.emka.fr

6. what is the emkaBATH4 system?
integrated hardware
• motors for tissue tensioning
• heating elements
• signal amplifiers
smart tools – swift services – sharp research
www.emka.fr

7. what is the emkaBATH4 system?
the emkaBATH4 mainframe comes with:
• a power supply unit
• a perfusate reservoir
• container for used perfusate
smart tools – swift services – sharp research
www.emka.fr

8. what is the emkaBATH4 system?
large range of hooks designed to
facilitate tissue manipulation
range of bath sizes
• 20ml
• 10ml
• 5ml
smart tools – swift services – sharp research
www.emka.fr

9. what is the emkaBATH4 system?
custom-designed it50 isometric
transducers
• robustness
• sensitivity
smart tools – swift services – sharp research
www.emka.fr

10. what is the emkaBATH4 system?
custom-designed it50 isometric transducers
• stainless steel body
• 0-50 g (0 - 0.5 N) measuring range
• displacement: 0.89 mm/50g
• sensitivity@Vcc=5V: 0.1 mV/g
smart tools – swift services – sharp research
www.emka.fr

11. what is the emkaBATH4 system?
microvessel study
• easily adapted for the study of up to 4 microvessels
• for vessels of diameter 100μm to 3 mm and up to 3.5mm long
• each microvessel bath incorporates its own isometric transducer,
measuring forces up to 30g
smart tools – swift services – sharp research
www.emka.fr

12. how does it work?
mainframe control panel provides access to all operations
• set temperature : perfusate is heated to the required temperature as it travels to the bath
• calibration : 0-1g / 0-10g / 0-50g
smart tools – swift services – sharp research
www.emka.fr

13. how does it work?
mainframe control panel provides
access to all operations
• set tension
(automated but manual override always possible)
• fill, empty bath
• wash, renew bath
smart tools – swift services – sharp research
www.emka.fr

14. how does it work?
data acquisition with iox or other data acquisition software
• USB connection to PC running iox software
• information displayed on the control panel is sent to iox (temperature,
tissue tension)
• protocols can also be exported from iox
• BNC outputs provide calibrated analog signal to any acquisition system
smart tools – swift services – sharp research
www.emka.fr

15. iox acquisition software
designed for maximum productivity
• full data display as graphs, tables, trends
• beat to beat calculation on fast beating tissues (papillary/atrial muscles)
• detailed calculation on slow contracting tissue (uterus, ileum)
• on-the-fly comment and mark addition
• preprogrammed action triggered by function key or timers
• automated control of stimulators, valves, motors
smart tools – swift services – sharp research
www.emka.fr

16. datanalyst software
powerful post-processing
• data extraction
• group averaging
• ED50
• ...
smart tools – swift services – sharp research
www.emka.fr

17. how does it work?
electrodes and stimulation
• electrodes and stimulators are available
from emka TECHNOLOGIES
• third-party stimulators can also be used
(iox control is not possible)
smart tools – swift services – sharp research
www.emka.fr

18. why use it?
simple to set up and run
• completely automated
• easy mounting and removal for cleaning
• corrosion-resistant
• external connections and peripheral devices reduced to a minimum
smart tools – swift services – sharp research
www.emka.fr

19. why use it?
smart features
open system: analog outputs
electric heating system for baths
• faster response when compared to air heated systems to maintain temperature control
• more accessible baths when compared with air heated system
smart tools – swift services – sharp research
www.emka.fr

20. why use it?
smart features
modular solution design
• customization (i.e. bath sizes, tissue-holder, additional measurements such as pH, etc.)
• up to 16 simultaneous baths with software control
smart tools – swift services – sharp research
www.emka.fr

21. why use it?
smart features
seamless hardware/software integration
• all bath operations are accessible from within the acquisition software
• filling/emptying and/or tissue tension operations are all set in the acquisition protocol
(no need of a separate tissue bath control application)
• quality control: tissue tension, and temperature data recorded
smart tools – swift services – sharp research
www.emka.fr

22. why use it?
smart features
fast fill, and empty of baths
pumps for liquid control
overflow-based bath renewal
tissue is never exposed to air: no risk of drying!
easy calibration
smart tools – swift services – sharp research
www.emka.fr

23. www.facebook.com/emkatechnologies
@emkaTECH

24. solutions for lifesciences
research
www.emka.fr