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Pathway Map Reference Guide Attention-grabber Focus on Your Pathway The most popular cell signaling pathways Sample & Assay Technologies
Table of contents AKT Signaling 4 Molecular Mechanisms of Cancer 24 cAMP Signaling 5 NFkB Family 25 Cellular Apoptosis 6 Notch Signaling 26 Chemokine Signaling 7 p38 Signaling 27 Cyclins and Cell Cycle Regulation 8 p53 Signaling 28 Cytokine Network 9 PI3K Signaling 29 DNA Repair Mechanisms 10 PPAR 30 EGF 11 Ras 31 Epithelial Tight Junctions 12 Rho Family GTPases 32 ErbB Family 13 SMAD Signaling Network 33 ERK Signaling 14 TCR Signaling 34 Estrogen 15 TGFb 35 Glucocorticoid Receptor Signaling 16 TNF Superfamily 36 GPCR 17 Toll-like Receptors 37 HIF1a 18 Transcriptional Network in IL-6 19 Embryonic Stem Cells Insulin Receptor 20 Ubiquitin-Proteasome– JAK/STAT 21 dependent Proteolysis 39 LDL Oxidation in Atherogenesis 22 VEGF 40 MAP Kinase Signaling 23 Wnt Signaling 41 Product listing 42 38 For up-to-date licensing information and product-specific disclaimers, see the respective QIAGEN kit handbook or user manual. QIAGEN kit handbooks and user manuals are available at www.qiagen.com or can be requested from QIAGEN Technical Services or your local distributor. Trademarks: QIAGEN®, EpiTect® (QIAGEN Group); PowerPoint® (Microsoft Corporation). Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are not be considered unprotected by law. The products featured in the guide are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease. © 2011 QIAGEN, all rights reserved 2 www.qiagen.com Pathway Map Reference Guide 07/2011
The Pathway Map Reference Guide This guide illustrates important signaling pathways with their related RT2 Profiler PCR Arrays and Cignal Reporter Assay Kits. To view the entire list of 500 pathway maps, editable PowerPoint® slides, and related QIAGEN products, visit: www.qiagen.com/pathway-central Disclaimer: We acknowledge Protein Lounge, Inc. as the source of the Pathway Maps. Any questions or comments regarding the validity or accuracy of the pathway maps should be directed to Protein Lounge, Inc. directly. Product information RT2 Profiler PCR Arrays RT2 Profiler PCR Arrays enable the analysis of key genes for a biological pathway or disease state using real-time PCR in 2 hours. RT2 Profiler PCR Arrays are available for all real-time PCR instruments. Associated pathway PCR arrays related to the top 50 pathways are provided in this guide. An example of a complete PCR array identifier catalog number is shown below: PAXX-###Y-# XX = species ### = unique pathway identifier Y = plate format # = pack size To view the entire list of available RT2 Profiler PCR Arrays, visit: www.qiagen.com/array-list Cignal Reporter Assay Kits Cignal Reporter Assay Kits provide a rapid, sensitive, and quantitative assessment of over 45 signal transduction pathways by measuring the activities of downstream transcription factors. GFP and luciferase reporter systems are available. For a complete list of Cignal Reporter Assay Kits, visit: www.qiagen.com/reporter-assays Pathway Map Reference Guide 07/2011 Sample Assay Technologies 3
Akt Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits PI3K-Akt Signaling Pathway PI3K/Akt CCS-1022L mTOR Signaling PAHS-098 MAPK/ERK CCS-010L Oncogenes Tumor Suppressor Genes PAHS-502 MAPK/JNK CCS-011L MAP Kinase Signaling Pathway 4 PAHS-058 PAHS-61 NFkB CCS-013L www.qiagen.com Pathway Map Reference Guide 07/2011
cAMP Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits cAMP/Ca2+ Signaling PathwayFinder PAHS-066 cAMP/PKA p53 Signaling Pathway PAHS-027 Amino Acid Deprivation CCS-5034L Synaptic Plasticity PAHS-126 PKC/Ca2+ CCS-015L MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L Pathway Map Reference Guide 07/2011 Sample Assay Technologies CCS-002L 5
Cellular Apoptosis Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Apoptosis p53/DNA Damage CCS-004L p53 Signaling Pathway PAHS-027 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 ATF6 CCS-9031L Autophagy 6 PAHS-012 PAHS-084 PI3K/Akt CCS-1022L www.qiagen.com Pathway Map Reference Guide 07/2011
Chemokine Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Chemokines Receptors PAHS-022 NFkB CCS-013L NFkB Signaling Pathway PAHS-025 MAPK/JNK CCS-011L Toll-like Receptor Signaling Pathway PAHS-018 MAPK/ERK CCS-010L MAP Kinase Signaling Pathway PAHS-061 Type I Interferon CCS-008L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 7
Cyclins and Cell Cycle Regulation Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Cell Cycle Cell Cycle CCS-003L p53 Signaling Pathway PAHS-027 p53/DNA Damage CCS-004L DNA Damage Signaling Pathway PAHS-029 PI3K/Akt CCS-1022L Cellular Senescence 8 PAHS-020 PAHS-050 Wnt CCS-018L www.qiagen.com Pathway Map Reference Guide 07/2011
Cytokine Network Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Common Cytokines PAHS-021 Interferon g CCS-009L Chemokines Receptors PAHS-022 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L Interferon a, b Response PAHS-016 Type I Interferon CCS-008L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 9
DNA Repair Mechanisms Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits DNA Repair PAHS-042 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 p53/DNA Damage CCS-004L Telomeres and Telomerase PAHS-010 Hedgehog CCS-6030L qBiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-5034L 10 www.qiagen.com Pathway Map Reference Guide 07/2011
EGF Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L Growth Factors PAHS-041 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGFR qBiomarker Somatic Mutation SMH-001 Estrogen Receptor CCS-005L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 11
Epithelial Tight Junctions Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Epithelial to Mesenchymal Transition PAHS-090 PKC/Ca2+ CCS-015L Endothelial Cell Biology PAHS-015 MAPK/ERK CCS-010L Primary Cilia PAHS-127 SP1 CCS-6027L Amino Acid Metabolism II PAHS-130 MAPK/JNK CCS-004L 12 www.qiagen.com Pathway Map Reference Guide 07/2011
ErbB Family Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits EGF/PDGF Signaling Pathway PAHS-040 Estrogen Receptor CCS-005L PI3K-Akt Signaling Pathway PAHS-058 Progesterone CCS-6043L Breast Cancer PAHS-131 PI3K/Akt CCS-1022L ErbB2 qBiomarker Somatic Mutation SMH-002 MAPK/ERK CCS-010L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 13
ERK Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L NFkB Signaling Pathway PAHS-025 NFkB CCS-013L 14 www.qiagen.com Pathway Map Reference Guide 07/2011
Estrogen Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Breast Cancer and ER Signaling PAHS-005 Estrogen Receptor CCS-005L Breast Cancer PAHS-131 Progesterone CCS-6043L Nuclear Receptors and Coregulators PAHS-056 Androgen CCS-1019L EGF/PDGF Signaling Pathway PAHS-040 C/EBP CCS-001L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 15
Glucocorticoid Receptor Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Inflammatory Cytokines and Receptors PAHS-011 Glucocorticoid Receptor CCS-006L Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L Neutrophins Receptors PAHS-031 VDRE CCS-2029L Stress Response to Cellular Damage PAHS-019 Androgen CCS-1019L 16 www.qiagen.com Pathway Map Reference Guide 07/2011
GPCR Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits GPCR Signaling PathwayFinder PAHS-071 cAMP/PKA CCS-002L Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L Primary Cilia PAHS-127 PKC/Ca2+ CCS-015L Neurotransmitter Receptors Regulators PAHS-060 Wnt CCS-018L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 17
HIF1a Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Hypoxia Signaling Pathway PAHS-032 Hypoxia CCS-007L VEGF Signaling PAHS-091 ATF6 CCS-9031L Angiogenic Growth Factors and Inhibitors PAHS-072 Amino Acid Deprivation CCS-5034L Angiogenesis PAHS-024 PKC/Akt 18 www.qiagen.com CCS-1022L Pathway Map Reference Guide 07/2011
IL-6 Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 NFkB CCS-013L Chemokines and Receptors PAHS-022 Interferon g CCS-009L Common Cytokines PAHS-021 Interferon Regulation CCS-7040L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 19
Insulin Receptor Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Insulin Signaling Pathway PAHS-030 PI3K/Akt CCS-1022L Adipogenesis PAHS-049 PPAR CCS-3026L Notch Signaling Pathway PAHS-059 MAPK/ERK CCS-010L Alzheimer‘s Disease PAHS-056 MAPK/JNK CCS-011L 20 www.qiagen.com Pathway Map Reference Guide 07/2011
JAK/STAT Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits JAK/STAT Signaling Pathway PAHS-039 Type I Interferon CCS-008L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon g CCS-009L Interferon a, b Response PAHS-016 STAT3 CCS-9028L Stem Cell Transcription Factors PAHS-501 Interferon Regulation CCS-7040L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 21
LDL Oxidation in Atherogenesis Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Atherosclerosis PAHS-038 Liver X Receptor CCS-004L Lipoprotein and Cholesterol Signaling PAHS-080 PPAR CCS-3026L Endothelial Cell Biology PAHS-015 Hepatocyte NF CCS-3039L Diabetes PAHS-023 NFkB CCS-013L 22 www.qiagen.com Pathway Map Reference Guide 07/2011
MAP Kinase Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L PI3K-Akt Signaling Pathway PAHS-058 MAPK/ERK CCS-010L NFkB Signaling Pathway PAHS-025 PI3K/Akt CCS-1022L Signal Transduction PathwayFinder PAHS-014 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 23
Molecular Mechanisms of Cancer Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Cancer PathwayFinder PAHS-033 p53 CCS-004L Epithelial to Mesenchymal Transition PAHS-090 Cell Cycle CCS-003L EpiTect Methyl qPCR Arrays MeAH-### Wnt CCS-018L qBiomarker Somatic Mutation SMH-### Notch CCS-014L 24 www.qiagen.com Pathway Map Reference Guide 07/2011
NFkB Family Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits NFkB Signaling Pathway PAHS-025 NFkB CCS-013L Toll-like Receptor Signaling Pathway PAHS-018 MAPK/JNK CCS-011L TNF Ligands and Receptors PAHS-063 MAPK/ERK CCS-010L MAP Kinase Signaling Pathway PAHS-061 SP1 CCS-6027L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 25
Notch Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Notch Signaling Pathway PAHS-059 Notch CCS-014L Stem Cell Signaling PAHS-047 Wnt CCS-018L Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L WNT Signaling Pathway PAHS-043 EGR1 CCS-8021L 26 www.qiagen.com Pathway Map Reference Guide 07/2011
p38 Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L NFkB Signaling Pathway PAHS-025 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 Amino Acid Deprivation CCS-5034L Toll-like Receptor Signaling Pathway PAHS-018 NFkB Pathway Map Reference Guide 07/2011 Sample Assay Technologies CCS-013L 27
p53 Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits p53 Signaling Pathway PAHS-027 p53/DNA Damage CCS-004L Cell Cycle PAHS-020 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 SP1 CCS-6027L qBiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-5034L 28 www.qiagen.com Pathway Map Reference Guide 07/2011
PI3K Signaling in B-Lymphocyte Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits PI3K-Akt Signaling Pathway PAHS-058 PI3K/Akt CCS-1022L T-Cell and B-Cell Activation PAHS-053 MAPK/ERK CCS-010L mTOR Signaling PAHS-098 MAPK/JNK CCS-011L Dendritic and Antigen Presenting Cell PAHS-406 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 29
PPAR Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Adipogenesis PAHS-049 PPAR CCS-3026L Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L Fatty Acid Metabolism PAHS-007 Liver X Receptor CCS-041L Insulin Signaling Pathway PAHS-030 Antioxidant Response CCS-5020L 30 www.qiagen.com Pathway Map Reference Guide 07/2011
Ras Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Oncogenes Tumor Suppressor Genes PAHS-502 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L p53/DNA Damage CCS-004L RTK Panel II qBiomarker Somatic Mutation SMH-009 Pathway Map Reference Guide 07/2011 Sample Assay Technologies 31
Rho Family GTPases Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Cell Motility PAHS-128 PKC/Ca2+ CCS-015L Cytoskeleton Regulators PAHS-088 PI3K/Akt CCS-1022L Epithelial to Mesenchymal Transition PAHS-090 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L 32 www.qiagen.com Pathway Map Reference Guide 07/2011
SMAD Signaling Network Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L Stem Cell Signaling PAHS-047 Interferon g CCS-009L Growth Factors PAHS-041 EGR1 CCS-8021L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 33
TCR Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits T-Cell Anergy and Immune Tolerance PAHS-074 Interferon g CCS-009L T-Cell and B-Cell Activation PAHS-053 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L Dendritic and Antigen Presenting Cell PAHS-406 Notch CCS-014L 34 www.qiagen.com Pathway Map Reference Guide 07/2011
TGFb Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L Growth Factors PAHS-041 Interferon g CCS-009L Th17 for Autoimmunity and Inflammation PAHS-073 EGR1 CCS-8021L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 35
TNF Superfamily Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L NFkB Signaling Pathway PAHS-025 NFkB CCS-013L Common Cytokines PAHS-021 Interferon g CCS-009L Toll-like Receptor Signaling PAHS-018 Interferon Regulation CCS-7040L 36 www.qiagen.com Pathway Map Reference Guide 07/2011
Toll-like Receptors Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Toll-like Receptor Signaling PAHS-018 NFkB CCS-013L Inflammasomes PAHS-097 Type I Interferon CCS-008L Innate and Adaptive Immune Response PAHS-052 Interferon Regulation CCS-7040L Dendritic and Antigen Presenting Cell PAHS-406 STAT3 CCS-9028L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 37
Transcriptional Network in Embryonic Stem Cells Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Embryonic Stem Cells PAHS-081 Nanog CCS-7037L Stem Cell PAHS-405 Oct4 CCS-025L Terminal Differentiation Markers PAHS-048 Sox2 CCS-038L qBiomarker Screening and Validation IPHS-### KLF4 CCS-4036L 38 www.qiagen.com Pathway Map Reference Guide 07/2011
Ubiquitin-Proteasome–dependent Proteolysis Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Ubiquitination (Ubiquitinylation) PAHS-079 ATF6 CCS-9031L Autophagy PAHS-084 Cell Cycle CCS-003L Unfolded Protein Response PAHS-089 ER Stress CCS-2032L Chromatin Modification Enzymes PAHS-085 Antioxidant Response CCS-5020L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 39
VEGF Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Angiogenic Growth Factors Inhibitors PAHS-072 Hypoxia CCS-007L VEGF Signaling PAHS-091 PI3K/Akt CCS-1022L Angiogenesis PAHS-024 TGFb CCS-017L Growth Factors PAHS-041 SP1 CCS-6027L 40 www.qiagen.com Pathway Map Reference Guide 07/2011
Wnt Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Wnt Signaling Pathway PAHS-043 Wnt CCS-018L Hedgehog Signaling Pathway PAHS-078 Notch CCS-014L Stem Cell Signaling PAHS-047 Hedgehog CCS-6030L Notch Signaling Pathway PAHS-059 TGFb CCS-017L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 41
Top 60 RT2 Profiler PCR Arrays RT2 Profiler PCR Arrays Cat. no. RT2 Profiler PCR Arrays Cat. no. Angiogenesis Lipoprotein and Cholesterol Signaling PAXX-080 PAXX-012 MAP Kinase (MAPK) Signaling Pathway PAXX-061 Atherosclerosis PAXX-038 Mesenchymal Stem Cell PAXX-082 Autophagy PAXX-084 Mitochondria PAXX-087 Breast Cancer and ER Signaling PAXX-005 Mitochondrial Energy Metabolism PAXX-008 Cancer Drug Resistance Metabolism PAXX-004 Neurogenesis and Neural Stem Cell PAXX-404 Cancer PathwayFinder PAXX-033 Neurotransmitter Receptors Regulators PAXX-060 Cell Cycle PAXX-020 Neurotrophins and Receptors PAXX-031 Common Cytokines PAXX-022 NFκB Signaling Pathway PAXX-025 Cytoskeleton Regulators PAXX-021 Notch Signaling Pathway PAXX-059 Dendritic and Antigen Presenting Cell PAXX-088 Obesity PAXX-017 Diabetes PAXX-406 Oncogenes Tumor Suppressor Genes PAXX-502 DNA Damage Signaling Pathway PAXX-029 Osteogenesis PAXX-026 DNA Repair PAXX-042 Oxidative Stress Antioxidant Defense PAXX-065 Embryonic Stem Cell PAXX-047 p53 Signaling Pathway PAXX-027 Endothelial Cell Biology PAXX-015 PI3K-AKT Signaling Pathway PAXX-058 Epigenetic Chromatin Mod Enzymes PAXX-085 Signal Transduction PathwayFinder PAXX-014 Epithelial to Mesenchymal Transition PAXX-090 Stem Cell PAXX-405 ECM and Adhesion Molecules PAXX-013 Stress and Toxicity PathwayFinder PAXX-003 Fibrosis PAXX-020 T-Cell and B-Cell Activation PAXX-053 Glucose Metabolism PAXX-006 T-Cell Anergy and Immune Tolerance PAXX-074 Growth Factors PAXX-041 TGFβ BMP Signaling Pathway PAXX-035 Hedgehog Signaling Pathway PAXX-078 Th17 for Autoimmunity Inflammation PAXX-073 Hypoxia Signaling Pathway PAXX-032 Th1-Th2-Th3 PAXX-034 Inflammatory Cytokines and Receptors PAXX-011 Toll-like Receptor Signaling Pathway PAXX-018 Inflammatory Response Autoimmunity PAXX-077 Transcription Factors PAXX-075 Innate Adaptive Immune Responses PAXX-052 Tumor Metastasis PAXX-028 Insulin Signaling Pathway PAXX-030 Unfolded Protein Response PAXX-089 Interferon α, β Response PAXX-016 VEGF Signaling PAXX-091 JAK/STAT Signaling Pathway 42 PAXX-024 Apoptosis PAXX-039 Wnt Signaling Pathway PAXX-043 www.qiagen.com Pathway Map Reference Guide 07/2011
Cignal Reporter Assay Kits Pathway Trxn. Factor Pathway Trxn. Factor Amino Acid Deprivation ATF4/3/2 MAPK/ERK Elk-1/SRF Androgen Androgen MAPK/JNK A P-1 Antioxidant Response Nrf2/1 MEF2 MEF2 ATF6 ATF6 c-Myc Myc/Max C/EBP C/EBP Nanog Nanog cAMP/PKA CREB NFkB NFkB Cell Cycle E2F/DP1 Notch RBP-Jk p53/DNA Damage p53 Oct4 Oct4 EGR1 EGR1 Pax6 Pax6 ER Stress CBF/NF-Y/YY1 PI3K/AKT FOXO Estrogen Receptor ER PKC/Ca2+ NFAT GATA GATA PPAR PPAR Glucocorticoid Receptor GR Progesterone Receptor PR Heat Shock Response HSF Retinoic Acid Receptor RAR Heavy Metal Stress MTF1 Retinoid X Receptor RXR Hedgehog GLI Sox2 Sox2 Hepatocyte Nuclear Factor 4 HNF4 SP1 SP1 Hypoxia HIF-1 STAT3 STAT3 Interferon Regulatory Factor IRF1 TGFb SMAD2/3/4 Type I Interferon a, b STAT1/2 Vitamin D Receptor VDR Interferon g STAT1/1 Wnt TCF/LEF KLF4 KLF4 Xenobiotic AhR Liver X Receptor LXRa Multi-Pathway Arrays Multi-Pathway Arrays Signal Transduction 45-Pathway Nuclear Receptors 10-Pathway Cancer 10-Pathway Stress Toxicity 10-Pathway Immune Signaling 10-Pathway Stem Cell Differentiation 10-Pathway Development 10-Pathway * #XXXXXX) = SAP Number. (Note: The catalog numbers shown are incomplete. See page 3 for instruction.) ( Pathway Map Reference Guide 07/2011 Sample Assay Technologies 43
Use your smart phone to scan this QR code and access more pathway maps. www.facebook.com/pathwaycentral Australia n 1-800-243-800 Austria n 0800-281011 Belgium n 0800-79612 Brazil n 0800-557779 Canada n 800-572-9613 China n 800-988-0325 Denmark n 80-885945 Finland n 0800-914416 France n 01-60-920-926 1069328 07/2011 Germany n 02103-29-12000 Hong Kong n 800 933 965 India n 1-800-102-4114 Ireland n 1800 555 049 Italy n 800 787980 Japan n 03-6890-7300 Korea (South) n 080-000-7145 Luxembourg n 8002 2076 Mexico n 01-800-7742-436 Netherlands n 0800-229592 Norway n 800-18859 Singapore n 1800-742-4368 Spain n 91-630-7050 Sweden n 020-790282 Switzerland n 055-254-22-11 UK n 01293-422-911 USA n 800-426-8157 www.qiagen.com Sample Assay Technologies

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Pathway map-reference-guide

  • 1. Pathway Map Reference Guide Attention-grabber Focus on Your Pathway The most popular cell signaling pathways Sample & Assay Technologies
  • 2. Table of contents AKT Signaling 4 Molecular Mechanisms of Cancer 24 cAMP Signaling 5 NFkB Family 25 Cellular Apoptosis 6 Notch Signaling 26 Chemokine Signaling 7 p38 Signaling 27 Cyclins and Cell Cycle Regulation 8 p53 Signaling 28 Cytokine Network 9 PI3K Signaling 29 DNA Repair Mechanisms 10 PPAR 30 EGF 11 Ras 31 Epithelial Tight Junctions 12 Rho Family GTPases 32 ErbB Family 13 SMAD Signaling Network 33 ERK Signaling 14 TCR Signaling 34 Estrogen 15 TGFb 35 Glucocorticoid Receptor Signaling 16 TNF Superfamily 36 GPCR 17 Toll-like Receptors 37 HIF1a 18 Transcriptional Network in IL-6 19 Embryonic Stem Cells Insulin Receptor 20 Ubiquitin-Proteasome– JAK/STAT 21 dependent Proteolysis 39 LDL Oxidation in Atherogenesis 22 VEGF 40 MAP Kinase Signaling 23 Wnt Signaling 41 Product listing 42 38 For up-to-date licensing information and product-specific disclaimers, see the respective QIAGEN kit handbook or user manual. QIAGEN kit handbooks and user manuals are available at www.qiagen.com or can be requested from QIAGEN Technical Services or your local distributor. Trademarks: QIAGEN®, EpiTect® (QIAGEN Group); PowerPoint® (Microsoft Corporation). Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are not be considered unprotected by law. The products featured in the guide are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease. © 2011 QIAGEN, all rights reserved 2 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 3. The Pathway Map Reference Guide This guide illustrates important signaling pathways with their related RT2 Profiler PCR Arrays and Cignal Reporter Assay Kits. To view the entire list of 500 pathway maps, editable PowerPoint® slides, and related QIAGEN products, visit: www.qiagen.com/pathway-central Disclaimer: We acknowledge Protein Lounge, Inc. as the source of the Pathway Maps. Any questions or comments regarding the validity or accuracy of the pathway maps should be directed to Protein Lounge, Inc. directly. Product information RT2 Profiler PCR Arrays RT2 Profiler PCR Arrays enable the analysis of key genes for a biological pathway or disease state using real-time PCR in 2 hours. RT2 Profiler PCR Arrays are available for all real-time PCR instruments. Associated pathway PCR arrays related to the top 50 pathways are provided in this guide. An example of a complete PCR array identifier catalog number is shown below: PAXX-###Y-# XX = species ### = unique pathway identifier Y = plate format # = pack size To view the entire list of available RT2 Profiler PCR Arrays, visit: www.qiagen.com/array-list Cignal Reporter Assay Kits Cignal Reporter Assay Kits provide a rapid, sensitive, and quantitative assessment of over 45 signal transduction pathways by measuring the activities of downstream transcription factors. GFP and luciferase reporter systems are available. For a complete list of Cignal Reporter Assay Kits, visit: www.qiagen.com/reporter-assays Pathway Map Reference Guide 07/2011 Sample Assay Technologies 3
  • 4. Akt Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits PI3K-Akt Signaling Pathway PI3K/Akt CCS-1022L mTOR Signaling PAHS-098 MAPK/ERK CCS-010L Oncogenes Tumor Suppressor Genes PAHS-502 MAPK/JNK CCS-011L MAP Kinase Signaling Pathway 4 PAHS-058 PAHS-61 NFkB CCS-013L www.qiagen.com Pathway Map Reference Guide 07/2011
  • 5. cAMP Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits cAMP/Ca2+ Signaling PathwayFinder PAHS-066 cAMP/PKA p53 Signaling Pathway PAHS-027 Amino Acid Deprivation CCS-5034L Synaptic Plasticity PAHS-126 PKC/Ca2+ CCS-015L MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L Pathway Map Reference Guide 07/2011 Sample Assay Technologies CCS-002L 5
  • 6. Cellular Apoptosis Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Apoptosis p53/DNA Damage CCS-004L p53 Signaling Pathway PAHS-027 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 ATF6 CCS-9031L Autophagy 6 PAHS-012 PAHS-084 PI3K/Akt CCS-1022L www.qiagen.com Pathway Map Reference Guide 07/2011
  • 7. Chemokine Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Chemokines Receptors PAHS-022 NFkB CCS-013L NFkB Signaling Pathway PAHS-025 MAPK/JNK CCS-011L Toll-like Receptor Signaling Pathway PAHS-018 MAPK/ERK CCS-010L MAP Kinase Signaling Pathway PAHS-061 Type I Interferon CCS-008L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 7
  • 8. Cyclins and Cell Cycle Regulation Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Cell Cycle Cell Cycle CCS-003L p53 Signaling Pathway PAHS-027 p53/DNA Damage CCS-004L DNA Damage Signaling Pathway PAHS-029 PI3K/Akt CCS-1022L Cellular Senescence 8 PAHS-020 PAHS-050 Wnt CCS-018L www.qiagen.com Pathway Map Reference Guide 07/2011
  • 9. Cytokine Network Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Common Cytokines PAHS-021 Interferon g CCS-009L Chemokines Receptors PAHS-022 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L Interferon a, b Response PAHS-016 Type I Interferon CCS-008L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 9
  • 10. DNA Repair Mechanisms Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits DNA Repair PAHS-042 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 p53/DNA Damage CCS-004L Telomeres and Telomerase PAHS-010 Hedgehog CCS-6030L qBiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-5034L 10 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 11. EGF Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L Growth Factors PAHS-041 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGFR qBiomarker Somatic Mutation SMH-001 Estrogen Receptor CCS-005L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 11
  • 12. Epithelial Tight Junctions Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Epithelial to Mesenchymal Transition PAHS-090 PKC/Ca2+ CCS-015L Endothelial Cell Biology PAHS-015 MAPK/ERK CCS-010L Primary Cilia PAHS-127 SP1 CCS-6027L Amino Acid Metabolism II PAHS-130 MAPK/JNK CCS-004L 12 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 13. ErbB Family Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits EGF/PDGF Signaling Pathway PAHS-040 Estrogen Receptor CCS-005L PI3K-Akt Signaling Pathway PAHS-058 Progesterone CCS-6043L Breast Cancer PAHS-131 PI3K/Akt CCS-1022L ErbB2 qBiomarker Somatic Mutation SMH-002 MAPK/ERK CCS-010L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 13
  • 14. ERK Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L NFkB Signaling Pathway PAHS-025 NFkB CCS-013L 14 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 15. Estrogen Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Breast Cancer and ER Signaling PAHS-005 Estrogen Receptor CCS-005L Breast Cancer PAHS-131 Progesterone CCS-6043L Nuclear Receptors and Coregulators PAHS-056 Androgen CCS-1019L EGF/PDGF Signaling Pathway PAHS-040 C/EBP CCS-001L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 15
  • 16. Glucocorticoid Receptor Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Inflammatory Cytokines and Receptors PAHS-011 Glucocorticoid Receptor CCS-006L Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L Neutrophins Receptors PAHS-031 VDRE CCS-2029L Stress Response to Cellular Damage PAHS-019 Androgen CCS-1019L 16 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 17. GPCR Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits GPCR Signaling PathwayFinder PAHS-071 cAMP/PKA CCS-002L Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L Primary Cilia PAHS-127 PKC/Ca2+ CCS-015L Neurotransmitter Receptors Regulators PAHS-060 Wnt CCS-018L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 17
  • 18. HIF1a Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Hypoxia Signaling Pathway PAHS-032 Hypoxia CCS-007L VEGF Signaling PAHS-091 ATF6 CCS-9031L Angiogenic Growth Factors and Inhibitors PAHS-072 Amino Acid Deprivation CCS-5034L Angiogenesis PAHS-024 PKC/Akt 18 www.qiagen.com CCS-1022L Pathway Map Reference Guide 07/2011
  • 19. IL-6 Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 NFkB CCS-013L Chemokines and Receptors PAHS-022 Interferon g CCS-009L Common Cytokines PAHS-021 Interferon Regulation CCS-7040L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 19
  • 20. Insulin Receptor Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Insulin Signaling Pathway PAHS-030 PI3K/Akt CCS-1022L Adipogenesis PAHS-049 PPAR CCS-3026L Notch Signaling Pathway PAHS-059 MAPK/ERK CCS-010L Alzheimer‘s Disease PAHS-056 MAPK/JNK CCS-011L 20 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 21. JAK/STAT Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits JAK/STAT Signaling Pathway PAHS-039 Type I Interferon CCS-008L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon g CCS-009L Interferon a, b Response PAHS-016 STAT3 CCS-9028L Stem Cell Transcription Factors PAHS-501 Interferon Regulation CCS-7040L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 21
  • 22. LDL Oxidation in Atherogenesis Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Atherosclerosis PAHS-038 Liver X Receptor CCS-004L Lipoprotein and Cholesterol Signaling PAHS-080 PPAR CCS-3026L Endothelial Cell Biology PAHS-015 Hepatocyte NF CCS-3039L Diabetes PAHS-023 NFkB CCS-013L 22 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 23. MAP Kinase Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L PI3K-Akt Signaling Pathway PAHS-058 MAPK/ERK CCS-010L NFkB Signaling Pathway PAHS-025 PI3K/Akt CCS-1022L Signal Transduction PathwayFinder PAHS-014 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 23
  • 24. Molecular Mechanisms of Cancer Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Cancer PathwayFinder PAHS-033 p53 CCS-004L Epithelial to Mesenchymal Transition PAHS-090 Cell Cycle CCS-003L EpiTect Methyl qPCR Arrays MeAH-### Wnt CCS-018L qBiomarker Somatic Mutation SMH-### Notch CCS-014L 24 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 25. NFkB Family Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits NFkB Signaling Pathway PAHS-025 NFkB CCS-013L Toll-like Receptor Signaling Pathway PAHS-018 MAPK/JNK CCS-011L TNF Ligands and Receptors PAHS-063 MAPK/ERK CCS-010L MAP Kinase Signaling Pathway PAHS-061 SP1 CCS-6027L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 25
  • 26. Notch Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Notch Signaling Pathway PAHS-059 Notch CCS-014L Stem Cell Signaling PAHS-047 Wnt CCS-018L Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L WNT Signaling Pathway PAHS-043 EGR1 CCS-8021L 26 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 27. p38 Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L NFkB Signaling Pathway PAHS-025 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 Amino Acid Deprivation CCS-5034L Toll-like Receptor Signaling Pathway PAHS-018 NFkB Pathway Map Reference Guide 07/2011 Sample Assay Technologies CCS-013L 27
  • 28. p53 Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits p53 Signaling Pathway PAHS-027 p53/DNA Damage CCS-004L Cell Cycle PAHS-020 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 SP1 CCS-6027L qBiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-5034L 28 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 29. PI3K Signaling in B-Lymphocyte Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits PI3K-Akt Signaling Pathway PAHS-058 PI3K/Akt CCS-1022L T-Cell and B-Cell Activation PAHS-053 MAPK/ERK CCS-010L mTOR Signaling PAHS-098 MAPK/JNK CCS-011L Dendritic and Antigen Presenting Cell PAHS-406 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 29
  • 30. PPAR Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Adipogenesis PAHS-049 PPAR CCS-3026L Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L Fatty Acid Metabolism PAHS-007 Liver X Receptor CCS-041L Insulin Signaling Pathway PAHS-030 Antioxidant Response CCS-5020L 30 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 31. Ras Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Oncogenes Tumor Suppressor Genes PAHS-502 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L p53/DNA Damage CCS-004L RTK Panel II qBiomarker Somatic Mutation SMH-009 Pathway Map Reference Guide 07/2011 Sample Assay Technologies 31
  • 32. Rho Family GTPases Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Cell Motility PAHS-128 PKC/Ca2+ CCS-015L Cytoskeleton Regulators PAHS-088 PI3K/Akt CCS-1022L Epithelial to Mesenchymal Transition PAHS-090 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L 32 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 33. SMAD Signaling Network Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L Stem Cell Signaling PAHS-047 Interferon g CCS-009L Growth Factors PAHS-041 EGR1 CCS-8021L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 33
  • 34. TCR Signaling Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits T-Cell Anergy and Immune Tolerance PAHS-074 Interferon g CCS-009L T-Cell and B-Cell Activation PAHS-053 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L Dendritic and Antigen Presenting Cell PAHS-406 Notch CCS-014L 34 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 35. TGFb Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L Growth Factors PAHS-041 Interferon g CCS-009L Th17 for Autoimmunity and Inflammation PAHS-073 EGR1 CCS-8021L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 35
  • 36. TNF Superfamily Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L NFkB Signaling Pathway PAHS-025 NFkB CCS-013L Common Cytokines PAHS-021 Interferon g CCS-009L Toll-like Receptor Signaling PAHS-018 Interferon Regulation CCS-7040L 36 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 37. Toll-like Receptors Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Toll-like Receptor Signaling PAHS-018 NFkB CCS-013L Inflammasomes PAHS-097 Type I Interferon CCS-008L Innate and Adaptive Immune Response PAHS-052 Interferon Regulation CCS-7040L Dendritic and Antigen Presenting Cell PAHS-406 STAT3 CCS-9028L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 37
  • 38. Transcriptional Network in Embryonic Stem Cells Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Embryonic Stem Cells PAHS-081 Nanog CCS-7037L Stem Cell PAHS-405 Oct4 CCS-025L Terminal Differentiation Markers PAHS-048 Sox2 CCS-038L qBiomarker Screening and Validation IPHS-### KLF4 CCS-4036L 38 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 39. Ubiquitin-Proteasome–dependent Proteolysis Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Ubiquitination (Ubiquitinylation) PAHS-079 ATF6 CCS-9031L Autophagy PAHS-084 Cell Cycle CCS-003L Unfolded Protein Response PAHS-089 ER Stress CCS-2032L Chromatin Modification Enzymes PAHS-085 Antioxidant Response CCS-5020L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 39
  • 40. VEGF Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Angiogenic Growth Factors Inhibitors PAHS-072 Hypoxia CCS-007L VEGF Signaling PAHS-091 PI3K/Akt CCS-1022L Angiogenesis PAHS-024 TGFb CCS-017L Growth Factors PAHS-041 SP1 CCS-6027L 40 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 41. Wnt Related products RT2 Profiler PCR Arrays Cignal Reporter Assay Kits Wnt Signaling Pathway PAHS-043 Wnt CCS-018L Hedgehog Signaling Pathway PAHS-078 Notch CCS-014L Stem Cell Signaling PAHS-047 Hedgehog CCS-6030L Notch Signaling Pathway PAHS-059 TGFb CCS-017L Pathway Map Reference Guide 07/2011 Sample Assay Technologies 41
  • 42. Top 60 RT2 Profiler PCR Arrays RT2 Profiler PCR Arrays Cat. no. RT2 Profiler PCR Arrays Cat. no. Angiogenesis Lipoprotein and Cholesterol Signaling PAXX-080 PAXX-012 MAP Kinase (MAPK) Signaling Pathway PAXX-061 Atherosclerosis PAXX-038 Mesenchymal Stem Cell PAXX-082 Autophagy PAXX-084 Mitochondria PAXX-087 Breast Cancer and ER Signaling PAXX-005 Mitochondrial Energy Metabolism PAXX-008 Cancer Drug Resistance Metabolism PAXX-004 Neurogenesis and Neural Stem Cell PAXX-404 Cancer PathwayFinder PAXX-033 Neurotransmitter Receptors Regulators PAXX-060 Cell Cycle PAXX-020 Neurotrophins and Receptors PAXX-031 Common Cytokines PAXX-022 NFκB Signaling Pathway PAXX-025 Cytoskeleton Regulators PAXX-021 Notch Signaling Pathway PAXX-059 Dendritic and Antigen Presenting Cell PAXX-088 Obesity PAXX-017 Diabetes PAXX-406 Oncogenes Tumor Suppressor Genes PAXX-502 DNA Damage Signaling Pathway PAXX-029 Osteogenesis PAXX-026 DNA Repair PAXX-042 Oxidative Stress Antioxidant Defense PAXX-065 Embryonic Stem Cell PAXX-047 p53 Signaling Pathway PAXX-027 Endothelial Cell Biology PAXX-015 PI3K-AKT Signaling Pathway PAXX-058 Epigenetic Chromatin Mod Enzymes PAXX-085 Signal Transduction PathwayFinder PAXX-014 Epithelial to Mesenchymal Transition PAXX-090 Stem Cell PAXX-405 ECM and Adhesion Molecules PAXX-013 Stress and Toxicity PathwayFinder PAXX-003 Fibrosis PAXX-020 T-Cell and B-Cell Activation PAXX-053 Glucose Metabolism PAXX-006 T-Cell Anergy and Immune Tolerance PAXX-074 Growth Factors PAXX-041 TGFβ BMP Signaling Pathway PAXX-035 Hedgehog Signaling Pathway PAXX-078 Th17 for Autoimmunity Inflammation PAXX-073 Hypoxia Signaling Pathway PAXX-032 Th1-Th2-Th3 PAXX-034 Inflammatory Cytokines and Receptors PAXX-011 Toll-like Receptor Signaling Pathway PAXX-018 Inflammatory Response Autoimmunity PAXX-077 Transcription Factors PAXX-075 Innate Adaptive Immune Responses PAXX-052 Tumor Metastasis PAXX-028 Insulin Signaling Pathway PAXX-030 Unfolded Protein Response PAXX-089 Interferon α, β Response PAXX-016 VEGF Signaling PAXX-091 JAK/STAT Signaling Pathway 42 PAXX-024 Apoptosis PAXX-039 Wnt Signaling Pathway PAXX-043 www.qiagen.com Pathway Map Reference Guide 07/2011
  • 43. Cignal Reporter Assay Kits Pathway Trxn. Factor Pathway Trxn. Factor Amino Acid Deprivation ATF4/3/2 MAPK/ERK Elk-1/SRF Androgen Androgen MAPK/JNK A P-1 Antioxidant Response Nrf2/1 MEF2 MEF2 ATF6 ATF6 c-Myc Myc/Max C/EBP C/EBP Nanog Nanog cAMP/PKA CREB NFkB NFkB Cell Cycle E2F/DP1 Notch RBP-Jk p53/DNA Damage p53 Oct4 Oct4 EGR1 EGR1 Pax6 Pax6 ER Stress CBF/NF-Y/YY1 PI3K/AKT FOXO Estrogen Receptor ER PKC/Ca2+ NFAT GATA GATA PPAR PPAR Glucocorticoid Receptor GR Progesterone Receptor PR Heat Shock Response HSF Retinoic Acid Receptor RAR Heavy Metal Stress MTF1 Retinoid X Receptor RXR Hedgehog GLI Sox2 Sox2 Hepatocyte Nuclear Factor 4 HNF4 SP1 SP1 Hypoxia HIF-1 STAT3 STAT3 Interferon Regulatory Factor IRF1 TGFb SMAD2/3/4 Type I Interferon a, b STAT1/2 Vitamin D Receptor VDR Interferon g STAT1/1 Wnt TCF/LEF KLF4 KLF4 Xenobiotic AhR Liver X Receptor LXRa Multi-Pathway Arrays Multi-Pathway Arrays Signal Transduction 45-Pathway Nuclear Receptors 10-Pathway Cancer 10-Pathway Stress Toxicity 10-Pathway Immune Signaling 10-Pathway Stem Cell Differentiation 10-Pathway Development 10-Pathway * #XXXXXX) = SAP Number. (Note: The catalog numbers shown are incomplete. See page 3 for instruction.) ( Pathway Map Reference Guide 07/2011 Sample Assay Technologies 43
  • 44. Use your smart phone to scan this QR code and access more pathway maps. www.facebook.com/pathwaycentral Australia n 1-800-243-800 Austria n 0800-281011 Belgium n 0800-79612 Brazil n 0800-557779 Canada n 800-572-9613 China n 800-988-0325 Denmark n 80-885945 Finland n 0800-914416 France n 01-60-920-926 1069328 07/2011 Germany n 02103-29-12000 Hong Kong n 800 933 965 India n 1-800-102-4114 Ireland n 1800 555 049 Italy n 800 787980 Japan n 03-6890-7300 Korea (South) n 080-000-7145 Luxembourg n 8002 2076 Mexico n 01-800-7742-436 Netherlands n 0800-229592 Norway n 800-18859 Singapore n 1800-742-4368 Spain n 91-630-7050 Sweden n 020-790282 Switzerland n 055-254-22-11 UK n 01293-422-911 USA n 800-426-8157 www.qiagen.com Sample Assay Technologies