Talk given to Burroughs Wellcome Fund - with Antony J Williams.

1. Open Science Landscape: One Future for Scientific Research? Sean Ekins, Ph.D., D.Sc. Collaborations in Chemistry, Fuquay-Varina, NC. Antony J. Williams, Ph.D., Royal Society of Chemistry, Wake Forest, NC. Slides for Burroughs Wellcome Foundation

4. Major collaborative grants in EU: Framework, IMI …NIH moving in same direction Cross continent collaboration CROs in China, India etc – Pharma’s in US / Europe More industry – academia collaboration and ‘not invented here’ a thing of the past More effort to go after rare and neglected diseases -Globalization and connectivity of scientists will be key – Current pace of change in pharma may not be enough. Need to rethink how we use all technologies & resources… Collaboration and Openness is Key

5. Data, Models and Software Becoming More Accessible- Free, Precompetitive and Open Efforts - Collaboration

6. Could All Pharmas Share Their Data?

9. Government Databases Should Come With a Health Warning Openness Can Bring Serious Quality Issues NPC Browser http://tripod.nih.gov/npc/ Database released and within days 100’s of errors found in structures Williams and Ekins, DDT, 16: 747-750 (2011) Science Translational Medicine 2011

11. Example of Social Collaboration in Science: Tweets, Blog Lead to The Green Solvents App Sean attends seminar on solvent selection guide Sean tweets during talk Mobile App developer Alex Clark responds to twitter and along with Sean Ekins, Antony Williams start an email discussion about Green Chemistry apps Sean blogs. 3 days later an App is created By Alex

13. Open Algorithms, Descriptors, Closed Data – Can We Unlock It? Gupta RR, et al., Drug Metab Dispos, 38: 2083-2090, 2010

14. Pfizer Merck GSK Novartis Lilly BMS Could combining models give greater coverage of ADME/ Tox chemistry space and improve predictions? Lundbeck Allergan Bayer AZ Roche BI Merk KGaA What Will It Take For Companies, Academics, Government Labs To Realize They Could Gain More By Sharing More?

15. Inside Company Collaborators Inside Academia Collaborators Molecules, Models, Data Molecules, Models, Data Inside Foundation Collaborators Molecules, Models, Data Inside Government Collaborators Molecules, Models, Data IP IP IP IP Shared IP Collaborative platform/s Bunin & Ekins DDT 16: 643-645, 2011 A Complex Ecosystem Of Collaborations: A New Business Model

16. 2020: A Drug Discovery Odyssey Could our Pharma R&D look like this Massive collaboration networks – software enabled. We are in “Generation App”. Crowdsourcing will have a role in R&D. Drug discovery possible by anyone with “app access” Ekins & Williams, Pharm Res, 27: 393-395, 2010.

17. Mobile Apps for Drug Discovery: Could They Facilitate Open Science? Williams et al DDT in press 2011 What if anyone could do the same to practice open science?

20. Thank You Email: ekinssean@yahoo.com Twitter: collabchem Blog: http://www.collabchem.com/ Slideshare: http://www.slideshare.net/ekinssean Email: williamsa@rsc.org Twitter: ChemConnector Blog: www.chemconnector.com Slideshare: www.slideshare.net/AntonyWilliams Many thanks to our collaborators In the long history of human kind (and animal kind, too) those who have learned to collaborate and improvise most effectively have prevailed. Charles Darwin