Received First Prize at the ASCICON 2009 on competitive Platform Presentation.

1. A STUDY ON PREVALENCE OF MICROVASCULAR COMPLICATIONS IN PATIENTS WITH NEWLY DETECTED DIABETES MELLITUS Dr. Tanoy Bose Laskar B, Bora w rejaMd, Dutta a Assam Medical College Dibrugarh

2. Introduction: The Devastating Trio: ◙ Neuropathy ◙ Nephropathy ◙ Retinopathy ↑ Glucose + ↓ Insulin: The driving forces Htn, Obesity, Dyslipidemia, Smoking: Accelerators Despite good long-term glycemic and BP control, diabetes remains a major cause of blindness, renal failure and amputations, all of which result in significant health care expenditure.

3. Objective: Determine the prevalence of microvascular complications in patients with newly diagnosed Diabetes Mellitus.

5. Hepatic disorders, CKD, Acute infections, Trauma, Burns, AMI, Malignancy, Leprosy, Diphtheria, B1B6B12 deficiency

6. Conditions altering urinary albumin excretion e.g UTI, CHF, Drugs

7. Drugs altering OGTT e.g Steroids, Quinine, OCP, Salicylates etc.

9. Summary of Results: [n=90] 95.56% cases = Type 2 DM Mean age of detection of DM = 45.21y MC complication: Distal Sym Sensory Per Neuropathy ( 56.66%) f/b Nephropathy (36.66%) & Retinopathy (20%) MC isolated complication: Neuropathy (23.33%) Prevalence of Triopathy : 15.55% 90.9% were asymptomatic for nephropathy as were 70.58% for neuropathy.

10. Summary of Results continued:[n=90] Aged ≥ 50 years 78.12% of neuropathy cases 50% of nephropathy cases 37.5 % of retinopathy cases Comorbidities: [Out of 54 Htnsives ( 60%) ] 61.11% had neuropathy (vs 47.22% in normo) 38.88% had retinopathy (vs 11.11% in normo) 37.03% had nephropathy (vs 11.11% in normo) Comorbidities: [BMI] 84.6% had neuropathy among cases with BMI≥25 vs 43.47% among those with BMI ≤24.9.

11. Conclusions: Prevalence of microvascular complications in newly detected DM is significantly alarming. Distal symmetrical sensory neuropathy is the most prevalent complication both in combination as well as in isolation. Increasing age, Hypertension and higher BMI contributes to the prevalence of microvascular complications significantly.

12. Take home message: Almost half of the battle is lost to the microvascular complications when Type 2 DM is diagnosed for the first time. Early detection, risk stratification and addressing the co morbidities remain the mainstay of controlling diabetic microvasculopathy and related morbidities.

13. Thank you