This document outlines the approach to evaluating and treating cholestasis in infants. It describes the etiologies of conjugated hyperbilirubinemia as either extrahepatic or intrahepatic in origin. Extrahepatic causes include biliary atresia and other biliary obstructions, while intrahepatic causes include idiopathic neonatal hepatitis, metabolic disorders, and genetic syndromes. The evaluation involves assessing the history, physical exam, liver function tests, imaging, and considering specific treatments depending on the underlying diagnosis.