Fibrinolytic agents

FIBRINOLYTICS [THROMBOLYTICS] DR.SOMASHEKARA.S.C DEPARTMENT OF PHARMACOLOGY SVS MEDICAL COLLEGE

FIBRINOLYTIC AGENTS 1. Streptokinase, Anistrplase 2. Tissue plasminogen activator (t-PA) Alteplase, Reteplase, Tenecteplase. 3. Urokinase

[object Object],[object Object],[object Object],[object Object],[object Object],STREPTOKINASE STREPTOKINASE Streptokinase Streptokinase

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Streptokinase

Anistreplase ,[object Object],[object Object],[object Object]

Urokinase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

tissue Plasminogen activator (t-PA)

Tissue plasminogen activator (t-PA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tissue plasminogen activator (t-PA) ,[object Object],[object Object],[object Object],[object Object]

USES OF FIBRINOLYTICS ,[object Object],[object Object],[object Object],[object Object]

Hemorrhagic toxicity ,[object Object],[object Object],[object Object],If heparin used concurrently  bleeding 2-4% intracranial hemorrhage (most serious)

Contraindications to thrombolytics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fibrinolytic therapy ,[object Object],[object Object],[object Object],[object Object]

Antifibrinolytic drugs Aminocaproic acid Tranexamic acid Aprotinin

Epsilon Aminocaproic acid Lysine analog MOA: acts by combining with lysine binding sites of plasminogen & plasmin, and prevents the binding of these to fibrin – prevents its lysis Specific antidote for fibrinolytic agents Dose: Initial priming dose 5gm oral/i.v…. 1g hrly till bleeding stops(max.30g in 24hrs)

ANTIFIBRINOLYTICS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fibrinolytic agents

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Fibrinolytic agents